Viscothionin isolated from Korean mistletoe improves nonalcoholic fatty liver disease via the activation of adenosine monophosphate-activated protein kinase

Journal of Agricultural and Food Chemistry

Volumn 62, Issue 49, 2014, Pages 11876-11883

  Kim, Sokho ^a   Lee, Dongho ^a,b   Kim, Jae Kyung ^c   Kim, Jae Hun ^c   Park, Jong Heum ^c   Lee, Ju Woon ^c   Kwon, Jungkee ^a  

^a Chonbuk National University   (South Korea)

^b Korea Food and Drug Administration   (South Korea)

^c Korea Atomic Energy Research Institute   (South Korea)

Author keywords

AMPK; Korean mistletoe; lipid accumulation; NAFLD; viscothionin

Indexed keywords

MAMMALS; PIGMENTS; PROTEINS; SIGNALING;

AMPK; KOREAN MISTLETOE; LIPID ACCUMULATIONS; NAFLD; VISCOTHIONIN;

ENZYMES;

ACETYL COENZYME A CARBOXYLASE; ENZYME ACTIVATOR; FATTY ACID SYNTHASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; PEPTIDE; PLANT EXTRACT; VISCOTHIONIN;

ANIMAL; C57BL MOUSE; CHEMISTRY; ENZYMOLOGY; GENETICS; HEPG2 CELL LINE; HUMAN; LIPID METABOLISM; MALE; METABOLISM; MOUSE; MOUSE MUTANT; NON-ALCOHOLIC FATTY LIVER DISEASE; PHOSPHORYLATION; SOUTH KOREA; VISCUM ALBUM;

ACETYL-COA CARBOXYLASE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; ENZYME ACTIVATORS; FATTY ACID SYNTHASE, TYPE I; HEP G2 CELLS; HUMANS; LIPID METABOLISM; MALE; MICE; MICE, INBRED C57BL; MICE, OBESE; MISTLETOE; NON-ALCOHOLIC FATTY LIVER DISEASE; PEPTIDES; PHOSPHORYLATION; PLANT EXTRACTS; REPUBLIC OF KOREA;

EID: 84916594560     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf503535s     Document Type: Article

References (31)

