Genetic moderation of child maltreatment effects on depression and internalizing symptoms by serotonin transporter linked polymorphic region (5-HTTLPR), brain-derived neurotrophic factor (BDNF), norepinephrine transporter (NET), and corticotropin releasing hormone receptor 1 (CRHR1) genes in African American children

Development and Psychopathology

Volumn 26, Issue , 2014, Pages 1219-1239

  Cicchetti, Dante ^a,b   Rogosch, Fred A ^b  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIVERSITY OF ROCHESTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CORTICOTROPIN RELEASING FACTOR RECEPTOR; CORTICOTROPIN RELEASING FACTOR RECEPTOR 1; NORADRENALIN TRANSPORTER; SEROTONIN TRANSPORTER; SLC6A2 PROTEIN, HUMAN; SLC6A4 PROTEIN, HUMAN;

AFRICAN AMERICAN; ANXIETY; CHILD; CHILD ABUSE; DEPRESSION; FEMALE; GENETICS; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; MALE; POVERTY; PSYCHOLOGY;

AFRICAN AMERICANS; ANXIETY; BRAIN-DERIVED NEUROTROPHIC FACTOR; CHILD; CHILD ABUSE; DEPRESSION; FEMALE; GENE-ENVIRONMENT INTERACTION; HUMANS; MALE; NOREPINEPHRINE PLASMA MEMBRANE TRANSPORT PROTEINS; POVERTY; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 84913583229     PISSN: 09545794     EISSN: 14692198     Source Type: Journal    
DOI: 10.1017/S0954579414000984     Document Type: Article

References (70)

