Therapeutic detoxification of quercetin against carbon tetrachloride-induced acute liver injury in mice and its mechanism

Journal of Zhejiang University: Science B

Volumn 15, Issue 12, 2014, Pages 1039-1047

  Zhang, Jia qi ^a   Shi, Liang ^a   Xu, Xi ning ^a   Huang, Si chong ^a   Lu, Bin ^a   Ji, Li li ^a   Wang, Zheng tao ^a  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Hepatotoxicity, Oxidative stress, Peroxiredoxin (Prx), Nuclear factor erythroid 2 related factor 2 (Nrf2), TrxR, Trx, HO 1

Indexed keywords

4 HYDROXYNONENAL; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CARBON TETRACHLORIDE; GLUTATHIONE; HEME OXYGENASE 1; MALONALDEHYDE; MESSENGER RNA; PEROXIREDOXIN 1; PEROXIREDOXIN 2; PEROXIREDOXIN 3; PEROXIREDOXIN 5; PEROXIREDOXIN 6; QUERCETIN; THIOREDOXIN 1; THIOREDOXIN 2; THIOREDOXIN REDUCTASE 1; THIOREDOXIN REDUCTASE 2; TRANSCRIPTION FACTOR NRF2; ANTIOXIDANT; HMOX1 PROTEIN, MOUSE; MEMBRANE PROTEIN; NFE2L2 PROTEIN, MOUSE; PEROXIREDOXIN; THIOREDOXIN; THIOREDOXIN REDUCTASE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; DRUG DETOXIFICATION; DRUG MECHANISM; DRUG SCREENING; ENZYME ACTIVITY; IN VIVO STUDY; LIVER INJURY; LIVER PROTECTION; MALE; MOUSE; NONHUMAN; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PROTEIN EXPRESSION; ANIMAL; BLOOD; CHEMISTRY; DRUG EFFECTS; DRUG-INDUCED LIVER INJURY; IMMUNOHISTOCHEMISTRY; INSTITUTE FOR CANCER RESEARCH MOUSE; LIVER; METABOLISM; PATHOLOGY; POLYMERASE CHAIN REACTION;

MUS;

ALANINE TRANSAMINASE; ANIMALS; ANTIOXIDANTS; ASPARTATE AMINOTRANSFERASES; CARBON TETRACHLORIDE; DRUG-INDUCED LIVER INJURY; GLUTATHIONE; HEME OXYGENASE-1; IMMUNOHISTOCHEMISTRY; LIVER; MALE; MALONDIALDEHYDE; MEMBRANE PROTEINS; MICE; MICE, INBRED ICR; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PEROXIREDOXINS; POLYMERASE CHAIN REACTION; QUERCETIN; RNA, MESSENGER; THIOREDOXIN-DISULFIDE REDUCTASE; THIOREDOXINS;

EID: 84915751365     PISSN: 16731581     EISSN: 18621783     Source Type: Journal    
DOI: 10.1631/jzus.B1400104     Document Type: Article

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