-
1
-
-
84889641544
-
From flavors and pharmaceuticals to advanced biofuels: production of isoprenoids in Saccharomyces cerevisiae
-
Tippmann S, Chen Y, Siewers V, Nielsen J. 2013. From flavors and pharmaceuticals to advanced biofuels: production of isoprenoids in Saccharomyces cerevisiae. Biotechnol. J. 8:1435-1444. http://dx.doi.org/10.1002/biot.201300028.
-
(2013)
Biotechnol. J.
, vol.8
, pp. 1435-1444
-
-
Tippmann, S.1
Chen, Y.2
Siewers, V.3
Nielsen, J.4
-
2
-
-
48149106189
-
Metabolic engineering of microorganisms for isoprenoid production
-
Kirby J, Keasling JD. 2008. Metabolic engineering of microorganisms for isoprenoid production. Nat. Prod. Rep. 25:656-661. http://dx.doi.org/10.1039/b802939c.
-
(2008)
Nat. Prod. Rep.
, vol.25
, pp. 656-661
-
-
Kirby, J.1
Keasling, J.D.2
-
3
-
-
84876784070
-
High-level semi-synthetic production of the potent antimalarial artemisinin
-
Paddon CJ, Westfall PJ, Pitera DJ, Benjamin K, Fisher K, McPhee D, Leavell MD, Tai A, Main A, Eng D, Polichuk DR, Teoh KH, Reed DW, Treynor T, Lenihan J, Fleck M, Bajad S, Dang G, Dengrove D, Diola D, Dorin G, Ellens KW, Fickes S, Galazzo J, Gaucher SP, Geistlinger T, Henry R, Hepp M, Horning T, Iqbal T, Jiang H, Kizer L, Lieu B, Melis D, Moss N, Regentin R, Secrest S, Tsuruta H, Vazquez R, Westblade LF, Xu L, Yu M, Zhang Y, Zhao L, Lievense J, Covello PS, Keasling JD, Reiling KK, Renninger NS, Newman JD. 2013. High-level semi-synthetic production of the potent antimalarial artemisinin. Nature 496:528-532. http://dx.doi.org/10.1038/nature12051.
-
(2013)
Nature
, vol.496
, pp. 528-532
-
-
Paddon, C.J.1
Westfall, P.J.2
Pitera, D.J.3
Benjamin, K.4
Fisher, K.5
McPhee, D.6
Leavell, M.D.7
Tai, A.8
Main, A.9
Eng, D.10
Polichuk, D.R.11
Teoh, K.H.12
Reed, D.W.13
Treynor, T.14
Lenihan, J.15
Fleck, M.16
Bajad, S.17
Dang, G.18
Dengrove, D.19
Diola, D.20
Dorin, G.21
Ellens, K.W.22
Fickes, S.23
Galazzo, J.24
Gaucher, S.P.25
Geistlinger, T.26
Henry, R.27
Hepp, M.28
Horning, T.29
Iqbal, T.30
Jiang, H.31
Kizer, L.32
Lieu, B.33
Melis, D.34
Moss, N.35
Regentin, R.36
Secrest, S.37
Tsuruta, H.38
Vazquez, R.39
Westblade, L.F.40
Xu, L.41
Yu, M.42
Zhang, Y.43
Zhao, L.44
Lievense, J.45
Covello, P.S.46
Keasling, J.D.47
Reiling, K.K.48
Renninger, N.S.49
Newman, J.D.50
more..
-
4
-
-
33645870422
-
Production of the antimalarial drug precursor artemisinic acid in engineered yeast
-
Ro DK, Paradise EM, Ouellet M, Fisher KJ, Newman KL, Ndungu JM, Ho KA, Eachus RA, Ham TS, Kirby J, Chang MC, Withers ST, Shiba Y, Sarpong R, Keasling JD. 2006. Production of the antimalarial drug precursor artemisinic acid in engineered yeast. Nature 440:940-943. http://dx.doi.org/10.1038/nature04640.
-
(2006)
Nature
, vol.440
, pp. 940-943
-
-
Ro, D.K.1
Paradise, E.M.2
Ouellet, M.3
Fisher, K.J.4
Newman, K.L.5
Ndungu, J.M.6
Ho, K.A.7
Eachus, R.A.8
Ham, T.S.9
Kirby, J.10
Chang, M.C.11
Withers, S.T.12
Shiba, Y.13
Sarpong, R.14
Keasling, J.D.15
-
5
-
-
80053412686
-
Identification and microbial production of a terpene-based advanced biofuel
-
Peralta-Yahya PP, Ouellet M, Chan R, Mukhopadhyay A, Keasling JD, Lee TS. 2011. Identification and microbial production of a terpene-based advanced biofuel. Nat. Commun. 2:483. http://dx.doi.org/10.1038/ncomms1494.
