Apolipoprotein A-I activates Cdc42 signaling through the ABCA1 transporter

Journal of Lipid Research

Volumn 47, Issue 4, 2006, Pages 794-803

  Nofer, Jerzy Roch ^a   Remaley, Alan T ^b   Feuerborn, Renata ^a   Wolińska, Iza ^a   Engel, Thomas ^a   Von Eckardstein, Arnold ^c   Assmann, Gerd ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

ATP binding cassette transporter A1; Cholesterol efflux; High density lipoproteins

Indexed keywords

ABC TRANSPORTER A1; ADENOSINE TRIPHOSPHATE; APOLIPOPROTEIN A1; APOLIPOPROTEIN C3; APOLIPOPROTEIN E; CYCLODEXTRIN; GLIBENCLAMIDE; GREEN FLUORESCENT PROTEIN; LIPOSOME; N (2,2,2 TRIFLUOROETHYL) N [4 [2,2,2 TRIFLUORO 1 HYDROXY 1 (TRIFLUOROMETHOXY)ETHYL]PHENYL]BENZENESULFONAMIDE; PROTEIN CDC42; PROTEIN KINASE; R 0264456; RETINOID; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ACTIN POLYMERIZATION; AGED; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG INHIBITION; FIBROBLAST; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TANGIER DISEASE;

AGED; APOLIPOPROTEIN A-I; ATP-BINDING CASSETTE TRANSPORTERS; CDC42 GTP-BINDING PROTEIN; CELLS, CULTURED; CHOLESTEROL; ENZYME ACTIVATION; FIBROBLASTS; GLYBURIDE; HUMANS; HYPOGLYCEMIC AGENTS; MALE; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; TANGIER DISEASE;

EID: 33645520691     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M500502-JLR200     Document Type: Article

References (39)

