UGT1A1 polymorphism predicts irinotecan toxicity: Evolving proof

AAPS PharmSci

Volumn 3, Issue 3, 2001, Pages

  Mani, Sridhar ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7 ETHYL 10 HYDROXYCAMPTOTHECIN; ANTINEOPLASTIC AGENT; BETA GLUCURONIDASE; DRUG METABOLITE; GLUCURONOSYLTRANSFERASE; IRINOTECAN; ISOENZYME;

ARTICLE; CRIGLER NAJJAR SYNDROME; DATA ANALYSIS; DRUG BILE LEVEL; DRUG GLUCURONIDATION; DRUG METABOLISM; ENZYME ACTIVITY; GENE EXPRESSION; GENE FUNCTION; GENETIC POLYMORPHISM; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; GENOTYPE; GILBERT DISEASE; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN;

EID: 0035783264     PISSN: 15221059     EISSN: None     Source Type: Journal    
DOI: 10.1208/ps0303_commentary2     Document Type: Article

References (7)

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6. Ando Y, Saka H, Ando M, Sawa T, Muro K, Ueoka H, Yokoyama A, Saitoh S, Shimokata K, Hasegawa Y. Polymorphisms of UDP-glucuronosyltransferase gene and irinotecan toxicity: a pharmacogenetic analysis. Cancer Res 2000; 60:6921-6.
7. Beutler E, Gelbart T, Demina A. Racial variability in the UDP-glucuronosyltransferase 1 (UGT1A1) promoter: a balanced polymorphism for regulation of bilirubin metabolism? Proc Natl Acad Sci U S A 1998; 95:8170-4