Gold nanoparticle-based gene delivery: Promises and challenges

Nanotechnology Reviews

Volumn 3, Issue 3, 2014, Pages 269-280

  Remant Bahadur, K C ^b   Thapa, Bindu ^b   Bhattarai, Narayan ^a  

^a North Carolina Agricultural and Technical State University   (United States)

^b UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Bioconjugation; Functionalization; Gene delivery; Gold nanoparticles

Indexed keywords

BIOCOMPATIBILITY; FIBER OPTIC SENSORS; GENE THERAPY; GENE TRANSFER; METAL NANOPARTICLES; NATURAL POLYMERS; OPTICAL PROPERTIES; SYNTHESIS (CHEMICAL);

BIO-CONJUGATION; BIOCOMPATIBLE POLYMER; BIOMEDICAL RESEARCH; CANCER GENE THERAPY; FUNCTIONALIZATIONS; FUNCTIONALIZED GOLD NANOPARTICLES; GENE DELIVERY; STATE OF THE ART;

GOLD NANOPARTICLES;

EID: 84912573397     PISSN: 21919089     EISSN: 21919097     Source Type: Journal    
DOI: 10.1515/ntrev-2013-0026     Document Type: Review

References (78)

1. Putnam D. Polymers for gene delivery across length scales. Nat. Mater. 2006, 5, 439-451.
2. Pack DW, Hoffman AS, Pun S, Stayton PS. Design and development of polymers for gene delivery. Nat. Rev. Drug Discov. 2005, 4, 581-593.
3. Morille M, Passirani C, Vonarbourg A, Clavreul A, Benoit JP. Progress in developing cationic vectors for non-viral systemic gene therapy against cancer. Biomaterials 2008, 29, 3477-3496.
4. Feldheim DL. Colby AF Jr., Eds., Metal Nanoparticles Synthesis, Characterization and Applications, Marcel Dekker: New York, 2002.
5. Saha K, Agasti SS, Kim C, Li X, Rotello VM. Gold nanoparticles in chemical and biological sensing. Chem. Rev. 2012, 112, 2739-2779.
6. Jain PK, Lee KS, El-Sayed IH, El-Sayed MA. Calculated absorption and scattering properties of gold nanoparticles of different size, shape, and composition: applications in biological imaging and biomedicine. J. Phys. Chem. B 2006, 110, 7238-7248.
7. Daniel MC, Astruc D. Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology. Chem. Rev. 2004, 104, 293-346.
8. Hostetler NJ, Wingate JE, Zhong CJ, Harris JE, Vachet RW, Clark MR, Londono JD, Green SJ, Stokes JJ, Wignall GD, Glish GL, Porter MD, Evans ND, Murray RW. Alkanethiolate gold cluster molecules with core diameters from 1.5 to 5.2 nm: core and monolayer properties as a function of core size. Langmuir 1998, 14, 17-30.
9. Rosi NL, Giljohann DA, Thaxton CS, Lytton-Jean AK, Han MS, Mirkin CA. Oligonucleotide-modified gold nanoparticles for intracellular gene regulation. Science 2006, 312, 1027-1030.
10. Kong WH, Bae KH, Jo SD, Kim JS, Park TG. Cationic lipid-coated gold nanoparticles as efficient and noncytotoxic intracellular siRNA delivery vehicles, Pharm. Res. 2012, 29, 362-374.
11. Ghosh P, Han G, De M, Kim CK, Rotello VM. Gold nanoparticles in delivery applications, Adv. Drug Deliv. Rev. 2008, 60, 1307-1315.
12. Alexis F, Pridgen E, Molnar LK, Farokhzad OC. Factors affecting the clearance and biodistribution of polymeric nanoparticles. Mol. Pharmaceut. 2008, 5, 505-515.
13. Dykxhoorn DM, Palliser D, Lieberman J. The silent treatment: siRNAs as small molecule drugs. Gene Ther. 2006, 13, 541-552.
14. Bonoiu AC, Mahajan SD, Ding H, Roy I, Yong KY, Kumar R, Hu R, Bergey EJ, Schwartz SA, Prasad PN. Nanotechnology approach for drug addiction therapy: gene silencing using delivery of gold nanorod-siRNA nanoplex in dopaminergic neurons. Proc. Natl. Acad. Sci. USA 2009, 106, 5546-5550.
15. Tang Z, Wang Y, Podsiadlo P, Kotov NA. Biomedical applications of layer-by-layer assembly: from biomimetics to tissue engineering. Adv. Mater. 2006, 18, 3203-3224.
16. Lee SK, Han MS, Asokan S, Tung CH. Effective gene silencing by multilayered siRNA coated gold nanoparticles. Small 2011, 7, 364-370.