1. Achenbach, T. M. (1991). Manual for the Teacher's Report Form and 1991 Profile.Burlington, VT: UniversityofVermont, DepartmentofPsychiatry.
2. Aguilera, M., Arias, B., Wichers, M., Barrantes-Vidal, N., Moya, J., Villa, H., et al. (2009). Early adversity and 5-HTT/BDNF genes: New evidence of gene-environment interactions on depressive symptoms in a general population. Psychological Medicine, 39, 1425-1432.
3. Banny, A., Cicchetti, D., Rogosch, F. A., Crick, N. R., & Oshri, A. (2013). Vulnerability to depression: A moderated mediation model of the roles of child maltreatment, peer victimization, and genetic variation among children from low socioeconomic status backgrounds. Development and Psy-chopathology, 25, 599-614.
4. Barnett, D., Manly, J. T., & Cicchetti, D. (1993). Defining child maltreatment: The interface between policy and research. In D. Cicchetti & S. L. Toth (Eds.), Child abuse, child development, and social policy (pp. 7-73). Norwood, NJ: Ablex.
5. Belsky, J., & Pluess, M. (2009). Beyond diathesis stress: Differential susceptibility to environmental influences. Psychological Bulletin, 135, 885-908.
6. Bolger, K. E., & Patterson, C. J. (2001). Pathways from child maltreatment to internalizing problems: Perceptions of control as mediators and moderators. Development and Psychopathology, 13, 913-940.
7. Bolger, K. E., Patterson, C. J., & Kupersmidt, J. B. (1998). Peer relationships and self-esteem among children who have been maltreated. Child Development, 69, 1171-1197.
8. Bradley, B., Westen, D., Mercer, K. B., Binder, E. B., Jovanovic, T., Crain, D., & Heim, C. (2011). Association between childhood maltreatment and adult emotional dysregulation in a low-income, urban, African American sample: Moderation by oxytocin receptor gene. Development and Psy-chopathology, 23, 439-452.
9. Bradley, R. G., Binder, E. B., Epstein, M. P., Tang, Y., Nair, H. P., Liu, W., et al. (2008). Influence of child abuse on adult depression: Moderation by the corticotrophin-releasing hormone receptor gene. Archives of General Psychiatry, 65, 190-200.
10. Brodsky, B., & Stanley, B. (2008). Adverse childhood experiences and suicidal behavior. Psychiatric Clinics of North America, 31, 223-235.
11. Brody, G. H., Yu, T., Beach, S. R. H., Windle, M., & Kogan, S. M. (2014). Harsh parenting and adolescent health: A longitudinal analysis with genetic moderation. Health Psychology, 33, 401-409.
12. Brody, G. H., Yu, T., Chen, Y., Evans, G. W., Beach, S. R. H., Windle, M., et al. (2013). Cumulative socioeconomic status risk, allostatic load, and adjustment: A prospective latent profile analysis with contextual and genetic protective factors. Developmental Psychology, 49, 913-927.
13. Byck, G. R., Bolland, J., Dick, D., Ashbeck, A. W., & Mustanski, B. S. (2013). Prevalence of mental health disorders among low-income African American adolescents. Social Psychiatry and Psychiatric Epidemiology, 48, 1555-1567.
14. Carson, N., Cook, B., & Alegria, M. (2010). Social determinants of mental health treatment among Haitian, African American, and White youth in community mental health centers. Journal of Health Care for the Poor and Underserved, 21(2 Suppl), 32-48.
15. Caspi, A., Hariri, A., Holmes, A., Uher, R., & Moffitt, T. E. (2010). Genetic sensitivity to the environment: The case of the serotonin transporter gene (5-HTT) and its implications for studying complex diseases and traits. American Journal of Psychiatry, 167, 509-527.
16. Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H. L., et al. (2003). Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene. Science, 301, 386-389.
17. Cicchetti, D. (2006). Development and psychopathology. In D. Cicchetti & D. J. Cohen (Eds.), Developmental psychopathology (Vol. 1, 2nd ed., pp. 1-23). Hoboken, NJ: Wiley.
18. Cicchetti, D., & Dawson, G. (2002). Multiple levels of analysis. Development and Psychopathology, 14, 417-420.
19. Cicchetti, D., & Lynch, M. (1995). Failures in the expectable environment and their impact on individual development: The case of child maltreatment. In D. Cicchetti & D. J. Cohen (Eds.), Developmental psychopathology: Vol. 2. Risk, disorder, and adaptation (pp. 32-71). New York: Wiley.
20. Cicchetti, D., & Manly, J. T. (1990). A personal perspective on conducting research with maltreating families: Problems and solutions. In G. Brody & I. Sigel (Eds.), Methods of family research: Families at risk (Vol. 2, pp. 87-133). Hillsdale, NJ: Erlbaum.
21. Cicchetti, D., & Rogosch, F. A. (1996). Equifinality and multifinality in developmental psychopathology. Development and Psychopathology, 8, 597-600.
22. Cicchetti, D., Rogosch, F. A., Gunnar, M. R., & Toth, S. L. (2010). The differential impacts of early abuse on internalizing problems and diurnal cortisol activity in school-aged children. Child Development, 25, 252-269.
23. Cicchetti, D., Rogosch, F. A., & Sturge-Apple, M. L. (2007). Interactions of child maltreatment and 5-HTT and monoamine oxidase A polymorphisms: Depressive symptomatology among adolescents from low-socio-economic status backgrounds. Development and Psychopathology, 19, 1161-1180.
