Changing folding and binding stability in a viral coat protein: A comparison between substitutions accessible through mutation and those fixed by natural selection

PLoS ONE

Volumn 9, Issue 11, 2014, Pages

  Miller, Craig R ^a   Lee, Kuo Hao ^a,b   Wichman, Holly A ^a   Ytreberg, F Marty ^a  

^a UNIVERSITY OF IDAHO   (United States)

^b KANSAS STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COAT PROTEIN; COAT PROTEIN F; UNCLASSIFIED DRUG; CAPSID PROTEIN; PROTEIN BINDING;

ADAPTATION; AMINO ACID SUBSTITUTION; ARTICLE; BACTERIOPHAGE PHI X 174; CONTROLLED STUDY; EFFECT SIZE; ENZYME ACTIVE SITE; MOLECULAR DYNAMICS; MOLECULAR EVOLUTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PHYSICAL CHEMISTRY; PROTEIN FOLDING; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE; THERMODYNAMICS; VIRUS CAPSID; CHEMICAL STRUCTURE; GENETIC SELECTION; GENETICS; METABOLISM; MUTATION; PROTEIN CONFORMATION; TEMPERATURE;

BACTERIOPHAGE PHI X 174; CAPSID PROTEINS; MODELS, MOLECULAR; MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STABILITY; SELECTION, GENETIC; TEMPERATURE;

EID: 84913534565     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0112988     Document Type: Article

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