Abieslactone induces cell cycle arrest and apoptosis in human hepatocellular carcinomas through the mitochondrial pathway and the generation of reactive oxygen species

PLoS ONE

Volumn 9, Issue 12, 2014, Pages

  Wang, Guo Wei ^a   Lv, Chao ^b,c   Shi, Zhi Ran ^b   Zeng, Ren Tao ^b   Dong, Xue Yun ^c   Zhang, Wei Dong ^a,b   Liu, Run Hui ^b   Shan, Lei ^b   Shen, Yun Heng ^b  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

^c FUJIAN UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ABIESLACTONE; CASPASE 3; CASPASE 9; CYCLIN D1; CYCLIN DEPENDENT KINASE 2; CYTOCHROME C; DOXORUBICIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN P21; PROTEIN P53; REACTIVE OXYGEN METABOLITE; CASPASE; LACTONE; TRITERPENE;

ABIES; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FLOW CYTOMETRY; G1 PHASE CELL CYCLE CHECKPOINT; HEPATOCELLULAR CARCINOMA CELL LINE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; INTRACELLULAR SIGNALING; LIVER CELL CARCINOMA; MEMBRANE DEPOLARIZATION; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN SECRETION; UPREGULATION; WESTERN BLOTTING; BIOSYNTHESIS; CARCINOMA, HEPATOCELLULAR; CELL CYCLE CHECKPOINT; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HEPG2 CELL LINE; LIVER NEOPLASMS; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION;

ABIES;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CARCINOMA, HEPATOCELLULAR; CASPASES; CELL CYCLE CHECKPOINTS; GENE EXPRESSION REGULATION, NEOPLASTIC; HEP G2 CELLS; HUMANS; LACTONES; LIVER NEOPLASMS; MITOCHONDRIA; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TRITERPENES;

EID: 84917741284     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0115151     Document Type: Article

References (45)

