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Volumn 13, Issue 1, 2015, Pages 55-68

Influenza-associated bacterial pneumonia; managing and controlling infection on two fronts

Author keywords

bacterial pneumonia; co pathogenesis; control; influenza virus; transmission

Indexed keywords

AMOXICILLIN PLUS CLAVULANIC ACID; AMPICILLIN; ANTIBIOTIC AGENT; CEPHALOSPORIN DERIVATIVE; CLINDAMYCIN; CORTICOSTEROID; CYTOKINE; DEXAMETHASONE; DOXYCYCLINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INFLUENZA VACCINE; LINEZOLID; MACROLIDE; OSELTAMIVIR; PNEUMOCOCCUS VACCINE; PROCALCITONIN; SIALIDASE INHIBITOR; VANCOMYCIN; ZANAMIVIR;

EID: 84916898829     PISSN: 14787210     EISSN: 17448336     Source Type: Journal    
DOI: 10.1586/14787210.2015.981156     Document Type: Review
Times cited : (16)

References (144)
  • 1
    • 34249938743 scopus 로고    scopus 로고
    • The annual impact of seasonal influenza in the US: Measuring disease burden and costs
    • Molinari NA, Ortega-Sanchez IR, Messonnier ML, et al. The annual impact of seasonal influenza in the US: measuring disease burden and costs. Vaccine 2007; 25(27):5086-96
    • (2007) Vaccine , vol.25 , Issue.27 , pp. 5086-5096
    • Molinari, N.A.1    Ortega-Sanchez, I.R.2    Messonnier, M.L.3
  • 2
    • 0014010379 scopus 로고
    • Immunity to influenza to antibody levels
    • Morris JA, Kasel JA, Saglam M, et al. Immunity to influenza to antibody levels. N Engl J Med 1966;274(10):527-35
    • (1966) N Engl J Med , vol.274 , Issue.10 , pp. 527-535
    • Morris, J.A.1    Kasel, J.A.2    Saglam, M.3
  • 3
    • 84871121907 scopus 로고    scopus 로고
    • Comparison of shedding characteristics of seasonal influenza virus (sub)types and influenza a(h1n1)pdm09; Germany 2007-2011
    • Suess T, Remschmidt C, Schink SB, et al. Comparison of shedding characteristics of seasonal influenza virus (sub)types and influenza A(H1N1)pdm09; Germany, 2007-2011. PLoS One 2012;7(12):e51653
    • (2012) Plos One , vol.7 , Issue.12 , pp. e51653
    • Suess, T.1    Remschmidt, C.2    Schink, S.B.3
  • 4
    • 0037311498 scopus 로고    scopus 로고
    • Influenza A and B virus infections in children
    • Peltola V, Ziegler T, Ruuskanen O. Influenza A and B virus infections in children. Clin Infect Dis 2003;36(3): 299-305
    • (2003) Clin Infect Dis , vol.36 , Issue.3 , pp. 299-305
    • Peltola, V.1    Ziegler, T.2    Ruuskanen, O.3
  • 5
    • 0023278193 scopus 로고
    • Influenza B in households: Virus shedding without symptoms or antibody response
    • Foy HM, Cooney MK, Allan ID, et al. Influenza B in households: virus shedding without symptoms or antibody response. Am J Epidemiol 1987;126(3):506-15
    • (1987) Am J Epidemiol , vol.126 , Issue.3 , pp. 506-515
    • Foy, H.M.1    Cooney, M.K.2    Allan, I.D.3
  • 6
    • 65249122476 scopus 로고    scopus 로고
    • Does influenza transmission occur from asymptomatic infection or prior to symptom onset?
    • Patrozou E, Mermel LA. Does influenza transmission occur from asymptomatic infection or prior to symptom onset?. Public Health Rep 2009;124(2):193-6
    • (2009) Public Health Rep , vol.124 , Issue.2 , pp. 193-196
    • Patrozou, E.1    Mermel, L.A.2
  • 7
    • 84901829676 scopus 로고    scopus 로고
    • Comparative community burden and severity of seasonal and pandemic influenza: Results of the flu watch cohort study
    • Hayward AC, Fragaszy EB, Bermingham A, et al. Comparative community burden and severity of seasonal and pandemic influenza: results of the Flu Watch cohort study. Lancet Respir Med 2014;2(6):445-54
    • (2014) Lancet Respir Med , vol.2 , Issue.6 , pp. 445-454
    • Hayward, A.C.1    Fragaszy, E.B.2    Bermingham, A.3
  • 8
    • 84859649544 scopus 로고    scopus 로고
    • Epidemiology, microbiology, and treatment considerations for bacterial pneumonia complicating influenza
    • Metersky ML, Masterton RG, Lode H, et al. Epidemiology, microbiology, and treatment considerations for bacterial pneumonia complicating influenza. Int J Infect Dis 2012;16(5):e321-31
    • (2012) Int J Infect Dis , vol.16 , Issue.5 , pp. e321-e331
    • Metersky, M.L.1    Masterton, R.G.2    Lode, H.3
  • 9
    • 77951636129 scopus 로고    scopus 로고
    • Clinical review: Primary influenza viral pneumonia
    • Rello J, Pop-Vicas A. Clinical review: primary influenza viral pneumonia. Crit Care 2009;13(6):235
    • (2009) Crit Care , vol.13 , Issue.6 , pp. 235
    • Rello, J.1    Pop-Vicas, A.2
  • 10
    • 84860238634 scopus 로고    scopus 로고
    • Critical illness from 2009 pandemic influenza a virus and bacterial coinfection in the united states
    • Rice TW, Rubinson L, Uyeki TM, et al. Critical illness from 2009 pandemic influenza A virus and bacterial coinfection in the United States. Crit Care Med 2012; 40(5):1487-98
    • (2012) Crit Care Med , vol.40 , Issue.5 , pp. 1487-1498
    • Rice, T.W.1    Rubinson, L.2    Uyeki, T.M.3
  • 11
    • 34547924444 scopus 로고    scopus 로고
    • Disease severity in patients with simultaneous influenza and bacterial pneumonia
    • Seki M, Kosai K, Yanagihara K, et al. Disease severity in patients with simultaneous influenza and bacterial pneumonia. Intern Med 2007;46(13):953-8
    • (2007) Intern Med , vol.46 , Issue.13 , pp. 953-958
    • Seki, M.1    Kosai, K.2    Yanagihara, K.3
  • 12
    • 77956581302 scopus 로고    scopus 로고
    • Postinfluenza bacterial pneumonia: Host defenses gone awry
    • Ballinger MN, Standiford TJ. Postinfluenza bacterial pneumonia: host defenses gone awry. J Interferon Cytokine Res 2010;30(9): 643-52
    • (2010) J Interferon Cytokine Res , vol.30 , Issue.9 , pp. 643-652
    • Ballinger, M.N.1    Standiford, T.J.2
  • 13
    • 84880556333 scopus 로고    scopus 로고
    • Identifying the interaction between influenza and pneumococcal pneumonia using incidence data
    • 191ra184
    • Shrestha S, Foxman B, Weinberger DM, et al. Identifying the interaction between influenza and pneumococcal pneumonia using incidence data. Sci Transl Med 2013; 5(191):191ra184
    • (2013) Sci Transl Med , vol.5 , Issue.191
    • Shrestha, S.1    Foxman, B.2    Weinberger, D.M.3
  • 14
    • 84887563483 scopus 로고    scopus 로고
    • Viral-bacterial interactions-therapeutic implications
    • Deng JC. Viral-bacterial interactions-therapeutic implications. Influenza Other Respir Viruses 2013;7 Suppl 3:24-35
    • (2013) Influenza Other Respir Viruses , vol.7 , pp. 24-35
    • Deng, J.C.1
  • 15
    • 31344482504 scopus 로고    scopus 로고
    • 1918 Influenza: The mother of all pandemics
    • Taubenberger JK, Morens DM. 1918 Influenza: The mother of all pandemics. Emerg Infect Dis 2006;12(1): 15-22
    • (2006) Emerg Infect Dis , vol.12 , Issue.1 , pp. 15-22
    • Taubenberger, J.K.1    Morens, D.M.2
  • 16
    • 51849103407 scopus 로고    scopus 로고
    • Predominant role of bacterial pneumonia as a cause of death in pandemic influenza: Implications for pandemic influenza preparedness
    • Morens DM, Taubenberger JK, Fauci AS. Predominant role of bacterial pneumonia as a cause of death in pandemic influenza: implications for pandemic influenza preparedness. J Infect Dis 2008;198(7): 962-70
    • (2008) J Infect Dis , vol.198 , Issue.7 , pp. 962-970
    • Morens, D.M.1    Taubenberger, J.K.2    Fauci, A.S.3
  • 17
    • 80053634686 scopus 로고    scopus 로고
    • Autopsy series of 68 cases dying before and during the 1918 influenza pandemic peak
    • Sheng ZM, Chertow DS, Ambroggio X, et al. Autopsy series of 68 cases dying before and during the 1918 influenza pandemic peak. Proc Natl Acad Sci USA 2011; 108(39):16416-21
    • (2011) Proc Natl Acad Sci USA , vol.108 , Issue.39 , pp. 16416-16421
    • Sheng, Z.M.1    Chertow, D.S.2    Ambroggio, X.3
  • 18
    • 84856340896 scopus 로고    scopus 로고
    • Pathogenic responses among young adults during the 1918 influenza pandemic
    • Shanks GD, Brundage JF. Pathogenic responses among young adults during the 1918 influenza pandemic. Emerg Infect Dis 2012;18(2):201-7
    • (2012) Emerg Infect Dis , vol.18 , Issue.2 , pp. 201-207
    • Shanks, G.D.1    Brundage, J.F.2
  • 19
    • 0015071795 scopus 로고
    • Bacterial pneumonia during the Hong Kong influenza epidemic of 1968-1969
    • Schwarzmann SW, Adler JL, Sullivan RJ, et al. Bacterial pneumonia during the Hong Kong influenza epidemic of 1968-1969. Arch Intern Med 1971;127(6):1037-41
    • (1971) Arch Intern Med , vol.127 , Issue.6 , pp. 1037-1041