1. Hersberger, M., and A. von Eckardstein. 2003. Low high-density lipoprotein cholesterol: physiological background, clinical importance and drug treatment. Drugs. 63: 1907-1945.
2. Assmann, G., and J-R. Nofer. 2003. Atheroprotective effects of high-density lipoproteins. Annu. Rev. Med. 54: 321-341.
3. Nofer, J-R., and A. T. Remaley. 2005. Tangier disease: still more questions than answers. Cell. Mol. Life Sci. 62: 2150-2160.
4. Wang, N., D. L. Silver, P. Costet, and A. R. Tall. 2000. Specific binding of apoA-I, enhanced cholesterol efflux, and altered plasma membrane morphology in cells expressing ABC1. J. Biol. Chem. 275: 33053-33058.
5. Oram, J. F., R. M. Lawn, M. R. Garvin, and D. P. Wade. 2000. ABCA1 is the cAMP-inducible apolipoprotein receptor that mediates cholesterol secretion from macrophages. J. Biol. Chem. 275: 34508-34511.
6. Fitzgerald, M. L., A. L. Morris, J. S. Rhee, L. P. Andersson, A. J. Mendez, and M. W. Freeman. 2002. Naturally occurring mutations in the largest extracellular loops of ABCA1 can disrupt its direct interaction with apolipoprotein A-I. J. Biol. Chem. 277: 33178-33187.
7. Fitzgerald, M. L., A. L. Morris, A. Chroni, A. J. Mendez, V. I. Zannis, and M. W. Freeman. 2004. ABCA1 is the cAMP-inducible apolipoprotein receptor that mediates cholesterol secretion from macrophages. J. Lipid Res. 45: 287-294.
8. Haidar, B., M. Denis, M. Marcil, L. Krimbou, and J. Genest, Jr. 2004. Apolipoprotein A-I activates cellular cAMP signaling through the ABCA1 transporter. J. Biol. Chem. 279: 9963-9969.
9. Mendez, A. J., J. F. Oram, and E. L. Bierman. 1991. Protein kinase C as a mediator of high density lipoprotein receptor-dependent efflux of intracellular cholesterol. J. Biol. Chem. 266: 10104-10111.
10. Yamauchi, Y., M. Hayashi, S. Abe-Dohmae, and S. Yokoyama. 2003. Apolipoprotein A-I activates protein kinase C alpha signaling to phosphorylate and stabilize ATP binding cassette transporter A1 for the high density lipoprotein assembly. J. Biol. Chem. 278: 47890-47897.
11. Tang, C., A. M. Vaughan, and J. F. Oram. 2004. Janus kinase 2 modulates the apolipoprotein interactions with ABCA1 required for removing cellular cholesterol. J. Biol. Chem. 279: 7622-7628.
12. See, R. H., R. A. Caday-Malcolm, R. R. Singaraja, S. Zhou, A. Silverston, M. T. Huber, J. Moran, E. R. James, R. Janoo, J. M. Savill, et al. 2002. Protein kinase A site-specific phosphorylation regulates ATP-binding cassette A1 (ABCA1)-mediated phospholipid efflux. J. Biol. Chem. 277: 41835-41842.
13. Haidar, B., M. Denis, L. Krimbou, M. Marcil, and J. Genest, Jr. 2002. cAMP induces ABCA1 phosphorylation activity and promotes cholesterol efflux from fibroblasts. J. Lipid Res. 43: 2087-2094.
14. Martinez, L. O., B. Agerholm-Larsen, N. Wang, W. Chen, and A. R. Tall. 2003. Phosphorylation of a PEST sequence in ABCA1 promotes calpain degradation and is reversed by apoA-I. J. Biol. Chem. 278: 37368-37374.
15. Nofer, J. R., R. Feuerborn, B. Levkau, A. Sokoll, U. Seedorf, and G. Assmann. 2003. Involvement of Cdc42 signaling in apoA-I-induced cholesterol efflux. J. Biol. Chem. 278: 53055-53062.
16. Ha, K. S., and J. H. Exton. 1993. Activation of actin polymerization by phosphatidic acid derived from phosphatidylcholine in IIC9 fibroblasts. J. Cell Biol. 123: 1789-1796.
17. Nofer, J. R., B. Levkau, I. Wolinska, R. Junker, M. Fobker, A. von Eckardstein, U. Seedorf, and G. Assmann. 2001. Suppression of endothelial cell apoptosis by high density lipoproteins (HDL) and HDL-associated lysosphingolipids. J. Biol. Chem. 276: 34480-34485.
18. Remaley, A. T., J. A. Stonik, S. J. Demosky, E. B. Neufeld, A. V. Bocharov, T. G. Vishnyakova, T. L. Eggerman, A. P. Patterson, N. J. Duverger, S. Santamarina-Fojo, et al. 2001. Apolipoprotein specificity for lipid efflux by the human ABCAI transporter. Biochem. Biophys. Res. Commun. 280: 818-823.
19. Krimbou, L., M. Denis, B. Haidar, M. Carrier, M. Marcil, and J. Genest, Jr. 2004. Molecular interactions between apoE and ABCA1: impact on apoE lipidation. J. Lipid Res. 45: 839-848.
20. Remaley, A. T., F. Thomas, J. A. Stonik, S. J. Demosky, S. E. Bark, E. B. Neufeld, A. V. Bocharov, T. G. Vishnyakova, A. P. Patterson, T. L. Eggerman, et al. 2003. Synthetic amphipathic helical peptides promote lipid efflux from cells by an ABCA1-dependent and an ABCA1-independent pathway. J. Lipid Res. 44: 828-836.
21. Arakawa, R., M. Hayashi, A. T. Remaley, B. H. Brewer, Y. Yamauchi, and S. Yokoyama. 2004. Phosphorylation and stabilization of ATP binding cassette transporter A1 by synthetic amphiphilic helical peptides. J. Biol. Chem. 279: 6217-6220.
