Trimetazidine prevents palmitate-induced mitochondrial fission and dysfunction in cultured cardiomyocytes

Biochemical Pharmacology

Volumn 91, Issue 3, 2014, Pages 323-336

  Kuzmicic, Jovan ^a,b   Parra, Valentina ^a,b,c   Verdejo, Hugo E ^a,d   López Crisosto, Camila ^a,b   Chiong, Mario ^a,b   García, Lorena ^a,b   Jensen, Michael D ^e   Bernlohr, David A ^f   Castro, Pablo F ^a,d   Lavandero, Sergio ^a,b,c  

^a PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

^b UNIVERSITY OF CHILE   (Chile)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^d PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

^e MAYO CLINIC   (United States)

^f UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Cardiomyocyte; Metabolism; Mitochondrial dynamics; Palmitate; Trimetazidine

Indexed keywords

ADENOSINE TRIPHOSPHATE; CERAMIDE; PALMITIC ACID; TRIMETAZIDINE; DRP1 PROTEIN, RAT; DYNAMIN; OXYGEN; PROTECTIVE AGENT; SPHINGOLIPID;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL PROTECTION; CONTROLLED STUDY; DRUG MECHANISM; DRUG SCREENING; FLUORESCENCE MICROSCOPY; HEART MUSCLE CELL; HEART PROTECTION; IMMUNOFLUORESCENCE; IN VITRO STUDY; LIPID STORAGE; LIPOTOXICITY; MASS SPECTROMETRY; MITOCHONDRIAL DYNAMICS; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; MITOCHONDRIAL VOLUME; MITOCHONDRION; NEWBORN; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RAT; ANIMAL; DRUG EFFECTS; HEART MITOCHONDRION; METABOLISM; SPRAGUE DAWLEY RAT;

ADENOSINE TRIPHOSPHATE; ANIMALS; CELLS, CULTURED; DYNAMINS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA, HEART; MITOCHONDRIAL DYNAMICS; MYOCYTES, CARDIAC; OXYGEN; OXYGEN CONSUMPTION; PALMITIC ACID; PROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; SPHINGOLIPIDS; TRIMETAZIDINE;

EID: 84916931707     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2014.07.022     Document Type: Article

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