1. Llovet JM, Burroughs A, Bruix J (2003) Hepatocellular carcinoma. Lancet 362: 1907-1917.
2. Breitenstein S, Apestegui C, Petrowsky H, Clavien PA (2009) "State of the art" in liver resection and living donor liver transplantation: a worldwide survey of 100 liver centers. World J Surg 33: 797-803.
3. Zender L, Spector MS, Xue W, Flemming P, Cordon-Cardo C, et al. (2006) Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. Cell 125: 1253-1267.
4. Ghobrial IM, Witzig TE, Adjei AA (2005) Targeting apoptosis pathways in cancer therapy. CA Cancer J Clin 55: 178-194.
5. Reed JC (2001) Apoptosis-regulating proteins as targets for drug discovery. Trends Mol Med 7: 314-319.
6. Budihardjo I, Oliver H, Lutter M, Luo X, Wang X (1999) Biochemical pathways of caspase activation during apoptosis. Annu Rev Cell Dev Biol 15: 269-290.
7. Zhang Y, Bao YL, Wu Y, Yu CL, Huang YX, et al. (2013) Alantolactone induces apoptosis in RKO cells through the generation of reactive oxygen species and the mitochondrial pathway. Mol Med Rep 8: 967-972.
8. Walensky LD, Gavathiotis E (2011) BAX unleashed: the biochemical transformation of an inactive cytosolic monomer into a toxic mitochondrial pore. Trends Biochem Sci 36: 642-652.
9. Czabotar PE, Colman PM, Huang DC (2009) Bax activation by Bim? Cell Death Differ 16: 1187-1191.
10. Dejean LM, Martinez-Caballero S, Guo L, Hughes C, Teijido O, et al. (2005) Oligomeric Bax is a component of the putative cytochrome c release channel MAC, mitochondrial apoptosis-induced channel. Mol Biol Cell 16: 2424-2432.
11. Chatterjee S, Kundu S, Bhattacharyya A (2008) Mechanism of cadmium induced apoptosis in the immunocyte. Toxicol Lett 177: 83-89.
12. Pathak N, Khandelwal S (2007) Role of oxidative stress and apoptosis in cadmium induced thymic atrophy and splenomegaly in mice. Toxicol Lett 169: 95-108.
13. Trachootham D, Alexandre J, Huang P (2009) Targeting cancer cells by ROS mediated mechanisms: a radical therapeutic approach? Nat Rev Drug Discov 8: 579-591.
14. Deavall DG, Martin EA, Horner JM, Roberts R (2012) Drug-induced oxidative stress and toxicity. J Toxicol 2012: 645460.
15. Martindale JL, Holbrook NJ (2002) Cellular response to oxidative stress: signaling for suicide and survival. J Cell Physiol 192: 1-15.
16. D'Alessio M, De Nicola M, Coppola S, Gualandi G, Pugliese L, et al. (2005) Oxidative Bax dimerization promotes its translocation to mitochondria independently of apoptosis. FASEB J 19: 1504-1506.
17. Oh SH, Lee BH, Lim SC (2004) Cadmium induces apoptotic cell death in WI 38 cells via caspase-dependent Bid cleavage and calpain-mediated mitochondrial Bax cleavage by Bcl-2-independent pathway. Biochem Pharmacol 68: 1845-1855.
18. Jungas T, Motta I, Duffieux F, Fanen P, Stoven V, et al. (2002) Glutathione levels and BAX activation during apoptosis due to oxidative stress in cells expressing wild-type and mutant cystic fibrosis transmembrane conductance regulator. J Biol Chem 277: 27912-27918.
19. Hanawa N, Shinohara M, Saberi B, Gaarde WA, Han D, et al. (2008) Role of JNK translocation to mitochondria leading to inhibition of mitochondria bioenergetics in acetaminophen-induced liver injury. J Biol Chem 283: 13565-13577.
20. Gong K, Li W (2011) Shikonin, a Chinese plant-derived naphthoquinone, induces apoptosis in hepatocellular carcinoma cells through reactive oxygen species: A potential new treatment for hepatocellular carcinoma. Free Radic Biol Med 51: 2259-2271.
21. Liu C, Gong K, Mao X, Li W (2011) Tetrandrine induces apoptosis by activating reactive oxygen species and repressing Akt activity in human hepatocellular carcinoma. Int J Cancer 129: 1519-1531.
22. Holmes FA, Walters RS, Theriault RL, Forman AD, Newton LK, et al. (1991) Phase II trial of taxol, an active drug in the treatment of metastatic breast cancer. J Natl Cancer Inst 83: 1797-1805.
23. Kawamori T, Lubet R, Steele VE, Kelloff GJ, Kaskey RB, et al. (1999) Chemopreventive effect of curcumin, a naturally occurring anti-inflammatory agent, during the promotion/progression stages of colon cancer. Cancer Res 59: 597-601.
24. Dong Y, Yang MM, Kwan CY, Dong Y, Yang MM, et al. (1997) In vitro inhibition of proliferation of HL-60 cells by tetrandrine and Coriolus versicolor peptide derived from Chinese medicinal herbs. Life Sci 60: 135-140.
25. Matsunaga S, Okada J, Uyeo S (1965) The structure of abieslactone, a methoxy-tetracyclic triterpene lactone. Chem Commun 21: 525-527.
26. Takayasu J, Tanaka R, Matsunaga S, Ueyama H, Tokuda H, et al. (1990) Anti-tumor-promoting activity of derivatives of abieslactone, a natural triterpenoid isolated from several Abies genus. Cancer Lett 53: 141-144.
27. Li X, Yang X, Liu Y, Gong N, Yao W, et al. (2013) Japonicone A suppresses growth of burkitt lymphoma cells through its effect on NF-kB. Clin Cancer Res 19: 2917-2928.
28. Wu M, Zhang H, Hu J, Weng Z, Li C, et al. (2013) Isoalantolactone inhibits UM-SCC-10A cell growth via cell cycle arrest and apoptosis induction. Plos One 8: e76000.
29. Li YL, Gao YX, Yang XW, Jin HZ, Ye J, et al. (2012) Cytotoxic triterpenoids from Abies recurvata. Phytochemistry 81: 159-164.
30. Xia JH, Zhang SD, Li YL, Wu L, Zhu ZJ, et al. (2012) Sesquiterpenoids and triterpenoids from Abies holophylla and their bioactivities. Phytochemistry 74: 178-184.
31. Lavoie S, Legault J, Gauthier C, Mshvildadze V, Mercier S, et al. (2012) Abibalsamins A and B, two new tetraterpenoids from Abies balsamea. Org Lett 14: 1504-1507.
32. Li YL, Zhang SD, Jin HZ, Tian JM, Shen YH, et al. (2012) Abiestetranes A and B, two unique tetraterpenes from Abies fabri. Tetrahedron 68: 7763-7767.
33. Orren DK, Petersen LN, Bohr VA (1997) Persistent DNA damage inhibits S phase and G 2 progression, and results in apoptosis. Mol Biol Cell 8: 1129-1142.
34. Shapiro GI, Harper JW (1999) Anticancer drug targets: cell cycle and checkpoint control. J Clin Invest 104: 1645-1653.
35. Fridman JS, Lowe SW (2003) Control of apoptosis by p53. Oncogene 22: 9030-9040.
36. Zhang Z, He H, Chen F, Huang C, Shi X (2002) MAPKs mediate S phase arrest induced by vanadate through a p53-dependent pathway in mouse epidermal C141 cells. Chem Res Toxicol 15: 950-956.
37. Gartel AL, Tyner AL (2002) The role of the cyclin-dependent kinase inhibitor p21 in apoptosis. Mol Cancer Ther 8: 639-649.
38. Ogryzko VV, Wong P, Howard BH (1997) WAF1 retards S-phase progression primarily by inhibition of cyclin-dependent kinases. Mol Cell Biol 17: 4877-4882.
39. Yin XM (2000) Signal transduction mediated by Bid, a pro-death Bcl-2 family proteins, connects the death receptor and mitochondria apoptosis pathways. Cell Res 10: 161-167.
40. Simon HU, Haj-Yehia A, Levi-Schaffer F (2000) Role of reactive oxygen species (ROS) in apoptosis induction. Apoptosis 5: 415-418.
41. Zamzami N, Marchetti P, Castedo M, Decaudin D, Macho A, et al. (1995) Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death. J Exp Med 182: 367-377.
42. Zafarullah M, Li WQ, Sylvester J, Ahmad M (2003) Molecular mechanisms of N-acetylcysteine actions. Cell Mol Life Sci 60: 6-20.
43. Sun ZJ, Chen G, Hu X, Zhang W, Liu Y, et al. (2010) Activation of PI3K/Akt/IKK-alpha/NF-kappaB signaling pathway is required for the apoptosis-evasion in human salivary adenoid cystic carcinoma: its inhibition by quercetin. Apoptosis 15: 850-863.
44. Vivanco I, Sawyers CL (2002) The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat Rev Cancer 2: 489-501.
45. Bharti AC, Aggarwal BB (2002) Nuclear factor-kappa B and cancer: its role in prevention and therapy. Biochem Pharmacol 64: 883-888.