Astroglial FMRP-dependent translational down-regulation of mglur5 underlies glutamate transporter GLT1 dysregulation in the fragile X mouse

Human Molecular Genetics

Volumn 22, Issue 10, 2013, Pages 2041-2054

  Higashimori, Haruki ^a   Morel, Lydie ^a   Huth, James ^a   Lindemann, Lothar ^c   Dulla, Chris ^a,b   Taylor, Amaro ^a   Freeman, Mike ^a   Yang, Yongjie ^a,b  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TUFTS UNIVERSITY   (United States)

^c F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

3,5 DIHYDROXYPHENYLGLYCINE; DIHYDROKAINIC ACID; EXCITATORY AMINO ACID TRANSPORTER 1; FRAGILE X MENTAL RETARDATION PROTEIN; MESSENGER RNA; METABOTROPIC RECEPTOR 5;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BASE MISPAIRING; BRAIN CORTEX; BRAIN SLICE; COCULTURE; CONTROLLED STUDY; DOWN REGULATION; FRAGILE X SYNDROME; IMMUNOPRECIPITATION; IMMUNOREACTIVITY; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NERVE CELL EXCITABILITY; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; ASTROCYTES; CEREBRAL CORTEX; DOWN-REGULATION; EXCITATORY AMINO ACID TRANSPORTER 2; FRAGILE X MENTAL RETARDATION PROTEIN; FRAGILE X SYNDROME; GENE KNOCKDOWN TECHNIQUES; GLUTAMIC ACID; HUMANS; KAINIC ACID; MICE; NEURONS; PROTEIN BIOSYNTHESIS; RECEPTORS, METABOTROPIC GLUTAMATE;

MUS;

EID: 84877084687     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddt055     Document Type: Article

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