The brain-derived neurotrophic factor Val66Met polymorphism moderates early deprivation effects on attention problems

Development and Psychopathology

Volumn 24, Issue 4, 2012, Pages 1215-1223

  Gunnar, Megan R ^a   Wenner, Jennifer A ^a   Thomas, Kathleen M ^a   Glatt, Charles E ^b   McKenna, Morgan C ^b   Clark, Andrew G ^b  

^a UNIVERSITY OF MINNESOTA   (United States)

^b Department of Obstetrics Gynecology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR;

ADOLESCENT; ADOPTION; AGE; ARTICLE; ATTENTION; ATTENTION DEFICIT DISORDER; CHILD; FEMALE; GENETIC PREDISPOSITION; GENETICS; HUMAN; MALE; ORPHANAGE; PSYCHOLOGICAL ASPECT; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; SOCIAL ISOLATION; STATISTICAL MODEL; TIME;

ADOLESCENT; ADOPTION; AGE FACTORS; ATTENTION; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; BRAIN-DERIVED NEUROTROPHIC FACTOR; CHILD; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LINEAR MODELS; MALE; ORPHANAGES; POLYMORPHISM, SINGLE NUCLEOTIDE; PSYCHOSOCIAL DEPRIVATION; SEX FACTORS; TIME FACTORS;

EID: 84867540902     PISSN: 09545794     EISSN: 14692198     Source Type: Journal    
DOI: 10.1017/S095457941200065X     Document Type: Article

References (53)

