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Volumn 84, Issue 1, 2013, Pages 49-57

DNA Methylation: A Mechanism for Embedding Early Life Experiences in the Genome

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTATION; ARTICLE; DNA METHYLATION; GENETIC EPIGENESIS; GENETICS; HUMAN; HUMAN GENOME; LIFE EVENT; MENTAL STRESS; PHENOTYPE; SIGNAL TRANSDUCTION;

EID: 84872933184     PISSN: 00093920     EISSN: 14678624     Source Type: Journal    
DOI: 10.1111/j.1467-8624.2012.01793.x     Document Type: Article
Times cited : (199)

References (58)
  • 1
    • 0029169506 scopus 로고
    • Eukaryotic DNA methyltransferases-Structure and function
    • Adams, R. L. (1995). Eukaryotic DNA methyltransferases-Structure and function. BioEssays, 17, 139-145.
    • (1995) BioEssays , vol.17 , pp. 139-145
    • Adams, R.L.1
  • 4
    • 0642306491 scopus 로고    scopus 로고
    • HIDden targets of microRNAs for growth control
    • Bergmann, A., & Lane, M. E. (2003). HIDden targets of microRNAs for growth control. Trends in Biochemical Sciences, 28, 461-463.
    • (2003) Trends in Biochemical Sciences , vol.28 , pp. 461-463
    • Bergmann, A.1    Lane, M.E.2
  • 5
    • 0033580326 scopus 로고    scopus 로고
    • A mammalian protein with specific demethylase activity for mCpG DNA [see comments]
    • Bhattacharya, S. K., Ramchandani, S., Cervoni, N., & Szyf, M. (1999). A mammalian protein with specific demethylase activity for mCpG DNA [see comments]. Nature, 397, 579-583.
    • (1999) Nature , vol.397 , pp. 579-583
    • Bhattacharya, S.K.1    Ramchandani, S.2    Cervoni, N.3    Szyf, M.4
  • 7
    • 34347352117 scopus 로고    scopus 로고
    • Epigenetic programming of the rRNA promoter by MBD3
    • Brown, S. E., & Szyf, M. (2007). Epigenetic programming of the rRNA promoter by MBD3. Molecular and Cellular Biology, 27, 4938-4952.
    • (2007) Molecular and Cellular Biology , vol.27 , pp. 4938-4952
    • Brown, S.E.1    Szyf, M.2
  • 8
    • 0037624040 scopus 로고    scopus 로고
    • Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene
    • Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., et al. (2003). Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene. Science, 301, 386-389.
    • (2003) Science , vol.301 , pp. 386-389
    • Caspi, A.1    Sugden, K.2    Moffitt, T.E.3    Taylor, A.4    Craig, I.W.5    Harrington, H.6
  • 9
    • 0035798693 scopus 로고    scopus 로고
    • Demethylase activity is directed by histone acetylation
    • Cervoni, N., & Szyf, M. (2001). Demethylase activity is directed by histone acetylation. Journal of Biological Chemistry, 276, 40778-40787.
    • (2001) Journal of Biological Chemistry , vol.276 , pp. 40778-40787
    • Cervoni, N.1    Szyf, M.2
  • 10
    • 0242332183 scopus 로고    scopus 로고
    • Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2
    • Chen, W. G., Chang, Q., Lin, Y., Meissner, A., West, A. E., Griffith, E. C., et al. (2003). Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2. Science, 302, 885-889.
    • (2003) Science , vol.302 , pp. 885-889
    • Chen, W.G.1    Chang, Q.2    Lin, Y.3    Meissner, A.4    West, A.E.5    Griffith, E.C.6
  • 11
    • 0025294471 scopus 로고
    • CpG methylation inhibits proenkephalin gene expression and binding of the transcription factor AP-2
    • Comb, M., & Goodman, H. M. (1990). CpG methylation inhibits proenkephalin gene expression and binding of the transcription factor AP-2. Nucleic Acids Research, 18, 3975-3982.
    • (1990) Nucleic Acids Research , vol.18 , pp. 3975-3982
    • Comb, M.1    Goodman, H.M.2
  • 12
    • 0042346416 scopus 로고    scopus 로고
    • Valproate induces replication-independent active DNA demethylation
    • Detich, N., Bovenzi, V., & Szyf, M. (2003). Valproate induces replication-independent active DNA demethylation. Journal of Biological Chemistry, 278, 27586-27592.
