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Volumn 60, Issue 2, 2014, Pages 670-678

Activated Nrf2 impairs liver regeneration in mice by activation of genes involved in cell-cycle control and apoptosis

Author keywords

[No Author keywords available]

Indexed keywords

BIM PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 2B; TRANSCRIPTION FACTOR NRF2;

EID: 84904764018     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.26964     Document Type: Article
Times cited : (75)

References (33)
  • 1
    • 84864344675 scopus 로고    scopus 로고
    • Targeting NADPH oxidases for the treatment of cancer and inflammation
    • Bonner MY, Arbiser JL. Targeting NADPH oxidases for the treatment of cancer and inflammation. Cell Mol Life Sci 2012;69:2435-2442.
    • (2012) Cell Mol Life Sci , vol.69 , pp. 2435-2442
    • Bonner, M.Y.1    Arbiser, J.L.2
  • 2
    • 34648813720 scopus 로고    scopus 로고
    • ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis
    • D'Autréaux B, Toledano MB. ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis. Nat Rev Mol Cell Biol 2007;8:813-824.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 813-824
    • D'Autréaux, B.1    Toledano, M.B.2
  • 3
    • 77953012548 scopus 로고    scopus 로고
    • Stress-activated cap'n'collar transcription factors in aging and human disease
    • Sykiotis GP, Bohmann D. Stress-activated cap'n'collar transcription factors in aging and human disease. Sci Signal 2010;3:re3.
    • (2010) Sci Signal , vol.3
    • Sykiotis, G.P.1    Bohmann, D.2
  • 4
    • 14044254798 scopus 로고    scopus 로고
    • Molecular mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene regulation
    • Kobayashi M, Yamamoto M. Molecular mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene regulation. Antioxid Redox Signal 2005;7:385-394.
    • (2005) Antioxid Redox Signal , vol.7 , pp. 385-394
    • Kobayashi, M.1    Yamamoto, M.2
  • 5
    • 33847050801 scopus 로고    scopus 로고
    • Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway
    • Kensler TW, Wakabayashi N, Biswal S. Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annu Rev Pharmacol Toxicol 2007;47:89-116.
    • (2007) Annu Rev Pharmacol Toxicol , vol.47 , pp. 89-116
    • Kensler, T.W.1    Wakabayashi, N.2    Biswal, S.3
  • 6
    • 79954416526 scopus 로고    scopus 로고
    • The cytoprotective role of the Keap1-Nrf2 pathway
    • Baird L, Dinkova-Kostova AT. The cytoprotective role of the Keap1-Nrf2 pathway. Arch Toxicol 2011:85:241-272.
    • (2011) Arch Toxicol , vol.85 , pp. 241-272
    • Baird, L.1    Dinkova-Kostova, A.T.2
  • 7
    • 84864348569 scopus 로고    scopus 로고
    • Nrf2 and cancer: the good, the bad and the importance of context
    • Sporn MB, Liby KT. Nrf2 and cancer: the good, the bad and the importance of context. Nat Rev Cancer 2012;12:564-571.
    • (2012) Nat Rev Cancer , vol.12 , pp. 564-571
    • Sporn, M.B.1    Liby, K.T.2
  • 8
    • 28144445947 scopus 로고    scopus 로고
    • Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity
    • Okawa H, Motohashi H, Kobayashi A, Aburatani H, Kensler TW, Yamamoto M. Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity. Biochem Biophys Res Commun 2006;339:79-88.
    • (2006) Biochem Biophys Res Commun , vol.339 , pp. 79-88
    • Okawa, H.1    Motohashi, H.2    Kobayashi, A.3    Aburatani, H.4    Kensler, T.W.5    Yamamoto, M.6
  • 9
    • 84878704486 scopus 로고    scopus 로고
    • Nrf2 protection against liver injury produced by various hepatotoxicants
    • Liu J, Wu KC, Lu Y-F, Ekuase E, Klaassen CD. Nrf2 protection against liver injury produced by various hepatotoxicants. Oxid Med Cell Longev 2013;2013:305861.
    • (2013) Oxid Med Cell Longev , vol.2013 , pp. 305861
    • Liu, J.1    Wu, K.C.2    Lu, Y.-F.3    Ekuase, E.4    Klaassen, C.D.5
  • 10
    • 77649273272 scopus 로고    scopus 로고
    • Nrf2 the rescue: effects of the antioxidative/electrophilic response on the liver
    • Klaassen CD, Reisman SA. Nrf2 the rescue: effects of the antioxidative/electrophilic response on the liver. Toxicol Appl Pharmacol 2010;244:57-65.
    • (2010) Toxicol Appl Pharmacol , vol.244 , pp. 57-65
    • Klaassen, C.D.1    Reisman, S.A.2
  • 12
    • 38049055294 scopus 로고    scopus 로고