17. Tao AR, Habas S, Yong P. Shape control of colloidal metal nanocrystals. Small 2008, 4, 310-325.
18. Radwan SH, Azzazy HME. Gold nanoparticles for molecular diagnostics. Expert Rev. Mol. Diagn. 2009, 9, 511-524.
19. Zayats M, Baron R, Popov I, Willner I. Biocatalytic growth of Au nanoparticles: from mechanistic aspects to biosensor design. Nano Lett. 2005, 5, 21-25.
20. Algar WR, Prasuhn DE, Stewart MH, Jennings TL, Blanco- Canosa JB, Dawson PE, Medintz IL. The controlled display of biomolecules on nanoparticles: a challenge suited to bioorthogonal chemistry. Bioconjugate Chem. 2011, 22, 825-858.
21. Bhattacharya R, Mukherjee P. Biological properties of "naked" metal nanoparticles. Adv. Drug Deliv. Rev. 2008, 60, 1289-1306.
22. Nel AE, Madler L, Velegol D, Xia T, Hoek EMV, Somasundaran P, Klaessig F, Castranova V, Thompson M. Understanding biophysicochemical interactions at the nano-bio interface. Nat. Mater. 2009, 8, 543-557.
23. Khalil IA, Kogure K, Akita H, Harashima H. Uptake pathways and subsequent intracellular trafficking in nonviral gene delivery. Pharmacol Rev 2006, 58, 32-45.
24. Yang NS, Burkholder J, Roberts B, Martinell B, McCabe D. In vivo and in vitro gene transfer to mammalian somatic cells by particle bombardment. Proc. Natl. Acad. Sci. USA 1990, 87, 9568-9572.
25. Larregina AT, Watkins SC, Erdos G, Spencer LA, Storkus WJ, Beer Stolz D, Falo LD Jr. Direct transfection and activation of human cutaneous dendritic cells. Gene Ther. 2001, 8, 608-617.
26. Dixit V, Van den Bossche J, Shreman DM, Thompson DH, Andres RP. Synthesis and grafting of thioctic acid-PEG-folate conjugates onto Au nanoparticles for selective targeting of folate receptor-positive tumor cells. Bioconjug. Chem. 2006, 17, 603-609.
27. Conde J, Ambrosone A, Sanz V, Hernandez Y, Marchesano V, Tian F, Child H, Berry CC, Ibarra MR Baptista PV, Tortiglione C, de la Fuente JM. Design of multifunctional gold nanoparticles for in vitro and in vivo gene silencing. ACS Nano 2012, 6, 8316-8324.
28. Elbakry A, Zaky A, Liebl R, Rachel R, Goepferich A, Breunig M. Layer-by-layer assembled gold nanoparticles for siRNA delivery. Nano Lett. 2009, 9, 2059-2064.
29. Mintzer MA, Simanek EE. Nonviral vectors for gene delivery. Chem. Rev. 2009, 109, 259-302.
30. Turkevitch J, Stevenson PC, Nucleation HJ. Growth process in the synthesis of colloidal gold. Discuss. Faraday Soc. 1951, 11, 55-75.
31. Yonezawa T, Kunitake T. Practical preparation of anionic mercapto ligand-stabilized gold nanoparticles and their immobilization. Colloids Surf. A: Physicochem. Eng. Asp. 1999, 149, 193-199.
32. Faraday M. Experimental relations of gold (and other metals) to light. Philos. Trans. 1857, 147, 145-181.
33. Brust M, Walker M, Bethell D, Schiffrin DJ, Whyman RJ. Synthesis of thiol-derivatized gold nanoparticles in a two phase liquid-liquid system. J. Chem. Soc. Chem. Commun. 1994, 801-802. DOI: 10.1039/C39940000801.
34. Prasad RLV, Stoeva SI, Sorensen CM, Klabunde KJ. Digestiveripening agents for gold nanoparticles: alternatives to thiols. Chem. Mater. 2003, 15, 935-942.
35. Sobhan MA, Withford MJ, Goldys EM. Enhanced stability of gold colloids produced by femtosecond laser synthesis in aqueous solution of CTAB. Langmuir 2010, 26, 3156-3159.
36. Maye MM, Zheng WX, Leibowitz FL, Ly NK, Zhong CJ. Heatinginduced evolution of thiolate-encapsulated gold nanoparticles: a strategy for size and shape manipulations. Langmuir 2000, 16, 490-497.
37. Aryal S, Dharmaraj N, Bhattarai SR, Khil MS, Kim HY. Deposition of gold nanoparticles on electrospun MgTiO3 ceramic nanofibers. J. Nanosci. Nanotech. 2006, 6, 510-513.
