A PGC-1α- and muscle fibre type-related decrease in markers of mitochondrial oxidative metabolism in skeletal muscle of humans with inherited insulin resistance

Diabetologia

Volumn 57, Issue 5, 2014, Pages 1006-1015

  Kristensen, Jonas M ^a,b,c   Skov, Vibe ^a   Petersson, Stine J ^a,b   Ørtenblad, Niels ^b   Wojtaszewski, Jørgen F P ^c   Beck Nielsen, Henning ^a   Højlund, Kurt ^a,b,c  

^a ODENSE UNIVERSITY HOSPITAL   (Denmark)

^b UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Gene expression; Insulin resistance; Mitochondria; Muscle fibre type; PGC 1 ; Skeletal muscle

Indexed keywords

ACYL COENZYME A DEHYDROGENASE; CELL NUCLEUS DNA; CITRATE SYNTHASE; COMPLEMENTARY DNA; INSULIN; MESSENGER RNA; MYOSIN HEAVY CHAIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; INSR PROTEIN, HUMAN; INSULIN RECEPTOR; LEUKOCYTE ANTIGEN; OXYGEN; PPARGC1A PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

ADULT; AEROBIC METABOLISM; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; FEMALE; GENE EXPRESSION; GENE MUTATION; HUMAN; HUMAN TISSUE; INSULIN RESISTANCE; MALE; MITOCHONDRIAL RESPIRATION; MUSCLE BIOPSY; MUSCLE CELL; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN CONTENT; REAL TIME POLYMERASE CHAIN REACTION; SKELETAL MUSCLE; CASE CONTROL STUDY; DNA MICROARRAY; FAMILY HEALTH; GENETIC TRANSCRIPTION; GENETICS; HETEROZYGOTE; METABOLISM; MIDDLE AGED; MITOCHONDRION; MUTATION; PHOSPHORYLATION; PROTEIN TERTIARY STRUCTURE; SIGNAL TRANSDUCTION; YOUNG ADULT;

ADULT; ANTIGENS, CD; CASE-CONTROL STUDIES; FAMILY HEALTH; FEMALE; HETEROZYGOTE; HUMANS; INSULIN RESISTANCE; MALE; MIDDLE AGED; MITOCHONDRIA; MUSCLE, SKELETAL; MUTATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OXIDATIVE PHOSPHORYLATION; OXYGEN; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; YOUNG ADULT;

EID: 84898598365     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-014-3187-y     Document Type: Article

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