    • (2003) Journal of Biological Chemistry , vol.278 , pp. 27586-27592
    • Detich, N.1    Bovenzi, V.2    Szyf, M.3
  • 13
    • 0038080948 scopus 로고    scopus 로고
    • The methyl donor S adenosylmethionine inhibits active demethylation of DNA: A candidate novel mechanism for the pharmacological effects of S adenosylmethionine
    • Detich, N., Hamm, S., Just, G., Knox, J. D., & Szyf, M. (2003). The methyl donor S adenosylmethionine inhibits active demethylation of DNA: A candidate novel mechanism for the pharmacological effects of S adenosylmethionine. Journal of Biological Chemistry, 278, 20812-20820.
    • (2003) Journal of Biological Chemistry , vol.278 , pp. 20812-20820
    • Detich, N.1    Hamm, S.2    Just, G.3    Knox, J.D.4    Szyf, M.5
  • 14
    • 0037183968 scopus 로고    scopus 로고
    • Promoter-specific activation and demethylation by MBD2/demethylase
    • Detich, N., Theberge, J., & Szyf, M. (2002). Promoter-specific activation and demethylation by MBD2/demethylase. Journal of Biological Chemistry, 277, 35791-35794.
    • (2002) Journal of Biological Chemistry , vol.277 , pp. 35791-35794
    • Detich, N.1    Theberge, J.2    Szyf, M.3
  • 15
    • 84862757461 scopus 로고    scopus 로고
    • Telomere length and early severe social deprivation: Linking early adversity and cellular aging
    • Advance online publication. doi:10.1038/mp.2011.53.
    • Drury, S. S., Theall, K., Gleason, M. M., Smyke, A. T., De Vivo, I., Wong, J. Y., et al. (in press). Telomere length and early severe social deprivation: Linking early adversity and cellular aging. Molecular Psychiatry. Advance online publication. doi:10.1038/mp.2011.53.
    • Molecular Psychiatry
    • Drury, S.S.1    Theall, K.2    Gleason, M.M.3    Smyke, A.T.4    De Vivo, I.5    Wong, J.Y.6
  • 16
    • 58149523262 scopus 로고    scopus 로고
    • Alternative splicing, methylation state, and expression profile of tropomyosin-related kinase B in the frontal cortex of suicide completers
    • Ernst, C., Deleva, V., Deng, X., Sequeira, A., Pomarenski, A., Klempan, T., et al. (2009). Alternative splicing, methylation state, and expression profile of tropomyosin-related kinase B in the frontal cortex of suicide completers. Archives of General Psychiatry, 66, 22-32.
    • (2009) Archives of General Psychiatry , vol.66 , pp. 22-32
    • Ernst, C.1    Deleva, V.2    Deng, X.3    Sequeira, A.4    Pomarenski, A.5    Klempan, T.6
  • 17
    • 0033527727 scopus 로고    scopus 로고
    • Nongenomic transmission across generations of maternal behavior and stress responses in the rat
    • Francis, D., Diorio, J., Liu, D., & Meaney, M. J. (1999). Nongenomic transmission across generations of maternal behavior and stress responses in the rat. Science, 286, 1155-1158.
    • (1999) Science , vol.286 , pp. 1155-1158
    • Francis, D.1    Diorio, J.2    Liu, D.3    Meaney, M.J.4
  • 18
    • 0026198118 scopus 로고
    • CpG methylation inhibits binding of several sequence-specific DNA-binding proteins from pea, wheat, soybean and cauliflower
    • Inamdar, N. M., Ehrlich, K. C., & Ehrlich, M. (1991). CpG methylation inhibits binding of several sequence-specific DNA-binding proteins from pea, wheat, soybean and cauliflower. Plant Molecular Biology, 17, 111-123.
    • (1991) Plant Molecular Biology , vol.17 , pp. 111-123
    • Inamdar, N.M.1    Ehrlich, K.C.2    Ehrlich, M.3
  • 19
    • 0035839136 scopus 로고    scopus 로고
    • Translating the histone code
    • Jenuwein, T., & Allis, C. D. (2001). Translating the histone code. Science, 293, 1074-1080.
    • (2001) Science , vol.293 , pp. 1074-1080
    • Jenuwein, T.1    Allis, C.D.2
  • 20
    • 79960249232 scopus 로고    scopus 로고
    • Genomic mapping of 5 hydroxy-methylcytosine in the human brain
    • Jin, S. G., Wu, X., Li, A. X., & Pfeifer, G. P. (2011). Genomic mapping of 5 hydroxy-methylcytosine in the human brain. Nucleic Acids Research, 39, 5015-5024.
