Inhibition of pulmonary antibacterial defense by interferon-γ during recovery from influenza infection

Nature Medicine

Volumn 14, Issue 5, 2008, Pages 558-564

  Sun, Keer ^a   Metzger, Dennis W ^a  

^a ALBANY MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NEUTRALIZING ANTIBODY; RECOMBINANT GAMMA INTERFERON;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY SPECIFICITY; ARTICLE; BACTERIAL INFECTION; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOKINE PRODUCTION; DISEASE PREDISPOSITION; DOWN REGULATION; IMMUNITY; INFLUENZA; INNATE IMMUNITY; LUNG ALVEOLUS MACROPHAGE; LUNG INFECTION; LUNG LAVAGE; MOUSE; NEUTROPHIL; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SECONDARY INFECTION; STREPTOCOCCUS INFECTION; STREPTOCOCCUS PNEUMONIAE; TREATMENT RESPONSE; VIRUS LOAD;

ANALYSIS OF VARIANCE; ANIMALS; ANTIGENS, CD4; ANTIGENS, CD8; BRONCHOALVEOLAR LAVAGE FLUID; COMPLEMENT C3; ENZYME-LINKED IMMUNOSORBENT ASSAY; IMMUNITY, NATURAL; INTERFERON TYPE II; INTERLEUKIN-10; LUNG; MACROPHAGES; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROSCOPY, FLUORESCENCE; ORTHOMYXOVIRIDAE INFECTIONS; PNEUMOCOCCAL INFECTIONS; RECEPTORS, IMMUNOLOGIC; RECEPTORS, INTERFERON;

BACTERIA (MICROORGANISMS); MUS;

EID: 43249118968     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm1765     Document Type: Article

References (44)

