Apolipoprotein A-I increases insulin secretion and production from pancreatic β-cells via a G-protein-cAMPPKA-FoxO1-dependent mechanism

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 34, Issue 10, 2014, Pages 2261-2267

  Cochran, Blake J ^a,b   Bisoendial, Radjesh J ^a,b,d   Hou, Liming ^a,b   Glaros, Elias N ^a   Rossy, Jérémie ^c   Thomas, Shane R ^a   Barter, Philip J ^a,b,e   Rye, Kerry Anne ^a,b,e  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b HEART RESEARCH INSTITUTE   (Australia)

^c UNIVERSITY OF NEW SOUTH WALES   (Australia)

^d CENTENARY INSTITUTE   (Australia)

^e University of Sydney   (Australia)

Author keywords

Apolipoprotein A I; Diabetes mellitus, type 2

Indexed keywords

2'5' DIDEOXYADENOSINE; ABC TRANSPORTER A1; ADENYLATE CYCLASE; ADENYLATE CYCLASE INHIBITOR; AMIDE; APOLIPOPROTEIN A1; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; GUANINE NUCLEOTIDE BINDING PROTEIN; HETEROTRIMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; INSULIN; MESSENGER RNA; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PROTEIN KINASE INHIBITOR; TRANSCRIPTION FACTOR FKHR; UNCLASSIFIED DRUG; ABC TRANSPORTER; ABCG1 PROTEIN, RAT; ENZYME INHIBITOR; FORKHEAD TRANSCRIPTION FACTOR; FOXO1 PROTEIN, MOUSE; FOXO1 PROTEIN, RAT; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; NERVE PROTEIN; SCARB1 PROTEIN, RAT; SCAVENGER RECEPTOR B;

ARTICLE; CLONAL BETA CELL LINE; CLONAL CELL LINE; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; INSULIN RELEASE; INSULIN SYNTHESIS; PANCREAS ISLET BETA CELL; SIGNAL TRANSDUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; C57BL MOUSE; DRUG EFFECTS; ENZYMOLOGY; GENETICS; MALE; METABOLISM; MOUSE; RAT; SECRETION (PROCESS); TIME; TUMOR CELL LINE; UPREGULATION;

ADENYLATE CYCLASE; ANIMALS; APOLIPOPROTEIN A-I; ATP-BINDING CASSETTE TRANSPORTERS; CELL LINE, TUMOR; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENZYME INHIBITORS; FORKHEAD TRANSCRIPTION FACTORS; GTP-BINDING PROTEIN ALPHA SUBUNITS; INSULIN; INSULIN-SECRETING CELLS; MALE; MICE; MICE, INBRED C57BL; NERVE TISSUE PROTEINS; RATS; SCAVENGER RECEPTORS, CLASS B; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFECTION; UP-REGULATION;

EID: 84913537584     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.114.304131     Document Type: Article

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