Doping hydroxylated cationic lipid into PEGylated cerasome boosts in vivo siRNA transfection efficacy

Bioconjugate Chemistry

Volumn 25, Issue 11, 2014, Pages 2055-2066

  Li, Yanyan ^a,b   Zheng, Shuquan ^a   Liang, Xiaolong ^a   Jin, Yushen ^a,b   Wu, Yidi ^a   Bai, Huichen ^c   Liu, Renfa ^a   Dai, Zhifei ^a   Liang, Zicai ^a   Shi, Tiejun ^b  

^a PEKING UNIVERSITY   (China)

^b HARBIN INSTITUTE OF TECHNOLOGY   (China)

^c Suzhou Ribo Life Science Co Ltd   (China)

Author keywords

[No Author keywords available]

Indexed keywords

RNA;

CATIONIC LIPIDS; CATIONICS; CERASOME; HYDROXYL GROUPS; IN-VIVO; NANOCARRIERS; NANOHYBRIDS; PEGYLATED; SMALL INTERFERING RNA; THERAPEUTIC APPLICATION;

LIPOSOMES;

HYDROXYL GROUP; LIPID; LIPOSOME; NANOCARRIER; NANOPARTICLE; PEGYLATED CATIONIC CERASOME; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; 1,2-DISTEAROYLPHOSPHATIDYLETHANOLAMINE; DRUG CARRIER; MACROGOL DERIVATIVE; PHOSPHATIDYLETHANOLAMINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CYTOPLASM; CYTOSOL; DRUG DELIVERY SYSTEM; ENDOCYTOSIS; GENE SILENCING; GENETIC TRANSFECTION; INTERNALIZATION; LIVER CELL; MACROPHAGE; MOUSE; NONHUMAN; REAL TIME POLYMERASE CHAIN REACTION; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; GENETICS; HELA CELL LINE; HEPG2 CELL LINE; HUMAN; HYDROXYLATION; LIVER; METABOLISM; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALS; BIOLOGICAL TRANSPORT; DRUG CARRIERS; GENE SILENCING; HELA CELLS; HEP G2 CELLS; HUMANS; HYDROXYLATION; LIPOSOMES; LIVER; MICE; MODELS, MOLECULAR; NANOPARTICLES; NUCLEIC ACID CONFORMATION; PHOSPHATIDYLETHANOLAMINES; POLYETHYLENE GLYCOLS; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 84913595858     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc500414e     Document Type: Article

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