Hypermethylation of hepatic Gck promoter in ageing rats contributes to diabetogenic potential

Diabetologia

Volumn 51, Issue 8, 2008, Pages 1525-1533

  Jiang, M H ^a   Fei, J ^a   Lan, M S ^b   Lu, Z P ^a   Liu, M ^c   Fan, W W ^a   Gao, X ^c   Lu, D R ^a  

^a FUDAN UNIVERSITY   (China)

^b CHILDREN S HOSPITAL   (United States)

^c FUDAN UNIVERSITY   (China)

Author keywords

Ageing; Diabetes; Glucokinase; Insulin resistance; Methylation

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; BISULFITE; DNA; GLUCOKINASE; GLYCOGEN; MESSENGER RNA;

AGED; AGING; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DIABETOGENESIS; DNA METHYLATION; ENZYME ACTIVITY; GENE; GENE AMPLIFICATION; GENE EXPRESSION; GENE SEQUENCE; GLUCOKINASE GENE; GLYCOGEN LIVER LEVEL; MALE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RAT;

AGING; ANIMALS; BASE SEQUENCE; DIABETES MELLITUS; DINUCLEOSIDE PHOSPHATES; DNA METHYLATION; DNA PRIMERS; GENETIC PREDISPOSITION TO DISEASE; GLUCOKINASE; INSULIN RESISTANCE; LIVER; LIVER GLYCOGEN; MALE; POLYMERASE CHAIN REACTION; PROMOTER REGIONS (GENETICS); RATS; RATS, WISTAR; RNA, MESSENGER;

EID: 48149092462     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-008-1034-8     Document Type: Article

References (50)