    • (2011) Nucleic Acids Research , vol.39 , pp. 5015-5024
    • Jin, S.G.1    Wu, X.2    Li, A.X.3    Pfeifer, G.P.4
  • 22
    • 0028968980 scopus 로고
    • Effect of bacterial endotoxin and interleukin-1 beta on hippocampal serotonergic neurotransmission, behavioral activity, and free corticosterone levels: An in vivo microdialysis study
    • Linthorst, A. C., Flachskamm, C., Muller-Preuss, P., Holsboer, F., & Reul, J. M. (1995). Effect of bacterial endotoxin and interleukin-1 beta on hippocampal serotonergic neurotransmission, behavioral activity, and free corticosterone levels: An in vivo microdialysis study. Journal of Neuroscience, 15, 2920-2934.
    • (1995) Journal of Neuroscience , vol.15 , pp. 2920-2934
    • Linthorst, A.C.1    Flachskamm, C.2    Muller-Preuss, P.3    Holsboer, F.4    Reul, J.M.5
  • 23
    • 15144344289 scopus 로고    scopus 로고
    • Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stress
    • Liu, D., Diorio, J., Tannenbaum, B., Caldji, C., Francis, D., Freedman, A., et al. (1997). Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stress. Science, 277, 1659-1662.
    • (1997) Science , vol.277 , pp. 1659-1662
    • Liu, D.1    Diorio, J.2    Tannenbaum, B.3    Caldji, C.4    Francis, D.5    Freedman, A.6
  • 26
    • 60749105468 scopus 로고    scopus 로고
    • Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse
    • McGowan, P. O., Sasaki, A., D'Alessio, A. C., Dymov, S., Labonte, B., Szyf, M., et al. (2009). Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nature Neuroscience, 12, 342-348.
    • (2009) Nature Neuroscience , vol.12 , pp. 342-348
    • McGowan, P.O.1    Sasaki, A.2    D'Alessio, A.C.3    Dymov, S.4    Labonte, B.5    Szyf, M.6
  • 27
    • 47749133462 scopus 로고    scopus 로고
    • Promoter-wide hypermethylation of the ribosomal RNA gene promoter in the suicide brain
    • e2085.
    • McGowan, P. O., Sasaki, A., Huang, T. C., Unterberger, A., Suderman, M., Ernst, C., et al. (2008). Promoter-wide hypermethylation of the ribosomal RNA gene promoter in the suicide brain. PLoS ONE, 3, e2085.
    • (2008) PLoS ONE , vol.3
    • McGowan, P.O.1    Sasaki, A.2    Huang, T.C.3    Unterberger, A.4    Suderman, M.5    Ernst, C.6
  • 29
    • 70549104872 scopus 로고    scopus 로고
    • Dynamic DNA methylation programs persistent adverse effects of early-life stress
    • Murgatroyd, C., Patchev, A. V., Wu, Y., Micale, V., Bockmuhl, Y., Fischer, D., et al. (2009). Dynamic DNA methylation programs persistent adverse effects of early-life stress. Nature Neuroscience, 12, 1559-1566.
    • (2009) Nature Neuroscience , vol.12 , pp. 1559-1566
    • Murgatroyd, C.1    Patchev, A.V.2    Wu, Y.3    Micale, V.4    Bockmuhl, Y.5    Fischer, D.6
  • 30
    • 84863057173 scopus 로고    scopus 로고
    • Differential patterns of whole-genome DNA methylation in orphans and children raised by their biological parents
    • Naumova, O., Lee, M., Koposov, R., Szyf, M., Dozier, M., & Grigorenko, E. (2012). Differential patterns of whole-genome DNA methylation in orphans and children raised by their biological parents. Development and Psychopathology, 24, 143-155.
    • (2012) Development and Psychopathology , vol.24 , pp. 143-155
    • Naumova, O.1    Lee, M.2    Koposov, R.3    Szyf, M.4    Dozier, M.5    Grigorenko, E.6
  • 31
    • 0032871399 scopus 로고    scopus 로고
    • MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex [see comments]
    • Ng, H. H., Zhang, Y., Hendrich, B., Johnson, C. A., Turner, B. M., Erdjument-Bromage, H., et al. (1999). MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex [see comments]. Nature Genetics, 23, 58-61.
    • (1999) Nature Genetics , vol.23 , pp. 58-61
    • Ng, H.H.1    Zhang, Y.2    Hendrich, B.3    Johnson, C.A.4    Turner, B.M.5    Erdjument-Bromage, H.6
  • 32
    • 47149100122 scopus 로고    scopus 로고
    • Prenatal exposure to maternal depression, neonatal methylation of human glucocorticoid receptor gene (NR3C1) and infant cortisol stress responses
    • Oberlander, T. F., Weinberg, J., Papsdorf, M., Grunau, R., Misri, S., & Devlin, A. M. (2008). Prenatal exposure to maternal depression, neonatal methylation of human glucocorticoid receptor gene (NR3C1) and infant cortisol stress responses. Epigenetics, 3, 97-106.
