Upregulated periostin promotes angiogenesis in keloids through activation of the ERK 1/2 and focal adhesion kinase pathways, as well as the upregulated expression of VEGF and angiopoietin-1

Molecular Medicine Reports

Volumn 11, Issue 2, 2015, Pages 857-864

  Zhang, Zhe ^a   Nie, Fangfei ^a   Chen, Xinlei ^a   Qin, Zelian ^a   Kang, Chunfu ^a   Chen, Bin ^a   Ma, Jianxun ^a   Pan, Bolin ^a   Ma, Yongguang ^a  

^a PEKING UNIVERSITY THIRD HOSPITAL   (China)

Author keywords

Angiogenesis; Endothelial cells; Fibroblast; Keloid; Periostin

Indexed keywords

ANGIOPOIETIN 1; ANGPT1 PROTEIN, HUMAN; CELL ADHESION MOLECULE; FOCAL ADHESION KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; POSTN PROTEIN, HUMAN; VASCULOTROPIN A;

ADOLESCENT; ADULT; AGED; ANGIOGENESIS; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CELL MOTION; CHILD; CYTOLOGY; DRUG EFFECTS; GENETICS; HUMAN; KELOID; METABOLISM; MIDDLE AGED; PATHOLOGY; SECRETION (PROCESS); SIGNAL TRANSDUCTION; SKIN; UMBILICAL VEIN ENDOTHELIAL CELL; UPREGULATION; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANGIOPOIETIN-1; CELL ADHESION MOLECULES; CELL MOVEMENT; CELLS, CULTURED; CHILD; FOCAL ADHESION KINASE 1; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; KELOID; MIDDLE AGED; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NEOVASCULARIZATION, PHYSIOLOGIC; SIGNAL TRANSDUCTION; SKIN; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A; YOUNG ADULT;

EID: 84916219791     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2014.2827     Document Type: Article

References (34)