1. Matteoni, C. A.; Younossi, Z. M.; Gramlich, T.; Boparai, N.; Liu, Y. C.; McCullough, A. J. Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity Gastroenterology 1999, 116, 1413-1419
2. Madan, K.; Bhardwaj, P.; Thareja, S.; Gupta, S. D.; Saraya, A. Oxidant stress and antioxidant status among patients with nonalcoholic fatty liver disease (NAFLD) J. Clin. Gastroenterol. 2006, 40, 930-935
3. Browning, J. D.; Horton, J. D. Molecular mediators of hepatic steatosis and liver injury J. Clin. Invest. 2004, 114, 147-152
4. Targher, G.; Bertolini, L.; Rodella, S.; Tessari, R.; Zenari, L.; Lippi, G.; Arcaro, G. Nonalcoholic fatty liver disease is independently associated with an increased incidence of cardiovascular events in type 2 diabetic patients Diabetes Care 2007, 30, 2119-2121
5. Charlton, M. Nonalcoholic fatty liver disease: a review of current understanding and future impact Clin. Gastroenterol. Hepatol. 2004, 2, 1048-1058
6. Steinberg, G. R.; Kemp, B. E. AMPK in health and disease Physiol. Rev. 2009, 89, 1025-1078
7. Musso, G.; Gambino, R.; Cassader, M. Emerging molecular targets for the treatment of nonalcoholic fatty liver disease Annu. Rev. Med. 2010, 61, 375-392
8. Chirala, S. S.; Jayakumar, A.; Gu, Z.-W.; Wakil, S. J. Human fatty acid synthase: role of interdomain in the formation of catalytically active synthase dimer Proc. Natl. Acad. Sci. U.S.A. 2001, 98, 3104-3108
9. Smith, S. The animal fatty acid synthase: one gene, one polypeptide, seven enzymes FASEB J. 1994, 8, 1248-1259
10. Bennett, M. K.; Lopez, J. M.; Sanchez, H. B.; Osborne, T. F. Sterol regulation of fatty acid synthase promoter coordinate feedback regulation of two major lipid pathways J. Biol. Chem. 1995, 270, 25578-25583
11. Kim, J. B.; Spiegelman, B. M. ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism Genes Dev. 1996, 10, 1096-1107
12. Eberle, D.; Hegarty, B.; Bossard, P.; Ferré, P.; Foufelle, F. SREBP transcription factors: master regulators of lipid homeostasis Biochimie 2004, 86, 839-848
13. Kienle, G. S.; Kiene, H. Review article: Influence of Viscum album L (European mistletoe) extracts on quality of life in cancer patients: a systematic review of controlled clinical studies Integr. Cancer Ther. 2010, 9, 142-157
14. Ostermann, T.; Bussing, A. Retrolective studies on the survival of cancer patients treated with mistletoe extracts: a meta-analysis Explore (N.Y.) 2012, 8, 277-281
15. Pearl, P. L.; Drillings, I. M.; Conry, J. A. Herbs in epilepsy: evidence for efficacy, toxicity, and interactions Semin. Pediatr. Neurol. 2011, 18, 203-208
16. Khil, L.-Y.; Kim, W.; Lyu, S.; Park, W. B.; Yoon, J.-W.; Jun, H.-S. Mechanisms involved in Korean mistletoe lectin-induced apoptosis of cancer cells World J. Gastroenterol. 2007, 13, 2811
17. Jung, H.-Y.; Kim, Y.-H.; Kim, I.-B.; Jeong, J.; Lee, J.-H.; Do, M.-S.; Jung, S.-P.; Kim, K.; Kim, J.-B. The Korean mistletoe (Viscum album coloratum) extract has an anti-obesity effect and protects against hepatic steatosis in mice with high-fat diet-induced obesity Evidence-Based Complement. Altern. Med. 2013, 168207 10.1155/2013/168207
18. Park, J. H.; Hyun, C. K.; Shin, H. K. Cytotoxic effects of the components in heat-treated mistletoe (Viscum album) Cancer Lett. 1999, 139, 207-213
19. Zang, M.; Zuccollo, A.; Hou, X.; Nagata, D.; Walsh, K.; Herscovitz, H.; Brecher, P.; Ruderman, N. B.; Cohen, R. A. AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells J. Biol. Chem. 2004, 279, 47898-47905
20. Chang, J. J.; Hsu, M. J.; Huang, H. P.; Chung, D. J.; Chang, Y. C.; Wang, C. J. Mulberry anthocyanins inhibit oleic acid induced lipid accumulation by reduction of lipogenesis and promotion of hepatic lipid clearance J. Agric. Food Chem. 2013, 61, 6069-6076
21. Liao, C. C.; Ou, T. T.; Huang, H. P.; Wang, C. J. The inhibition of oleic acid induced hepatic lipogenesis and the promotion of lipolysis by caffeic acid via up-regulation of AMP-activated kinase J. Sci. Food Agric. 2014, 94, 1154-1162
22. Zhang, T.; Yamamoto, N.; Ashida, H. Chalcones suppress fatty acid-induced lipid accumulation through a LKB1/AMPK signaling pathway in HepG2 cells Food Funct. 2014, 5, 1134-1141
23. Hjelkrem, M. C.; Torres, D. M.; Harrison, S. A. Nonalcoholic fatty liver disease Minerva Med. 2008, 99, 583-593
24. Angulo, P. Nonalcoholic fatty liver disease Rev. Gastroenterol. Mex. 2005, 70 (Suppl. 3) 52-56
25. Day, C. P. Pathogenesis of steatohepatitis Best Pract. Res. Clin. Gastroenterol. 2002, 16, 663-678
26. Park, S. H.; Gammon, S. R.; Knippers, J. D.; Paulsen, S. R.; Rubink, D. S.; Winder, W. W. Phosphorylation-activity relationships of AMPK and acetyl-CoA carboxylase in muscle J. Appl. Physiol. 2002, 92, 2475-2482
27. Viollet, B.; Foretz, M.; Guigas, B.; Horman, S.; Dentin, R.; Bertrand, L.; Hue, L.; Andreelli, F. Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders J. Physiol. 2006, 574, 41-53
28. Brown, M. S.; Goldstein, J. L. The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor Cell 1997, 89, 331-340
29. Hardie, D. G. AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy Nat. Rev. Mol. Cell Biol. 2007, 8, 774-785
30. Yamabe, N.; Noh, J. S.; Park, C. H.; Kang, K. S.; Shibahara, N.; Tanaka, T.; Yokozawa, T. Evaluation of loganin, iridoid glycoside from Corni Fructus, on hepatic and renal glucolipotoxicity and inflammation in type 2 diabetic db/db mice Eur. J. Pharmacol. 2010, 648, 179-187
31. Wymann, M. P.; Schneiter, R. Lipid signalling in disease Nat. Rev. Mol. Cell Biol. 2008, 9, 162-176