-
(2011)
Nat. Commun.
, vol.2
, pp. 483
-
-
Peralta-Yahya, P.P.1
Ouellet, M.2
Chan, R.3
Mukhopadhyay, A.4
Keasling, J.D.5
Lee, T.S.6
-
6
-
-
84872377725
-
Carotenoid-based phenotypic screen of the yeast deletion collection reveals new genes with roles in isoprenoid production
-
Özaydin B, Burd H, Lee TS, Keasling JD. 2013. Carotenoid-based phenotypic screen of the yeast deletion collection reveals new genes with roles in isoprenoid production. Metab. Eng. 15:174-183. http://dx.doi.org/10.1016/j.ymben.2012.07.010.
-
(2013)
Metab. Eng.
, vol.15
, pp. 174-183
-
-
Özaydin, B.1
Burd, H.2
Lee, T.S.3
Keasling, J.D.4
-
7
-
-
0016123102
-
Effect of altered sterol composition on growth characteristics of Saccharomyces cerevisiae
-
Thompson ED, Parks LW. 1974. Effect of altered sterol composition on growth characteristics of Saccharomyces cerevisiae. J. Bacteriol. 120:779-784.
-
(1974)
J. Bacteriol.
, vol.120
, pp. 779-784
-
-
Thompson, E.D.1
Parks, L.W.2
-
8
-
-
0036894215
-
Drug susceptibilities of yeast cells are affected by membrane lipid composition
-
Mukhopadhyay K, Kohli A, Prasad R. 2002. Drug susceptibilities of yeast cells are affected by membrane lipid composition. Antimicrob. Agents Chemother. 46:3695-3705. http://dx.doi.org/10.1128/AAC.46.12.3695-3705.2002.
-
(2002)
Antimicrob. Agents Chemother.
, vol.46
, pp. 3695-3705
-
-
Mukhopadhyay, K.1
Kohli, A.2
Prasad, R.3
-
9
-
-
80052611253
-
Efficient accumulation of oleic acid in Saccharomyces cerevisiae caused by expression of rat elongase 2 gene (rELO2) and its contribution to tolerance to alcohols
-
Yazawa H, Kamisaka Y, Kimura K, Yamaoka M, Uemura H. 2011. Efficient accumulation of oleic acid in Saccharomyces cerevisiae caused by expression of rat elongase 2 gene (rELO2) and its contribution to tolerance to alcohols. Appl. Microbiol. Biotechnol. 91:1593-1600. http://dx.doi.org/10.1007/s00253-011-3410-4.
-
(2011)
Appl. Microbiol. Biotechnol.
, vol.91
, pp. 1593-1600
-
-
Yazawa, H.1
Kamisaka, Y.2
Kimura, K.3
Yamaoka, M.4
Uemura, H.5
-
10
-
-
79951769821
-
Total fatty acid content of the plasma membrane of Saccharomyces cerevisiae is more responsible for ethanol tolerance than the degree of unsaturation
-
Kim HS, Kim NR, Choi W. 2011. Total fatty acid content of the plasma membrane of Saccharomyces cerevisiae is more responsible for ethanol tolerance than the degree of unsaturation. Biotechnol. Lett. 33:509-515. http://dx.doi.org/10.1007/s10529-010-0465-8.
-
(2011)
Biotechnol. Lett.
, vol.33
, pp. 509-515
-
-
Kim, H.S.1
Kim, N.R.2
Choi, W.3
-
11
-
-
79953214587
-
Terminal olefin (1-alkene) biosynthesis by a novel P450 fatty acid decarboxylase from Jeotgalicoccus species
-
Rude MA, Baron TS, Brubaker S, Alibhai M, Del Cardayre SB, Schirmer A. 2011. Terminal olefin (1-alkene) biosynthesis by a novel P450 fatty acid decarboxylase from Jeotgalicoccus species. Appl. Environ. Microbiol. 77: 1718-1727. http://dx.doi.org/10.1128/AEM.02580-10.
-
(2011)
Appl. Environ. Microbiol.