38. Andrews PR, Craik DJ, Martin JL. Functional group contributions to drug-receptor interactions. J. Med. Chem. 1984, 27, 1648-1657.
39. Han G, Chari NS, Verma A, Hong R, Martin CT, Rotello VM. Controlled recovery of the transcription of nanoparticlebound DNA by intracellular concentrations of glutathione. Bioconjugate Chem. 2005, 16, 1356-1359.
40. Oishil M, Nakaogami J, Ishii T, Nagasaki Y. Smart PEGylated gold nanoparticles for the cytoplasmic delivery of siRNA to induce enhanced gene silencing. Chem. Lett. 2006, 35, 1046-1047.
41. Wang Z, Kanaras AG, Bates AD, Cosstick R, Brust M. Enzymatic DNA processing on gold nanoparticles. J. Mater. Chem. 2004, 14, 578-580.
42. Giljohann DA, Seferos DS, Prigodich AE, Patel PC, Mirkin CA. Gene regulation with polyvalent siRNA-nanoparticle conjugates. J. Am. Chem. Soc. 2009, 131, 2072-2073.
43. Giljohann DA, Seferos DS, Patel PC, Millstone JE, Rosi NL, Mirkin CA. Oligonucleotide loading determines cellular uptake of DNA-modified gold nanoparticles. Nano Lett. 2007, 7, 3818-3821.
44. Mirkin CA, Letsinger RL, Mucic RC, Storhoff JJ. A DNA-based method for rationally assembling nanoparticles into macroscopic materials. Nature 1996, 382, 607-609.
45. Jin R, Wu G, Li Z, Mirkin CA, Schatz GC. What controls the melting properties of DNA-linked gold nanoparticle assemblies? J. Am. Chem. Soc. 2003, 125, 1643-1654.
46. Lee SH, Bae KH, Kim SH, Lee KR, Park TG. Amine-functionalized gold nanoparticles as non-cytotoxic and efficient intracellular siRNA delivery carriers. Int. J. Pharm. 2008, 364, 94-101.
47. Hurst SJ, Lytton-Jean AK, Mirkin CA. Maximizing DNA loading on a range of gold nanoparticle sizes. Anal. Chem. 2006, 78, 8313-8318.
48. Han G, Martin CT, Rotello VM. Stability of gold nanoparticlebound DNA toward biological, physical, and chemical agents. Chem. Biol. Drug Des. 2006, 67, 78-82.
49. McIntosh CM, Esposito EA, Boal AK, Simard JM, Martin CT, Totello VM. Inhibition of DNA transcription using cationic mixed monolayer protected gold clusters. J. Am. Chem. Soc. 2001, 123, 7626-7629.
50. Sandhu KK, McIntosh CM, Simard JM, Smith SW, Rotello VM. Gold nanoparticle-mediated transfection of mammalian cells. Bioconjug. Chem. 2002, 13, 3-6.
51. Thomas M, Klibanov AM. Conjugation to gold nanoparticles enhances polyethylenimine's transfer of plasmid DNA into mammalian cells. Proc. Natl. Acad. Sci. USA 2003, 100, 9138-9143.
52. Niidome T, Nakashima K, Takahashi H, Niddome Y. Preparation of primary amine-modified gold nanoparticles and their transfection ability into cultivated cells. Chem. Commun. 2004, 1978-1979. DOI: 10.1039/B406189F.
53. Li P, Li D, Zhang L, Li G, Wang E. Cationic lipid bilayer coated gold nanoparticles-mediated transfection of mammalian cells. Biomaterials 2008, 29, 3617-3624.
54. Ghosh PS, Kim CK, Han G, Forbes NS, Rotello VM. Efficient gene delivery vectors by tuning the surface charge density of amino acid-functionalized gold nanoparticles. ACS Nano. 2008, 11, 2213-2218.
55. Cebrián V, Martín-Saavedra F, Yagüe C, Arruebo M, Santamaría J, Vilaboa N. Size-dependent transfection efficiency of PEI-coated gold nanoparticles. Acta Biomaterialia 2011, 7, 3645-3655.
56. Moghimi SH, Symonds P, Murray JC, Hunter AC, Debska G, Szewczyk A. A two-stage poly(ethylenimine)-mediated cytotoxicity: implications for gene transfer/therapy. Mol. Ther. 2005, 11, 990-995.
57. Zintchenko A, Philipp A, Dehshahri A, Wagner E. Simple modifications of branched PEI lead to highly efficient siRNA carriers with low toxicity. Bioconjug. Chem. 2008, 19, 1448-1455.
58. Song WJ, Du JZ, Sun TM, Zhang PZ, Wang J. Gold nanoparticles capped with polyethyleneimine for enhanced siRNA delivery. Small 2010, 6, 239-246.
