메뉴 건너뛰기




Volumn 33, Issue 10, 2012, Pages 3025-3035

Gene delivery using dendrimer-entrapped gold nanoparticles as nonviral vectors

Author keywords

Gene delivery; Gold nanoparticles; PAMAM dendrimers; Transfection efficiency

Indexed keywords

3-DIMENSIONAL; ATOMIC FORCE; BIOMEDICAL APPLICATIONS; CELL LINES; EFFICIENT INTERACTION; ENHANCED GREEN FLUORESCENT PROTEIN; GEL-RETARDATION ASSAY; GENE DELIVERY; GENE DELIVERY VECTORS; GENE TRANSFECTION; GOLD NANOPARTICLES; MICROSCOPIC IMAGING; MOLAR RATIO; NON-VIRAL GENE DELIVERY; NONVIRAL VECTORS; PAMAM DENDRIMER; POLYAMIDOAMINE DENDRIMERS; POLYPLEXES; SPHERICAL MORPHOLOGIES; TRANSFECTION EFFICIENCY; ZETA POTENTIAL MEASUREMENTS;

EID: 84856275170     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2011.12.045     Document Type: Article
Times cited : (229)

References (59)
  • 1
    • 79952486101 scopus 로고    scopus 로고
    • Transfection of shRNA-encoding minivector DNA of a few hundred base pairs to regulate gene expression in lymphoma cells
    • Zhao N., Fogg J.M., Zechiedrich L., Zu Y. Transfection of shRNA-encoding minivector DNA of a few hundred base pairs to regulate gene expression in lymphoma cells. Gene Ther 2011, 18:220-224.
    • (2011) Gene Ther , vol.18 , pp. 220-224
    • Zhao, N.1    Fogg, J.M.2    Zechiedrich, L.3    Zu, Y.4
  • 2
    • 37349011012 scopus 로고    scopus 로고
    • Modulation of metabolic brain networks after subthalamic gene therapy for parkinson's disease
    • Feigin A., Kaplitt M.G., Tang C., Lin T., Mattis P., Dhawan V., et al. Modulation of metabolic brain networks after subthalamic gene therapy for parkinson's disease. Proc Natl Acad Sci U S A 2007, 104:19559-19564.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 19559-19564
    • Feigin, A.1    Kaplitt, M.G.2    Tang, C.3    Lin, T.4    Mattis, P.5    Dhawan, V.6
  • 3
    • 75149135184 scopus 로고    scopus 로고
    • Parkinson disease: another player in gene therapy for parkinson disease
    • Kaplitt M.G. Parkinson disease: another player in gene therapy for parkinson disease. Nat Rev Neurol 2010, 6:7-8.
    • (2010) Nat Rev Neurol , vol.6 , pp. 7-8
    • Kaplitt, M.G.1
  • 4
    • 77953138185 scopus 로고    scopus 로고
    • Toward gene therapy for cystic fibrosis using a lentivirus pseudotyped with sendai virus envelopes
    • Mitomo K., Griesenbach U., Inoue M., Somerton L., Meng C., Akiba E., et al. Toward gene therapy for cystic fibrosis using a lentivirus pseudotyped with sendai virus envelopes. Mol Ther 2010, 18:1173-1182.
    • (2010) Mol Ther , vol.18 , pp. 1173-1182
    • Mitomo, K.1    Griesenbach, U.2    Inoue, M.3    Somerton, L.4    Meng, C.5    Akiba, E.6
  • 6
    • 34250308295 scopus 로고    scopus 로고
    • Recent developments in the use of adenoviruses and immunotoxins in cancer gene therapy
    • Yang Z.R., Wang H.F., Zhao J., Peng Y.Y., Wang J., Guinn B.A., et al. Recent developments in the use of adenoviruses and immunotoxins in cancer gene therapy. Cancer Gene Ther 2007, 14:599-615.
    • (2007) Cancer Gene Ther , vol.14 , pp. 599-615
    • Yang, Z.R.1    Wang, H.F.2    Zhao, J.3    Peng, Y.Y.4    Wang, J.5    Guinn, B.A.6
  • 8
    • 0033972869 scopus 로고    scopus 로고
    • Nonviral gene therapy: promises and challenges
    • Li S., Huang L. Nonviral gene therapy: promises and challenges. Gene Ther 2000, 7:31-34.
    • (2000) Gene Ther , vol.7 , pp. 31-34
    • Li, S.1    Huang, L.2
  • 9
    • 22244459917 scopus 로고    scopus 로고
    • Gene therapy: twenty-first century medicine
    • Verma I.M., Weitzman M.D. Gene therapy: twenty-first century medicine. Annu Rev Biochem 2005, 74:711-738.
    • (2005) Annu Rev Biochem , vol.74 , pp. 711-738
    • Verma, I.M.1    Weitzman, M.D.2
