Conformational activation of antithrombin by heparin involves an altered exosite interaction with protease

Journal of Biological Chemistry

Volumn 289, Issue 49, 2014, Pages 34049-34064

  Izaguirre, Gonzalo ^a   Aguila, Sonia ^b   Qi, Lixin ^a   Swanson, Richard ^a   Roth, Ryan ^a   Rezaie, Alireza R ^c   Gettins, Peter G W ^a   Olson, Steven T ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b UNIVERSITY OF MURCIA   (Spain)

^c SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CHEMICAL ACTIVATION;

ACTIVATION STATE; ALANINE MUTATIONS; ALLOSTERIC ACTIVATION; ATTRACTIVE INTERACTIONS; CONFORMATIONAL CHANGE; EXOSITE INTERACTIONS; HEPARIN BINDING; MICHAELIS COMPLEX;

POLYSACCHARIDES;

ALANINE; ANTITHROMBIN; ARGININE; ASPARAGINE; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 9A; BLOOD CLOTTING INHIBITOR; GLUTAMINE; HEPARIN; HISTIDINE; LYSINE; PROTEINASE; SERINE PROTEINASE INHIBITOR; TYROSINE; AMINO ACID; BLOOD CLOTTING FACTOR 10A INHIBITOR; PROTEIN BINDING; RECOMBINANT PROTEIN;

ALLOSTERISM; ARTICLE; BINDING SITE; CONFORMATION; CONFORMATIONAL ACTIVATION; CONTROLLED STUDY; ENZYME ACTIVATION; EXOSITE; MUTATION; PROTEIN INTERACTION; BACULOVIRIDAE; CHEMICAL STRUCTURE; CHEMISTRY; GENE EXPRESSION; GENETICS; HUMAN; METABOLISM; STRUCTURE ACTIVITY RELATION;

ALLOSTERIC REGULATION; AMINO ACIDS; ANTITHROMBINS; BACULOVIRIDAE; BINDING SITES; FACTOR IXA; FACTOR XA; FACTOR XA INHIBITORS; GENE EXPRESSION; HEPARIN; HUMANS; MODELS, MOLECULAR; MUTATION; PROTEIN BINDING; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84917708924     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.611707     Document Type: Article

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