24. Cicchetti, D., Rogosch, F. A., Sturge-Apple, M., & Toth, S. L. (2010). Interaction of child maltreatment and 5-HTT polymorphisms: Suicidal ideation among children from low SES backgrounds. Journal of Pediatric Psychology, 35, 536-546.
25. Cicchetti, D., & Toth, S. L. (1995). A developmental psychopathology perspective on child abuse and neglect. Journal of the American Academy of Child & Adolescent Psychiatry, 34, 541-565.
26. Cicchetti, D., & Toth, S. L. (2009). The past achievements and future promises of developmental psychopathology: The coming of age of a discipline. Journal of Child Psychology and Psychiatry, 50, 16-25.
27. Cicchetti, D., & Toth, S. L. (in press). A multilevel perspective on child maltreatment. In M. Lamb & C. Garcia Coll (Eds.), Handbook of child psychology and developmental science: Vol. 3. Socioemotional process (7th ed.). Hoboken, NJ: Wiley.
28. Cicchetti, D., & Tucker, D. (Eds.). (1994). Neural plasticity, sensitive periods, and psychopathology [Special Issue]. Development and Psychopa-thology, 6, 531-814.
29. Cicchetti, D., & Valentino, K. (2006). An ecological transactional perspective on child maltreatment: Failure of the average expectable environment and its influence upon child development. In D. Cicchetti & D. J. Cohen (Eds.), Developmental psychopathology (Vol. 3, 2nd ed., pp. 129-201). Hoboken, NJ: Wiley.
30. Cutuli, J. J., Raby, K. L., Cicchetti, D., Englund, M. M., & Egeland, B. (2013). Contributions of maltreatment and serotonin transporter genotype to depression in childhood, adolescence, and early adulthood. Journal of Affective Disorders, 149, 30-37.
31. DeYoung, C, Cicchetti, D., & Rogosch, F. A. (2011). Moderation of the association between childhood maltreatment and neuroticism by the corti-cotropin-releasing hormone receptor 1 gene. Journal of Child Psychology and Psychiatry, 52, 898-906.
32. Duncan, L. E., & Keller, M. C. (2011). A critical review of the first 10 years of candidate gene-by-environment interaction research in psychiatry. American Journal of Psychiatry, 168, 1041-1049.
33. Duncan, L. E., Pollastri, A. R., & Smoller, J. W. (2014). Mind the gap: Why many geneticists and psychological scientists have discrepant views about gene-environment interaction (G x E) research. American Psychologist, 69, 249.
34. Ellis, B. J., Boyce, W. T., Belsky, J., Bakermans-Kranenburg, M. J., & van IJzendoorn, M. H. (2011). Differential susceptibility to the environment: An evolutionary-neurodevelopmental theory. Development and Psycho-pathology, 23, 7-28.
35. English, D., Lambert, S. F., & Ialongo, N. (2014). Longitudinal associations between experienced racial discrimination and depressive symptoms in African American adolescents. Developmental Psychology, 50, 1190-1196.
36. English, D. J., Upadhyaya, M. P., Litrownik, A. J., Marshall, J. M., Runyan, D. K., Graham, J. C, et al. (2005). Maltreatment's wake: The relationship of maltreatment dimensions to child outcomes. Child Abuse and Neglect, 29, 594-619.
37. Escoffier, L., & Lischer, H. (2011). Arlequin version 3.5 [Computer software]. Bern, Switzerland: Swiss Institute of Bioinformatics.
38. Falush, D., Stephens, M., & Pritchard, J. K. (2003). Inference of population structure using multilocus genotype data: Linked loci and correlated allele frequencies. Genetics, 164, 1567-1587.
39. Falush, D., Stephens, M., & Pritchard, J. K. (2007). Inference of population structure using multilocus genotype data: Dominant and null alleles. Molecular Ecology Notes, 7, 574-578.
40. Gelernter, J., Kranzler, H., & Cubells, J. F. (1997). Serotonin transporter protein (SLC6A4) allele and haplotype frequencies and linkage disequilibria in African-and European-American and Japanese populations and in alcohol-dependent subjects. Human Genetics, 101, 243-246.
41. Gottesman, I. I., & Shields, J. (1972). Schizophrenia and genetics: A twin study vantage point. Oxford: Academic Press.
42. Grigorenko, E. L., & Cicchetti, D. (2012). Genomic sciences for develop-mentalists: The current state of affairs. Development and Psychopathol-ogy, 24, 1157-1164.
43. Gunnar, M. R., Wenner, J. A., Thomas, K. M., Glatt, C. E., McKenna, M. C, & Clark, A. G. (2012). The brain-derived neurotrophic factor Val66Met polymorphism moderates early deprivation effects on attention problems. Development and Psychopathology, 24, 1215-1223.
44. Heim, C, Newport, J. D., Mletzko, T, Miller, A. H., & Nemeroff, C. B. (2008). The link between childhood trauma and depression: Insights from HPA axis studies in humans. Psychoneuroendocrinology, 33, 693-710.
45. Hu, X., Oroszi, G., Chun, J., Smith, T L., Goldman, D., & Schuckit, M. A. (2005). An expanded evaluation of the relationship of four alleles to the level of response to alcohol and the alcoholism risk. Alcoholism: Clinical and Experimental Research, 29, 8-16.
46. Hubisz, M. J., Falush, D., Stephens, M., & Pritchard, J. K. (2009). Inferring weak population structure with assistance of sample group information Molecular Ecology Resources, 5, 1322-1332.