    • Schwarzmann, S.W.1    Adler, J.L.2    Sullivan, R.J.3
  • 20
    • 70449653474 scopus 로고    scopus 로고
    • Critically ill patients with 2009 influenza a (h1n1) infection in canada
    • Kumar A, Zarychanski R, Pinto R, et al. Critically ill patients with 2009 influenza A (H1N1) infection in Canada. Jama 2009; 302(17):1872-9
    • (2009) Jama , vol.302 , Issue.17 , pp. 1872-1879
    • Kumar, A.1    Zarychanski, R.2    Pinto, R.3
  • 21
    • 84873723419 scopus 로고    scopus 로고
    • The impact of bacterial and viral co-infection in severe influenza
    • Blyth CC, Webb SA, Kok J, et al. The impact of bacterial and viral co-infection in severe influenza. Influenza Other Respir Viruses 2013;7(2):168-76
    • (2013) Influenza Other Respir Viruses , vol.7 , Issue.2 , pp. 168-176
    • Blyth, C.C.1    Webb, S.A.2    Kok, J.3
  • 22
    • 84880053278 scopus 로고    scopus 로고
    • The occurrence and impact of bacterial organisms complicating critical care illness associated with 2009 influenza a(h1n1) infection
    • Muscedere J, Ofner M, Kumar A, et al. The occurrence and impact of bacterial organisms complicating critical care illness associated with 2009 influenza A(H1N1) infection. Chest 2013;144(1):39-47
    • (2013) Chest , vol.144 , Issue.1 , pp. 39-47
    • Muscedere, J.1    Ofner, M.2    Kumar, A.3
  • 23
    • 9844220300 scopus 로고    scopus 로고
    • Efficacy and safety of the neuraminidase inhibitor zanamivir in the treatment of influenza virus infections
    • GG167 Influenza Study Group
    • Hayden FG, Osterhaus AD, Treanor JJ, et al. Efficacy and safety of the neuraminidase inhibitor zanamivir in the treatment of influenza virus infections. GG167 Influenza Study Group. N Engl J Med 1997;337(13):874-80
    • (1997) N Engl J Med , vol.337 , Issue.13 , pp. 874-880
    • Hayden, F.G.1    Osterhaus, A.D.2    Treanor, J.J.3
  • 24
    • 0034720503 scopus 로고    scopus 로고
    • Efficacy and safety of oseltamivir in treatment of acute influenza: A randomised controlled trial
    • Neuraminidase Inhibitor Flu Treatment Investigator Group
    • Nicholson KG, Aoki FY, Osterhaus AD, et al. Efficacy and safety of oseltamivir in treatment of acute influenza: a randomised controlled trial. Neuraminidase Inhibitor Flu Treatment Investigator Group. Lancet 2000;355(9218):1845-50
    • (2000) Lancet , vol.355 , Issue.9218 , pp. 1845-1850
    • Nicholson, K.G.1    Aoki, F.Y.2    Osterhaus, A.D.3
  • 25
    • 17744412173 scopus 로고    scopus 로고
    • Efficacy and safety of the oral neuraminidase inhibitor oseltamivir in treating acute influenza: A randomized controlled trial
    • US Oral Neuraminidase Study Group
    • Treanor JJ, Hayden FG, Vrooman PS, et al. Efficacy and safety of the oral neuraminidase inhibitor oseltamivir in treating acute influenza: a randomized controlled trial. US Oral Neuraminidase Study Group. Jama 2000;283(8):1016-24
    • (2000) Jama , vol.283 , Issue.8 , pp. 1016-1024
    • Treanor, J.J.1    Hayden, F.G.2    Vrooman, P.S.3
  • 26
    • 33847155159 scopus 로고    scopus 로고
    • Infectious diseases society of america/american thoracic society consensus guidelines on the management of community-acquired pneumonia in adults
    • Mandell LA, Wunderink RG, Anzueto A, et al. Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults. Clin Infect Dis 2007;44(Suppl 2):S27-72
    • (2007) Clin Infect Dis , vol.44 , pp. S27-72
    • Mandell, L.A.1    Wunderink, R.G.2    Anzueto, A.3
  • 27
    • 84895522595 scopus 로고    scopus 로고
    • Pneumococcal disease seasonality: Incidence, severity and the role of influenza activity
    • Weinberger DM, Harboe ZB, Viboud C, et al. Pneumococcal disease seasonality: incidence, severity and the role of influenza activity. Eur Respir J 2014;43(3):833-41
    • (2014) Eur Respir J , vol.43 , Issue.3 , pp. 833-841
    • Weinberger, D.M.1    Harboe, Z.B.2    Viboud, C.3
  • 28
    • 84885043619 scopus 로고    scopus 로고
    • Serotype-specific effect of influenza on adult invasive pneumococcal pneumonia
    • Weinberger DM, Harboe ZB, Viboud C, et al. Serotype-specific effect of influenza on adult invasive pneumococcal pneumonia. J Infect Dis 2013;208(8):1274-80
    • (2013) J Infect Dis , vol.208 , Issue.8 , pp. 1274-1280
    • Weinberger, D.M.1    Harboe, Z.B.2    Viboud, C.3
  • 29
    • 84874686768 scopus 로고    scopus 로고
    • Effect of the 2009 influenza a(h1n1) pandemic on invasive pneumococcal pneumonia
    • Fleming-Dutra KE, Taylor T, Link-Gelles R, et al. Effect of the 2009 influenza A(H1N1) pandemic on invasive pneumococcal pneumonia. J Infect Dis 2013;207(7): 1135-43
    • (2013) J Infect Dis , vol.207 , Issue.7 , pp. 1135-1143
    • Fleming-Dutra, K.E.1    Taylor, T.2    Link-Gelles, R.3
  • 30
    • 84894305348 scopus 로고    scopus 로고
    • Impact of the 2009 influenza a h1n1 pandemic on invasive pneumococcal disease in adults
    • Pedro-Botet ML, Burgos J, Lujan M, et al. Impact of the 2009 influenza A H1N1 pandemic on invasive pneumococcal disease in adults. Scand J Infect Dis 2014;46(3):185-92
    • (2014) Scand J Infect Dis , vol.46 , Issue.3 , pp. 185-192
    • Pedro-Botet, M.L.1    Burgos, J.2    Lujan, M.3
  • 31
    • 77049186858 scopus 로고
    • Influenza
    • Stuart-Harris CH. Influenza. Practitioner 1953;171(1026):595-600
    • (1953) Practitioner , vol.171 , Issue.1026 , pp. 595-600
    • Stuart-Harris, C.H.1
  • 32
    • 83155173349 scopus 로고    scopus 로고
    • Critically ill children during the 2009-2010 influenza pandemic in the united states
    • Randolph AG, Vaughn F, Sullivan R, et al. Critically ill children during the 2009-2010 influenza pandemic in the United States. Pediatrics 2011;128(6): e1450-8
    • (2011) Pediatrics , vol.128 , Issue.6 , pp. e1450-e1458
    • Randolph, A.G.1    Vaughn, F.2    Sullivan, R.3
  • 33
    • 44149101259 scopus 로고    scopus 로고
    • Pneumonia caused by methicillin-resistant Staphylococcus aureus
    • Rubinstein E, Kollef MH, Nathwani D. Pneumonia caused by methicillin-resistant Staphylococcus aureus. Clin Infect Dis 2008;46(Suppl 5):S378-85
    • (2008) Clin Infect Dis , vol.46 , pp. S378-S385
    • Rubinstein, E.1    Kollef, M.H.2    Nathwani, D.3
  • 34
    • 77952508365 scopus 로고    scopus 로고
    • Community-acquired pneumonia due to pandemic a(h1n1 2009 influenza virus and methicillin resistant staphylococcus aureus co-infection
    • Murray RJ, Robinson JO, White JN, et al. Community-acquired pneumonia due to pandemic A(H1N1)2009 influenza virus and methicillin resistant Staphylococcus aureus co-infection. PLoS One 2010;5(1): e8705
    • (2010) Plos One , vol.5 , Issue.1 , pp. e8705
    • Murray, R.J.1    Robinson, J.O.2    White, J.N.3
  • 35
    • 84863229862 scopus 로고    scopus 로고
    • Myocardial injury and bacterial pneumonia contribute to the pathogenesis of fatal influenza B virus infection
    • Paddock CD, Liu L, Denison AM, et al. Myocardial injury and bacterial pneumonia contribute to the pathogenesis of fatal influenza B virus infection. J Infect Dis 2012;205(6):895-905
    • (2012) J Infect Dis , vol.205 , Issue.6 , pp. 895-905
    • Paddock, C.D.1    Liu, L.2    Denison, A.M.3
  • 36
    • 84858848392 scopus 로고    scopus 로고
    • Otolaryngological complications in patients infected with the influenza a (h1n1) virus
    • Gutierrez C, Nazar GA, Torres JP. Otolaryngological complications in patients infected with the influenza A (H1N1) virus. Otolaryngol Head Neck Surg 2012;146(3): 478-82
    • (2012) Otolaryngol Head Neck Surg , vol.146 , Issue.3 , pp. 478-482
    • Gutierrez, C.1    Nazar, G.A.2    Torres, J.P.3
  • 37
    • 0026641129 scopus 로고
    • Meningococcal disease and influenza-like syndrome: A new approach to an old question
    • Hubert B, Watier L, Garnerin P, et al. Meningococcal disease and influenza-like syndrome: a new approach to an old question. J Infect Dis 1992;166(3):542-5
    • (1992) J Infect Dis , vol.166 , Issue.3 , pp. 542-545
    • Hubert, B.1    Watier, L.2    Garnerin, P.3
  • 38
    • 1642358931 scopus 로고    scopus 로고
    • A 20-year ecological study of the temporal association between influenza and meningococcal disease
    • Jensen ES, Lundbye-Christensen S, Samuelsson S, et al. A 20-year ecological study of the temporal association between influenza and meningococcal disease. Eur J Epidemiol 2004;19(2):181-7
    • (2004) Eur J Epidemiol , vol.19 , Issue.2 , pp. 181-187