59. Grabar KC, Allison KJ, Baker BE, Bright RM, Brown KR, Freeman RG, Fox AP, Keating CD, Musick MD, Natan MJ. Two-dimensional arrays of colloidal gold particles: a flexible approach to macroscopic metal surfaces. Langmuir 1996, 12, 2353-2361.
60. Nandanan E, Jana NR, Ying JY. Functionalization of gold nanospheres and nanorods by chitosan oligosaccharide derivatives. Adv. Mater. 2008, 20, 2068-2073.
61. Zhou X, Zhang X, Yu X, Zha X, Fu Q, Liu B, Wang X, Chen Y, Shan Y, Jin Y, Wu Y, Liu J, Kong W, Shen J. The effect of conjugation to gold nanoparticles on the ability of low molecular weight chitosan to transfer DNA vaccine. Biomaterials 2008, 29, 111-117.
62. Bhattarai SR, Remant Bahadur KC, Aryal S, Bhattarai N, Kim SY, Keun H, Hwang PH, Kim HY. Hydrophobically modified chitosan/gold nanoparticles for DNA delivery. Nanopart. Res. 2008, 10, 151-162.
63. Hu C, Peng Q, Chen F, Zhong Z, Zhuo R. Low molecular weight polyethylenimine conjugated gold nanoparticles as efficient gene vectors. Bioconjug. Chem. 2010, 21, 836-843.
64. Sun X, Dong S, Wang E. One-step preparation of highly concentrated well-stable gold colloids by direct mix of polyelectrolyte and HAuCl4 aqueous solutions at room temperature. J. Colloid Interface Sci. 2005, 288, 301-303.
65. Kim K, Lee HB, Lee JW, Park HK, Shin KS. Self-assembly of poly(ethylenimine)-capped Au nanoparticles at a toluene-water interface for efficient surface-enhanced Raman scattering. Langmuir 2008, 24, 7178-7183.
66. Lee H, Dellatore SM, Miller WM, Messersmith PB. Musselinspired surface chemistry for multifunctional coatings. Science 2007, 318, 426-430.
67. Lee H, Scherer NF, Messersmith PB. Single-molecule mechanics of mussel adhesion. Proc. Natl. Acad. Sci. USA 2006, 103, 12999-13003.
68. Lee Y, Lee SH, Kim JS, Maruyama A, Chen X, Park TG. Controlled synthesis of PEI-coated gold nanoparticles using reductive catechol chemistry for siRNA delivery. J. Control. Release 2011, 155, 3-10.
69. Shan Y, Luo T, Peng C, Sheng R, Cao A, Cao X, Shen M, Guo R, Tomás H, Shi X. Gene delivery using dendrimer-entrapped gold nanoparticles as nonviral vectors. Biomaterials 2012, 33, 3025-3035.
70. Yan X, Blacklock J, Li J, Mohwald H. One-pot synthesis of polypeptide-gold nanoconjugates for in vitro gene transfection. ACS Nano 2012, 6, 111-117.
71. Malhotra M, Tomaro-Duchesneau C, Prakash S. Synthesis of TAT peptide-tagged PEGylated chitosan nanoparticles for siRNA delivery targeting neurodegenerative diseases. Biomaterials 2013, 34, 1270-1280.
72. Wang H, Chen Y, Li XY, Liu Y. Synthesis of oligo(ethylenediamino)- beta-cyclodextrin modified gold nanoparticle as a DNA concentrator. Mol. Pharm. 2007, 4, 189-198.
73. Kawano T, Yamagata M, Takahashi H, Niidome Y, Yamada S, Katayama Y, Niidome T. Stabilizing of plasmid DNA in vivo by PEG-modified cationic gold nanoparticles and the gene expression assisted with electrical pulses. J. Control. Release 2006, 111, 382-389.
74. Lee JS, Green JJ, Love KT, Sunshine J, Langer R, Anderson DG. Gold, poly(β-amino ester) nanoparticles for small interfering RNA delivery. Nano Lett. 2009, 9, 2402-2406.
75. Li PC, Li D, Zhang LX, Li GP, Wang EK. Cationic lipid bilayer coated gold nanoparticles-mediated transfection of mammalian cells. Biomaterials 2008, 29, 3617-3624.
76. Rhim WK, Kim JS, Nam JM. Lipid-gold-nanoparticle hybrid-based gene delivery. Small 2008, 4, 1651-1655.
77. KC RB, Thapa B, XU P. Design of serum compatible tetrary complexes for gene delivery, Macromol. Biosci. 2012, 12, 569-716.
78. Lee MY, Park SJ Park K, Kim KS, Lee H, Hahn SK. Target-specific gene silencing of layer-by-layer assembled gold-cysteamine/ siRNA/PEI/HA nanocomplex. ACS Nano 2011, 5, 6138-6147.