    • Impaired liver regeneration in Nrf2 knockout mice: role of ROS-mediated insulin/IGF-1 resistance
    • Beyer TA, Xu W, Teupser D, auf dem Keller U, Bugnon P, Hildt E, et al. Impaired liver regeneration in Nrf2 knockout mice: role of ROS-mediated insulin/IGF-1 resistance. EMBO J 2008;27:212-223.
    • (2008) EMBO J , vol.27 , pp. 212-223
    • Beyer, T.A.1    Xu, W.2    Teupser, D.3    auf dem Keller, U.4    Bugnon, P.5    Hildt, E.6
  • 13
    • 77956963188 scopus 로고    scopus 로고
    • FGF receptors 1 and 2 control chemically induced injury and compound detoxification in regenerating livers of mice
    • Böhm F, Speicher T, Hellerbrand C, Dickson C, Partanen JM, Ornitz DM, et al. FGF receptors 1 and 2 control chemically induced injury and compound detoxification in regenerating livers of mice. Gastroenterology 2010;139:1385-1396.
    • (2010) Gastroenterology , vol.139 , pp. 1385-1396
    • Böhm, F.1    Speicher, T.2    Hellerbrand, C.3    Dickson, C.4    Partanen, J.M.5    Ornitz, D.M.6
  • 15
    • 0034059141 scopus 로고    scopus 로고
    • DNA excision in liver by an albumin-Cre transgene occurs progressively with age
    • Postic C, Magnuson MA. DNA excision in liver by an albumin-Cre transgene occurs progressively with age. Genesis 2000;26:149-150.
    • (2000) Genesis , vol.26 , pp. 149-150
    • Postic, C.1    Magnuson, M.A.2
  • 16
    • 0037256608 scopus 로고    scopus 로고
    • Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model
    • Weber LWD, Boll M, Stampfl A. Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model. Crit Rev Toxicol 2003;33:105-136.
    • (2003) Crit Rev Toxicol , vol.33 , pp. 105-136
    • Weber, L.W.D.1    Boll, M.2    Stampfl, A.3
  • 17
    • 0032904641 scopus 로고    scopus 로고
    • Toxicity of hepatotoxins: new insights into mechanisms and therapy
    • Wu J, Danielsson A, Zern MA. Toxicity of hepatotoxins: new insights into mechanisms and therapy. Exp Opin Invest Drugs 1999;8:585-607.
    • (1999) Exp Opin Invest Drugs , vol.8 , pp. 585-607
    • Wu, J.1    Danielsson, A.2    Zern, M.A.3
  • 19
    • 79952300405 scopus 로고    scopus 로고
    • Activin a, p15INK4b signaling, and cell competition promote stem/progenitor cell repopulation of livers in aging rats
    • Menthena A, Koehler CI, Sandhu JS, Yovchev MI, Hurston E, Shafritz DA, et al. Activin a, p15INK4b signaling, and cell competition promote stem/progenitor cell repopulation of livers in aging rats. Gastroenterology 2011;140:1009-1020.
    • (2011) Gastroenterology , vol.140 , pp. 1009-1020
    • Menthena, A.1    Koehler, C.I.2    Sandhu, J.S.3    Yovchev, M.I.4    Hurston, E.5    Shafritz, D.A.6
  • 20
    • 77957237159 scopus 로고    scopus 로고
    • Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis
    • Malhotra D, Portales-Casamar E, Singh A, Srivastava S, Arenillas D, Happel C, et al. Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis. Nucl Acids Res 2010;38:5718-5734.
    • (2010) Nucl Acids Res , vol.38 , pp. 5718-5734
    • Malhotra, D.1    Portales-Casamar, E.2    Singh, A.3    Srivastava, S.4    Arenillas, D.5    Happel, C.6
  • 21
    • 84867317004 scopus 로고    scopus 로고
    • Identification of novel Nrf2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha
    • Chorley BN, Campbell MR, Wang X, Karaca M, Sambandan D, Bangura F, et al. Identification of novel Nrf2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha. Nucl Acids Res 2012;40:7416-7429.
    • (2012) Nucl Acids Res , vol.40 , pp. 7416-7429
    • Chorley, B.N.1    Campbell, M.R.2    Wang, X.3    Karaca, M.4    Sambandan, D.5    Bangura, F.6
  • 22
    • 52649098886 scopus 로고    scopus 로고
    • The Nrf2 transcription factor protects from toxin-induced liver injury and fibrosis
    • Xu W, Hellerbrand C, Köhler U, Bugnon P, Kan Y, Werner S, et al. The Nrf2 transcription factor protects from toxin-induced liver injury and fibrosis. Lab Invest 2008:88:1068-1078.
    • (2008) Lab Invest , vol.88 , pp. 1068-1078
    • Xu, W.1    Hellerbrand, C.2    Köhler, U.3    Bugnon, P.4    Kan, Y.5    Werner, S.6
  • 23
    • 77952374580 scopus 로고    scopus 로고
    • Nrf2 establishes a glutathione-mediated gradient of UVB cytoprotection in the epidermis
