Circulating polymers in α1-antitrypsin deficiency

European Respiratory Journal

Volumn 43, Issue 5, 2014, Pages 1501-1504

  Tan, Lu ^a   Dickens, Jennifer A ^a   DeMeo, Dawn L ^b   Miranda, Elena ^c   Perez, Juan ^d   Rashid, S Tamir ^a   Day, James ^a   Ordoñez, Adriana ^a   Marciniak, Stefan J ^a   Haq, Imran ^a   Barker, Alan F ^e   Campbell, Edward J ^f,g   Eden, Edward ^h   McElvaney, Noel G ⁱ   Rennard, Stephen I ^j   Sandhaus, Robert A ^k   Stocks, James M ^l   Stoller, James K ^m   Strange, Charlie ⁿ   Turino, Gerard ^h   Rouhani, Farshid N ^o   Brantly, Mark ^o   Lomas, David A ^p   more..

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d UNIVERSITY OF MÁLAGA   (Spain)

^e OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^f INTERMOUNTAIN HEALTHCARE   (United States)

^g HerediLab Inc   (United States)

^h ST LUKE S ROOSEVELT HOSPITAL CENTER   (United States)

ⁱ BEAUMONT HOSPITAL   (Ireland)

^j UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^k DEPARTMENT OF MEDICINE   (United States)

^l UNIVERSITY OF TEXAS HEALTH CENTER   (United States)

^m LERNER RESEARCH INSTITUTE   (United States)

ⁿ MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^o UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^p UNIVERSITY COLLEGE LONDON   (United Kingdom)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1 ANTITRYPSIN; CIRCULATING POLYMER; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 2C1; POLYMER; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; SERPINA1 PROTEIN, HUMAN;

ALLELE; ALPHA 1 ANTITRYPSIN DEFICIENCY; ANTIBODY SPECIFICITY; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL FEATURE; DISEASE ASSOCIATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; HOMOZYGOTE; HUMAN; LETTER; LIVER TRANSPLANTATION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN POLYMERIZATION; PROTEIN SYNTHESIS; SEX DIFFERENCE; SMOKING; WESTERN BLOTTING; BIOPSY; BLOOD; CHEMISTRY; GENETICS; IMMUNOPRECIPITATION; INFLAMMATION; MALE; METABOLISM; MIDDLE AGED; SENSITIVITY AND SPECIFICITY;

ALLELES; ALPHA 1-ANTITRYPSIN; ALPHA 1-ANTITRYPSIN DEFICIENCY; BIOLOGICAL MARKERS; BIOPSY; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; IMMUNOPRECIPITATION; INFLAMMATION; MALE; MIDDLE AGED; PHENOTYPE; POLYMERS; SENSITIVITY AND SPECIFICITY;

EID: 84899840452     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00111213     Document Type: Letter

References (10)

1. 1-antitrypsin accumulation in the liver. Nature 1992; 357: 605-607.
2. 1- antitrypsin by cigarette smoke induces polymerization: a novel mechanism of early-onset emphysema. Am J Respir Cell Mol Biol 2011; 45: 261-269.
3. 1-antitrypsin deficiency-related panniculitis. Demonstration of skin polymers and high dosing requirements of intravenous augmentation therapy. Dermatology 2009; 218: 370-375.
4. 1 antitrypsin and its polymers. Ann Rheum Dis 2011; 70: 1851-1856.
5. 1-antitrypsin deficiency. Hepatology 2010; 52: 1078-1088.
6. 1-antitrypsin deficiency. Thorax 2007; 62: 806-813.
7. 1- antitrypsin polymerizes in the lung and acts as a neutrophil chemoattractant. Chest 2004; 125: 1952-1957.
8. 52-deleted) forms loop-sheet polymers in vivo: evidence for the C sheet mechanism of polymerisation. J Biol Chem 1995; 270: 16864-16870.
9. 1-antitrypsin. Nat Struct Biol 1996; 3: 910-911.
10. 1-antitrypsin and increase the clearance of intracellular aggregates. J Med Chem 2007; 50: 5357-5363.