Tolerance to acetaminophen hepatotoxicity in the mouse model of autoprotection is associated with induction of flavin-containing monooxygenase-3 (FMO3) in hepatocytes

Toxicological Sciences

Volumn 141, Issue 1, 2014, Pages 263-277

  Rudraiah, Swetha ^a   Rohrer, Philip R ^a   Gurevich, Igor ^b   Goedken, Michael J ^c   Rasmussen, Theodore ^a   Hines, Ronald N ^d   Manautou, José E ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b Cellular Dynamics International   (United States)

^c RUTGERS UNIVERSITY   (United States)

^d U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Acetaminophen; Autoprotection; Fmo3; Hepatotoxicity; Inhibitor; Methimazole

Indexed keywords

DIMETHYLANILINE MONOOXYGENASE; FLAVIN CONTAINING MONOOXYGENASE 3; MESSENGER RNA; PARACETAMOL; THIAMAZOLE; UNCLASSIFIED DRUG; XENOBIOTIC AGENT; ALANINE AMINOTRANSFERASE; DIMETHYLANILINE MONOOXYGENASE (N-OXIDE FORMING); OXYGENASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL CLONE; CONTROLLED STUDY; CYTOTOXICITY; FEMALE; GENE CONTROL; LIVER CELL; LIVER PROTECTION; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECTS; DRUG RESISTANCE; DRUG-INDUCED LIVER INJURY; ENZYME INDUCTION; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOLOGY;

ACETAMINOPHEN; ALANINE TRANSAMINASE; ANIMALS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE; DRUG-INDUCED LIVER INJURY; ENZYME INDUCTION; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEPATOCYTES; MALE; MICE, INBRED C57BL; OXYGENASES;

EID: 84913621659     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfu124     Document Type: Article

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