Hypermethylation of Cox5a promoter is associated with mitochondrial dysfunction in skeletal muscle of high fat diet-induced insulin resistant rats

PLoS ONE

Volumn 9, Issue 12, 2014, Pages

  Gong, Ying Ying ^a   Liu, Yuan Yuan ^a   Li, Jin ^a   Su, Lei ^a   Yu, Shuang ^a   Zhu, Xiao Nan ^b   Cao, Xiao Pei ^a   Xiao, Hai Peng ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b SUN YAT SEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; ADENOSINE TRIPHOSPHATE; BISULFITE; COX5A PROTEIN; CYTOCHROME C OXIDASE; MESSENGER RNA; MITOCHONDRIAL PROTEIN; PALMITIC ACID; UNCLASSIFIED DRUG; COX5A PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA METHYLATION; DOWN REGULATION; ENZYME ACTIVITY; GENE EXPRESSION; GENETIC ASSOCIATION; GENOME; INSULIN RESISTANCE; LIPID DIET; MALE; MUSCLE MITOCHONDRION; MYOTUBE; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PROMOTER REGION; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; SKELETAL MUSCLE; ADVERSE EFFECTS; ANIMAL; CELL CULTURE; CHEMICALLY INDUCED; DNA MICROARRAY; DNA SEQUENCE; DRUG EFFECTS; GENETICS; METABOLISM; OBESITY; WISTAR RAT;

RATTUS;

ANIMALS; CELLS, CULTURED; DIET, HIGH-FAT; DNA METHYLATION; DOWN-REGULATION; ELECTRON TRANSPORT COMPLEX IV; INSULIN RESISTANCE; MALE; MITOCHONDRIA, MUSCLE; MUSCLE, SKELETAL; OBESITY; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OXIDATIVE PHOSPHORYLATION; PROMOTER REGIONS, GENETIC; RATS; RATS, WISTAR; SEQUENCE ANALYSIS, DNA;

EID: 84914706089     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0113784     Document Type: Article

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