Effects of cyclization on stability, structure, and activity of α-conotoxin RgIA at the α9α10 nicotinic acetylcholine receptor and GABA B receptor

Journal of Medicinal Chemistry

Volumn 54, Issue 19, 2011, Pages 6984-6992

  Halai, Reena ^a   Callaghan, Brid ^a,b   Daly, Norelle L ^a   Clark, Richard J ^a   Adams, David J ^a,b   Craik, David J ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b RMIT UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID B RECEPTOR; ALPHA 9 ALPHA 10 NICOTINIC ACETYLCHOLINE RECEPTOR; ALPHA CONOTOXIN RGIA; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BLOOD ANALYSIS; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CYCLIZATION; DRUG ACTIVITY; DRUG SELECTIVITY; DRUG STABILITY;

AMINO ACID SEQUENCE; ANIMALS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, N-TYPE; CONOTOXINS; CYCLIZATION; DRUG STABILITY; FEMALE; GANGLIA, SPINAL; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NEURONS; OOCYTES; PEPTIDES, CYCLIC; PROTEIN CONFORMATION; PROTEIN FOLDING; RATS; RATS, WISTAR; RECEPTORS, GABA-A; RECEPTORS, NICOTINIC; SERUM; XENOPUS;

EID: 80053923631     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm201060r     Document Type: Article

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