1. Brundage, J.F. Interactions between influenza and bacterial respiratory pathogens: implications for pandemic preparedness. Lancet Infect. Dis. 6, 303-312 (2006).
2. Stiver, H.G. The threat and prospects for control of an influenza pandemic. Expert Rev. Vaccines 3, 35-42 (2004).
3. Spooner, L.H., Scoot, L.H. & Heath, E.H. A bacteriologic study of the influenza epidemic at Camp Devens, Mass. J. Am. Med. Assoc. 72, 155-159 (1919).
4. Hall, J.N., Stone, M.C. & Simpson, J.C. The epidemic of pneumonia following influenza at Camp Logan, Texas. J. Am. Med. Assoc. 71, 1986-1987 (1918).
5. Klugman, K.P. & Madhi, S.A. Pneumococcal vaccines and flu preparedness. Science 316, 49-50 (2007).
6. Craft, A.W., Reid, M.M. & Low, W.T. Effect of virus infections on polymorph function in children. BMJ 1, 1570 (1976).
7. Abramson, J.S., Giebink, G.S., Mills, E.L. & Quie, P.G. Polymorphonuclear leukocyte dysfunction during influenza virus infection in chinchillas. J. Infect. Dis. 143, 836-845 (1981).
8. McNamee, L.A. & Harmsen, A.G. Both influenza-induced neutrophil dysfunction and neutrophil-independent mechanisms contribute to increased susceptibility to a secondary Streptococcus pneumoniae infection. Infect. Immun. 74, 6707-6721 (2006).
9. van der Sluijs, K.F. et al. Involvement of the platelet-activating factor receptor in host defense against Streptococcus pneumoniae during postinfluenza pneumonia. Am. J. Physiol. Lung Cell. Mol. Physiol. 290, L194-L199 (2006).
10. McCullers, J.A. & Rehg, J.E. Lethal synergism between influenza virus and Streptococcus pneumoniae: characterization of a mouse model and the role of platelet-activating factor receptor. J. Infect. Dis. 186, 341-350 (2002).
11. van der Sluijs, K.F. et al. IL-10 is an important mediator of the enhanced susceptibility to pneumococcal pneumonia after influenza infection. J. Immunol. 172, 7603-7609 (2004).
12. van der Sluijs, K.F. et al. Influenza-induced expression of indoleamine 2,3-dioxygenase enhances interleukin-10 production and bacterial outgrowth during secondary pneumococcal pneumonia. J. Infect. Dis. 193, 214-222 (2006).
13. LeVine, A.M., Koeningsknecht, V. & Stark, J.M. Decreased pulmonary clearance of S. pneumoniae following influenza A infection in mice. J. Virol. Methods 94, 173-186 (2001).
14. Dockrell, D.H. et al. Alveolar macrophage apoptosis contributes to pneumococcal clearance in a resolving model of pulmonary infection. J. Immunol. 171, 5380-5388 (2003).
15. + lung cells are impaired by anthrax toxins after spore infection. J. Infect. Dis. 194, 86-94 (2006).
16. La Gruta, N.L., Kedzierska, K., Stambas, J. & Doherty, P.C. A question of self-preservation: immunopathology in influenza virus infection. Immunol. Cell Biol. 85, 85-92 (2007).
17. Brown, D.M., Dilzer, A.M., Meents, D.L. & Swain, S.L. CD4 T cell-mediated protection from lethal influenza: perforin and antibody-mediated mechanisms give a one-two punch. J. Immunol. 177, 2888-2898 (2006).
18. Arredouani, M. et al. The scavenger receptor MARCO is required for lung defense against pneumococcal pneumonia and inhaled particles. J. Exp. Med. 200, 267-272 (2004).
19. Speert, D.P. & Thorson, L. Suppression by human recombinant γ interferon of in vitro macrophage nonopsonic and opsonic phagocytosis and killing. Infect. Immun. 59, 1893-1898 (1991).
20. Lundborg, M., Johansson, A., Lastbom, L. & Camner, P. Ingested aggregates of ultrafine carbon particles and interferon-γ impair rat alveolar macrophage function. Environ. Res. 81, 309-315 (1999).
21. Swain, S.L., Dutton, R.W. & Woodland, D.L. T cell responses to influenza virus infection: effector and memory cells. Viral Immunol. 17, 197-209 (2004).
22. Carneiro-Sampaio, M. & Coutinho, A. Immunity to microbes: lessons from primary immunodeficiencies. Infect. Immun. 75, 1544-1555 (2007).
23. Mellman, I. & Steinman, R.M. Dendritic cells: specialized and regulated antigen processing machines. Cell 106, 255-258 (2001).
24. Couch, R.B. The effects of influenza on host defenses. J. Infect. Dis. 144, 284-291 (1981).
25. McCullers, J.A. Insights into the interaction between influenza virus and pneumococcus. Clin. Microbiol. Rev. 19, 571-582 (2006).
26. Nugent, K.M. & Pesanti, E.L. Tracheal function during influenza infections. Infect. Immun. 42, 1102-1108 (1983).
27. Hayden, F.G. et al. Local and systemic cytokine responses during experimental human influenza A virus infection. Relation to symptom formation and host defense. J. Clin. Invest. 101, 643-649 (1998).
28. Kaiser, L., Fritz, R.S., Straus, S.E., Gubareva, L. & Hayden, F.G. Symptom pathogenesis during acute influenza: interleukin-6 and other cytokine responses. J. Med. Virol. 64, 262-268 (2001).
29. McCullers, J.A. & Bartmess, K.C. Role of neuraminidase in lethal synergism between influenza virus and Streptococcus pneumoniae. J. Infect. Dis. 187, 1000-1009 (2003).
30. Price, G.E., Gaszewska-Mastarlarz, A. & Moskophidis, D. The role of α/β and γ interferons in development of immunity to influenza A virus in mice. J. Virol. 74, 3996-4003 (2000).
31. Wiley, J.A., Cerwenka, A., Harkema, J.R., Dutton, R.W. & Harmsen, A.G. Production of interferon-γ by influenza hemagglutinin-specific CD8 effector T cells influences the development of pulmonary immunopathology. Am. J. Pathol. 158, 119-130 (2001).
32. Didierlaurent, A. et al. Sustained desensitization to bacterial Toll-like receptor ligands after resolution of respiratory influenza infection. J. Exp. Med. 205, 323-329 (2008).
33. Holt, P.G. et al. Downregulation of the antigen presenting cell function(s) of pulmonary dendritic cells in vivo by resident alveolar macrophages. J. Exp. Med. 177, 397-407 (1993).
34. Thepen, T., Hoeben, K., Breve, J. & Kraal, G. Alveolar macrophages down-regulate local pulmonary immune responses against intratracheally administered T cell-dependent, but not T cell-independent antigens. Immunology 76, 60-64 (1992).
35. Thepen, T., Van Rooijen, N. & Kraal, G. Alveolar macrophage elimination in vivo is associated with an increase in pulmonary immune response in mice. J. Exp. Med. 170, 499-509 (1989).
36. Iwasaki, A. Mucosal dendritic cells. Annu. Rev. Immunol. 25, 381-418 (2007).
37. Bot, A., Bot, S. & Bona, C.A. Protective role of γ interferon during the recall response to influenza virus. J. Virol. 72, 6637-6645 (1998).
38. Kodihalli, S., Sivanandan, V., Nagaraja, K.V., Shaw, D. & Halvorson, D.A. Effect of avian influenza virus infection on the phagocytic function of systemic phagocytes and pulmonary macrophages of turkeys. Avian Dis. 38, 93-102 (1994).
39. Jakab, G.J. Immune impairment of alveolar macrophage phagocytosis during influenza virus pneumonia. Am. Rev. Respir. Dis. 126, 778-782 (1982).
40. Kim, K.D. et al. Adaptive immune cells temper initial innate responses. Nat. Med. 13, 1248-1252 (2007).
41. Palm, N.W. & Medzhitov, R. Not so fast: adaptive suppression of innate immunity. Nat. Med. 13, 1142-1144 (2007).
42. Barton, E.S. et al. Herpesvirus latency confers symbiotic protection from bacterial infection. Nature 447, 326-329 (2007).
43. Raju, B. et al. Aerosolized g interferon (IFN-γ) induces expression of the genes encoding the IFN-γ-inducible 10-kilodalton protein but not inducible nitric oxide synthase in the lung during tuberculosis. Infect. Immun. 72, 1275-1283 (2004).
44. van der Laan, L.J. et al. Regulation and functional involvement of macrophage scavenger receptor MARCO in clearance of bacteria in vivo. J. Immunol. 162, 939-947 (1999).