    • Jensen, E.S.1    Lundbye-Christensen, S.2    Samuelsson, S.3
  • 39
    • 0025745201 scopus 로고
    • Influenza A and meningococcal disease
    • Cartwright KA, Jones DM, Smith AJ, et al. Influenza A and meningococcal disease. Lancet 1991;338(8766):554-7
    • (1991) Lancet , vol.338 , Issue.8766 , pp. 554-557
    • Cartwright, K.A.1    Jones, D.M.2    Smith, A.J.3
  • 40
    • 0015495970 scopus 로고
    • A simultaneous outbreak of meningococcal and influenza infections
    • Young LS, LaForce FM, Head JJ, et al. A simultaneous outbreak of meningococcal and influenza infections. N Engl J Med 1972;287(1):5-9
    • (1972) N Engl J Med , vol.287 , Issue.1 , pp. 5-9
    • Young, L.S.1    Laforce, F.M.2    Head, J.J.3
  • 41
    • 0025897190 scopus 로고
    • A cluster of meningococcal disease on a school bus following epidemic influenza
    • Harrison LH, Armstrong CW, Jenkins SR, et al. A cluster of meningococcal disease on a school bus following epidemic influenza. Arch Intern Med 1991;151(5):1005-9
    • (1991) Arch Intern Med , vol.151 , Issue.5 , pp. 1005-1009
    • Harrison, L.H.1    Armstrong, C.W.2    Jenkins, S.R.3
  • 42
    • 84896399845 scopus 로고    scopus 로고
    • The co-pathogenesis of influenza viruses with bacteria in the lung
    • McCullers JA. The co-pathogenesis of influenza viruses with bacteria in the lung. Nat Rev Microbiol 2014;12(4):252-62
    • (2014) Nat Rev Microbiol , vol.12 , Issue.4 , pp. 252-262
    • McCullers, J.A.1
  • 43
    • 0022969002 scopus 로고
    • Adherence of type i Streptococcus pneumoniae to tracheal epithelium of mice infected with influenza A/PR8 virus
    • Plotkowski MC, Puchelle E, Beck G, et al. Adherence of type I Streptococcus pneumoniae to tracheal epithelium of mice infected with influenza A/PR8 virus. Am Rev Respir Dis 1986;134(5):1040-4
    • (1986) Am Rev Respir Dis , vol.134 , Issue.5 , pp. 1040-1044
    • Plotkowski, M.C.1    Puchelle, E.2    Beck, G.3
  • 44
    • 0028278094 scopus 로고
    • Apoptosis: A mechanism of cell killing by influenza A and B viruses
    • Hinshaw VS, Olsen CW, Dybdahl-Sissoko N, et al. Apoptosis: a mechanism of cell killing by influenza A and B viruses. J Virol 1994;68(6): 3667-73
    • (1994) J Virol , vol.68 , Issue.6 , pp. 3667-3673
    • Hinshaw, V.S.1    Olsen, C.W.2    Dybdahl-Sissoko, N.3
  • 45
    • 33746483285 scopus 로고    scopus 로고
    • Insights into the interaction between influenza virus and pneumococcus
    • McCullers JA. Insights into the interaction between influenza virus and pneumococcus. Clin Microbiol Rev 2006;19(3):571-82
    • (2006) Clin Microbiol Rev , vol.19 , Issue.3 , pp. 571-582
    • McCullers, J.A.1
  • 46
    • 84904178449 scopus 로고    scopus 로고
    • Influenza promotes pneumococcal growth during coinfection by providing host sialylated substrates as a nutrient source
    • Siegel SJ, Roche AM, Weiser JN. Influenza promotes pneumococcal growth during coinfection by providing host sialylated substrates as a nutrient source. Cell Host Microbe 2014;16(1):55-67
    • (2014) Cell Host Microbe , vol.16 , Issue.1 , pp. 55-67
    • Siegel, S.J.1    Roche, A.M.2    Weiser, J.N.3
  • 47
    • 32444435643 scopus 로고    scopus 로고
    • Respiratory viruses augment the adhesion of bacterial pathogens to respiratory epithelium in a viral speciesand cell type-dependent manner
    • Avadhanula V, Rodriguez CA, Devincenzo JP, et al. Respiratory viruses augment the adhesion of bacterial pathogens to respiratory epithelium in a viral speciesand cell type-dependent manner. J Virol 2006;80(4):1629-36
    • (2006) J Virol , vol.80 , Issue.4 , pp. 1629-1636
    • Avadhanula, V.1    Rodriguez, C.A.2    Devincenzo, J.P.3
  • 48
    • 77950492924 scopus 로고    scopus 로고
    • Influenza virus infection decreases tracheal mucociliary velocity and clearance of streptococcus pneumoniae
    • Pittet LA, Hall-Stoodley L, Rutkowski MR, et al. Influenza virus infection decreases tracheal mucociliary velocity and clearance of Streptococcus pneumoniae. Am J Respir Cell Mol Biol 2010;42(4):450-60
    • (2010) Am J Respir Cell Mol Biol , vol.42 , Issue.4 , pp. 450-460
    • Pittet, L.A.1    Hall-Stoodley, L.2    Rutkowski, M.R.3
  • 49
    • 84880666005 scopus 로고    scopus 로고
    • Depletion of alveolar macrophages during influenza infection facilitates bacterial superinfections
    • Ghoneim HE, Thomas PG, McCullers JA. Depletion of alveolar macrophages during influenza infection facilitates bacterial superinfections. J Immunol 2013;191(3): 1250-9
    • (2013) J Immunol , vol.191 , Issue.3 , pp. 1250-1259
    • Ghoneim, H.E.1    Thomas, P.G.2    McCullers, J.A.3
  • 50
    • 84855968386 scopus 로고    scopus 로고
    • Potential role for alternatively activated macrophages in the secondary bacterial infection during recovery from influenza
    • Chen WH, Toapanta FR, Shirey KA, et al. Potential role for alternatively activated macrophages in the secondary bacterial infection during recovery from influenza. Immunol Lett 2012;141(2):227-34
    • (2012) Immunol Lett , vol.141 , Issue.2 , pp. 227-234
    • Chen, W.H.1    Toapanta, F.R.2    Shirey, K.A.3
  • 51
    • 43249118968 scopus 로고    scopus 로고
    • Inhibition of pulmonary antibacterial defense by interferon-gamma during recovery from influenza infection
    • Sun K, Metzger DW. Inhibition of pulmonary antibacterial defense by interferon-gamma during recovery from influenza infection. Nat Med 2008;14(5): 558-64
    • (2008) Nat Med , vol.14 , Issue.5 , pp. 558-564
    • Sun, K.1    Metzger, D.W.2
  • 52
    • 84876004877 scopus 로고    scopus 로고
    • Kinetics of coinfection with influenza A virus and Streptococcus pneumoniae
    • Smith AM, Adler FR, Ribeiro RM, et al. Kinetics of coinfection with influenza A virus and Streptococcus pneumoniae. PLoS Pathog 2013;9(3):e1003238
    • (2013) PLoS Pathog , vol.9 , Issue.3 , pp. e1003238
    • Smith, A.M.1    Adler, F.R.2    Ribeiro, R.M.3
  • 53
    • 84869135096 scopus 로고    scopus 로고
    • Type i interferon induction during influenza virus infection increases susceptibility to secondary streptococcus pneumoniae infection by negative regulation of gammadelta t cells
    • Li W, Moltedo B, Moran TM. Type I interferon induction during influenza virus infection increases susceptibility to secondary Streptococcus pneumoniae infection by negative regulation of gammadelta T cells. J Virol 2012;86(22): 12304-12
    • (2012) J Virol , vol.86 , Issue.22 , pp. 12304-12312
    • Li, W.1    Moltedo, B.2    Moran, T.M.3
  • 54
    • 77949882545 scopus 로고    scopus 로고
    • Dysregulated macrophage-inflammatory protein-2 expression drives illness in bacterial superinfection of influenza
    • Zavitz CC, Bauer CM, Gaschler GJ, et al. Dysregulated macrophage-inflammatory protein-2 expression drives illness in bacterial superinfection of influenza. J Immunol 2010;184(4):2001-13
    • (2010) J Immunol , vol.184 , Issue.4 , pp. 2001-2013
    • Zavitz, C.C.1    Bauer, C.M.2    Gaschler, G.J.3
  • 55
    • 68849124811 scopus 로고    scopus 로고
    • Type i IFNs mediate development of postinfluenza bacterial pneumonia in mice
    • Shahangian A, Chow EK, Tian X, et al. Type I IFNs mediate development of postinfluenza bacterial pneumonia in mice. J Clin Invest 2009;119(7):1910-20
    • (2009) J Clin Invest , vol.119 , Issue.7 , pp. 1910-1920
    • Shahangian, A.1    Chow, E.K.2    Tian, X.3
  • 56
    • 80455158415 scopus 로고    scopus 로고
    • Lethal synergism of 2009 pandemic h1n1 influenza virus and streptococcus pneumoniae coinfection is associated with loss of murine lung repair responses
    • Kash JC, Walters KA, Davis AS, et al. Lethal synergism of 2009 pandemic H1N1 influenza virus and Streptococcus pneumoniae coinfection is associated with loss of murine lung repair responses. MBio 2011;2:5
    • (2011) M. Bio , vol.2 , pp. 5
    • Kash, J.C.1    Walters, K.A.2    Davis, A.S.3
  • 57
    • 79955121049 scopus 로고    scopus 로고
    • Microbiota regulates immune defense against respiratory tract influenza a virus infection
    • Ichinohe T, Pang IK, Kumamoto Y, et al. Microbiota regulates immune defense against respiratory tract influenza A virus infection. Proc Natl Acad Sci USA 2011; 108(13):5354-9
    • (2011) Proc Natl Acad Sci USA , vol.108 , Issue.13 , pp. 5354-5359
    • Ichinohe, T.1    Pang, I.K.2    Kumamoto, Y.3
  • 58
    • 84864311450 scopus 로고    scopus 로고
    • Commensal bacteria calibrate the activation threshold of innate antiviral immunity