, vol.77
, pp. 1718-1727
-
-
Rude, M.A.1
Baron, T.S.2
Brubaker, S.3
Alibhai, M.4
Del Cardayre, S.B.5
Schirmer, A.6
-
12
-
-
84858450288
-
Perstraction of intracellular pigments by submerged cultivation of Monascus in nonionic surfactant micelle aqueous solution
-
Hu Z, Zhang X, Wu Z, Qi H, Wang Z. 2012. Perstraction of intracellular pigments by submerged cultivation of Monascus in nonionic surfactant micelle aqueous solution. Appl. Microbiol. Biotechnol. 94:81-89. http://dx.doi.org/10.1007/s00253-011-3851-9.
-
(2012)
Appl. Microbiol. Biotechnol.
, vol.94
, pp. 81-89
-
-
Hu, Z.1
Zhang, X.2
Wu, Z.3
Qi, H.4
Wang, Z.5
-
13
-
-
77955430862
-
Cloning of casbene and neocembrene synthases from Euphorbiaceae plants and expression in Saccharomyces cerevisiae
-
Kirby J, Nishimoto M, Park JG, Withers ST, Nowroozi F, Behrendt D, Rutledge EJ, Fortman JL, Johnson HE, Anderson JV, Keasling JD. 2010. Cloning of casbene and neocembrene synthases from Euphorbiaceae plants and expression in Saccharomyces cerevisiae. Phytochemistry 71: 1466-1473. http://dx.doi.org/10.1016/j.phytochem.2010.06.001.
-
(2010)
Phytochemistry
, vol.71
, pp. 1466-1473
-
-
Kirby, J.1
Nishimoto, M.2
Park, J.G.3
Withers, S.T.4
Nowroozi, F.5
Behrendt, D.6
Rutledge, E.J.7
Fortman, J.L.8
Johnson, H.E.9
Anderson, J.V.10
Keasling, J.D.11
-
14
-
-
57049089897
-
Induction of multiple pleiotropic drug resistance genes in yeast engineered to produce an increased level of anti-malarial drug precursor, artemisinic acid
-
Ro DK, Ouellet M, Paradise EM, Burd H, Eng D, Paddon CJ, Newman JD, Keasling JD. 2008. Induction of multiple pleiotropic drug resistance genes in yeast engineered to produce an increased level of anti-malarial drug precursor, artemisinic acid. BMC Biotechnol. 8:83. http://dx.doi.org/10.1186/1472-6750-8-83.
-
(2008)
BMC Biotechnol.
, vol.8
, pp. 83
-
-
Ro, D.K.1
Ouellet, M.2
Paradise, E.M.3
Burd, H.4
Eng, D.5
Paddon, C.J.6
Newman, J.D.7
Keasling, J.D.8
-
15
-
-
41549107616
-
Engineering triterpene production in Saccharomyces cerevisiae-beta-amyrin synthase from Artemisia annua
-
Kirby J, Romanini DW, Paradise EM, Keasling JD. 2008. Engineering triterpene production in Saccharomyces cerevisiae-beta-amyrin synthase from Artemisia annua. FEBS J. 275:1852-1859. http://dx.doi.org/10.1111/j.1742-4658.2008.06343.x.
-
(2008)
FEBS J.
, vol.275
, pp. 1852-1859
-
-
Kirby, J.1
Romanini, D.W.2
Paradise, E.M.3
Keasling, J.D.4
-
16
-
-
67651171257
-
Distributions of enzyme residues yielding mutants with improved substrate specificities from two different directed evolution strategies
-
Paramesvaran J, Hibbert EG, Russell AJ, Dalby PA. 2009. Distributions of enzyme residues yielding mutants with improved substrate specificities from two different directed evolution strategies. Protein Eng. Des. Sel. 22:401-411. http://dx.doi.org/10.1093/protein/gzp020.
-
(2009)
Protein Eng. Des. Sel.
, vol.22
, pp. 401-411
-
-
Paramesvaran, J.1
Hibbert, E.G.2
Russell, A.J.3
Dalby, P.A.4
-
17
-
-
80052102623
-
Strategy and success for the directed evolution of enzymes
-
Dalby PA. 2011. Strategy and success for the directed evolution of enzymes. Curr. Opin. Struct. Biol. 21:473-480. http://dx.doi.org/10.1016/j.sbi.2011.05.003.
-
(2011)
Curr. Opin. Struct. Biol.