47. Kaufman, J., Yang, B., Douglas-Palumberi, H., Grasso, D., Lipschitz, D., Houshyar, S., et al. (2006). Brain-derived neurotrophic factor-5-HTTLPR gene interactions and environmental modifiers of depression in children. Biological Psychiatry, 59, 673-680.
48. Kaufman, J., Yang, B., Douglas-Palumberi, H., Houshyar, S., Lipschitz, D., & Krystal, J. (2004). Social supports and serotonin transporter gene moderate depression in maltreated children. Proceedings of the National Academy of Sciences, 101, 17316-17321.
49. Keller, M. C. (2014). Gene x Environment interaction studies have not properly controlled for potential confounders: The problem and the (simple) solution. Biological Psychiatry, 75, 18-24.
50. Kodjo, C. M., & Audinger, P. (2004). Predictors for emotionally distressed adolescents to receive mental health care. Journal of Adolescent Health, 35, 369-373.
51. Kovacs, M. (1982). The Children's Depression Inventory: A self-rated depression scale for school-aged youngsters. Unpublished manuscript, University of Pittsburgh.
52. Kovacs, M. (1992). Children's Depression Inventory manual. North Tona-wanda, NY: Multi-Health Systems.
53. Lai, C. Q., Tucker, K. L., Choudhry, S., Parnell, L. D., Mattei, J., Garcia-Bailo, B., et al. (2009). Population admixture associated with disease prevalence in the Boston Puerto Rican health study. Human Genetics, 125, 199-205.
54. Lesch, K. P., Bengel, D., Heils, A., Sabol, S. Z., Greenberg, B. D., Petri, S., et al. (1996). Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science, 274, 1527-1531.
55. Manly, J. T (2005). Advances in research definitions of child maltreatment. Child Abuse and Neglect, 29, 425-439.
56. Manly, J. T, Cicchetti, D., & Barnett, D. (1994). The impact of subtype, frequency, chronicity, and severity of child maltreatment on social competence and behavior problems. Development and Psychopathology, 6, 121-143.
57. Manly, J. T, Kim, J. E., Rogosch, F. A., & Cicchetti, D. (2001). Dimensions of child maltreatment and children's adjustment: Contributions of developmental timing and subtype. Development and Psychopathology, 13, 759-782.
58. Masten, A. S., & Cicchetti, D. (2010). Developmental cascades. Development and Psychopathology, 22, 491-495.
59. McGrath, L. M., Weill, S., Robinson, E. B., Macrae, R., & Smoller, J. W. (2012). Bringing a developmental perspective to anxiety genetics. Development and Psychopathology, 24, 1179-1193.
60. Meaney, M. J. (2010). Epigenetics and the biological definition of Gene x Environment interactions. Child Development, 81, 41-79.
61. Moffitt, T E., Caspi, A., & Rutter, M. (2005). Measured gene-environment interactions in psychopathology. Perspectives in Psychological Science, 1, 5-27.
62. Odgerel, Z., Talati, A., Hamilton, S. P., Levinson, D. F., & Weissman, M. M., (2013). Genotyping serotonin transporter polymorphisms 5-HTTLPR and rs25531 in European-and African-American subjects from the National Institute of Mental Health's Collaborative Center for Genomic Studies. Translational Psychiatry, 3(9), e307, 1-6.
63. Polanczyk, G., Caspi, A., Williams, B., Price, T S., Danese, A., Sugden, K., et al. (2009). Protective effects of CRHR1 gene variants on the development of adult depression following childhood maltreatment. Archives of General Psychiatry, 66, 978-985.
64. Ressler, K. J., Bradley, B., Mercer, K. B., Deveau, T C, Smith, A. K., Gillespie, C. F, et al. (2010). Polymorphisms in CRHR1 and the serotonin transporter loci: Gene x Gene x Environment interactions on depressive symptoms. American Journal of Medical Genetics, 153B, 812-824.
65. Sedlak, A. J., Mettenburg, J., Basena, M., Petta, I., McPherson, K., Greene, A., etal. (2010). Fourth National Incidence Study ofChild Abuse and Neglect (NIS-4): Report to Congress, Executive summary. Washington, DC: US Department of Health and Human Services, Administration for Children and Families.
66. Szyf, M., & Bick, J. (2013). DNA methylation: A mechanism for embedding early life experiences in the genome. Child Development, 84, 49-57.
67. Toth, S. L., Manly, J. T, & Cicchetti, D. (1992). Child maltreatment and vulnerability to depression. Development and Psychopathology, 4, 97-112.
68. Uher, R., Mors, O., Rietschel, M., Rajewska-Rager, A., Petrovic, A., Zobel, A., et al. (2011). Early and delayed onset of response to antidepressants in individual trajectories of change during treatment of major depression: A secondary analysis of data from the Genome-Based Therapeutic Drugs for Depression (GENDEP) study. Journal of Clinical Psychiatry, 72, 1478-1484.
69. Widom, C. S., DuMont, K., & Czaja, S. J. (2007). A prospective investigation of major depressive disorder and co-morbidity in abused and neglected grown-up children (grown up). Archives of General Psychiatry, 64, 49-56.
70. Yaeger, R., Alvial-Bront, A., Abdul, K., Nolan, P. C, Grann, V. R., Bir-chette, M. G., et al. (2008). Comparing genetic ancestry and self-described race in African Americans born in the United States and in Africa. Cancer Epidemiology, Biomarkers & Prevention, 17, 1329-1338.