    • Abt MC, Osborne LC, Monticelli LA, et al. Commensal bacteria calibrate the activation threshold of innate antiviral immunity. Immunity 2012;37(1):158-70
    • (2012) Immunity , vol.37 , Issue.1 , pp. 158-170
    • Abt, M.C.1    Osborne, L.C.2    Monticelli, L.A.3
  • 59
    • 84880125235 scopus 로고    scopus 로고
    • Bacterial colonization dampens influenza-mediated acute lung injury via induction of M2 alveolar macrophages
    • Wang J, Li F, Sun R, et al. Bacterial colonization dampens influenza-mediated acute lung injury via induction of M2 alveolar macrophages. Nat Commun 2013;4:2106
    • (2013) Nat Commun , vol.4 , pp. 2106
    • Wang, J.1    Li, F.2    Sun, R.3
  • 60
    • 84875981136 scopus 로고    scopus 로고
    • Influenza virus aerosols in human exhaled breath: Particle size culturability and effect of surgical masks
    • Milton DK, Fabian MP, Cowling BJ, et al. Influenza virus aerosols in human exhaled breath: particle size, culturability, and effect of surgical masks. PLoS Pathog 2013;9(3): e1003205
    • (2013) PLoS Pathog , vol.9 , Issue.3 , pp. e1003205
    • Milton, D.K.1    Fabian, M.P.2    Cowling, B.J.3
  • 61
    • 84874741309 scopus 로고    scopus 로고
    • Exposure to influenza virus aerosols during routine patient care
    • Bischoff WE, Swett K, Leng I, et al. Exposure to influenza virus aerosols during routine patient care. J Infect Dis 2013; 207(7):1037-46
    • (2013) J Infect Dis , vol.207 , Issue.7 , pp. 1037-1046
    • Bischoff, W.E.1    Swett, K.2    Leng, I.3
  • 62
    • 84884263936 scopus 로고
    • Aerosol transmission is an important mode of influenza a virus spread
    • Cowling BJ, Ip DK, Fang VJ, et al. Aerosol transmission is an important mode of influenza A virus spread. Nat Commun 2013;4:1935
    • (1935) Nat Commun , vol.2013 , pp. 4
    • Cowling, B.J.1    Ip, D.K.2    Fang, V.J.3
  • 63
    • 79958723427 scopus 로고    scopus 로고
    • Transocular entry of seasonal influenza-attenuated virus aerosols and the efficacy of n95 respirators, surgical masks, and eye protection in humans
    • Bischoff WE, Reid T, Russell GB, et al. Transocular entry of seasonal influenza-attenuated virus aerosols and the efficacy of n95 respirators, surgical masks, and eye protection in humans. J Infect Dis 2011;204(2):193-9
    • (2011) J Infect Dis , vol.204 , Issue.2 , pp. 193-199
    • Bischoff, W.E.1    Reid, T.2    Russell, G.B.3
  • 64
    • 84879813037 scopus 로고    scopus 로고
    • Improved understanding of factors driving methicillin-resistant staphylococcus aureus epidemic waves
    • Chatterjee SS, Otto M. Improved understanding of factors driving methicillin-resistant Staphylococcus aureus epidemic waves. Clin Epidemiol 2013;5: 205-17
    • (2013) Clin Epidemiol , vol.5 , pp. 205-217
    • Chatterjee, S.S.1    Otto, M.2
  • 65
    • 84894279388 scopus 로고    scopus 로고
    • Whole-genome sequencing shows that patient-to-patient transmission rarely accounts for acquisition of staphylococcus aureus in an intensive care unit
    • Price JR, Golubchik T, Cole K, et al. Whole-genome sequencing shows that patient-to-patient transmission rarely accounts for acquisition of Staphylococcus aureus in an intensive care unit. Clin Infect Dis 2014;58(5):609-18
    • (2014) Clin Infect Dis , vol.58 , Issue.5 , pp. 609-618
    • Price, J.R.1    Golubchik, T.2    Cole, K.3
  • 66
    • 84872515273 scopus 로고    scopus 로고
    • Whole-genome sequencing for analysis of an outbreak of methicillin-resistant Staphylococcus aureus: A descriptive study
    • Harris SR, Cartwright EJ, Torok ME, et al. Whole-genome sequencing for analysis of an outbreak of methicillin-resistant Staphylococcus aureus: a descriptive study. Lancet Infect Dis 2013;13(2):130-6
    • (2013) Lancet Infect Dis , vol.13 , Issue.2 , pp. 130-136
    • Harris, S.R.1    Cartwright, E.J.2    Torok, M.E.3
  • 67
    • 33749640606 scopus 로고    scopus 로고
    • Gesundheit sneezing, common colds, allergies, and staphylococcus aureus dispersion
    • Bischoff WE, Wallis ML, Tucker BK, et al. Gesundheit sneezing, common colds, allergies, and Staphylococcus aureus dispersion. J Infect Dis 2006;194(8): 1119-26
    • (2006) J Infect Dis , vol.194 , Issue.8 , pp. 1119-1126
    • Bischoff, W.E.1    Wallis, M.L.2    Tucker, B.K.3
  • 68
    • 0028937827 scopus 로고
    • Effect of experimental influenza a virus infection on isolation of streptococcus pneumoniae and other aerobic bacteria from the oropharynges of allergic and nonallergic adult subjects
    • Wadowsky RM, Mietzner SM, Skoner DP, et al. Effect of experimental influenza A virus infection on isolation of Streptococcus pneumoniae and other aerobic bacteria from the oropharynges of allergic and nonallergic adult subjects. Infect Immunity 1995;63(4):1153-7
    • (1995) Infect Immunity , vol.63 , Issue.4 , pp. 1153-1157
    • Wadowsky, R.M.1    Mietzner, S.M.2    Skoner, D.P.3
  • 69
    • 77956989122 scopus 로고    scopus 로고
    • Influenza enhances susceptibility to natural acquisition of and disease due to Streptococcus pneumoniae in ferrets
    • McCullers JA, McAuley JL, Browall S, et al. Influenza enhances susceptibility to natural acquisition of and disease due to Streptococcus pneumoniae in ferrets. J Infect Dis 2010;202(8):1287-95
    • (2010) J Infect Dis , vol.202 , Issue.8 , pp. 1287-1295
    • McCullers, J.A.1    McAuley, J.L.2    Browall, S.3
  • 70
    • 0035168322 scopus 로고    scopus 로고
    • Effect of influenza A virus infection on nasopharyngeal colonization and otitis media induced by transparent or opaque phenotype variants of Streptococcus pneumoniae in the chinchilla model
    • Tong HH, Weiser JN, James MA, DeMaria TF. Effect of influenza A virus infection on nasopharyngeal colonization and otitis media induced by transparent or opaque phenotype variants of Streptococcus pneumoniae in the chinchilla model. Infect Immun 2001;69(1):602-6
    • (2001) Infect Immun , vol.69 , Issue.1 , pp. 602-606
    • Tong, H.H.1    Weiser, J.N.2    James, M.A.3    Demaria, T.F.4
  • 71
    • 80052383971 scopus 로고    scopus 로고
    • Synergistic stimulation of type i interferons during influenza virus coinfection promotes Streptococcus pneumoniae colonization in mice
    • Nakamura S, Davis KM, Weiser JN. Synergistic stimulation of type I interferons during influenza virus coinfection promotes Streptococcus pneumoniae colonization in mice. J Clin Invest 2011;121(9):3657-65
    • (2011) J Clin Invest , vol.121 , Issue.9 , pp. 3657-3665
    • Nakamura, S.1    Davis, K.M.2    Weiser, J.N.3
  • 72
    • 84867627559 scopus 로고    scopus 로고
    • Associations between pathogens in the upper respiratory tract of young children: Interplay between viruses and bacteria
    • Van Den Bergh MR, Biesbroek G, Rossen JW, et al. Associations between pathogens in the upper respiratory tract of young children: interplay between viruses and bacteria. PLoS One 2012;7(10):e47711
    • (2012) Plos One , vol.7 , Issue.10 , pp. e47711
    • Van Den Bergh, M.R.1    Biesbroek, G.2    Rossen, J.W.3
  • 73
    • 77953519376 scopus 로고    scopus 로고
    • Influenza A virus facilitates Streptococcus pneumoniae transmission and disease
    • Diavatopoulos DA, Short KR, Price JT, et al. Influenza A virus facilitates Streptococcus pneumoniae transmission and disease. FASEB J 2010;24(6):1789-98
    • (2010) Faseb J. , vol.24 , Issue.6 , pp. 1789-1798
    • Diavatopoulos, D.A.1    Short, K.R.2    Price, J.T.3
  • 74
    • 0023136546 scopus 로고
    • Role of Staphylococcus protease in the development of influenza pneumonia
    • Tashiro M, Ciborowski P, Klenk HD, et al. Role of Staphylococcus protease in the development of influenza pneumonia. Nature 1987;325(6104):536-7
    • (1987) Nature , vol.325 , Issue.6104 , pp. 536-537
    • Tashiro, M.1    Ciborowski, P.2    Klenk, H.D.3
  • 75
    • 0023111155 scopus 로고
    • Synergistic role of staphylococcal proteases in the induction of influenza virus pathogenicity
    • Tashiro M, Ciborowski P, Reinacher M, et al. Synergistic role of staphylococcal proteases in the induction of influenza virus pathogenicity. Virology 1987;157(2):421-30
    • (1987) Virology , vol.157 , Issue.2 , pp. 421-430
    • Tashiro, M.1    Ciborowski, P.2    Reinacher, M.3
  • 76
    • 0031957615 scopus 로고    scopus 로고
    • Role of the microbiology laboratory in the diagnosis of lower respiratory tract infections