, vol.21
, pp. 473-480
-
-
Dalby, P.A.1
-
18
-
-
82955239933
-
Structure of a three-domain sesquiterpene synthase: a prospective target for advanced biofuels production
-
McAndrew RP, Peralta-Yahya PP, DeGiovanni A, Pereira JH, Hadi MZ, Keasling JD, Adams PD. 2011. Structure of a three-domain sesquiterpene synthase: a prospective target for advanced biofuels production. Structure 19:1876-1884. http://dx.doi.org/10.1016/j.str.2011.09.013.
-
(2011)
Structure
, vol.19
, pp. 1876-1884
-
-
McAndrew, R.P.1
Peralta-Yahya, P.P.2
DeGiovanni, A.3
Pereira, J.H.4
Hadi, M.Z.5
Keasling, J.D.6
Adams, P.D.7
-
19
-
-
34347206860
-
High-efficiency yeast transformation using the LiAc/SS carrier DNA/PEG method
-
Gietz RD, Schiestl RH. 2007. High-efficiency yeast transformation using the LiAc/SS carrier DNA/PEG method. Nat. Protoc. 2:31-34. http://dx.doi.org/10.1038/nprot.2007.13.
-
(2007)
Nat. Protoc.
, vol.2
, pp. 31-34
-
-
Gietz, R.D.1
Schiestl, R.H.2
-
20
-
-
0344938045
-
The effect of different alcohols and other polar organic additives on the cloud point of Triton X-100 in water
-
Gu TR, Galera-Gomez PA. 1999. The effect of different alcohols and other polar organic additives on the cloud point of Triton X-100 in water. Colloids Surf. A Physicochem. Eng. Asp. 147:365-370. http://dx.doi.org/10.1016/S0927-7757(98)00710-9.
-
(1999)
Colloids Surf. A Physicochem. Eng. Asp.
, vol.147
, pp. 365-370
-
-
Gu, T.R.1
Galera-Gomez, P.A.2
-
21
-
-
77956371200
-
Combining metabolic and protein engineering of a terpenoid biosynthetic pathway for overproduction and selectivity control
-
Leonard E, Ajikumar PK, Thayer K, Xiao WH, Mo JD, Tidor B, Stephanopoulos G, Prather KL. 2010. Combining metabolic and protein engineering of a terpenoid biosynthetic pathway for overproduction and selectivity control. Proc. Natl. Acad. Sci. U. S. A. 107:13654-13659. http://dx.doi.org/10.1073/pnas.1006138107.
-
(2010)
Proc. Natl. Acad. Sci. U. S. A.
, vol.107
, pp. 13654-13659
-
-
Leonard, E.1
Ajikumar, P.K.2
Thayer, K.3
Xiao, W.H.4
Mo, J.D.5
Tidor, B.6
Stephanopoulos, G.7
Prather, K.L.8
-
22
-
-
84877698856
-
High-throughput screening for terpene-synthase-cyclization activity and directed evolution of a terpene synthase
-
Lauchli R, Rabe KS, Kalbarczyk KZ, Tata A, Heel T, Kitto RZ, Arnold FH. 2013. High-throughput screening for terpene-synthase-cyclization activity and directed evolution of a terpene synthase. Angew. Chem. Int. Ed. Engl. 52:5571-5574. http://dx.doi.org/10.1002/anie.201301362.
-
(2013)
Angew. Chem. Int. Ed. Engl.
, vol.52
, pp. 5571-5574
-
-
Lauchli, R.1
Rabe, K.S.2
Kalbarczyk, K.Z.3
Tata, A.4
Heel, T.5
Kitto, R.Z.6
Arnold, F.H.7
-
23
-
-
84860696106
-
Functional characterization of four sesquiterpene synthases from Ricinus communis (castor bean)
-
Xie X, Kirby J, Keasling JD. 2012. Functional characterization of four sesquiterpene synthases from Ricinus communis (castor bean). Phytochemistry 78:20-28. http://dx.doi.org/10.1016/j.phytochem.2012.02.022.
-
(2012)
Phytochemistry
, vol.78
, pp. 20-28
-
-
Xie, X.1
Kirby, J.2
Keasling, J.D.3
-
24
-
-
84864080802
-
Effective improvement of D-phenylglycine aminotransferase solubility by protein crystal contact engineering
-
Chantarasiri A, Meevootisom V, Isarangkul D, Wiyakrutta S. 2012. Effective improvement of D-phenylglycine aminotransferase solubility by protein crystal contact engineering. J. Mol. Microbiol. Biotechnol. 22: 147-155. http://dx.doi.org/10.1159/000339833.
