Evidence for the involvement of N-methylthiourea, a ring cleavage metabolite, in the hepatotoxicity of methimazole in glutathione-depleted mice: Structure-toxicity and metabolic studies

Chemical Research in Toxicology

Volumn 13, Issue 3, 2000, Pages 170-176

  Mizutani, Tamio ^a   Yoshida, Kaoru ^a   Murakami, Mihoko ^a   Shirai, Mutsuko ^a   Kawazoe, Sadahiro ^a  

^a KYOTO PREFECTURAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; BUTHIONINE SULFOXIMINE; GLUTATHIONE PEROXIDASE; THIAMAZOLE; THIOUREA DERIVATIVE; UNSPECIFIC MONOOXYGENASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; ENZYME ACTIVITY; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; PATHOGENESIS; STRUCTURE ACTIVITY RELATION;

ANIMALS; BUTHIONINE SULFOXIMINE; DISEASE MODELS, ANIMAL; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GLUTATHIONE; HEPATITIS, TOXIC; LIVER; MALE; METHIMAZOLE; MICE; MICE, INBRED ICR; NECROSIS; STRUCTURE-ACTIVITY RELATIONSHIP; THIOUREA;

ANIMALIA;

EID: 0034122751     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx990155o     Document Type: Article

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