    • Reimer LG, Carroll KC. Role of the microbiology laboratory in the diagnosis of lower respiratory tract infections. Clin Infect Dis 1998;26(3):742-8
    • (1998) Clin Infect Dis , vol.26 , Issue.3 , pp. 742-748
    • Reimer, L.G.1    Carroll, K.C.2
  • 77
    • 0041353475 scopus 로고    scopus 로고
    • Bacterial infection in exacerbated copd with changes in sputum characteristics
    • Monso E, Garcia-Aymerich J, Soler N, et al. Bacterial infection in exacerbated COPD with changes in sputum characteristics. Epidemiol Infect 2003; 131(1):799-804
    • (2003) Epidemiol Infect , vol.131 , Issue.1 , pp. 799-804
    • Monso, E.1    Garcia-Aymerich, J.2    Soler, N.3
  • 78
    • 42049092349 scopus 로고    scopus 로고
    • Assessment of the usefulness of sputum Gram stain and culture for diagnosis of community-acquired pneumonia requiring hospitalization
    • Cr171-6
    • Miyashita N, Shimizu H, Ouchi K, et al. Assessment of the usefulness of sputum Gram stain and culture for diagnosis of community-acquired pneumonia requiring hospitalization. Med Sci Monit 2008;14(4): Cr171-6
    • (2008) Med Sci Monit , vol.14 , Issue.4
    • Miyashita, N.1    Shimizu, H.2    Ouchi, K.3
  • 79
    • 84905118207 scopus 로고    scopus 로고
    • The role of multiplex PCR test in identification of bacterial pathogens in lower respiratory tract infections
    • Aydemir O, Aydemir Y, Ozdemir M. The role of multiplex PCR test in identification of bacterial pathogens in lower respiratory tract infections. Pak J Med Sci 2014;30(5): 1011-16
    • (2014) Pak J Med Sci , vol.30 , Issue.5 , pp. 1011-1016
    • Aydemir, O.1    Aydemir, Y.2    Ozdemir, M.3
  • 80
    • 84908551308 scopus 로고    scopus 로고
    • The use of a multiplex real-time PCR assay for diagnosing acute respiratory viral infections in children attending an emergency unit
    • Epub ahead of print
    • Mengelle C, Mansuy JM, Pierre A, et al. The use of a multiplex real-time PCR assay for diagnosing acute respiratory viral infections in children attending an emergency unit. J Clin Virol 2014. [Epub ahead of print
    • (2014) J Clin Virol
    • Mengelle, C.1    Mansuy, J.M.2    Pierre, A.3
  • 81
    • 0038556795 scopus 로고    scopus 로고
    • Nucleic acid amplification tests for the diagnosis of pneumonia
    • Murdoch DR. Nucleic acid amplification tests for the diagnosis of pneumonia. Clin Infect Dis 2003;36(9):1162-70
    • (2003) Clin Infect Dis , vol.36 , Issue.9 , pp. 1162-1170
    • Murdoch, D.R.1
  • 82
    • 58149269488 scopus 로고    scopus 로고
    • Biological markers to determine eligibility in trials for community-acquired pneumonia: A focus on procalcitonin
    • Niederman MS. Biological markers to determine eligibility in trials for community-acquired pneumonia: a focus on procalcitonin. Clin Infect Dis 2008; 47(Suppl 3):S127-32
    • (2008) Clin Infect Dis , vol.47 , pp. S127-S132
    • Niederman, M.S.1
  • 83
    • 80054782329 scopus 로고    scopus 로고
    • Role of procalcitonin and C-reactive protein in differentiation of mixed bacterial infection from 2009 h1n1 viral pneumonia
    • Ahn S, Kim WY, Kim SH, et al. Role of procalcitonin and C-reactive protein in differentiation of mixed bacterial infection from 2009 H1N1 viral pneumonia. Influenza Other Respir Viruses 2011;5(6): 398-403
    • (2011) Influenza Other Respir Viruses , vol.5 , Issue.6 , pp. 398-403
    • Ahn, S.1    Kim, W.Y.2    Kim, S.H.3
  • 84
    • 0034125698 scopus 로고    scopus 로고
    • Physiology and genetics of procalcitonin
    • Maruna P, Nedelnikova K, Gurlich R. Physiology and genetics of procalcitonin. Physiol Res 2000;49(Suppl 1):S57-61
    • (2000) Physiol Res , vol.49 , pp. S57-61
    • Maruna, P.1    Nedelnikova, K.2    Gurlich, R.3
  • 85
    • 84876502043 scopus 로고    scopus 로고
    • Can procalcitonin tests aid in identifying bacterial infections associated with influenza pneumonia? A systematic review and meta-analysis
    • Wu MH, Lin CC, Huang SL, et al. Can procalcitonin tests aid in identifying bacterial infections associated with influenza pneumonia?. A systematic review and meta-analysis. Influenza Other Respir Viruses 2013;7(3):349-55
    • (2013) Influenza Other Respir Viruses , vol.7 , Issue.3 , pp. 349-355
    • Wu, M.H.1    Lin, C.C.2    Huang, S.L.3
  • 86
    • 79959555491 scopus 로고    scopus 로고
    • Imaging of pulmonary viral pneumonia
    • Franquet T. Imaging of pulmonary viral pneumonia. Radiology 2011;260(1):18-39
    • (2011) Radiology , vol.260 , Issue.1 , pp. 18-39
    • Franquet, T.1
  • 87
    • 80054878313 scopus 로고    scopus 로고
    • CT of viral lower respiratory tract infections in adults: Comparison among viral organisms and between viral and bacterial infections
    • Miller WT Jr, Mickus TJ, Barbosa E Jr, et al. CT of viral lower respiratory tract infections in adults: comparison among viral organisms and between viral and bacterial infections. AJR Am J Roentgenol 2011; 197(5):1088-95
    • (2011) AJR Am J Roentgenol , vol.197 , Issue.5 , pp. 1088-1095
    • Miller, W.T.1    Mickus, T.J.2    Barbosa, E.3
  • 88
    • 63649087759 scopus 로고    scopus 로고
    • Seasonal influenza in adults and children-diagnosis, treatment, chemoprophylaxis, and institutional outbreak management: Clinical practice guidelines of the infectious diseases society of america
    • Harper SA, Bradley JS, Englund JA, et al. Seasonal influenza in adults and children-diagnosis, treatment, chemoprophylaxis, and institutional outbreak management: clinical practice guidelines of the Infectious Diseases Society of America. Clin Infect Dis 2009; 48(8):1003-32
    • (2009) Clin Infect Dis , vol.48 , Issue.8 , pp. 1003-1032
    • Harper, S.A.1    Bradley, J.S.2    Englund, J.A.3
  • 89
    • 38949197905 scopus 로고    scopus 로고
    • Antiviral therapy and outcomes of influenza requiring hospitalization in ontario, canada
    • McGeer A, Green KA, Plevneshi A, et al. Antiviral therapy and outcomes of influenza requiring hospitalization in Ontario, Canada. Clin Infect Dis 2007;45(12): 1568-75
    • (2007) Clin Infect Dis , vol.45 , Issue.12 , pp. 1568-1575
    • McGeer, A.1    Green, K.A.2    Plevneshi, A.3
  • 90
    • 77953690216 scopus 로고    scopus 로고
    • Outcomes of adults hospitalised with severe influenza
    • Lee N, Choi KW, Chan PK, et al. Outcomes of adults hospitalised with severe influenza. Thorax 2010;65(6):510-15
    • (2010) Thorax , vol.65 , Issue.6 , pp. 510-515
    • Lee, N.1    Choi, K.W.2    Chan, P.K.3
  • 91
    • 22244471025 scopus 로고    scopus 로고
    • Influenza virus neuraminidase contributes to secondary bacterial pneumonia
    • Peltola VT, Murti KG, McCullers JA. Influenza virus neuraminidase contributes to secondary bacterial pneumonia. J Infect Dis 2005;192(2):249-57
    • (2005) J Infect Dis , vol.192 , Issue.2 , pp. 249-257
    • Peltola, V.T.1    Murti, K.G.2    McCullers, J.A.3
  • 92
    • 0042259159 scopus 로고    scopus 로고
    • Impact of oseltamivir treatment on influenza-related lower respiratory tract complications and hospitalizations
    • Kaiser L, Wat C, Mills T, et al. Impact of oseltamivir treatment on influenza-related lower respiratory tract complications and hospitalizations. Arch Intern Med 2003; 163(14):1667-72
    • (2003) Arch Intern Med , vol.163 , Issue.14 , pp. 1667-1672
    • Kaiser, L.1    Wat, C.2    Mills, T.3
  • 93
    • 79960757788 scopus 로고    scopus 로고
    • Oseltamivir and risk of lower respiratory tract complications in patients with flu symptoms: A meta-analysis of eleven randomized clinical trials
    • Hernan MA, Lipsitch M. Oseltamivir and risk of lower respiratory tract complications in patients with flu symptoms: a meta-analysis of eleven randomized clinical trials. Clin Infect Dis 2011;53(3):277-9
    • (2011) Clin Infect Dis , vol.53 , Issue.3 , pp. 277-279
    • Hernan, M.A.1    Lipsitch, M.2
  • 94
    • 72449184233 scopus 로고    scopus 로고
    • Neuraminidase inhibitors for preventing and treating influenza in healthy adults: Systematic review and meta-analysis
    • Jefferson T, Jones M, Doshi P, Del Mar C. Neuraminidase inhibitors for preventing and treating influenza in healthy adults: systematic review and meta-analysis. Bmj 2009;339:b5106
    • (2009) Bmj , vol.339 , pp. b5106
    • Jefferson, T.1    Jones, M.2    Doshi, P.3    Del Mar, C.4
  • 95
    • 72449183788 scopus 로고    scopus 로고
    • Why don't we have all the evidence on oseltamivir?