-
(2012)
J. Mol. Microbiol. Biotechnol.
, vol.22
, pp. 147-155
-
-
Chantarasiri, A.1
Meevootisom, V.2
Isarangkul, D.3
Wiyakrutta, S.4
-
25
-
-
79960321967
-
Functional expression of a plant hydroxynitrile lyase in Escherichia coli by directed evolution: creation and characterization of highly in vivo soluble mutants
-
Asano Y, Dadashipour M, Yamazaki M, Doi N, Komeda H. 2011. Functional expression of a plant hydroxynitrile lyase in Escherichia coli by directed evolution: creation and characterization of highly in vivo soluble mutants. Protein Eng. Des. Sel. 24:607-616. http://dx.doi.org/10.1093/protein/gzr030.
-
(2011)
Protein Eng. Des. Sel.
, vol.24
, pp. 607-616
-
-
Asano, Y.1
Dadashipour, M.2
Yamazaki, M.3
Doi, N.4
Komeda, H.5
-
26
-
-
33646178621
-
Designed divergent evolution of enzyme function
-
Yoshikuni Y, Ferrin TE, Keasling JD. 2006. Designed divergent evolution of enzyme function. Nature 440:1078-1082. http://dx.doi.org/10.1038/nature04607.
-
(2006)
Nature
, vol.440
, pp. 1078-1082
-
-
Yoshikuni, Y.1
Ferrin, T.E.2
Keasling, J.D.3
-
27
-
-
79957980223
-
Industrial fermentation of renewable diesel fuels
-
Westfall PJ, Gardner TS. 2011. Industrial fermentation of renewable diesel fuels. Curr. Opin. Biotechnol. 22:344-350. http://dx.doi.org/10.1016/j.copbio.2011.04.023.
-
(2011)
Curr. Opin. Biotechnol.
, vol.22
, pp. 344-350
-
-
Westfall, P.J.1
Gardner, T.S.2
-
28
-
-
35148889024
-
Identification of isopentenol biosynthetic genes from Bacillus subtilis by a screening method based on isoprenoid precursor toxicity
-
Withers ST, Gottlieb SS, Lieu B, Newman JD, Keasling JD. 2007. Identification of isopentenol biosynthetic genes from Bacillus subtilis by a screening method based on isoprenoid precursor toxicity. Appl. Environ. Microbiol. 73:6277-6283. http://dx.doi.org/10.1128/AEM.00861-07.
-
(2007)
Appl. Environ. Microbiol.
, vol.73
, pp. 6277-6283
-
-
Withers, S.T.1
Gottlieb, S.S.2
Lieu, B.3
Newman, J.D.4
Keasling, J.D.5
-
29
-
-
51949110360
-
Quantitative exploration of the catalytic landscape separating divergent plant sesquiterpene synthases
-
O'Maille PE, Malone A, Dellas N, Andes Hess B, Jr, Smentek L, Sheehan I, Greenhagen BT, Chappell J, Manning G, Noel JP. 2008. Quantitative exploration of the catalytic landscape separating divergent plant sesquiterpene synthases. Nat. Chem. Biol. 4:617-623.
-
(2008)
Nat. Chem. Biol.
, vol.4
, pp. 617-623
-
-
O'Maille, P.E.1
Malone, A.2
Dellas, N.3
Andes Hess, B.4
Smentek, L.5
Sheehan, I.6
Greenhagen, B.T.7
Chappell, J.8
Manning, G.9
Noel, J.P.10
-
30
-
-
38949096144
-
Functional plasticity of paralogous diterpene synthases involved in conifer defense
-
Keeling CI, Weisshaar S, Lin RP, Bohlmann J. 2008. Functional plasticity of paralogous diterpene synthases involved in conifer defense. Proc. Natl. Acad. Sci. U. S. A. 105:1085-1090. http://dx.doi.org/10.1073/pnas.0709466105.
-
(2008)
Proc. Natl. Acad. Sci. U. S. A.
, vol.105
, pp. 1085-1090
-
-
Keeling, C.I.1
Weisshaar, S.2
Lin, R.P.3
Bohlmann, J.4
-
31
-
-
0141519339
-
Widespread selection for local RNA secondary structure in coding regions of bacterial genes
-
Katz L, Burge CB. 2003. Widespread selection for local RNA secondary structure in coding regions of bacterial genes. Genome Res. 13:2042-2051. http://dx.doi.org/10.1101/gr.1257503.
-
(2003)
Genome Res.
, vol.13
, pp. 2042-2051
-
-
Katz, L.1
Burge, C.B.2
|