1. Bran GM, Goessler UR, Hormann K, Riedel F and Sadick H: Keloids: Current concepts of pathogenesis (Review). Int J Mol Med 24: 283-293, 2009.
2. Alster TS and Tanzi EL: Hypertrophic scars and keloids: etiology and management. Am J Clin Dermatol 4: 235-243, 2003.
3. Love PB and Kundu RV: Keloids: an update on medical and surgical treatments. J Drugs Dermatol 12: 403-409, 2013.
4. Ishiko T, Naitoh M, Kubota H, et al: Chondroitinase injection improves keloid pathology by reorganizing the extracellular matrix with regenerated elastic fibers. J Dermatol 40: 380-383, 2013.
5. Fujiwara M, Muragaki Y and Ooshima A: Upregulation of transforming growth factor-beta1 and vascular endothelial growth factor in cultured keloid fibroblasts: relevance to angiogenic activity. Arch Dermatol Res 297: 161-169, 2005.
6. Bux S and Madaree A: Keloids show regional distribution of proliferative and degenerate connective tissue elements. Cells Tissues Organs 191: 213-234, 2010.
7. Gira AK, Brown LF, Washington CV, Cohen C and Arbiser JL: Keloids demonstrate high-level epidermal expression of vascular endothelial growth factor. J Am Acad Dermatol 50: 850-853, 2004.
8. Trompezinski S, Pernet I and Mayoux C: Transforming growth factor-beta1 and ultraviolet A1 radiation increase production of vascular endothelial growth factor but not endothelin-1 in human dermal fibroblasts. Br J Dermatol. 143: 539-545, 2000.
9. Mogili NS, Krishnaswamy VR, Jayaraman M, Rajaram R, Venkatraman A and Korrapati PS: Altered angiogenic balance in keloids: a key to therapeutic intervention. Transl Res 159: 182-189, 2012.
10. Syed F and Bayat A: Notch signaling pathway in keloid disease: enhanced fibroblast activity in a Jagged-1 peptide-dependent manner in lesional vs. extralesional fibroblasts. Wound Repair Regen 20: 688-706, 2012.
11. Song ZH and Qin ZL: Expression of periostin and the effect of hydrocortisone on it in human fibroblasts of scar. Beijing Da Xue Xue Bao 40: 301-305, 2008 (In Chinese).
12. Norris RA, Damon B, Mironov V, et al: Periostin regulates collagen fibrillogenesis and the biomechanical properties of connective tissues. J Cell Biochem 101: 695-711, 2007.
13. Ruan K, Bao S and Ouyang G: The multifaceted role of periostin in tumorigenesis. Cell Mol Life Sci 66: 2219-2230, 2009.
14. Wu SQ, Lv YE, Lin BH, et al: Silencing of periostin inhibits nicotine-mediated tumor cell growth and epithelial-mesenchymal transition in lung cancer cells. Mol Med Rep 7: 875-880, 2013.
15. Elliott CG, Wang J, Guo X, et al: Periostin modulates myofibroblast differentiation during full-thickness cutaneous wound repair. J Cell Sci 125: 121-132, 2012.
16. Zhu M, Fejzo MS, Anderson L, et al: Periostin promotes ovarian cancer angiogenesis and metastasis. Gynecol Oncol 119: 337-344, 2010.
17. Qiu F, Shi CH, Zheng J and Liu YB: Periostin mediates the increased pro-angiogenic activity of gastric cancer cells under hypoxic conditions. J Biochem Mol Toxicol 27: 364-369, 2013.
18. Shao R, Bao S, Bai X, et al: Acquired expression of periostin by human breast cancers promotes tumor angiogenesis through up-regulation of vascular endothelial growth factor receptor 2 expression. Mol Cell Biol 24: 3992-4003, 2004.
19. Beer TW, Baldwin HC, Goddard JR, Gallagher PJ and Wright DH: Angiogenesis in pathological and surgical scars. Hum Pathol 29: 1273-1278, 1998.
20. Liu C, Song ZH and Qin ZL: Construction of periostin shRNA vectors and their effects on the expression of periostin in fibroblasts. Beijing Da Xue Xue Bao 42: 503-508, 2010 (In Chinese).
21. Vincent AS, Phan TT, Mukhopadhyay A, Lim HY, Halliwell B and Wong KP: Human skin keloid fibroblasts display bioenergetics of cancer cells. J Invest Dermatol 128: 702-709, 2008.
22. Niessen FB, Spauwen PH, Schalkwijk J and Kon M: On the nature of hypertrophic scars and keloids: a review. Plast Reconstr Surg 104: 1435-1458, 1999.
23. Oh CK, Kwon YW, Kim YS, Jang HS and Kwon KS: Expression of basic fibroblast growth factor, vascular endothelial growth factor, and thrombospondin-1 related to microvessel density in nonaggressive and aggressive basal cell carcinomas. J Dermatol 30: 306-313, 2003.
24. Amadeu T, Braune A, Mandarim-de-Lacerda C, Porto LC, Desmouliere A and Costa A: Vascularization pattern in hypertrophic scars and keloids: a stereological analysis. Pathol Res Pract 199: 469-473, 2003.
25. Appleton I, Brown NJ and Willoughby DA: Apoptosis, necrosis, and proliferation: possible implications in the etiology of keloids. Am J Pathol 149: 1441-1447, 1996.
26. Takanami I, Abiko T and Koizumi S: Expression of periostin in patients with non-small cell lung cancer: correlation with angiogenesis and lymphangiogenesis. Int J Biol Markers 23: 182-186, 2008.
27. Orecchia P, Conte R, Balza E, et al: Identification of a novel cell binding site of periostin involved in tumour growth. Eur J Cancer 47: 2221-2229, 2011.
28. Powazniak Y, Kempfer AC, de la Paz Dominguez M, et al: Effect of estradiol, progesterone and testosterone on apoptosis-and proliferation-induced MAPK signaling in human umbilical vein endothelial cells. Mol Med Rep 2: 441-447, 2009.
29. Esfahanian N, Shakiba Y, Nikbin B, et al: Effect of metformin on the proliferation, migration, and MMP-2 and -9 expression of human umbilical vein endothelial cells. Mol Med Rep 5: 1068-1074, 2012.
30. Baek YY, Cho DH, Choe J, et al: Extracellular taurine induces angiogenesis by activating ERK-, Akt-, and FAK-dependent signal pathways. Eur J Pharmacol 674: 188-199, 2012.
31. Eichmann A and Simons M: VEGF signaling inside vascular endothelial cells and beyond. Curr Opin Cell Biol 24: 188-193, 2012.
32. Koh GY: Orchestral actions of angiopoietin-1 in vascular regeneration. Trends Mol Med 19: 31-39, 2013.
33. Lv Y, Wang W, Jia WD, et al: High preoparative levels of serum periostin are associated with poor prognosis in patients with hepatocellular carcinoma after hepatectomy. Eur J Surg Oncol 39: 1129-1135, 2013.
34. Ben QW, Zhao Z, Ge SF, Zhou J, Yuan F and Yuan YZ: Circulating levels of periostin may help identify patients with more aggressive colorectal cancer. Int J Oncol 34: 821-828, 2009.