    • Godlee F, Clarke M. Why don't we have all the evidence on oseltamivir?. BMJ 2009;339: b5351
    • (2009) BMJ , vol.339 , pp. b5351
    • Godlee, F.1    Clarke, M.2
  • 96
    • 78751698009 scopus 로고    scopus 로고
    • Ensuring safe and effective drugs: Who can do what it takes?
    • Cochrane Acute Respiratory Infections Group
    • Jefferson T, Doshi P, Thompson M, Heneghan C; Cochrane Acute Respiratory Infections Group. Ensuring safe and effective drugs: who can do what it takes?. Bmj 2011;342:c7258
    • (2011) Bmj , vol.342 , pp. c7258
    • Jefferson, T.1    Doshi, P.2    Thompson, M.3    Heneghan, C.4
  • 97
    • 69449095308 scopus 로고    scopus 로고
    • Neuraminidase inhibitors for treatment and prophylaxis of influenza in children: Systematic review and meta-analysis of randomised controlled trials
    • Shun-Shin M, Thompson M, Heneghan C, et al. Neuraminidase inhibitors for treatment and prophylaxis of influenza in children: systematic review and meta-analysis of randomised controlled trials. Bmj 2009;339:b3172
    • (2009) Bmj , vol.339 , pp. b3172
    • Shun-Shin, M.1    Thompson, M.2    Heneghan, C.3
  • 98
    • 84893909238 scopus 로고    scopus 로고
    • Neuraminidase inhibitors for preventing and treating influenza in healthy adults and children
    • Jefferson T, Jones MA, Doshi P, et al. Neuraminidase inhibitors for preventing and treating influenza in healthy adults and children. Cochrane Database Syst Rev 2014;4:CD008965
    • (2014) Cochrane Database Syst Rev , vol.4 , pp. CD008965
    • Jefferson, T.1    Jones, M.A.2    Doshi, P.3
  • 99
    • 84916906084 scopus 로고    scopus 로고
    • The effect of intravenous peramivir, compared with oral oseltamivir, on the outcome of post-influenza pneumococcal pneumonia in mice
    • Epub ahead of print
    • Tanaka A, Nakamura S, Seki M, et al. The effect of intravenous peramivir, compared with oral oseltamivir, on the outcome of post-influenza pneumococcal pneumonia in mice. Antivir Ther 2014; Epub ahead of print
    • (2014) Antivir Ther
    • Tanaka, A.1    Nakamura, S.2    Seki, M.3
  • 100
    • 33846188500 scopus 로고    scopus 로고
    • Pandemic flu: Clinical management of patients with an influenza-like illness during an influenza pandemic provisional guidelines from the british infection society, british thoracic society, and health protection agency in collaboration with the department of health
    • British Infection Society; British Thoracic Society; Health Protection Agency
    • British Infection Society; British Thoracic Society; Health Protection Agency. Pandemic flu: clinical management of patients with an influenza-like illness during an influenza pandemic. Provisional guidelines from the British Infection Society, British Thoracic Society, and Health Protection Agency in collaboration with the Department of Health. Thorax 2007;62(Suppl 1):1-46
    • (2007) Thorax , vol.62 , pp. 1-46
  • 101
    • 70349772459 scopus 로고    scopus 로고
    • Bacterial coinfections in lung tissue specimens from fatal cases of 2009 pandemic influenza a (h1n1) - United states, may-august 2009
    • Centers for Disease Control and Prevention (CDC
    • Centers for Disease Control and Prevention (CDC). Bacterial coinfections in lung tissue specimens from fatal cases of 2009 pandemic influenza A (H1N1) - United States, May-August 2009. MMWR Morb Mortal Wkly Rep 2009;58(38): 1071-4
    • (2009) MMWR Morb Mortal Wkly Rep , vol.58 , Issue.38 , pp. 1071-1074
  • 103
    • 84859040061 scopus 로고    scopus 로고
    • Doxycycline treatment attenuates acute lung injury in mice infected with virulent influenza h3n2 virus: Involvement of matrix metalloproteinases
    • Ng HH, Narasaraju T, Phoon MC, et al. Doxycycline treatment attenuates acute lung injury in mice infected with virulent influenza H3N2 virus: involvement of matrix metalloproteinases. Exp Mol Pathol 2012;92(3):287-95
    • (2012) Exp Mol Pathol , vol.92 , Issue.3 , pp. 287-295
    • Ng, H.H.1    Narasaraju, T.2    Phoon, M.C.3
  • 104
    • 84897146084 scopus 로고    scopus 로고
    • Leucomycin a, a 16-membered macrolide antibiotic, inhibits influenza a virus infection and disease progression
    • Sugamata R, Sugawara A, Nagao T, et al. Leucomycin A, a 16-membered macrolide antibiotic, inhibits influenza A virus infection and disease progression. J Antibiot 2014;67(3):213-22
    • (2014) J Antibiot , vol.67 , Issue.3 , pp. 213-222
    • Sugamata, R.1    Sugawara, A.2    Nagao, T.3
  • 105
    • 84875433744 scopus 로고    scopus 로고
    • Macrolide-based regimens in absence of bacterial co-infection in critically ill h1n1 patients with primary viral pneumonia
    • Martin-Loeches I, Bermejo-Martin JF, et al. Macrolide-based regimens in absence of bacterial co-infection in critically ill H1N1 patients with primary viral pneumonia. Intensive Care Med 2013; 39(4):693-702
    • (2013) Intensive Care Med , vol.39 , Issue.4 , pp. 693-702
    • Martin-Loeches, I.1    Bermejo-Martin, J.F.2
  • 106
    • 84881392472 scopus 로고    scopus 로고
    • Linezolid decreases susceptibility to secondary bacterial pneumonia postinfluenza infection in mice through its effects on IFN-gamma
    • Breslow-Deckman JM, Mattingly CM, Birket SE, et al. Linezolid decreases susceptibility to secondary bacterial pneumonia postinfluenza infection in mice through its effects on IFN-gamma. J Immunol 2013;191(4):1792-9
    • (2013) J Immunol , vol.191 , Issue.4 , pp. 1792-1799
    • Breslow-Deckman, J.M.1    Mattingly, C.M.2    Birket, S.E.3
  • 107
    • 58849132964 scopus 로고    scopus 로고
    • Treatment with protein synthesis inhibitors improves outcomes of secondary bacterial pneumonia after influenza
    • Karlstrom A, Boyd KL, English BK, McCullers JA. Treatment with protein synthesis inhibitors improves outcomes of secondary bacterial pneumonia after influenza. J Infect Dis 2009;199(3):311-19
    • (2009) J Infect Dis , vol.199 , Issue.3 , pp. 311-319
    • Karlstrom, A.1    Boyd, K.L.2    English, B.K.3    McCullers, J.A.4
  • 108
    • 84874589858 scopus 로고    scopus 로고
    • Effect of linezolid on clinical severity and pulmonary cytokines in a murine model of influenza a and staphylococcus aureus coinfection
    • Liu X, He Y, Xiao K, et al. Effect of linezolid on clinical severity and pulmonary cytokines in a murine model of influenza A and Staphylococcus aureus coinfection. PLoS One 2013;8(3):e57483
    • (2013) Plos One , vol.8 , Issue.3 , pp. e57483
    • Liu, X.1    He, Y.2    Xiao, K.3
  • 109
    • 0031954367 scopus 로고    scopus 로고
    • Therapeutic effect of erythromycin on influenza virus-induced lung injury in mice
    • Sato K, Suga M, Akaike T, et al. Therapeutic effect of erythromycin on influenza virus-induced lung injury in mice. Am J Respir Crit Care Med 1998; 157(3 Pt 1):853-7
    • (1998) Am J Respir Crit Care Med , vol.157 , Issue.3 , pp. 853-857
    • Sato, K.1    Suga, M.2    Akaike, T.3
  • 110
    • 84856937734 scopus 로고    scopus 로고
    • Linezolid in methicillin-resistant staphylococcus aureus nosocomial pneumonia: A randomized controlled study
    • Wunderink RG, Niederman MS, Kollef MH, et al. Linezolid in methicillin-resistant Staphylococcus aureus nosocomial pneumonia: a randomized, controlled study. Clin Infect Dis 2012; 54(5):621-9
    • (2012) Clin Infect Dis , vol.54 , Issue.5 , pp. 621-629
    • Wunderink, R.G.1    Niederman, M.S.2    Kollef, M.H.3
  • 111
    • 84898857321 scopus 로고    scopus 로고
