Novel endosomolytic poly(amido amine) polymer conjugates for systemic delivery of siRNA to hepatocytes in rodents and nonhuman primates

Bioconjugate Chemistry

Volumn 25, Issue 5, 2014, Pages 896-906

  Parmar, Rubina Giare ^a   Poslusney, Micheal ^a   Busuek, Marina ^a   Williams, J Michael ^a   Garbaccio, Robert ^a   Leander, Karen ^a   Walsh, Eileen ^a   Howell, Bonnie ^a   Sepp Lorenzino, Laura ^a   Riley, Sean ^a   Patel, Mihir ^a   Kemp, Eric ^a   Latham, Andrew ^a   Leone, Anthony ^a   Soli, Eric ^b   Burke, Rob S ^a   Carr, Brian ^a   Colletti, Steven L ^a   Wang, Weimin ^a  

^a Department of Medicinal Chemistry ^*  (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOLOGY; FUNCTIONAL POLYMERS; MAMMALS; SULFUR COMPOUNDS;

AMINE POLYMERS; AMPHIPATHIC; HEPATOCYTES; NON-HUMAN PRIMATE; POLYAMIDOAMINES; POLYMER CONJUGATE; SIRNA DELIVERY; SMALL INTERFERING RNA; SYSTEMIC DELIVERIES; THERAPEUTIC AGENTS;

RNA;

ACRYLAMIDE; AMINE; MONOMER; POLYAMIDOAMINE; POLYMER; SMALL INTERFERING RNA; POLYAMINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL TYPE; CONTROLLED STUDY; DRUG CONJUGATION; DRUG UPTAKE; ENDOSOME; ERYTHROCYTE; FEMALE; GENE DELIVERY SYSTEM; HEMOLYSIS; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL; LIVER TOXICITY; NONHUMAN; PRIMATE; RAT; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; CYTOLOGY; DRUG DELIVERY SYSTEM; GENE SILENCING; HEPG2 CELL LINE; HUMAN; LIVER; METABOLISM; MOUSE; RHESUS MONKEY; SPRAGUE DAWLEY RAT; SYNTHESIS;

ANIMALS; DRUG DELIVERY SYSTEMS; ENDOSOMES; FEMALE; GENE SILENCING; HEP G2 CELLS; HEPATOCYTES; HUMANS; LIVER; MACACA MULATTA; MICE; MOLECULAR STRUCTURE; POLYAMINES; RATS; RATS, SPRAGUE-DAWLEY; RNA, SMALL INTERFERING;

EID: 84901058514     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc400527e     Document Type: Article

References (13)

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