Epoxidation activities of human cytochromes P450c17 and P450c21

Biochemistry

Volumn 53, Issue 48, 2014, Pages 7531-7540

  Yoshimoto, Francis K ^a   Peng, Hwei Ming ^a   Zhang, Haoming ^b   Anderson, Sean M ^a   Auchus, Richard J ^a,b  

^a Division of Metabolism Endocrinology and Diabetes   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CARBON; CHEMICAL BONDS; ENZYMES; HYDROXYLATION; OXYGEN;

ALTERNATIVE SUBSTRATES; CARBON-CARBON DOUBLE BONDS; COMBINATORIAL BIOSYNTHESIS; CYTOCHROME P450 ENZYMES; HYDROXYLASE ACTIVITY; OLEFINIC SUBSTRATES; SUBSTRATE MODIFICATIONS; SUPER OXIDE DISMUTASE;

SUBSTRATES;

16,17 DEHYDROPREGNENOLONE; 16,17 DEHYDROPROGESTERONE; ABIRATERONE; CATALASE; DYDROGESTERONE; EPOXIDE; FORMIC ACID; HYDROGEN PEROXIDE; KETOCONAZOLE; PREGNENOLONE; PROGESTERONE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE; SILICA GEL; STEROID 17ALPHA MONOOXYGENASE; STEROID 21 MONOOXYGENASE; SUPEROXIDE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG; CYP17A1 PROTEIN, HUMAN; CYP21A2 PROTEIN, HUMAN; RECOMBINANT PROTEIN; STEROID;

ARTICLE; CATALYSIS; CONTROLLED STUDY; COVALENT BOND; CRYSTAL STRUCTURE; ELECTROPHILICITY; ENZYME ACTIVITY; ENZYME INACTIVATION; EPOXIDATION; HUMAN; HYDROXYLATION; ISOMERIZATION; MASS SPECTROMETRY; NEGATIVE FEEDBACK; NONHUMAN; OXIDATION; PROTEIN PURIFICATION; SYNTHESIS; AMINO ACID SUBSTITUTION; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME SPECIFICITY; GENETICS; KINETICS; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SITE DIRECTED MUTAGENESIS;

AMINO ACID SUBSTITUTION; EPOXY COMPOUNDS; HUMANS; HYDROXYLATION; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; MUTAGENESIS, SITE-DIRECTED; RECOMBINANT PROTEINS; STEROID 17-ALPHA-HYDROXYLASE; STEROID 21-HYDROXYLASE; STEROIDS; SUBSTRATE SPECIFICITY;

EID: 84916211937     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi5011865     Document Type: Article

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