    • (2008) Epigenetics , vol.3 , pp. 97-106
    • Oberlander, T.F.1    Weinberg, J.2    Papsdorf, M.3    Grunau, R.4    Misri, S.5    Devlin, A.M.6
  • 33
    • 52949099506 scopus 로고    scopus 로고
    • GABAA receptor promoter hypermethylation in suicide brain: Implications for the involvement of epigenetic processes
    • Poulter, M. O., Du, L., Weaver, I. C., Palkovits, M., Faludi, G., Merali, Z., et al. (2008). GABAA receptor promoter hypermethylation in suicide brain: Implications for the involvement of epigenetic processes. Biological Psychiatry, 64, 645-652.
    • (2008) Biological Psychiatry , vol.64 , pp. 645-652
    • Poulter, M.O.1    Du, L.2    Weaver, I.C.3    Palkovits, M.4    Faludi, G.5    Merali, Z.6
  • 34
    • 30744448194 scopus 로고    scopus 로고
    • The influence of birth weight and socioeconomic position on cognitive development: Does the early home and learning environment modify their effects?
    • Power, C., Jefferis, B. J., Manor, O., & Hertzman, C. (2006). The influence of birth weight and socioeconomic position on cognitive development: Does the early home and learning environment modify their effects?Journal of Pediatrics, 148, 54-61.
    • (2006) Journal of Pediatrics , vol.148 , pp. 54-61
    • Power, C.1    Jefferis, B.J.2    Manor, O.3    Hertzman, C.4
  • 35
    • 84872941094 scopus 로고    scopus 로고
    • The signature of maternal rearing in the methylome in rhesus macaque prefrontal cortex and T cells. Unpublished manuscript.
    • Provencal, N., Suderman, M., Suomi, S., & Szyf, M. (2012). The signature of maternal rearing in the methylome in rhesus macaque prefrontal cortex and T cells. Unpublished manuscript.
    • (2012)
    • Provencal, N.1    Suderman, M.2    Suomi, S.3    Szyf, M.4
  • 37
    • 0019318994 scopus 로고
    • DNA methylation and gene function
    • Razin, A., & Riggs, A. D. (1980). DNA methylation and gene function. Science, 210, 604-610.
    • (1980) Science , vol.210 , pp. 604-610
    • Razin, A.1    Riggs, A.D.2
  • 38
    • 0021168535 scopus 로고
    • DNA methylation patterns. Formation and function
    • Razin, A., & Szyf, M. (1984). DNA methylation patterns. Formation and function. Biochimica et Biophysica Acta, 782, 331-342.
    • (1984) Biochimica et Biophysica Acta , vol.782 , pp. 331-342
    • Razin, A.1    Szyf, M.2
  • 39
    • 79952171975 scopus 로고    scopus 로고
    • Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor
    • Ressler, K. J., Mercer, K. B., Bradley, B., Jovanovic, T., Mahan, A., Kerley, K., et al. (2011). Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor. Nature, 470, 492-497.
    • (2011) Nature , vol.470 , pp. 492-497
    • Ressler, K.J.1    Mercer, K.B.2    Bradley, B.3    Jovanovic, T.4    Mahan, A.5    Kerley, K.6
  • 40
    • 67649206975 scopus 로고    scopus 로고
    • Interaction between the seratonin transporter gene (5-HTTLPR), stressful life events, and risk of depression
    • Risch, N., Herrell, R., Lehner, T., Liang, K. L., Eaves, L., Hoh, J., et al. (2009). Interaction between the seratonin transporter gene (5-HTTLPR), stressful life events, and risk of depression. Journal of American Medical Association, 23, 2462-2471.
    • (2009) Journal of American Medical Association , vol.23 , pp. 2462-2471
    • Risch, N.1    Herrell, R.2    Lehner, T.3    Liang, K.L.4    Eaves, L.5    Hoh, J.6
  • 41
    • 63449085750 scopus 로고    scopus 로고
    • Lasting epigenetic influence of early-life adversity on the BDNF gene
    • Roth, T. L., Lubin, F. D., Funk, A. J., & Sweatt, J. D. (2009). Lasting epigenetic influence of early-life adversity on the BDNF gene. Biological Psychiatry, 65, 760-769.
