Peroxiredoxin gene expression signatures in liver reflect toxic insult

Assay and Drug Development Technologies

Volumn 8, Issue 4, 2010, Pages 512-517

  Young, Rachel ^a,b   Hayes, John D ^c   Brown, Ken ^d   Wolf, C Roland ^c,d   Whitelaw, C Bruce A ^a,e  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UMR1313 GÉNÉTIQUE ANIMALE ET BIOLOGIE INTÉGRATIVE   (France)

^c UNIVERSITY OF DUNDEE   (United Kingdom)

^d CXR Biosciences Ltd   (United Kingdom)

^e UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PEROXIREDOXIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DEATH; GENE EXPRESSION; GENE FUNCTION; LIVER; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; REAL TIME POLYMERASE CHAIN REACTION;

ANIMALS; CELL DEATH; GENE EXPRESSION; GENE EXPRESSION PROFILING; LIVER; MALE; MICE; MICE, INBRED C57BL; NF-E2-RELATED FACTOR 2; OXIDATION-REDUCTION; OXIDATIVE STRESS; PEROXIREDOXINS; REACTIVE OXYGEN SPECIES; TRANSCRIPTION FACTORS;

EID: 77956410550     PISSN: 1540658X     EISSN: None     Source Type: Journal    
DOI: 10.1089/adt.2009.0246     Document Type: Article

References (32)

