Loss of SIRT4 decreases GLT-1-dependent glutamate uptake and increases sensitivity to kainic acid

Journal of Neurochemistry

Volumn 131, Issue 5, 2014, Pages 573-581

  Shih, Jennifer ^a,b   Liu, Lei ^a   Mason, Andrew ^a   Higashimori, Haruki ^a   Donmez, Gizem ^a  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TUFTS UNIVERSITY   (United States)

Author keywords

Excitotoxicity; GLT 1; Glutamate transport; Kainic acid; Sirtuins

Indexed keywords

ADENOSINE TRIPHOSPHATE; GLUTAMIC ACID; KAINIC ACID; SIRTUIN 4; VESICULAR GLUTAMATE TRANSPORTER 1; AMINO ACID RECEPTOR STIMULATING AGENT; EXCITATORY AMINO ACID TRANSPORTER 2; MITOCHONDRIAL PROTEIN; SIRT4 PROTEIN, MOUSE; SIRTUIN;

ADULT; AMINO ACID TRANSPORT; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; FEMALE; HIPPOCAMPUS; MALE; MOUSE; NERVE EXCITABILITY; NEUROPROTECTION; NONHUMAN; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SEIZURE; UPREGULATION; ANIMAL; ANIMAL EMBRYO; BIOTINYLATION; BRAIN; CELL CULTURE; CHEMICALLY INDUCED; CYTOLOGY; DEFICIENCY; DISEASE MODEL; DRUG EFFECTS; GENE EXPRESSION REGULATION; KNOCKOUT MOUSE; METABOLISM; NERVE CELL; PATHOLOGY; SYNAPTOSOME; ULTRASTRUCTURE;

ANIMALS; BIOTINYLATION; BRAIN; CELLS, CULTURED; DISEASE MODELS, ANIMAL; EMBRYO, MAMMALIAN; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID TRANSPORTER 2; FEMALE; GENE EXPRESSION REGULATION; GLUTAMIC ACID; KAINIC ACID; MALE; MICE; MICE, KNOCKOUT; MITOCHONDRIAL PROTEINS; NEURONS; SEIZURES; SIRTUINS; SYNAPTOSOMES;

EID: 84915750006     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.12942     Document Type: Article

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