    • Adjunctive corticosteroid therapy improves lung immunopathology and survival during severe secondary pneumococcal pneumonia in mice
    • Ghoneim HE, McCullers JA. Adjunctive corticosteroid therapy improves lung immunopathology and survival during severe secondary pneumococcal pneumonia in mice. J Infect Dis 2013;209(9):1459-68
    • (2013) J Infect Dis , vol.209 , Issue.9 , pp. 1459-1468
    • Ghoneim, H.E.1    McCullers, J.A.2
  • 112
    • 84883177257 scopus 로고    scopus 로고
    • Marked improvement of severe lung immunopathology by influenza-associated pneumococcal superinfection requires the control of both bacterial replication and host immune responses
    • Damjanovic D, Lai R, Jeyanathan M, et al. Marked improvement of severe lung immunopathology by influenza-associated pneumococcal superinfection requires the control of both bacterial replication and host immune responses. Am J Pathol 2013; 183(3):868-80
    • (2013) Am J Pathol , vol.183 , Issue.3 , pp. 868-880
    • Damjanovic, D.1    Lai, R.2    Jeyanathan, M.3
  • 113
    • 79955505106 scopus 로고    scopus 로고
    • Early corticosteroids in severe influenza a/h1n1 pneumonia and acute respiratory distress syndrome
    • Brun-Buisson C, Richard JC, Mercat A, et al. Early corticosteroids in severe influenza A/H1N1 pneumonia and acute respiratory distress syndrome. Am J Respir Crit Care Med 2011;183(9):1200-6
    • (2011) Am J Respir Crit Care Med , vol.183 , Issue.9 , pp. 1200-1206
    • Brun-Buisson, C.1    Richard, J.C.2    Mercat, A.3
  • 114
    • 79953816521 scopus 로고    scopus 로고
    • Use of early corticosteroid therapy on icu admission in patients affected by severe pandemic (h1n1)v influenza a infection
    • Martin-Loeches I, Lisboa T, Rhodes A, et al. Use of early corticosteroid therapy on ICU admission in patients affected by severe pandemic (H1N1)v influenza A infection. Intensive Care Med 2011;37(2):272-83
    • (2011) Intensive Care Med , vol.37 , Issue.2 , pp. 272-283
    • Martin-Loeches, I.1    Lisboa, T.2    Rhodes, A.3
  • 115
    • 76549126643 scopus 로고    scopus 로고
    • H1n1 influenza a virus-associated acute lung injury: Response to combination oseltamivir and prolonged corticosteroid treatment
    • Quispe-Laime AM, Bracco JD, Barberio PA, et al. H1N1 influenza A virus-associated acute lung injury: response to combination oseltamivir and prolonged corticosteroid treatment. Intensive Care Med 2010;36(1): 33-41
    • (2010) Intensive Care Med , vol.36 , Issue.1 , pp. 33-41
    • Quispe-Laime, A.M.1    Bracco, J.D.2    Barberio, P.A.3
  • 116
    • 2642536741 scopus 로고    scopus 로고
    • Inflammation, immunity, and hmg-coa reductase inhibitors: Statins as anti-inflammatory agents?
    • Schonbeck U, Libby P. Inflammation, immunity, and HMG-CoA reductase inhibitors: statins as anti-inflammatory agents?. Circulation 2004;109(21 Suppl 1): Ii18-26
    • (2004) Circulation , vol.109 , Issue.21 , pp. Ii18-26
    • Schonbeck, U.1    Libby, P.2
  • 117
    • 84555195641 scopus 로고    scopus 로고
    • Association between use of statins and mortality among patients hospitalized with laboratory-confirmed influenza virus infections: A multistate study
    • Vandermeer ML, Thomas AR, Kamimoto L, et al. Association between use of statins and mortality among patients hospitalized with laboratory-confirmed influenza virus infections: a multistate study. J Infect Dis 2012;205(1):13-19
    • (2012) J Infect Dis , vol.205 , Issue.1 , pp. 13-19
    • Vandermeer, M.L.1    Thomas, A.R.2    Kamimoto, L.3
  • 118
    • 26244441019 scopus 로고    scopus 로고
    • The effect of prior statin use on 30-day mortality for patients hospitalized with community-acquired pneumonia
    • Mortensen EM, Restrepo MI, Anzueto A, Pugh J. The effect of prior statin use on 30-day mortality for patients hospitalized with community-acquired pneumonia. Respir Res 2005;6(1):82
    • (2005) Respir Res , vol.6 , Issue.1 , pp. 82
    • Mortensen, E.M.1    Restrepo, M.I.2    Anzueto, A.3    Pugh, J.4
  • 119
    • 84902659631 scopus 로고    scopus 로고
    • Simvastatin modulates cellular components in influenza A virus-infected cells
    • Mehrbod P, Hair-Bejo M, Tengku Ibrahim TA, et al. Simvastatin modulates cellular components in influenza A virus-infected cells. Int J Mol Med 2014; 34(1):61-73
    • (2014) Int J Mol Med , vol.34 , Issue.1 , pp. 61-73
    • Mehrbod, P.1    Hair-Bejo, M.2    Tengku Ibrahim, T.A.3
  • 120
    • 84899680709 scopus 로고    scopus 로고
    • Protective effect of fluvastatin on influenza virus infection
    • Peng J, Zhang D, Ma Y, et al. Protective effect of fluvastatin on influenza virus infection. Mol Med Rep 2014;9(6):2221-6
    • (2014) Mol Med Rep , vol.9 , Issue.6 , pp. 2221-2226
    • Peng, J.1    Zhang, D.2    Ma, Y.3
  • 121
    • 84155162558 scopus 로고    scopus 로고
    • Efficacy and effectiveness of influenza vaccines: A systematic review and meta-analysis
    • Osterholm MT, Kelley NS, Sommer A, Belongia EA. Efficacy and effectiveness of influenza vaccines: a systematic review and meta-analysis. Lancet Infect Dis 2012;12(1): 36-44
    • (2012) Lancet Infect Dis , vol.12 , Issue.1 , pp. 36-44
    • Osterholm, M.T.1    Kelley, N.S.2    Sommer, A.3    Belongia, E.A.4
  • 122
    • 3142572775 scopus 로고    scopus 로고
    • Vaccination with formalin-inactivated influenza vaccine protects mice against lethal influenza Streptococcus pyogenes superinfection
    • Okamoto S, Kawabata S, Fujitaka H, et al. Vaccination with formalin-inactivated influenza vaccine protects mice against lethal influenza Streptococcus pyogenes superinfection. Vaccine 2004;22(21-22): 2887-93
    • (2004) Vaccine , vol.22 , Issue.21-22 , pp. 2887-2893
    • Okamoto, S.1    Kawabata, S.2    Fujitaka, H.3
  • 123
    • 84885070843 scopus 로고    scopus 로고
    • Live attenuated influenza vaccine, but not pneumococcal conjugate vaccine, protects against increased density and duration of pneumococcal carriage after influenza infection in pneumococcal colonized mice
    • Mina MJ, Klugman KP, McCullers JA. Live attenuated influenza vaccine, but not pneumococcal conjugate vaccine, protects against increased density and duration of pneumococcal carriage after influenza infection in pneumococcal colonized mice. J Infect Dis 2013;208(8):1281-5
    • (2013) J Infect Dis , vol.208 , Issue.8 , pp. 1281-1285
    • Mina, M.J.1    Klugman, K.P.2    McCullers, J.A.3
  • 124
    • 79955112552 scopus 로고    scopus 로고
    • Inactivated and live attenuated influenza vaccines protect mice against influenza: Streptococcus pyogenes super-infections
    • Chaussee MS, Sandbulte HR, Schuneman MJ, et al. Inactivated and live, attenuated influenza vaccines protect mice against influenza: Streptococcus pyogenes super-infections. Vaccine 2011;29(21): 3773-81
    • (2011) Vaccine , vol.29 , Issue.21 , pp. 3773-3781
    • Chaussee, M.S.1    Sandbulte, H.R.2    Schuneman, M.J.3
  • 125
    • 84903362395 scopus 로고    scopus 로고
    • Live attenuated influenza vaccine enhances colonization of streptococcus pneumoniae and staphylococcus aureus in mice
    • Mina MJ, McCullers JA, Klugman KP. Live attenuated influenza vaccine enhances colonization of streptococcus pneumoniae and staphylococcus aureus in mice. MBio 2014;5:1
    • (2014) M. Bio , vol.5 , pp. 1
    • Mina, M.J.1    McCullers, J.A.2    Klugman, K.P.3
  • 126
    • 84907454989 scopus 로고    scopus 로고