22. Yancey, P. G., A. E. Bortnick, G. Kellner-Weibel, M. de la Llera-Moya, M. C. Phillips, and G. H. Rothblat. 2003. Importance of different pathways of cellular cholesterol efflux. Arterioscler. Thromb. Vasc. Biol. 23: 712-719.
23. Nieland, T. J., A. Chroni, M. L. Fitzgerald, Z. Maliga, V. I. Zannis, T. Kirchhausen, and M. Krieger. 2004. Cross-inhibition of SR-BI- and ABCA1-mediated cholesterol transport by the small molecules BLT-4 and glyburide. J. Lipid Res. 45: 1256-1265.
24. Millatt, L. J., V. Bocher, J. C. Fruchart, and B. Staels. 2003. Liver X receptors and the control of cholesterol homeostasis: potential therapeutic targets for the treatment of atherosclerosis. Biochim. Biophys. Acta. 1631: 107-118.
25. Tang, C., A. M. Vaughan, G. M. Anantharamaiah, and J. F. Oram. 2006. Janus kinase 2 modulates the lipid-removing but not protein-stabilizing interactions of amphipathic helices with ABCA1. J. Lipid Res. 47: 107-114.
26. Vedhachalam, C., L. Liu, M. Nickel, P. Dhanasekaran, G. M. Anantharamaiah, S. Lund-Katz, G. H. Rothblat, and M. C. Phillips. 2004. Influence of apoA-I structure on the ABCA1-mediated efflux of cellular lipids. J. Biol. Chem. 279: 49931-49939.
27. Hirano, K., F. Matsuura, K. Tsukamoto, Z. Zhang, A. Matsuyama, K. Takaishi, R. Komuro, T. Suehiro, S. Yamashita, Y. Takai, et al. 2000. Decreased expression of a member of the Rho GTPase family, Cdc42Hs, in cells from Tangier disease - the small G protein may play a role in cholesterol efflux. FEBS Lett. 484: 275-279.
28. Tsukamoto, K., K. Hirano, S. Yamashita, N. Sakai, C. Ikegami, Z. Zhang, F. Matsuura, H. Hiraoka, A. Matsuyama, M. Ishigami, et al. 2002. Retarded intracellular lipid transport associated with reduced expression of Cdc42, a member of Rho-GTPases, in human aged skin fibroblasts: a possible function of Cdc42 in mediating intracellular lipid transport. Arterioscler. Thromb. Vasc. Biol. 22: 1899-1904.
29. Zhang, Z., K. Hirano, K. Tsukamoto, C. Ikegami, M. Koseki, K. Saijo, T. Ohno, N. Sakai, H. Hiraoka, I. Shimomura, et al. 2005. Defective cholesterol efflux in Werner syndrome fibroblasts and its phenotypic correction by Cdc42, a RhoGTPase. Exp. Gerontol. 40: 286-294.
30. Nofer, J-R., M. Walter, and G. Assmann. 2005. Current understanding of the role of high density lipoproteins (HDL) in atherosclerosis and senescence. Expert Rev. Cardiovasc. Ther. 3: 1071-1086.
31. Tsukamoto, K., K. Hirano, K. Tsujii, C. Ikegami, Z. Zhongyan, Y. Nishida, T. Ohama, F. Matsuura, S. Yamashita, and Y. Matsuzawa. 2001. ATP-binding cassette transporter-1 induces rearrangement of actin cytoskeletons possibly through Cdc42/N-WASP. Biochem. Biophys. Res. Commun. 287: 757-765.
32. Buechler, C., S. M. Bared, C. Aslanidis, M. Ritter, W. Drobnik, and G. Schmitz. 2002. Molecular and functional interaction of the ATP-binding cassette transporter A1 with Fas-associated death domain protein. J. Biol. Chem. 277: 41307-41310.
33. Fitzgerald, M. L., K. Okuhira, G. F. Short 3rd, J. J. Manning, S. A. Bell, and M. W. Freeman. 2004. ATP-binding cassette transporter A1 contains a novel C-terminal VFVNFA motif that is required for its cholesterol efflux and apoA-I binding activities. J. Biol. Chem. 279: 48477-48485.
34. Okuhira, K., M. L. Fitzgerald, D. A. Sarracino, J. J. Manning, S. A. Bell, J. L. Goss, and M. W. Freeman. 2005. Purification of ATP-binding cassette transporter A1 and associated binding proteins reveals the importance of beta1-syntrophin in cholesterol efflux. J. Biol. Chem. 280: 39653-39664.
35. Buechler, C., A. Boettcher, S. M. Bared, M. C. Probst, and G. Schmitz. 2002. The carboxyterminus of the ATP-binding cassette transporter A1 interacts with a beta2-syntrophin/utrophin complex. Biochem. Biophys. Res. Commun. 293: 759-765.
36. Munehira, Y., T. Ohnishi, S. Kawamoto, A. Furuya, K. Shitara, M. Imamura, T. Yokota, S. Takeda, T. Amachi, M. Matsuo, et al. 2004. Alpha1-syntrophin modulates turnover of ABCA1. J. Biol. Chem. 279: 15091-15095.
37. Oak, S. A., Y. W. Zhou, and H. W. Jarrett. 2003. Skeletal muscle signaling pathway through the dystrophin glycoprotein complex and Rac1. J. Biol. Chem. 278: 39287-39295.
38. Drobnik, W., H. Borsukova, A. Bottcher, A. Pfeiffer, G. Liebisch, G. J. Schutz, H. Schindler, and G. Schmitz. 2002. Apo AI/ABCA1-dependent and HDL3-mediated lipid efflux from compositionally distinct cholesterol-based microdomains. Traffic. 3: 268-278.
39. van Eck, M., I. S. Bot, W. E. Kaminski, E. Orso, G. Rothe, J. Twisk, A. Bottcher, E. S. van Amersfoort, T. A. Christiansen-Weber, W. P. Fung-Leung, et al. 2002. Leukocyte ABCA1 controls susceptibility to atherosclerosis and macrophage recruitment into tissues. Proc. Natl. Acad. Sci. USA. 99: 6298-6303.