Synthesis of halogenated pregnanes, mechanistic probes of steroid hydroxylases CYP17A1 and CYP21A2

Journal of Steroid Biochemistry and Molecular Biology

Volumn 128, Issue 1-2, 2012, Pages 38-50

  Yoshimoto, Francis K ^a   Desilets, Melissa C ^a   Auchus, Richard J ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

17 BROMOPREGNENOLON 3 ACETATE; 17 FLUORO 20 OXO PREGN 5 EN 3BETA YL ACETATE; 17 FLUOROPROGESTERONE; 21,21,21 TRIBROMO PREGN 4 ENE 3,20 DIONE; 21,21,21 TRIBROMO PREGN 5 EN 3BETA OL 20 ONE; 21,21,21 TRIBROMO PREGN 5 ENE 3BETA (T BUTYL) DIMETHYLSILOXY 20 ONE; 21,21,21 TRIBROMO PREGN 5 ENE 3BETA (T BUTYL)DIMETHYLSILOXY 20 OL; 21,21,21 TRIBROMOPROGESTERONE; 21,21,21 TRICHLORO 3BETA TRICHLOROACETOXY PREGN 5 EN 20 ONE; 21,21,21 TRICHLORO PREGN 4 ENE 3,20 DIONE; 21,21,21 TRICHLORO PREGN 5 EN 3BETA OL 20-ONE; 21,21,21 TRICHLORO PREGN 5 ENE 3BETA (T BUTYL) DIMETHYLSILYLOXY 20 OL; 21,21,21 TRICHLORO PREGN 5 ENE 3BETA (T BUTYL) DIMETHYLSILYLOXY 20 ONE; 21,21,21 TRICHLOROPROGESTERONE; 21,21,21 TRIFLUORO 3BETA HYDROXY PREGN 5 EN 20 ONE; 3BETA (T BUTYL)DIMETHYL SILOXY ANDROST 5 ENE 17BETA CARBOXALDEHYDE; 3BETA (T BUTYL)DIMETHYL SILOXY ANDROST 5 ENE 17BETA METHANOL; 3BETA HYDROXY ANDROST 5 ENE 17BETA CARBOXYLIC ACID; 5,6,17 TRIBROMO 20 OXO PREGN 5 ENE 3BETA YL ACETATE; CHLOROFORM; CYTOCHROME P450 17; CYTOCHROME P450 REDUCTASE; METHYL 3BETA (T BUTYL)DIMETHYL SILOXY ANDROST 5 ENE 17BETA CARBOXYLATE; METHYL 3BETA HYDROXY ANDROST 5 ENE 17BETA CARBOXYLATE; PREGN 5 ENE 21 N PYRIDYL 3BETA OL 20 ONE IODIDE; PREGNANE DERIVATIVE; PREGNENOLONE; PROGESTERONE; STEROID 21 MONOOXYGENASE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; CONTROLLED STUDY; DECARBOXYLATION; ENZYME ACTIVITY; ENZYME BINDING; HALOGENATION; IN VIVO STUDY; ISOMERIZATION; NONHUMAN; NUCLEOPHILICITY; OXIDATION; OXYGENATION; STEROID HYDROXYLATION; STEROIDOGENESIS;

CHOLESTEROL OXIDASE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENZYME ASSAYS; HUMANS; MICROSOMES; OXIDATION-REDUCTION; PREGNANES; RECOMBINANT PROTEINS; STEROID 17-ALPHA-HYDROXYLASE; STEROID 21-HYDROXYLASE; STEROIDS, BROMINATED; STEROIDS, CHLORINATED; STEROIDS, FLUORINATED; SUBSTRATE SPECIFICITY; YEASTS;

EID: 82755187500     PISSN: 09600760     EISSN: 18791220     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2011.09.007     Document Type: Article

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