Keloids show regional distribution of proliferative and degenerate connective tissue elements

Cells Tissues Organs

Volumn 191, Issue 3, 2010, Pages 213-234

  Bux, Shamin ^a   Madaree, Anil ^a  

^a UNIVERSITY OF KWAZULU NATAL   (South Africa)

Author keywords

Degeneration; Hyalinization; Keloids; Proliferation; Vascularization; Wound healing

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; CELL PROLIFERATION; CHILD; CLINICAL ARTICLE; CLINICAL FEATURE; CONNECTIVE TISSUE; DNA SYNTHESIS; EXTRACELLULAR MATRIX; FEMALE; HISTOLOGY; HUMAN; HUMAN TISSUE; INFORMED CONSENT; KELOID; MALE; MICROSCOPY; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN SYNTHESIS; SCHOOL CHILD; SKIN BIOPSY; VASCULARIZATION; FIBROBLAST; INFLAMMATION; METABOLISM; MICROVASCULATURE; MIDDLE AGED; NECROSIS; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; ULTRASTRUCTURE; WOUND HEALING;

COLLAGEN; DNA;

ADOLESCENT; ADULT; CELL PROLIFERATION; CHILD; COLLAGEN; DNA; EXTRACELLULAR MATRIX; FEMALE; FIBROBLASTS; HUMANS; INFLAMMATION; KELOID; MALE; MICROVESSELS; MIDDLE AGED; NECROSIS; NEOVASCULARIZATION, PATHOLOGIC; PROTEIN BIOSYNTHESIS; WOUND HEALING;

EID: 77952313225     PISSN: 14226405     EISSN: None     Source Type: Journal    
DOI: 10.1159/000231899     Document Type: Article

References (26)

1. Amadeu, T.P., B. Coulomb, A. Desmouliere, A.M. Costa (2003) Cutaneous wound healing: myofibroblastic differentiation and in vitro models. Int J Low Extrem Wounds 2 : 60-68.
2. Bayat, A., G. Arscott, W.E. Ollier, M.W. Ferguson, D.A. Mc Grouther (2004) Description of site-specific morphology of keloid phenotypes in an Afrocaribbean population. Br J Plast Surg 57: 122-133.
3. Blackburn, W.R., B. Cosman (1966) Histologic basis of keloid and hypertrophic scar differentiation: clinicopathologic correlation. Arch Pathol 82: 65-71.
4. Border, W.A., N.A. Noble (1994) Transforming growth factor beta in tissue fibrosis. N Engl J Med 331: 1286-1292.
5. Chen, W., X. Fu, X. Sun, T. Sun, Z. Zhao, Z. Sheng (2003) Analysis of differentially expressed genes in keloids and normal skin with cDNA microarray. J Surg Res 113: 208-216.
6. Clore, J.N., I.K. Cohen, R.F. Diegelmann (1979) Quantitative assay of types I and III collagen synthesized by keloid biopsyes and fibroblasts. Biochim Biophys Acta 586: 384-390.
7. Cobbold, C.A. (2001) The role of nitric oxide in the formation of keloid and hypertrophic lesions. Med Hypotheses 57: 497-502.
8. Ehrlich, H.P., A. Desmouliere, R.F. Diegelmann, I.K. Cohen, C.C. Compton, W.L. Garner, Y. Kapanci, G. Gabbiani (1994) Morphological and immunochemical differences between keloid and hypertrophic scar. Am J Pathol 145: 105-113.
9. Friedl, P., Y. Hegerfeldt, M. Tusch (2004) Collective cell migration in morphogenesis and cancer. Int J Dev Biol 48: 441-449.
10. Jagadeesan, J., A. Bayat (2007) Transforming growth factor beta (TGFbeta) and keloid disease. Int J Surg 5: 278-285.
11. Kiehart, D.P., C.G. Galbraith, K.A. Edwards, W.L. Rickoll, R.A. Montague (2000) Multiple forces contribute to cell sheet morphogenesis for dorsal closure in Drosophila. J Cell Biol 149: 471-490.
12. Kischer, C.W., M.R. Shetlar (1974) Collagen and mucopolysaccharides in the hypertrophic scar. Connect Tissue Res 2: 205-213.
13. Luo, S., M. Benathan, W. Raffoul, R.G. Panizzon, D.V. Egloff (2001) Abnormal balance between proliferation and apoptotic cell death in fibroblasts derived from keloid lesions. Plast Reconstr Surg 107: 87-96.
14. Mukhopadhyay, A., E.K. Tan, Y.T. Khoo, S.Y. Chan, I.J. Lim, T.T. Phan (2005) Conditioned medium from keloid keratinocyte/keloid fibroblast coculture induces contraction of fibroblast-populated collagen lattices. Br J Dermatol 152: 639-645.
15. Murata, H., L. Zhou, S. Ochoa, A. Hasan, E. Badiavas, V. Falanga (1997) TGF-beta3 stimulates and regulates collagen synthesis through TGF-beta1-dependent and independent mechanisms. J Invest Dermatol 108: 258-262.
16. Naitoh, M., N. Hosokawa, H. Kubota, T. Tanaka, H. Shirane, M. Sawada, Y. Nishimura, K. Nagata (2001) Upregulation of HSP47 and collagen type III in the dermal fibrotic disease, keloid. Biochem Biophys Res Commun 280: 1316-1322.
17. Robles, D.T., D. Berg (2007) Abnormal wound healing: keloids. Clin Dermatol 25: 26-32.
18. Russell, S.B., K.M. Trupin, S. Rodriguez-Eaton, J.D. Russell, J.S. Trupin (1988) Reduced growth-factor requirement of keloid-derived fibroblasts may account for tumor growth. Proc Natl Acad Sci USA 85: 587-591.
19. Slemp, A.E., R.E. Kirschner (2006) Keloids and scars: a review of keloids and scars, their pathogenesis, risk factors, and management. Curr Opin Pediatr 18: 396-402.
20. Sottile, J. (2004) Regulation of angiogenesis by extracellular matrix. Biochim Biophys Acta 1654: 13-22.
21. Sun, Y., J.X. Song, Z.M. Wang, J.P. Chen, Y. Chen, X.J. Tan, J. Bai (2006) Expressions of TGF-betaR I, Smad2, Smad3 and Smad7 in keloids (in Chinese). Zhonghua Zheng Xing Wai Ke Za Zhi 22: 368-370.
22. Tranquillo, R.T., J.D. Murray (1992) Continuum model of fibroblast-driven wound contraction: inflammation-mediation. J Theor Biol 158: 135-172.
23. Ueda, K., Y. Yasuda, E. Furuya, S. Oba (2004) Inadequate blood supply persists in keloids. Scand J Plast Reconstr Surg Hand Surg 38: 267-271.
24. Uitto, J. (2007) IL-6 signaling pathway in keloids: a target for pharmacologic intervention? J Invest Dermatol 127: 6-8.
25. Uitto, J., A.J. Perejda, R.P. Abergel, M.L. Chu, F. Ramirez (1985) Altered steady-state ratio of type I/III procollagen mRNAs correlates with selectively increased type I procollagen biosynthesis in cultured keloid fibroblasts. Proc Natl Acad Sci USA 82: 5935-5939.
26. Uzawa, K., M.K. Marshall, E.P. Katz, H. Tanzawa, H.N. Yeowell, M. Yamauchi (1998) Altered posttranslational modifications of collagen in keloid. Biochem Biophys Res Commun 249: 652-655.