1. Ablow, J. C., Measelle, J. R., Kraemer, H. C., Harrington, R., Luby, J., & Smider, N. (1999). The MacArthur three-city outcome study: Evaluating multi-informant measures of young children's symptomatology. Journal of American Academy of Child & Adolescent Psychiatry, 38, 1580-1590.
2. Aguilera,M.B.,Arias,B.,Wichers,M.,Barrantes-Vidal,N.,Moya, J.,Villa,H., et al. (2009). Early adversity and 5-HTT/BDNF genes: New evidence of gene-environment interactions on depressive symptoms in a general population. Psychological Medicine, 39, 1425-1432.
3. Aiken, L. S., & West, S. G. (1991). Multiple regression: Testing and interpreting interactions Newbury Park, CA: Sage.
4. Bartkowska, K., Turlejski, K., & Djavadian, R. L. (2010). Neurotrophins and their receptors in early development of the mammalian nervous system. Acta Neurobiologiae Experimentalis (Wars), 70, 454-467.
5. Belsky, J., Bakermans-Kranenburg, M., & van IJzendoorn, M. (2007). For better and for worse: Differential susceptibility to environmental influences. Current Directions in Psychological Science, 16, 305-309.
6. Belsky, J., Jonassaint,C., Pluess,M., Stanton, M.,Brummet,B., &Williams,R. (2009). Vulnerability genes or plasticity genes? Molecular Psychiatry, 14, 746-754.
7. Belsky, J., & Pluess, M. (2009). Beyond diathesis-stress: Differential susceptibility to environmental influences. Psychological Bulletin, 135, 885-908.
8. Bock, J., Gruss, M., Becker, S., & Braun, K. (2005). Experience-induced changes of dendritic spine densities in the prefrontal and sensory cortex: Correlations with developmental time windows. Cerebral Cortex, 15, 802-808.
9. Boyle, M. H., Offord, D. R., Racine, Y., Szatmari, P., & Sanford, M. (1993). Evaluation of the revised Ontario Health Study Scales. Journal of Child Psychology and Psychiatry, 34, 189-213.
10. Branaschewski, T., Becker, K., Scherag, S., Franke, B., & Coghill, D. (2010). Molecular genetics of attention deficit/hyperactivity disorder: An overview. European Child and Adolescent Psychiatry, 19, 237-257.
11. Braun, K., Lange, E., Metzger, M., & Poegoel, G. (2000). Maternal separation followed by early social deprivation afffects the development of monoaminergic fiber systems in the medial prefrontal cortex of Octodon degus. Neuroscience, 95, 309-318.
12. Bruce, J., Tarullo, A. R., & Gunnar, M. R. (2009). Disinhibited social behavior among internationally adopted children. Development and Psychopathology, 21, 151-171.
13. Calabrese, F., Molteni, R., Racagni, G.,&Riva, M. A. (2009). Neuronal plasticity: A link between stress and mood disorders. Psychoneuoendocrinology, 341(Suppl. 1), S208-S216.
14. Carlson, M.,&Earls, F. (1997). Psychological and neuroendocrinological sequelae of early social deprivation in institutionalized children in Romania. Annals of the New York Academy of Sciences, 807, 419-428.
15. Colvert, E., Rutter, M., Beckett, C., Castle, J., Groothues, C., Hawkins, A., et al. (2008). Emotional difficulties in early adolescence following severe early deprivation: Findings from the English and Romanian Adoptees Study. Development and Psychopathology, 20, 547-567.
16. Drury, S. S., Gleason, M. M., Theall, K. P., Smyke, A. T., Nelson, C. A., Fox, N. A., et al. (2011). Genetic sensitivity to the caregiving context: The influence of 5HTTLPR and BDNF Val66Met on indiscriminate social behavior. Physiology & Behavior.
17. Egan, M. F., Kojima, M., Callicott, J. H., Goldberg, T. E., Kolachana, B. S., Bertolino, A., et al. (2003). The BDNF Val66Met polymorphism affects activity dependent secretion of BDNF and human memory and hippocampal function. Cell, 112, 257-269.
18. Essex, M. J., Boyce, T., Goldstein, L. H., Armstrong, J. M., Kraemer, H. C., & Kupfer, D. (2002). The confluence of mental, physical, social, and academic difficulties in middle childhood. II: Developing the MacArthur Health and Behavior Questionnaire. Journal of the American Academy of Child & Adolescent Psychiatry, 41, 588-603.
19. Faraone, S. V., Perlis, R. H., Doyle, A. E., Smoller, J. W., Goralnick, J. J., Holmgren, M. A., et al. (2005). Molecular genetics of attention-deficit/hyperactivity disorder. Biological Psychiatry, 57, 1313-1323.
20. Gatt, J. M., Nemeroff, C. B., Dobson-Stone, C., Paul, R. H., Bryant, R. A., Schofield, P. R., et al. (2009). Interactions between BDNF Val66Met polymorphism and early life stress predict brain and arousal pathways to syndromal depression and anxiety. Molecular Psychiatry, 14, 681-695.
21. Gunnar, M. R. (2001). Effects of early deprivation: Findings from orphanage-reared infants and children. In C. A. Nelson & M. Luciana (Eds.), Handbook of developmental cognitive neuroscience (pp. 617-629). Cambridge, MA: MIT Press.
22. Gunnar, M. R., & van Dulmen, M. (2007). Behavior problems in postinstitutionalized internationally adopted children. Development and Psychopathology, 19, 129-148.
23. Hayden, E. P., Klein, D. N., Dougherty, L. R., Olino, T. M., Dyson, M. W., Durbin, C. E., et al. (2010). The role of brain-derived neurotrophic factor genotype, parental depression, and relationship discord in predicting early-emerging negative emotionality. Psychological Science, 21, 1678-1685.
24. Hellerstedt,W. L.,Madsen, N. J., Gunnar, M. R.,Grotevant,H.D., Lee, R. M., & Johnson, D. E. (2008). The international adoption project: Populationbased surveillance ofMinnesota parents who adopted children internationally. Maternal and Child Health Journal, 12, 162-171.
25. Hildyard, K. L., &Wolfe, D. A. (2002). Child neglect: Developmental issues and outcomes. Child Abuse & Neglect, 26, 679-695.
26. Johnson, D. E. (2000). Medical and developmental sequale of early childhood institutionalization in Eastern European adoptees. Minnesota Symposium on Child Psychology, 31, 113-162.
27. Johnson, A. E., Bruce, J., Tarullo, A. R., & Gunnar, M. R. (2011). Growth delay as an index of allostatic load in young children: Predictions to disinhibited social approach and diurnal cortisol activity. Development and Psychopathology, 23, 859-871.
