The PPARγ agonist pioglitazone crosses the blood-brain barrier and reduces tumor growth in a human xenograft model

Cancer Chemotherapy and Pharmacology

Volumn 71, Issue 4, 2013, Pages 929-936

  Grommes, Christian ^a,b   Karlo, J Colleen ^a   Caprariello, Andrew ^a   Blankenship, D'Arbra ^a   Dechant, Anne ^a   Landreth, Gary E ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Blood brain barrier; Glioblastoma; Osmotic pump; Pioglitazone; PPAR ; Xenograft

Indexed keywords

PIOGLITAZONE; 2,4 THIAZOLIDINEDIONE DERIVATIVE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BLOOD BRAIN BARRIER; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DRUG BRAIN LEVEL; DRUG MECHANISM; DRUG PENETRATION; GLIOMA; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR INVASION; TUMOR VOLUME; TUMOR XENOGRAFT; ANIMAL; BAGG ALBINO MOUSE; BRAIN TUMOR; DRUG EFFECT; DRUG POTENTIATION; DRUG SCREENING; PATHOLOGY; TUMOR CELL LINE;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; GLIOMA; HUMANS; MICE; MICE, INBRED BALB C; NEOPLASM INVASIVENESS; PPAR GAMMA; THIAZOLIDINEDIONES; TUMOR BURDEN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

MLCS; MLOWN;

EID: 84878865441     PISSN: 03445704     EISSN: 14320843     Source Type: Journal    
DOI: 10.1007/s00280-013-2084-2     Document Type: Article

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