The Critical Role of Hinge-Region Expulsion in the Induced-Fit Heparin Binding Mechanism of Antithrombin

Journal of Molecular Biology

Volumn 386, Issue 5, 2009, Pages 1278-1289

  Langdown, Jonathan ^a   Belzar, Klara J ^a   Savory, Wendy J ^a   Baglin, Trevor P ^a   Huntington, James A ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

allosteric; antithrombin; heparin; pentasaccharide; serpin

Indexed keywords

ANTITHROMBIN; FONDAPARINUX; HEPARIN;

ALLOSTERISM; ARTICLE; BINDING AFFINITY; BINDING SITE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DISULFIDE BOND; FLUORESCENCE SPECTROSCOPY; HINGE REGION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEINASE INHIBITION;

EID: 60849096635     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2009.01.028     Document Type: Article

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