28. Kaufman, J., Yang, B. Z., Douglas-Palumberi, H., Grasso, D., Lipschitz, D., Houshyar, S., et al. (2006). Brain-derived neurotrophic factor-5HTTLPR gene interactions and environmental modifiers of depression in children. Biological Psychiatry, 59, 673-680.
29. Kreppner, J. A., O'Connor, T. G., & Rutter, M. (2001). Can inattention/overactivity be an institutional deprivation syndrome? Journal of Abnormal Child Psychology, 29, 513-528.
30. Kuczewski, N., Porcher, C.,& Gaiarsa, J. L. (2010). Activity-dependent dendritic secretion of brain-derived neurotrophic factor modulates synaptic plasticity. European Journal of Neuroscience, 32, 1239-1244.
31. Laucht, M., Skowronek, M. H., Becker, K., Schmidt, M. H., Esser, G., & Schulze, T. G. (2007). Interacting effects of the dopamine transporter gene and psychosocial adversity on attention-deficit/hyperactivity disorder symptoms among 15-year-olds from a high-risk community sample. Archives of General Psychiatry, 64, 585-590.
32. Lemery-Chalfant, K., Schreiber, J. E., Schmidt, N. L., Van Hulle, C. A., Essex, M. J., & Goldsmith, H. H. (2007). Assessing internalizing, externalizing, and attention problems in young children: Validation of the MacArthur HBQ. Journal American Academy of Child & Adolescent Psychiatry, 46, 1315-1323.
33. Lippmann,M., Bress, A., Nemeroff, C. B., Plotsky, P.M.,&Monteggia, L.M. (2007). Long-term behavioural and molecular alterations associated with maternal separation in rats. European Journal of Neuroscience, 25, 3091-3098.
34. Nederhof, E., Bouma, E. M., Riese, H., Laceulle, O. M., Ormel, J., & Oldehinkel, A. J. (2010). Evidence for plasticity genotypes in a gene-gene environment interaction: The TRAILS study. Genes, Brain, and Behavior, 9, 968-973.
35. Numakawa, T., Yokomaku, D., Richards, M., Hori, H., Adachi, N., & Kunugi, H. (2010). Functional interactions between steroid hormones and neurotrophin BDNF.World Journal of Biological Chemistry, 1, 133-143.
36. Oh, S., & Lewis, C. (2008). Korean preschoolers' advanced inhibitory control and its relation to other executive skills and mental state understanding. Child Development, 79, 80-99.
37. Petryshen, T. L., Sabeti, P. C., Aldinger, K. A., Fry, B., Fan, J. B., Schaffner, S. F., et al. (2010). Population genetic study of the brain-derived neurotrophic factor (BDNF) gene. Molecular Psychiatry, 15, 810-815.
38. Pluess, M., & Belsky, J. (2010). Differential susceptibility to parenting and quality child care. Developmental Psychology, 46, 379-390.
39. Poelmans, G., Pauls, D. L., Buitelaar, J. K., & Franke, B. (2011). Integrated genome-wide association study findings: Identification of a neurodevelopmental network for attention-deficit/hyperacticity disorder. American Journal of Psychiatry, 168, 365-377.
40. Polanczyk, G., de Lima, M. S., Horta, B. L., Biederman, J., & Rohde, L. A. (2007). The worldwide prevalence of ADHD: A systematic review and metaregression analysis. American Journal of Psychiatry, 164, 942-948.
41. Pollak, S. D., Nelson, C. A., Schlaak, M. F., Roeber, B. J., Wewerka, S. S., Wiik, K. L., et al. (2010). Neurodevelopmental effects of early deprivation in postinstitutionalized children. Child Development, 81, 224-236.
42. Roceri, M., Cirulli, F., Pessina, C., Peretto, P., Racagni, G., & Riva, M. A. (2004). Postnatal repeated maternal deprivation produces age-dependent changes in brain-derived neurotrophic factor expression in selected rat brain regions. Biological Psychiatry, 55, 708-714.
43. Roceri, M., Hendriks, W., Racagni, G., Ellenbroek, B. A., & Riva, M. A. (2002). Early maternal deprivation reduces the expression of BDNF and NMDA receptor subunits in rat hippocampus. Molecular Psychiatry, 7, 609-616.
44. Roth, T. L., Lubin, F. D., Funk, A. J., & Sweatt, J. D. (2009). Lasting epigenetic influence of early-life adversity on the BDNF gene. Biological Psychiatry, 65, 760-769.
45. Roth, T. L., & Sweatt, J. D. (2011). Epigenetic marking of the BDNF gene by early-life adverse experience. Hormones and Behavior, 59, 315-320.
46. Roy, P., Rutter, M., & Pickels, A. (2000). Institutional care: Risk from family background or pattern of rearing? Journal of Child Psychology and Psychiatry, 41, 139-149.
47. Rutter, M. L., Kreppner, J. M., & O'Connor, T. G. (2001). Specificity and heterogeneity in children's responses to profound institutional privation. British Journal of Psychiatry, 179, 97-103.
48. Sakata, K.,Woo,N. H.,Martinowich, K., Greene, J. S., Schloesser, R. J., Shen, L., et al. (2009). Critical role of promoter IV-driven BDNF transcription in GABAergic tranmission and synaptic platicity in the prefrontal cortex. Proceedings of the National Academy of Science, 106, 5942-5947.
49. Shirtcliff, E. A., & Essex, M. J. (2008). Concurrent and longitudinal associations of basal and diurnal cortisol with mental health symptoms in early adolescence. Developmental Psychobiology, 50, 690-703.
50. Stevens, S., Kumsta, R., Kreppner, J., Brookes, K., Rutter, M., & Sonuga-Barke, E. J. S. (2009). Dopamine transporter gene polymorphism moderates the effects of severe deprivation on ADHD symptoms: Developmental continuities in gene environment inter-play. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 150B, 753-761.
51. Stevens, S. E., Sonuga-Barke, E. J., Kreppner, J. M., Beckett, C., Castle, J., Colvert, E., et al. (2008). Inattention/overactivity following early severe institutional deprivation: Presentation and associations in early adolescence. Journal of Abnormal Child Psychology, 36, 385-398.
52. Suzuki, A., Matsumoto, Y., Shibuya, N., Sadahiro, R., Kamata, M., Goto, K., et al. (2011). The brain-derived neurotrophic factor Val66Met polymorphism modulates the effects of parental rearing on personality traits in healthy subjects. Genes, Brain, and Behavior, 10, 385-391.
53. Wermter, A. K., Laucht, M., Schimmelmann, B. G., Banaschweski, T., Sonuga-Barke, E. J., Rietschel, M., et al. (2010). From nature versus nurture, via nature and nurture, to Gene-Environment interaction in mental disorders. European Child and Adolescent Psychiatry, 19, 199-210.