Gene transfection efficacy and biocompatibility of polycation/DNA complexes coated with enzyme degradable PEGylated hyaluronic acid

Biomaterials

Volumn 34, Issue 27, 2013, Pages 6495-6503

  Zhang, Wendi ^a   Cheng, Qiang ^b   Guo, Shutao ^a   Lin, Daoshu ^a   Huang, Pingsheng ^a   Liu, Juan ^c   Wei, Tuo ^c   Deng, Liandong ^a   Liang, Zicai ^b   Liang, Xing Jie ^c   Dong, Anjie ^a  

^a TIANJIN UNIVERSITY   (China)

^b PEKING UNIVERSITY   (China)

^c NATIONAL CENTER FOR NANOSCIENCE AND TECHNOLOGY   (China)

Author keywords

Gene delivery; Hyaluronic acid; PDMAEMA; PEG dilemma; PEGylation

Indexed keywords

ENDOSOMAL ESCAPES; GENE DELIVERY; GENE TRANSFECTION; N ,N-DIMETHYLAMINOETHYL METHACRYLATE; PDMAEMA; PEGYLATION; POLYGLUTAMIC ACIDS; RECEPTOR-MEDIATED ENDOCYTOSIS;

BIOCOMPATIBILITY; DEGRADATION; EFFICIENCY; GENE EXPRESSION; GENE TRANSFER; HYALURONIC ACID; MOLECULAR BIOLOGY; ORGANIC ACIDS; POLYMERS; SYNTHESIS (CHEMICAL); ZETA POTENTIAL;

PLASTIC COATINGS;

(N,N DIMETHYLAMINOETHYL METHACRYLATE); HYALURONIC ACID; HYALURONIDASE; METHACRYLIC ACID DERIVATIVE; NANOPARTICLE; POLYCAPROLACTONE; POLYCATION; POLYGLUTAMIC ACID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOCOMPATIBILITY; CONTROLLED STUDY; CYTOTOXICITY; ENDOCYTOSIS; ENZYME DEGRADATION; GENE EXPRESSION; GENETIC TRANSFECTION; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PARTICLE SIZE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; ZETA POTENTIAL;

ANIMALS; DNA; HEP G2 CELLS; HUMANS; HYALURONIC ACID; MALE; MICE; MICE, INBRED C57BL; NANOPARTICLES; POLYAMINES; POLYESTERS; POLYETHYLENE GLYCOLS; POLYGLUTAMIC ACID; TRANSFECTION;

EID: 84879108730     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2013.04.030     Document Type: Article

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