Why human cytochrome P450c21 is a progesterone 21-hydroxylase

Biochemistry

Volumn 50, Issue 19, 2011, Pages 3968-3974

  Mizrachi, Dario ^a   Wang, Zhu ^b   Sharma, Kamalesh K ^a   Gupta, Manisha K ^a   Xu, Keliang ^a   Dwyer, Christopher R ^a   Auchus, Richard J ^a  

^a UNIVERSITY OF TEXAS AT DALLAS   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPUTER MODELS; HUMAN CYTOCHROME; HYDROGEN ATOMS; HYDROXYLASE ACTIVITY; MOLECULAR DYNAMICS SIMULATIONS; PRIMARY CARBON; SUBSTRATE-BINDING;

AMINO ACIDS; CRYSTAL STRUCTURE; HYDROGEN; HYDROXYLATION; METABOLISM; MOLECULAR DYNAMICS; MOLECULAR OXYGEN; OXYGENATION; PORPHYRINS; SUBSTRATES;

BINDING SITES;

STEROID 21 MONOOXYGENASE;

ARTICLE; COMPUTER MODEL; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME METABOLISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROXYLATION; MOLECULAR DYNAMICS; MUTATIONAL ANALYSIS; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; COMPUTER SIMULATION; HEK293 CELLS; HUMANS; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; PROGESTERONE; STEROID 21-HYDROXYLASE; SUBSTRATE SPECIFICITY;

EID: 79955868223     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi102078e     Document Type: Article

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