1. FS Facchini N Hua F Abbasi GM Reaven 2001 Insulin resistance as a predictor of age-related diseases J Clin Endocrinol Metab 86 3574 3578
2. GM Reaven EP Reaven 1985 Age, glucose intolerance, and non-insulin-dependent diabetes mellitus J Am Geriatr Soc 33 286 290
3. JW Rowe KL Minaker JA Pallotta JS Flier 1983 Characterization of the insulin resistance of aging J Clin Invest 71 1581 1587
4. L Fontana S Klein 2007 Aging, adiposity, and calorie restriction JAMA 297 986 994
5. KJ Stewart 2005 Physical activity and aging Ann N Y Acad Sci 1055 193 206
6. N Burns FM Finucane M Hatunic 2007 Early-onset type 2 diabetes in obese white subjects is characterised by a marked defect in beta cell insulin secretion, severe insulin resistance and a lack of response to aerobic exercise training Diabetologia 50 1500 1508
7. RC da Silva WL Miranda AR Chacra SA Dib 2007 Insulin resistance, beta-cell function, and glucose tolerance in Brazilian adolescents with obesity or risk factors for type 2 diabetes mellitus J Diabetes Complications 21 84 92
8. JB Meigs MK Rutter LM Sullivan CS Fox RB D'Agostino Sr PW Wilson 2007 Impact of insulin resistance on risk of type 2 diabetes and cardiovascular disease in people with metabolic syndrome Diabetes Care 30 1219 1225
9. S Pereira EB Marliss JA Morais S Chevalier R Gougeon 2008 Insulin resistance of protein metabolism in type 2 diabetes Diabetes 57 56 63
10. I Raz R Eldor S Cernea E Shafrir 2005 Diabetes: insulin resistance and derangements in lipid metabolism. Cure through intervention in fat transport and storage Diabetes Metab Res Rev 21 3 14
11. LC Groop E Widen E Ferrannini 1993 Insulin resistance and insulin deficiency in the pathogenesis of type 2 (non-insulin-dependent) diabetes mellitus: errors of metabolism or of methods? Diabetologia 36 1326 1331
12. DG Walker S Rao 1964 The role of glucokinase in the phosphorylation of glucose by rat liver Biochem J 90 360 368
13. MA Magnuson TL Andreone RL Printz S Koch DK Granner 1989 Rat glucokinase gene: structure and regulation by insulin Proc Natl Acad Sci U S A 86 4838 4842
14. M Salas E Vinuela A Sols 1963 Insulin-dependent synthesis of liver glucokinase in the rat J Biol Chem 238 3535 3538
15. PB Iynedjian A Gjinovci AE Renold 1988 Stimulation by insulin of glucokinase gene transcription in liver of diabetic rats J Biol Chem 263 740 744
16. PB Iynedjian PR Pilot T Nouspikel 1989 Differential expression and regulation of the glucokinase gene in liver and islets of Langerhans Proc Natl Acad Sci U S A 86 7838 7842
17. JF Caro S Triester VK Patel EB Tapscott NL Frazier GL Dohm 1995 Liver glucokinase: decreased activity in patients with type II diabetes Horm Metab Res 27 19 22
18. M Stoffel P Patel YM Lo 1992 Missense glucokinase mutation in maturity-onset diabetes of the young and mutation screening in late-onset diabetes Nat Genet 2 153 156
19. N Vionnet M Stoffel J Takeda 1992 Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus Nature 356 721 722
20. C Ling P Poulsen S Simonsson 2007 Genetic and epigenetic factors are associated with expression of respiratory chain component NDUFB6 in human skeletal muscle J Clin Invest 117 3427 3435
21. M Templeton 1961 Microdetermination of glycogen with anthrone reagent J Histochem Cytochem 9 670 672
22. J Van Der Vies 1954 Two methods for the determination of glycogen in liver Biochem J 57 410 416
23. J Chen DA Rider R Ruan 2006 Identification of valid housekeeping genes and antioxidant enzyme gene expression change in the aging rat liver J Gerontol A Biol Sci Med Sci 61 20 27
24. DG Ginzinger 2002 Gene quantification using real-time quantitative PCR: an emerging technology hits the mainstream Exp Hematol 30 503 512
25. F Bontemps L Hue HG Hers 1978 Phosphorylation of glucose in isolated rat hepatocytes. Sigmoidal kinetics explained by the activity of glucokinase alone Biochem J 174 603 611
26. AL Davidson WJ Arion 1987 Factors underlying significant underestimations of glucokinase activity in crude liver extracts: physiological implications of higher cellular activity Arch Biochem Biophys 253 156 167
27. C Grunau SJ Clark A Rosenthal 2001 Bisulfite genomic sequencing: systematic investigation of critical experimental parameters Nucleic Acids Res 29 E65 E65
28. I Bogdarina HC Murphy SP Burns AJ Clark 2004 Investigation of the role of epigenetic modification of the rat glucokinase gene in fetal programming Life Sci 74 1407 1415
29. LC Li R Chui K Nakajima BR Oh HC Au R Dahiya 2000 Frequent methylation of estrogen receptor in prostate cancer: correlation with tumor progression Cancer Res 60 702 706
30. DS Millar KK Ow CL Paul PJ Russell PL Molloy SJ Clark 1999 Detailed methylation analysis of the glutathione S-transferase pi (GSTP1) gene in prostate cancer Oncogene 18 1313 1324
31. CL Paul SJ Clark 1996 Cytosine methylation: quantitation by automated genomic sequencing and GENESCAN analysis Biotechniques 21 126 133
32. C Stirzaker DS Millar CL Paul 1997 Extensive DNA methylation spanning the Rb promoter in retinoblastoma tumors Cancer Res 57 2229 2237
33. J Lewin AO Schmitt P Adorjan T Hildmann C Piepenbrock 2004 Quantitative DNA methylation analysis based on four-dye trace data from direct sequencing of PCR amplificates Bioinformatics 20 3005 3012
34. V Ngo D Gourdji JN Laverriere 1996 Site-specific methylation of the rat prolactin and growth hormone promoters correlates with gene expression Mol Cell Biol 16 3245 3254
35. Q Tao KD Robertson A Manns A Hildesheim RF Ambinder 1998 Epstein-Barr virus (EBV) in endemic Burkitt's lymphoma: molecular analysis of primary tumor tissue Blood 91 1373 1381
36. A Murumagi P Vahamurto P Peterson 2003 Characterization of regulatory elements and methylation pattern of the autoimmune regulator (AIRE) promoter J Biol Chem 278 19784 19790
37. A Salavert PB Iynedjian 1982 Regulation of phosphoenolpyruvate carboxykinase (GTP) synthesis in rat liver cells. Rapid induction of specific mRNA by glucagon or cyclic AMP and permissive effect of dexamethasone J Biol Chem 257 13404 13412
38. P Bossard R Parsa JF Decaux P Iynedjian J Girard 1993 Glucose administration induces the premature expression of liver glucokinase gene in newborn rats. Relation with DNase-I-hypersensitive sites Eur J Biochem 215 883 892
39. MB Davidson 1979 The effect of aging on carbohydrate metabolism: a review of the English literature and a practical approach to the diagnosis of diabetes mellitus in the elderly Metabolism 28 688 705
40. T Ferre A Pujol E Riu F Bosch A Valera 1996 Correction of diabetic alterations by glucokinase Proc Natl Acad Sci U S A 93 7225 7230
41. L Agius M Peak CB Newgard AM Gomez-Foix JJ Guinovart 1996 Evidence for a role of glucose-induced translocation of glucokinase in the control of hepatic glycogen synthesis J Biol Chem 271 30479 30486
42. C Postic M Shiota KD Niswender 1999 Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase J Biol Chem 274 305 315
43. L Harndahl D Schmoll AW Herling L Agius 2006 The role of glucose 6-phosphate in mediating the effects of glucokinase overexpression on hepatic glucose metabolism FEBS J 273 336 346
44. LJ Hampson L Agius 2005 Increased potency and efficacy of combined phosphorylase inactivation and glucokinase activation in control of hepatocyte glycogen metabolism Diabetes 54 617 623
45. RR Gomis C Favre M Garcia-Rocha JM Fernandez-Novell JC Ferrer JJ Guinovart 2003 Glucose 6-phosphate produced by gluconeogenesis and by glucokinase is equally effective in activating hepatic glycogen synthase J Biol Chem 278 9740 9746
46. J Seoane AM Gomez-Foix RM O'Doherty C Gomez-Ara CB Newgard JJ Guinovart 1996 Glucose 6-phosphate produced by glucokinase, but not hexokinase I, promotes the activation of hepatic glycogen synthase J Biol Chem 271 23756 23760
47. BE Antonsson VI Avramis J Nyce JS Holcenberg 1987 Effect of 5-azacytidine and congeners on DNA methylation and expression of deoxycytidine kinase in the human lymphoid cell lines CCRF/CEM/0 and CCRF/CEM/dCk-1 Cancer Res 47 3672 3678
48. MA Magnuson KD Shelton 1989 An alternate promoter in the glucokinase gene is active in the pancreatic beta cell J Biol Chem 264 15936 15942
49. T Frese I Bazwinsky E Muhlbauer E Peschke 2007 Circadian and age-dependent expression patterns of GLUT2 and glucokinase in the pancreatic beta-cell of diabetic and nondiabetic rats Horm Metab Res 39 567 574
50. RC Adelman 1970 An age-dependent modification of enzyme regulation J Biol Chem 245 1032 1035