    • (2009) Biological Psychiatry , vol.65 , pp. 760-769
    • Roth, T.L.1    Lubin, F.D.2    Funk, A.J.3    Sweatt, J.D.4
  • 45
    • 0034610814 scopus 로고    scopus 로고
    • The language of covalent histone modifications
    • Strahl, B. D., & Allis, C. D. (2000). The language of covalent histone modifications. Nature, 403, 41-45.
    • (2000) Nature , vol.403 , pp. 41-45
    • Strahl, B.D.1    Allis, C.D.2
  • 46
    • 84872968233 scopus 로고    scopus 로고
    • Epigenetic response to childhood abuse in the human hippocampus. Unpublished manuscript.
    • Suderman, M., McGowan, P. O., Hallett, M., Meaney, M. J., & Szyf, M. (2012). Epigenetic response to childhood abuse in the human hippocampus. Unpublished manuscript.
    • (2012)
    • Suderman, M.1    McGowan, P.O.2    Hallett, M.3    Meaney, M.J.4    Szyf, M.5
  • 47
    • 84872954624 scopus 로고    scopus 로고
    • Conserved epigenetic sensitivity to early life experience in the rat and human hippocampus. Proceedings of the National Academy of Sciences of the United States of America.
    • Suderman, M., McGowan, P. O., Sasaki, A., Huang, T. C. T., Hallett, M., Meaney, M. J., et al. (in press). Conserved epigenetic sensitivity to early life experience in the rat and human hippocampus. Proceedings of the National Academy of Sciences of the United States of America.
    • Suderman, M.1    McGowan, P.O.2    Sasaki, A.3    Huang, T.C.T.4    Hallett, M.5    Meaney, M.J.6
  • 51
    • 84872934409 scopus 로고    scopus 로고
    • MBD2 mediates epigenetic programming of the glucocorticoid receptor. Unpublished manuscript.
    • Weaver, I. C., Brown, S. E., Hellstrom, I. C., Meaney, M. J., & Szyf, M. (2012). MBD2 mediates epigenetic programming of the glucocorticoid receptor. Unpublished manuscript.
    • (2012)
    • Weaver, I.C.1    Brown, S.E.2    Hellstrom, I.C.3    Meaney, M.J.4    Szyf, M.5
  • 53
    • 33847093463 scopus 로고    scopus 로고
    • The transcription factor nerve growth factor-inducible protein a mediates epigenetic programming: Altering epigenetic marks by immediate-early genes
    • Weaver, I. C., D'Alessio, A. C., Brown, S. E., Hellstrom, I. C., Dymov, S., Sharma, S., et al. (2007). The transcription factor nerve growth factor-inducible protein a mediates epigenetic programming: Altering epigenetic marks by immediate-early genes. Journal of Neuroscience, 27, 1756-1768.
    • (2007) Journal of Neuroscience , vol.27 , pp. 1756-1768
    • Weaver, I.C.1    D'Alessio, A.C.2    Brown, S.E.3    Hellstrom, I.C.4    Dymov, S.5    Sharma, S.6
  • 54
    • 0033868452 scopus 로고    scopus 로고
    • Inhibition of histone deacetylases: A new strategy to target epigenetic modifications for anticancer treatment
    • Weidle, U. H., & Grossmann, A. (2000). Inhibition of histone deacetylases: A new strategy to target epigenetic modifications for anticancer treatment. Anticancer Research, 20, 1471-1485.
    • (2000) Anticancer Research , vol.20 , pp. 1471-1485
    • Weidle, U.H.1    Grossmann, A.2
  • 57
    • 0035915422 scopus 로고    scopus 로고
    • Histone acetylation by p300 is involved in CREB-mediated transcription on chromatin
    • Yuan, L. W., & Gambee, J. E. (2001). Histone acetylation by p300 is involved in CREB-mediated transcription on chromatin. Biochimica et Biophysica Acta, 1541, 161-169.
    • (2001) Biochimica et Biophysica Acta , vol.1541 , pp. 161-169
    • Yuan, L.W.1    Gambee, J.E.2
  • 58
    • 33749590330 scopus 로고    scopus 로고
    • Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation
    • Zhou, Z., Hong, E. J., Cohen, S., Zhao, W. N., Ho, H. Y., Schmidt, L., et al. (2006). Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation. Neuron, 52, 255-269.
    • (2006) Neuron , vol.52 , pp. 255-269
    • Zhou, Z.1    Hong, E.J.2    Cohen, S.3    Zhao, W.N.4    Ho, H.Y.5    Schmidt, L.6


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