Keloids: An update on medical and surgical treatments

Journal of Drugs in Dermatology

Volumn 12, Issue 4, 2013, Pages 403-409

  Love, Porcia B ^a   Kundu, Roopal V ^b  

^a DUKE UNIVERSITY HOSPITAL   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLEOMYCIN; CORTICOSTEROID; FLUOROURACIL; INTERFERON; MITOMYCIN; ONION EXTRACT; SILICONE; STEROID; VERAPAMIL;

ARTICLE; CLINICAL EXAMINATION; CRYOTHERAPY; DRUG MECHANISM; GENETIC PREDISPOSITION; HISTOPATHOLOGY; HUMAN; KELOID; NEODYMIUM YAG LASER; PATHOPHYSIOLOGY; PROPHYLAXIS; SKIN SURGERY; TREATMENT OUTCOME; WOUND DRESSING;

FOREIGN-BODY REACTION; HUMANS; KELOID; PATIENT EDUCATION AS TOPIC; RECURRENCE; SKIN; WOUND CLOSURE TECHNIQUES; WOUND HEALING;

EID: 84875849206     PISSN: 15459616     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Addison T. On the Keloid of Alibert, and on True Keloid. Med Chir Trans. 1854;37:27-47.
2. Viera MH, Caperton CV, Berman B. Advances in the treatment of keloids. J Drugs Dermatol. 2011;10(5):468-480.
3. Olaitan PB. Keloids: assessment of effects and psychosocial-impacts on subjects in a black African population. Indian J Dermatol Venereol Leprol. 2009;75(4):368-372
4. Bux S, Madaree A. Involvement of upper torso stress amplification, tissue compression and distortion in the pathogenesis of keloids. Med Hypotheses. 2012;78(3):356-363
5. Bettinger DA, Yager DR, Diegelmann RF, Cohen IK. The effect of TGF-beta on keloid fibroblast proliferation and collagen synthesis. Plast Reconstr Surg. 1996;98(5):827-833 (Pubitemid 26322164)
6. Tziotzios C, Profyris C, Sterling J. Cutaneous scarring: Pathophysiology, molecular mechanisms, and scar reduction therapeutics Part II. Strategies to reduce scar formation after dermatologic procedures. J Am Acad Dermatol. 2012;66(1):13-24.
7. Brown JJ, Ollier W, Arscott G, et al. Genetic susceptibility to keloid scarring: SMAD gene SNP frequencies in Afro-Caribbeans. Exp Dermatol. 2008;17(7):610-613. (Pubitemid 351803083)
8. Marneros AG, Norris JE, Olsen BR, Reichenberger E. Clinical genetics of familial keloids. Arch Dermatol. 2001;137(11):1429-1434. (Pubitemid 33064238)
9. Marneros AG, Norris JE, Watanabe S, Reichenberger E, Olsen BR. Genome scans provide evidence for keloid susceptibility loci on chromosomes 2q23 and 7p11. J Invest Dermatol. 2004;122(5):1126-1132 (Pubitemid 38651086)
10. Smith JC, Boone BE, Opalenik SR, Williams SM, Russell SB. Gene profiling of keloid fibroblasts shows altered expression in multiple fibrosis-associated pathways. J Invest Dermatol. 2008;128(5):1298-1310. (Pubitemid 351543197)
11. Bajaj V, Langtry JA. Surgical excision of acne keloidalis nuchae with secondary intention healing. Clin Exp Dermatol. 2008;33(1):53-55 (Pubitemid 350308522)
12. Shockman S, Paghdal KV, Cohen G. Medical and surgical management of keloids: a review. J Drugs Dermatol. 2010;9(10):1249-1257
13. Lee JY, Yang CC, Chao SC, Wong TW. Histopathological differential diagnosis of keloid and hypertrophic scar. Am J Dermatopathol. 2004;26(5):379-384. (Pubitemid 39287358)
14. Mustoe TA, Cooter RD, Gold MH, et al; International Advisory Panel on Scar Management. International clinical recommendations on scar management. Plast Reconstr Surg. 2002;110(2):560-571. (Pubitemid 34815962)
15. Fulton JE Jr. Silicone gel sheeting for the prevention and management of evolving hypertrophic and keloid scars. Dermatol Surg. 1995;21(11):947-951
16. Berman B, Flores F. Comparison of a silicone gel-filled cushion and silicon gel sheeting for the treatment of hypertrophic or keloid scars. Dermatol Surg. 1999;25(6):484-486. (Pubitemid 29279591)
17. de Oliveira GV, Nunes TA, Magna LA, et al. Silicone versus nonsilicone gel dressings: a controlled trial. Dermatol Surg. 2001;27(8):721-726. (Pubitemid 32738241)
18. Berman B, Perez OA, Konda S, et al. A review of the biologic effects, clinical efficacy, and safety of silicone elastomer sheeting for hypertrophic and keloid scar treatment and management. Dermatol Surg. 2007;33(11):1291-1302 (Pubitemid 47624077)
19. Gilman TH. Silicone sheet for treatment and prevention of hypertrophic scar: a new proposal for the mechanism of efficacy. Wound Rep Regen. 2003;11(3):235-236. (Pubitemid 36648883)
20. Knighton DR, Silver IA, Hunt TK. Regulation of wound-healing angiogenesis-effect of oxygen gradients and inspired oxygen concentration. Surgery. 1981;90(2):262-270 (Pubitemid 11047238)
21. O'Brien L, Pandit A. Silicon gel sheeting for preventing and treating hypertrophic and keloid scars. Cochrane Database Sys Rev. 2006;(1):CD003826
22. Puzey G. The use of pressure garments on hypertrophic scars. J Tissue Viability 2002;12(1):11-15.
23. Kelly AP. Medical and surgical therapies for keloids. Dermatol Ther 2004;17(2):212-218. (Pubitemid 38656914)
24. Migliario M, Rizzi M, Rocchetti V, Cannas M, Renò F. In vitro toxicity of photodynamic antimicrobial chemotherapy on human keratinocytes proliferation. Leasers Med Sci. 2013;28(2):565-569.
25. Anzarut A, Olson J, Singh P. Rowe BH, Tredget EE. The effectiveness of pressure garment therapy for the prevention of abnormal scarring after burn injury: a meta-analysis. J Plast Reconstr Aesthet Surg. 2009;62(1):77-84.
26. Steinstraesser L, Flak E, Witte B, et al. Pressure garment therapy alone and in combination with silicone for the prevention of hypertrophic scarring randomized controlled trial with intraindividual comparison. Plast Reconstr Surg. 2011;128(4):306e-313e.