Cadmium induces apoptotic cell death in WI 38 cells via caspase-dependent Bid cleavage and calpain-mediated mitochondrial Bax cleavage by Bcl-2-independent pathway

Biochemical Pharmacology

Volumn 68, Issue 9, 2004, Pages 1845-1855

  Oh, Seon Hee ^a   Lee, Byung Hoon ^b   Lim, Sung Chul ^a  

^a Chosun University   (South Korea)

^b Wonkwang University   (South Korea)

Author keywords

Apoptosis; Bax cleavage; Cadmium; Calpain; Caspase; Lung epithelial fibroblast (WI 38) cell

Indexed keywords

ACETYLCYSTEINE; BENZYLOXYCARBONYLISOLEUCYLGLUTAMYLTHREONYLASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CADMIUM; CALPAIN; CASPASE; CASPASE 3; CASPASE 8; CASPASE 8 INHIBITOR; CASPASE 9; CYTOCHROME C; DNA; DNA NUCLEOTIDYLEXOTRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROPIDIUM IODIDE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BID; PROTEIN P18; PROTEIN P53; REACTIVE OXYGEN METABOLITE; URIDINE TRIPHOSPHATE;

APOPTOSIS; ARTICLE; CELL DEATH; CELL LINE; CONTROLLED STUDY; CYTOSOL; ENZYME INHIBITION; HUMAN; HUMAN CELL; LUNG ALVEOLUS EPITHELIUM; LUNG FIBROBLAST; MITOCHONDRION; NICK END LABELING; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; CADMIUM; CALPAIN; CARRIER PROTEINS; CASPASE 8; CASPASE 9; CASPASES; CELL LINE; CYTOCHROME C GROUP; ENZYME ACTIVATION; HUMANS; MITOCHONDRIA; POLY(ADP-RIBOSE) POLYMERASES; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 4644320547     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2004.06.021     Document Type: Article

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