Cross-sectional and longitudinal associations between circulating leptin and knee cartilage thickness in older adults

Annals of the Rheumatic Diseases

Volumn 74, Issue 1, 2015, Pages 82-88

  Stannus, Oliver P ^a   Cao, Yuelong ^a,b   Antony, Benny ^a   Blizzard, Leigh ^a   Cicuttini, Flavia ^c   Jones, Graeme ^a   Ding, Changhai ^a,c  

^a UNIVERSITY OF TASMANIA   (Australia)

^b SHUGUANG HOSPITAL AFFILIATED TO SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^c MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN;

ADULT; AGED; ARTICLE; BODY FAT; BODY HEIGHT; BODY MASS; BODY WEIGHT; CARTILAGE; CARTILAGE THICKNESS; COHORT ANALYSIS; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; FEMALE; HUMAN; KNEE CARTILAGE; KNEE RADIOGRAPHY; LONGITUDINAL STUDY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; THICKNESS; ADIPOSE TISSUE; ARTICULAR CARTILAGE; BLOOD; FEMUR; KNEE; KNEE OSTEOARTHRITIS; MIDDLE AGED; OBESITY; ORGAN SIZE; PATELLA; PATHOLOGY; STATISTICS; TIBIA;

ADIPOSE TISSUE; AGED; BODY MASS INDEX; CARTILAGE, ARTICULAR; FEMALE; FEMUR; HUMANS; KNEE JOINT; LEPTIN; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; OBESITY; ORGAN SIZE; OSTEOARTHRITIS, KNEE; PATELLA; STATISTICS AS TOPIC; TIBIA;

EID: 84917680165     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/annrheumdis-2013-203308     Document Type: Article

References (41)

