Engineering functional antithrombin exosites in α 1- proteinase inhibitor that specifically promote the inhibition of factor Xa and factor IXa

Journal of Biological Chemistry

Volumn 284, Issue 3, 2009, Pages 1550-1558

  Izaguirre, Gonzalo ^a   Rezaie, Alireza R ^b   Olson, Steven T ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITHROMBIN; ASSOCIATION RATE CONSTANTS; BINDING STUDIES; COMBINED EFFECTS; ENHANCING EFFECTS; EXOSITES; INHIBITING FACTORS; LOOP RESIDUES; MICHAELIS COMPLEXES; PROTEINASE INHIBITORS; REACTIVE SITES; SELECTIVE INHIBITORS;

POLYSACCHARIDES; RATE CONSTANTS;

ASSOCIATION REACTIONS;

ALPHA 1 ANTITRYPSIN; ANTITHROMBIN; ARGININE; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 9A; GLUTAMIC ACID; GLUTAMIC ACID 255; HEPARIN; MUTANT PROTEIN; PROTEIN INHIBITOR; PROTEINASE; SERINE PROTEINASE INHIBITOR; THROMBIN; TRYPSIN; TYROSINE; TYROSINE 253; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING KINETICS; COMPARATIVE STUDY; EMBRYO; GENE MUTATION; HOMOLOGOUS RECOMBINATION; HUMAN; HUMAN CELL; INHIBITION KINETICS; MICHAELIS MENTEN KINETICS; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; PROTEIN ENGINEERING; PROTEIN FOLDING; PROTEIN FUNCTION; REACTION ANALYSIS; SEQUENCE ANALYSIS;

ALPHA 1-ANTITRYPSIN; AMINO ACID SUBSTITUTION; FACTOR IXA; FACTOR XA; HEPARIN; HUMANS; PROTEIN BINDING; RECOMBINANT PROTEINS;

EID: 59449098023     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M807340200     Document Type: Article

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