    • Use of 13-valent pneumococcal conjugate vaccine and 23-valent pneumococcal polysaccharide vaccine among adults aged â 65 years: Recommendations of the advisory committee on immunization practices (acip
    • Prevention CfDCa. Use of 13-Valent Pneumococcal Conjugate Vaccine and 23-Valent Pneumococcal Polysaccharide Vaccine Among Adults Aged â 65 Years: Recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Morb Mortal Wkly Rep 2014;63:822-5
    • (2014) MMWR Morb Mortal Wkly Rep , vol.63 , pp. 822-825
    • Cfdca, P.1
  • 127
    • 84880722937 scopus 로고    scopus 로고
    • Immunogenicity and safety of a 13-valent pneumococcal conjugate vaccine compared to a 23-valent pneumococcal polysaccharide vaccine in pneumococcal vaccine-naive adults
    • Jackson LA, Gurtman A, van Cleeff M, et al. Immunogenicity and safety of a 13-valent pneumococcal conjugate vaccine compared to a 23-valent pneumococcal polysaccharide vaccine in pneumococcal vaccine-naive adults. Vaccine 2013;31(35): 3577-84
    • (2013) Vaccine , vol.31 , Issue.35 , pp. 3577-3584
    • Jackson, L.A.1    Gurtman, A.2    Van Cleeff, M.3
  • 128
    • 84880723200 scopus 로고    scopus 로고
    • Immunogenicity and safety of a 13-valent pneumococcal conjugate vaccine in adults 70 years of age and older previously vaccinated with 23-valent pneumococcal polysaccharide vaccine
    • Jackson LA, Gurtman A, Rice K, et al. Immunogenicity and safety of a 13-valent pneumococcal conjugate vaccine in adults 70 years of age and older previously vaccinated with 23-valent pneumococcal polysaccharide vaccine. Vaccine 2013; 31(35):3585-93
    • (2013) Vaccine , vol.31 , Issue.35 , pp. 3585-3593
    • Jackson, L.A.1    Gurtman, A.2    Rice, K.3
  • 129
    • 84877890366 scopus 로고    scopus 로고
    • Impact of 13-valent pneumococcal conjugate vaccine (PCV13) in a pandemic similar to the 2009 h1n1 in the united states
    • McGarry LJ, Gilmore KE, Rubin JL, et al. Impact of 13-valent pneumococcal conjugate vaccine (PCV13) in a pandemic similar to the 2009 H1N1 in the United States. BMC infect Dis 2013;13:229
    • (2013) BMC Infect Dis , vol.13 , pp. 229
    • McGarry, L.J.1    Gilmore, K.E.2    Rubin, J.L.3
  • 130
    • 84877115048 scopus 로고    scopus 로고
    • Effectiveness of vaccination with 23-valent pneumococcal polysaccharide vaccine in preventing hospitalization with laboratory confirmed influenza during the 2009-2010 and 2010-2011 seasons
    • Dominguez A, Castilla J, Godoy P, et al. Effectiveness of vaccination with 23-valent pneumococcal polysaccharide vaccine in preventing hospitalization with laboratory confirmed influenza during the 2009-2010 and 2010-2011 seasons. Hum Vaccin Immunother 2013;9(4):865-73
    • (2013) Hum Vaccin Immunother , vol.9 , Issue.4 , pp. 865-873
    • Dominguez, A.1    Castilla, J.2    Godoy, P.3
  • 131
    • 84876296164 scopus 로고    scopus 로고
    • Benefit of conjugate pneumococcal vaccination in preventing influenza hospitalization in children: A case-control study
    • Dominguez A, Castilla J, Godoy P, et al. Benefit of conjugate pneumococcal vaccination in preventing influenza hospitalization in children: a case-control study. Pediatr Infect Dis J 2013;32(4):330-4
    • (2013) Pediatr Infect Dis J , vol.32 , Issue.4 , pp. 330-334
    • Dominguez, A.1    Castilla, J.2    Godoy, P.3
  • 132
    • 0033618436 scopus 로고    scopus 로고
    • The additive benefits of influenza and pneumococcal vaccinations during influenza seasons among elderly persons with chronic lung disease
    • Nichol KL. The additive benefits of influenza and pneumococcal vaccinations during influenza seasons among elderly persons with chronic lung disease. Vaccine 1999;17(Suppl 1):S91-3
    • (1999) Vaccine , vol.17 , pp. S91-S93
    • Nichol, K.L.1
  • 133
    • 84916906083 scopus 로고    scopus 로고
    • PHAC. Available from
    • PHAC. Available from: http://www.phacaspc. gc.ca/nois-sinp/guide/ac-sa-eng.php
  • 134
    • 84894131507 scopus 로고    scopus 로고
    • Efficacy of face masks and respirators in preventing upper respiratory tract bacterial colonization and co-infection in hospital healthcare workers
    • Macintyre CR, Wang Q, Rahman B, et al. Efficacy of face masks and respirators in preventing upper respiratory tract bacterial colonization and co-infection in hospital healthcare workers. Preventive medicine 2014;62C:1-7
    • (2014) Preventive Medicine , pp. 1-7
    • MacIntyre, C.R.1    Wang, Q.2    Rahman, B.3
  • 135
    • 48749088916 scopus 로고    scopus 로고
    • Bacterial pneumonia and pandemic influenza planning
    • Gupta RK, George R, Nguyen-Van-Tam JS. Bacterial pneumonia and pandemic influenza planning. Emerg Infect Dis 2008;14(8): 1187-92
    • (2008) Emerg Infect Dis , vol.14 , Issue.8 , pp. 1187-1192
    • Gupta, R.K.1    George, R.2    Nguyen-Van-Tam, J.S.3
  • 136
    • 84912127239 scopus 로고    scopus 로고
    • High nasopharyngeal pneumococcal density, increased by viral coinfection, is associated with invasive pneumococcal pneumonia
    • Wolter N, Tempia S, Cohen C, et al. High nasopharyngeal pneumococcal density, increased by viral coinfection, is associated with invasive pneumococcal pneumonia. J Infect Dis 2014;210(10):1649-57
    • (2014) J Infect Dis , vol.210 , Issue.10 , pp. 1649-1657
    • Wolter, N.1    Tempia, S.2    Cohen, C.3
  • 137
    • 84891368100 scopus 로고    scopus 로고
    • HIV and influenza virus infections are associated with increased blood pneumococcal load: A prospective, hospital-based observational study in south africa, 2009-2011
    • Wolter N, Cohen C, Tempia S, et al. HIV and influenza virus infections are associated with increased blood pneumococcal load: a prospective, hospital-based observational study in South Africa, 2009-2011. J Infect Dis 2014;209(1):56-65
    • (2014) J Infect Dis , vol.209 , Issue.1 , pp. 56-65
    • Wolter, N.1    Cohen, C.2    Tempia, S.3
  • 139
    • 70350752187 scopus 로고    scopus 로고
    • Intervention strategies for an influenza pandemic taking into account secondary bacterial infections
    • Jr., Handel A, Longini IMAntia R. Intervention strategies for an influenza pandemic taking into account secondary bacterial infections. Epidemics 2009;1(3): 185-95
    • (2009) Epidemics , vol.1 , Issue.3 , pp. 185-195
    • Handel, A.1    Longini, I.M.2    Antia, R.3
  • 140
    • 33745589720 scopus 로고
    • The epidemic respiratory infection at camp cody, n.M
    • Lamb FH, Brannin EB. The epidemic respiratory infection at Camp Cody, N.M. JAMA 1919;72(15):1056-62
    • (1919) Jama , vol.72 , Issue.15 , pp. 1056-1062
    • Lamb, F.H.1    Brannin, E.B.2
  • 141
    • 33745606446 scopus 로고    scopus 로고
    • The guinea pig as a transmission model for human influenza viruses
    • Lowen AC, Mubareka S, Tumpey TM, et al. The guinea pig as a transmission model for human influenza viruses. Proc Natl Acad Sci U S A 2006;103(26):9988-92
    • (2006) Proc Natl Acad Sci U S A , vol.103 , Issue.26 , pp. 9988-9992
    • Lowen, A.C.1    Mubareka, S.2    Tumpey, T.M.3
  • 142
    • 84903775329 scopus 로고    scopus 로고
    • Pneumolysin expression by streptococcus pneumoniae protects colonized mice from influenza virus-induced disease
    • Wolf AI, Strauman MC, Mozdzanowska K, et al. Pneumolysin expression by streptococcus pneumoniae protects colonized mice from influenza virus-induced disease. Virology 2014;462:463:254-65
    • (2014) Virology , vol.462 , Issue.463 , pp. 254-265
    • Wolf, A.I.1    Strauman, M.C.2    Mozdzanowska, K.3


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