1. Sowers MR, Karvonen-Gutierrez CA. The evolving role of obesity in knee osteoarthritis. Curr Opin Rheumatol 2010;22:533-7.
2. Otero M, Lago R, Gomez R, et al. Leptin: a metabolic hormone that functions like a proinflammatory adipokine. Drug News Perspect 2006;19:21-6.
3. Presle N, Pottie P, Dumond H, et al. Differential distribution of adipokines between serum and synovial fluid in patients with osteoarthritis. Contribution of joint tissues to their articular production. Osteoarthritis Cartilage 2006;14:690-5.
4. Dumond H, Presle N, Terlain B, et al. Evidence for a key role of leptin in osteoarthritis. Arthritis Rheum 2003;48:3118-29.
5. de Boer TN, van Spil WE, Huisman AM, et al. Serum adipokines in osteoarthritis; comparison with controls and relationship with local parameters of synovial inflammation and cartilage damage. Osteoarthritis Cartilage 2012.
6. Simopoulou T, Malizos KN, Iliopoulos D, et al. Differential expression of leptin and leptin 's receptor isoform (Ob-Rb) mRNA between advanced and minimally affected osteoarthritic cartilage; effect on cartilage metabolism. Osteoarthritis Cartilage 2007;15:872-83.
7. Pottie P, Presle N, Terlain B, et al. Obesity and osteoarthritis: more complex than predicted!. Ann Rheum Dis 2006;65:1403-5.
8. Griffin TM, Huebner JL, Kraus VB, et al. Extreme obesity due to impaired leptin signaling in mice does not cause knee osteoarthritis. Arthritis Rheum 2009;60:2935-44.
9. Ding C, Parameswaran V, Cicuttini F, et al. Association between leptin, body composition, sex and knee cartilage morphology in older adults: the Tasmanian older adult cohort (TASOAC) study. Ann Rheum Dis 2008;67:1256-61.
10. Stannus OP, Jones G, Quinn SJ, et al. The association between leptin, interleukin-6, and hip radiographic osteoarthritis in older people: a cross-sectional study. Arthritis Res Ther 2010;12:R95.
11. Eckstein F, Ateshian G, Burgkart R, et al. Proposal for a nomenclature for magnetic resonance imaging based measures of articular cartilage in osteoarthritis. Osteoarthritis Cartilage 2006;14:974-83.
12. Eckstein F, Charles HC, Buck RJ, et al. Accuracy and precision of quantitative assessment of cartilage morphology by magnetic resonance imaging at 3.0T. Arthritis Rheum 2005;52:3132-6.
13. Reichenbach S, Yang M, Eckstein F, et al. Does cartilage volume or thickness distinguish knees with and without mild radiographic osteoarthritis? The Framingham Study. Ann Rheum Dis 2010;69:143-9.
14. Jones G, Ding C, Scott F, et al. Early radiographic osteoarthritis is associated with substantial changes in cartilage volume and tibial bone surface area in both males and females. Osteoarthritis Cartilage 2004;12:169-74.
15. Ding C, Garnero P, Cicuttini F, et al. Knee cartilage defects: association with early radiographic osteoarthritis, decreased cartilage volume, increased joint surface area and type II collagen breakdown. Osteoarthritis Cartilage 2005;13:198-205.
16. Ding C, Martel-Pelletier J, Pelletier JP, et al. Meniscal tear as an osteoarthritis risk factor in a largely non-osteoarthritic cohort: a cross-sectional study. J Rheumatol 2007;34:776-84.
17. Ding C, Martel-Pelletier J, Pelletier JP, et al. Knee meniscal extrusion in a largely non-osteoarthritic cohort: association with greater loss of cartilage volume. Arthritis Res Ther 2007;9.
18. Dore D, Martens A, Quinn S, et al. Bone marrow lesions predict site-specific cartilage defect development and volume loss: a prospective study in older adults. Arthritis Res Ther 2010;12.
19. Altman RD, Gold GE. Atlas of individual radiographic features in osteoarthritis, revised. Osteoarthritis Cartilage 2007;15(Suppl A):A1-56.
20. Sandell LJ. Obesity and osteoarthritis: is leptin the link? Arthritis Rheum 2009;60:2858-60.
21. Bao JP, Chen WP, Feng J, et al. Leptin plays a catabolic role on articular cartilage. Mol Biol Rep 2010;37:3265-72.
22. Teichtahl AJ, Wluka AE, Proietto J, et al. Obesity and the female sex, risk factors for knee osteoarthritis that may be attributable to systemic or local leptin biosynthesis and its cellular effects. Med Hypotheses 2005;65:312-5.
23. Faggioni R, Feingold KR, Grunfeld C. Leptin regulation of the immune response and the immunodeficiency of malnutrition. FASEB J 2001;15:2565-71.
24. Otero M, Gomez Reino JJ, Gualillo O. Synergistic induction of nitric oxide synthase type II: in vitro effect of leptin and interferon-gamma in human chondrocytes and ATDC5 chondrogenic cells. Arthritis Rheum 2003;48:404-9.
25. Bernotiene E, Palmer G, Talabot-Ayer D, et al. Delayed resolution of acute inflammation during zymosan-induced arthritis in leptin-deficient mice. Arthritis Res Ther 2004;6:R256-63.
26. Hui W, Litherland GJ, Elias MS, et al. Leptin produced by joint white adipose tissue induces cartilage degradation via upregulation and activation of matrix metalloproteinases. Ann Rheum Dis 2012;71:455-62.
27. Iwamoto J, Takeda T, Sato Y, et al. Serum leptin concentration positively correlates with body weight and total fat mass in postmenopausal Japanese women with osteoarthritis of the knee. Arthritis 2011;2011:580632.
28. Miller GD, Nicklas BJ, Davis CC, et al. Is serum leptin related to physical function and is it modifiable through weight loss and exercise in older adults with knee osteoarthritis? Int J Obes Relat Metab Disord 2004;28:1383-90.
29. Yusuf E, Ioan-Facsinay A, Bijsterbosch J, et al. Association between leptin, adiponectin and resistin and long-term progression of hand osteoarthritis. Ann Rheum Dis 2011;70:1282-4.
30. Massengale M, Reichmann WM, Losina E, et al. The relationship between hand osteoarthritis and serum leptin concentration in participants of the third National Health and Nutrition Examination Survey. Arthritis Res Ther 2012;14:R132.
31. Conde J, Scotece M, LÃ3pez Vn, et al. Adiponectin and leptin induce VCAM-1 expression in human and murine chondrocytes. PLoS ONE 2012;7:e52533.
32. Berry PA, Jones SW, Cicuttini FM, et al. Temporal relationship between serum adipokines, biomarkers of bone and cartilage turnover, and cartilage volume loss in a population with clinical knee osteoarthritis. Arthritis Rheum 2011;63:700-7.
33. Koskinen A, Juslin S, Nieminen R, et al. Adiponectin associates with markers of cartilage degradation in osteoarthritis and induces production of proinflammatory and catabolic factors through mitogen-activated protein kinase pathways. Arthritis Res Ther;2011;13:R184.
34. Blumenkrantz G, Majumdar S. Quantitative magnetic resonance imaging of articular cartilage in osteoarthritis. Eur Cell Mater 2007;13:76-86.
35. Cohen ZA, McCarthy DM, Kwak SD, et al. Knee cartilage topography, thickness, and contact areas from MRI: in-vitro calibration and in-vivo measurements. Osteoarthritis Cartilage 1999;7:95-109.
36. Moisio K, Eckstein F, Chmiel JS, et al. Denuded subchondral bone and knee pain in persons with knee osteoarthritis. Arthritis Rheum 2009;60:3703-10.
37. Balamoody S, Williams TG, Waterton JC, et al. Comparison of 3 T MR scanners in regional cartilage-thickness analysis in osteoarthritis: a cross-sectional multicenter, multivendor study. Arthritis Res Ther 2010;12:R202.
38. Stannus OP, Jones G, Quinn SJ, et al. The association between leptin, interleukin-6 and hip radiographic osteoarthritis in older people: a cross-sectional study. Arthritis Res Ther 2010;12:R95.
39. Biswal S, Hastie T, Andriacchi TP, et al. Risk factors for progressive cartilage loss in the knee: a longitudinal magnetic resonance imaging study in forty-three patients. Arthritis Rheum 2002;46:2884-92.
40. Anandacoomarasamy A, Leibman S, Smith G, et al. Weight loss in obese people has structure-modifying effects on medial but not on lateral knee articular cartilage. Ann Rheum Dis 2012;71:26-32.
41. Kapur S, Amoui M, Kesavan C, et al. Leptin receptor (Lepr) is a negative modulator of bone mechanosensitivity and genetic variations in Lepr may contribute to the differential osteogenic response to mechanical stimulation in the C57BL/6J and C3H/HeJ pair of mouse strains. J Biol Chem 2010;285:37607-18.