    • Schäfer M, Dütsch S, auf dem Keller U, Navid F, Schwarz A, Johnson DA, et al. Nrf2 establishes a glutathione-mediated gradient of UVB cytoprotection in the epidermis. Genes Dev 2010;24:1045-1058.
    • (2010) Genes Dev , vol.24 , pp. 1045-1058
    • Schäfer, M.1    Dütsch, S.2    auf dem Keller, U.3    Navid, F.4    Schwarz, A.5    Johnson, D.A.6
  • 24
    • 84865280525 scopus 로고    scopus 로고
    • Keap1: one stone kills three birds Nrf2, IKK and Bcl-2/Bcl-xL
    • Tian H, Zhang B, Di J, Jiang G, Chen F, Li H, et al. Keap1: one stone kills three birds Nrf2, IKK and Bcl-2/Bcl-xL. Cancer Lett 2012;325:26-34.
    • (2012) Cancer Lett , vol.325 , pp. 26-34
    • Tian, H.1    Zhang, B.2    Di, J.3    Jiang, G.4    Chen, F.5    Li, H.6
  • 25
    • 0034693101 scopus 로고    scopus 로고
    • A potential role for p15(Ink4b) and p57(Kip2) in liver development
    • Awad MM, Sanders JA, Gruppuso PA. A potential role for p15(Ink4b) and p57(Kip2) in liver development. FEBS Lett 2000;483:160-164.
    • (2000) FEBS Lett , vol.483 , pp. 160-164
    • Awad, M.M.1    Sanders, J.A.2    Gruppuso, P.A.3
  • 26
  • 27
    • 79959617179 scopus 로고    scopus 로고
    • Bim: guardian of tissue homeostasis and critical regulator of the immune system, tumorigenesis and bone biology
    • Akiyama T, Tanaka S. Bim: guardian of tissue homeostasis and critical regulator of the immune system, tumorigenesis and bone biology. Arch Immunol Ther Exp 2011;59:277-287.
    • (2011) Arch Immunol Ther Exp , vol.59 , pp. 277-287
    • Akiyama, T.1    Tanaka, S.2
  • 28
    • 84886873169 scopus 로고    scopus 로고
    • The Bcl-2 homology 3 (BH3)-only proteins Bim and Bid are functionally active and restrained by anti-apoptotic B-cell CLL/lymphoma 2 (Bcl-2) family proteins in healthy liver
    • Kodama T, Hikita H, Kawaguchi T, Saito Y, Tanaka S, Shigekawa M, et al. The Bcl-2 homology 3 (BH3)-only proteins Bim and Bid are functionally active and restrained by anti-apoptotic B-cell CLL/lymphoma 2 (Bcl-2) family proteins in healthy liver. J Biol Chem 2013;288:30009-30018.
    • (2013) J Biol Chem , vol.288 , pp. 30009-30018
    • Kodama, T.1    Hikita, H.2    Kawaguchi, T.3    Saito, Y.4    Tanaka, S.5    Shigekawa, M.6
  • 29
    • 84873732409 scopus 로고    scopus 로고
    • Nrf2-induced anti-apoptotic Bcl-xl protein enhances cell survival and drug resistance
    • Niture SK, Jaiswal AK. Nrf2-induced anti-apoptotic Bcl-xl protein enhances cell survival and drug resistance. Free Radic Biol Med 2012;57:119-131.
    • (2012) Free Radic Biol Med , vol.57 , pp. 119-131
    • Niture, S.K.1    Jaiswal, A.K.2
  • 30
    • 84858964113 scopus 로고    scopus 로고
    • Nrf2 up-regulates anti-apoptotic protein Bcl-2 and prevents cellular apoptosis
    • Niture SK, Jaiswal AK. Nrf2 up-regulates anti-apoptotic protein Bcl-2 and prevents cellular apoptosis. J Biol Chem 2012;287:9873-9878.
    • (2012) J Biol Chem , vol.287 , pp. 9873-9878
    • Niture, S.K.1    Jaiswal, A.K.2
  • 31
    • 84901392171 scopus 로고    scopus 로고
    • Regulation of the G1/S transition in hepatocytes: involvement of the cyclin-dependent kinase Cdk1 in the DNA replication
    • Corlu A, Loyer P. Regulation of the G1/S transition in hepatocytes: involvement of the cyclin-dependent kinase Cdk1 in the DNA replication. Int J Hepatol 2012;2012:689324.
    • (2012) Int J Hepatol , vol.2012 , pp. 689324
    • Corlu, A.1    Loyer, P.2
  • 32
    • 84863764614 scopus 로고    scopus 로고
    • Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming
    • Mitsuishi Y, Taguchi K, Kawatani Y, Shibata T, Nukiwa T, Aburatani H, et al. Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming. Cancer Cell 2012;22:66-79.
    • (2012) Cancer Cell , vol.22 , pp. 66-79
    • Mitsuishi, Y.1    Taguchi, K.2    Kawatani, Y.3    Shibata, T.4    Nukiwa, T.5    Aburatani, H.6
  • 33
    • 0025948113 scopus 로고
    • The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity
    • Rushmore TH, Morton MR, Pickett CB. The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity. J Biol Chem 1991;266:11632-11639.
    • (1991) J Biol Chem , vol.266 , pp. 11632-11639
    • Rushmore, T.H.1    Morton, M.R.2    Pickett, C.B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.