Graphene quantum dots induce apoptosis, autophagy, and inflammatory response via p38 mitogen-activated protein kinase and nuclear factor-κB mediated signaling pathways in activated THP-1 macrophages

Toxicology

Volumn 327, Issue , 2015, Pages 62-76

  Qin, Yiru ^a,b   Zhou, Zhi Wei ^a   Pan, Shu Ting ^a,c   He, Zhi Xu ^d   Zhang, Xueji ^e   Qiu, Jia Xuan ^c   Duan, Wei ^f   Yang, Tianxin ^g   Zhou, Shu Feng ^a,b  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

^c NANCHANG UNIVERSITY   (China)

^d GUIZHOU MEDICAL UNIVERSITY   (China)

^e UNIVERSITY OF SCIENCE AND TECHNOLOGY BEIJING   (China)

^f DEAKIN UNIVERSITY   (Australia)

^g UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

Autophagy; Graphene quantum dot; Inflammation; Nanotoxicity; Programmed cell death

Indexed keywords

BECLIN 1; CASPASE 3; CASPASE 9; GRAPHENE; GRAPHENE QUANTUM DOT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 8; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN BAD; PROTEIN BAX; PROTEIN BCL 2; QUANTUM DOT; REACTIVE OXYGEN METABOLITE; SYNAPTOTAGMIN I; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; GRAPHITE;

APOPTOSIS; ARTICLE; AUTOPHAGY; CELL INTERACTION; CELL MEMBRANE; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOKINE PRODUCTION; EPITHELIAL MESENCHYMAL TRANSITION; HUMAN; HUMAN CELL; IMMUNOTOXICITY; INFLAMMATION; MACROPHAGE ACTIVATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; CELL LINE; CHEMICALLY INDUCED; DRUG EFFECTS; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYMOLOGY; MACROPHAGE; METABOLISM; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

APOPTOSIS; AUTOPHAGY; BLOTTING, WESTERN; CELL LINE; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITHELIAL-MESENCHYMAL TRANSITION; GRAPHITE; HUMANS; INFLAMMATION; MACROPHAGE ACTIVATION; MACROPHAGES; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; QUANTUM DOTS; REACTIVE OXYGEN SPECIES; REAL-TIME POLYMERASE CHAIN REACTION;

EID: 84913529833     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2014.10.011     Document Type: Article

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