1. Kang KW , Choi SH , Kim SG: Peroxynitrite activates NF-E2-related factor 2/ antioxidant response element through the pathway of phosphatidylinositol 3-kinase: the role of nitric oxide synthase in rat glutathione S -transferase A2 induction . Nitric Oxide 2002 ; 7: 244-253 .
2. Yu X , Kensler T: Nrf2 as a target for cancer chemoprevention . Mutat Res 2005 ; 591: 93-102 .
3. Numazawa S , Ishikawa M , Yoshida A , Tanaka S , Yoshida T: Atypical protein kinase C mediates activation of NF-E2-related factor 2 in response to oxidative stress . Am J Physiol, Cell Physiol 2003 ; 285: C334-C342 .
4. Meister A: Transport and metabolism of glutathione and gamma-glutamyl amino acids . Biochem Soc Trans 1983 ; 11: 793-794 .
5. Bailey HH , Gipp JJ , Ripple M , Wilding G , Mulcahy RT: Increase in gammaglutamylcysteine synthetase activity and steady-state messenger RNA levels in melphalan-resistant DU-145 human prostate carcinoma cells expressing elevated glutathione levels . Cancer Res 1992 ; 52: 5115-5118 .
6. Mulcahy RT , Untawale S , Gipp JJ: Transcriptional up-regulation of gammaglutamylcysteine synthetase gene expression in melphalan-resistant human prostate carcinoma cells . Mol Pharmacol 1994 ; 46: 909-914 .
7. Tipnis SR , Blake DG , Shepherd AG , McLellan LI: Overexpression of the regulatory subunit of gamma-glutamylcysteine synthetase in HeLa cells increases gamma-glutamylcysteine synthetase activity and confers drug resistance . Biochem J 1999 ; 337 ( Pt 3): 559-566 .
8. Talalay P , Fahey JW , Holtzclaw WD , Prestera T , Zhang Y: Chemoprotection against cancer by phase 2 enzyme induction . Toxicol Lett 1995 ; 82-83: 173-179 .
9. Radjendirane V , Joseph P , Jaiswal AK: Antioxidant regulation of genes encoding enzymes that detoxify xenobiotics and carcinogens . In: Oxidative Stress and Signal Transduction ( Cadenas E , Forman HJ , eds.) Chapman and Hall, New york, pp. 441 - 469 , 1997 .
10. Morse D , Choi AM: Heme oxygenase-1: the "emerging molecule" has arrived . Am J Respir Cell Mol Biol 2002 ; 27: 8-16 .
11. Otterbein LE , Choi AM: Heme oxygenase: colors of defense against cellular stress . Am J Physiol Lung Cell Mol Physiol 2000 ; 279: L1029-L1037 .
12. Rhee SG , Kang SW , Chang TS , Jeong W , Kim K: Peroxiredoxin, a novel family of peroxidases . IUBMB Life 2001 ; 52: 35-41 .
13. Fujii J , Ikeda Y: Advances in our understanding of peroxiredoxin, a multifunctional, mammalian redox protein . Redox Rep 2002 ; 7: 123-130 .
14. Kim H , Lee TH , Park ES , Suh JM , Park SJ , Chung HK , et al .: Role of peroxiredoxins in regulating intracellular hydrogen peroxide and hydrogen peroxide-induced apoptosis in thyroid cells . J Biol Chem 2000 ; 275: 18266-18270 .
15. Wen ST , Van Etten RA: The PAG gene product, a stress-induced protein with antioxidant properties, is an Abl SH3-binding protein and a physiological inhibitor of c-Abl tyrosine kinase activity . Genes Dev 1997 ; 11: 2456-2467 .
16. Hofmann B , Hecht HJ , Flohé L: Peroxiredoxins . Biol Chem 2002 ; 383: 347-364 .
17. Bryk R , Griffin P , Nathan C: Peroxynitrite reductase activity of bacterial peroxiredoxins . Nature 2000 ; 407: 211-215 .
18. Halliwell B , Gutteridge JM: Free Radicals in Biology and Medicine , 3rd ed . Oxford University Press , Oxford, United Kingdom , pp. 105 - 245 , 1999 .
19. Ishii T , Itoh K , Takahashi S , Sato H , Yanagawa T , Katoh Y , et al .: Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages . J Biol Chem 2000 ; 275: 16023-16029 .
20. Kensler TW , Wakabayashi N , Biswal S: Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway . Annu Rev Pharmacol Toxicol 2007 ; 47: 89-116 .
21. Wang X , Phelan SA , Forsman-Semb K , Taylor EF , Petros C, Brown A , et al.: Mice with targeted mutation of peroxiredoxin 6 develop normally but are susceptible to oxidative stress . J Biol Chem 2003 ; 278: 25179-25190 .
22. Vasey DB , Wolf CR , MacArtney T , Brown K , Whitelaw CB: p21-LacZ reporter mice reflect p53-dependent toxic insult . Toxicol Appl Pharmacol 2008 ; 227: 440-450 .
23. Monroe DH , Holeski CJ , Eaton DL: Effects of single-dose and repeated-dose pretreatment with 2(3)-tert-butyl-4-hydroxyanisole (BHA) on the hepatobiliary disposition and covalent binding to DNA of aflatoxin B1 in the rat . Food Chem Toxicol 1986 ; 24: 1273-1281 .
24. Zhu JH , Zhang X , McClung JP , Lei XG: Impact of Cu, Zn-superoxide dismutase and Se-dependent glutathione peroxidase-1 knockouts on acetaminophen-induced cell death and related signaling in murine liver . Exp Biol Med (Maywood) 2006 ; 231: 1726-1732 .
25. Immenschuh S , Tan M , Ramadori G: Nitric oxide mediates the lipopolysaccharide dependent upregulation of the heme oxygenase-1 gene expression in cultured rat Kupffer cells . J Hepatol 1999 ; 30: 61-69 .
26. Rushmore TH , Morton MR , Pickett CB: The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity . J Biol Chem 1991 ; 266: 11632-11639 .
27. Wasserman WW , Fahl WE: Functional antioxidant responsive elements . Proc Natl Acad Sci USA 1997 ; 94: 5361-5366 .
28. Nioi P , McMahon M , Itoh K , Yamamoto M , Hayes JD: Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD(P) H:quinone oxidoreductase 1 gene: reassessment of the ARE consensus sequence . Biochem J 2003 ; 374: 337-348 .
29. Lu C , Fu W , Zhao D , Mattson MP: The DNA damaging agent etoposide activates a cell survival pathway involving alpha-amino-3-hydroxy-5- methylisoxazole 4-propionate receptors and mitogen-activated protein kinases in hippocampal neurons . J Neurosci Res 2002 ; 70: 671-679 .
30. Miao W , Hu L , Scrivens PJ , Batist G: Transcriptional regulation of NF-E2 p45- related factor (NRF2) expression by the aryl hydrocarbon receptor-xenobiotic response element signaling pathway: direct cross-talk between phase I and II drug-metabolizing enzymes . J Biol Chem 2005 ; 280: 20340-20348 .
31. Ishii , T ., Itoh , K ., Akasaka , J ., Yanagawa , T ., Takahashi , S. , Yoshida, H. , et al.: Induction of murine intestinal and hepatic peroxiredoxin MSP23 by dietary butylated hydroxyanisole . Carcinogenesis . 2000 ; 21: 1013-1016 .
32. de Haan LH, Pot GK, Aarts JM, Rietjens IM, Alink GM: I n vivo relevance of two critical levels for NAD(P)H:quinone oxidoreductase (NQO1)-mediated cellular protection against electrophile toxicity found in vitro . Toxicol In Vitro 2006 ; 20: 594-600 .