  • 11
    • 0032580348 scopus 로고    scopus 로고
    • Human gene therapy
    • Anderson W.F. Human gene therapy. Nature 1998, 392:25-30.
    • (1998) Nature , vol.392 , pp. 25-30
    • Anderson, W.F.1
  • 12
    • 0038745599 scopus 로고    scopus 로고
    • Progress and problems with the use of viral vectors for gene therapy
    • Thomas C.E., Ehrhardt A., Kay M.A. Progress and problems with the use of viral vectors for gene therapy. Nat Rev Genet 2003, 4:346-358.
    • (2003) Nat Rev Genet , vol.4 , pp. 346-358
    • Thomas, C.E.1    Ehrhardt, A.2    Kay, M.A.3
  • 14
    • 0035135747 scopus 로고    scopus 로고
    • Viral vectors for gene therapy: the art of turning infectious agents into vehicles of therapeutics
    • Kay M.A., Glorioso J.C., Naldini L. Viral vectors for gene therapy: the art of turning infectious agents into vehicles of therapeutics. Nat Med 2001, 7:33-40.
    • (2001) Nat Med , vol.7 , pp. 33-40
    • Kay, M.A.1    Glorioso, J.C.2    Naldini, L.3
  • 15
    • 0003008343 scopus 로고    scopus 로고
    • Synthetic dna delivery systems
    • Luo D., Saltzman W.M. Synthetic dna delivery systems. Nat Biotechnol 2000, 18:33-37.
    • (2000) Nat Biotechnol , vol.18 , pp. 33-37
    • Luo, D.1    Saltzman, W.M.2
  • 16
    • 79751506542 scopus 로고    scopus 로고
    • Gene therapy finds its niche
    • Sheridan C. Gene therapy finds its niche. Nat Biotechnol 2011, 29:121-128.
    • (2011) Nat Biotechnol , vol.29 , pp. 121-128
    • Sheridan, C.1
  • 17
    • 28844460780 scopus 로고    scopus 로고
    • Intracellular trafficking of nonviral vectors
    • Medina-Kauwe L.K., Xie J., Hamm-Alvarez S. Intracellular trafficking of nonviral vectors. Gene Ther 2005, 12:1734-1751.
    • (2005) Gene Ther , vol.12 , pp. 1734-1751
    • Medina-Kauwe, L.K.1    Xie, J.2    Hamm-Alvarez, S.3
  • 20
    • 28744443398 scopus 로고    scopus 로고
    • Dendrimers in biomedical applications-reflections on the field
    • Svenson S., Tomalia D.A. Dendrimers in biomedical applications-reflections on the field. Adv Drug Deliv Rev 2005, 57:2106-2129.
    • (2005) Adv Drug Deliv Rev , vol.57 , pp. 2106-2129
    • Svenson, S.1    Tomalia, D.A.2
  • 21
    • 64549134676 scopus 로고    scopus 로고
    • Nonviral vectors for gene delivery
    • Mintzer M.A., Simanek E.E. Nonviral vectors for gene delivery. Chem Rev 2009, 109:259-302.
    • (2009) Chem Rev , vol.109 , pp. 259-302
    • Mintzer, M.A.1    Simanek, E.E.2
  • 25
    • 77953702051 scopus 로고    scopus 로고
    • Dendrimer toxicity: let's meet the challenge
    • Jain K., Kesharwani P., Gupta U., Jain N.K. Dendrimer toxicity: let's meet the challenge. Int J Pharm 2010, 394:122-142.
    • (2010) Int J Pharm , vol.394 , pp. 122-142
    • Jain, K.1    Kesharwani, P.2    Gupta, U.3    Jain, N.K.4
  • 27
    • 56449116768 scopus 로고    scopus 로고
    • Biodegradable pamam ester for enhanced transfection efficiency with low cytotoxicity
    • Nam H.Y., Nam K., Hahn H.J., Kim B.H., Lim H.J., Kim H.J., et al. Biodegradable pamam ester for enhanced transfection efficiency with low cytotoxicity. Biomaterials 2009, 30:665-673.
    • (2009) Biomaterials , vol.30 , pp. 665-673
    • Nam, H.Y.1    Nam, K.2    Hahn, H.J.3    Kim, B.H.4    Lim, H.J.5    Kim, H.J.6
  • 28
    • 0027655718 scopus 로고
    • Polyamidoamine cascade polymers mediate efficient transfection of cells in culture
    • Haensler J., Szoka F.C. Polyamidoamine cascade polymers mediate efficient transfection of cells in culture. Bioconjug Chem 1993, 4:372-379.
    • (1993) Bioconjug Chem , vol.4 , pp. 372-379
    • Haensler, J.1    Szoka, F.C.2
  • 30
    • 77957732047 scopus 로고    scopus 로고
    • Effects of pegylation and acetylation of pamam dendrimers on dna binding, cytotoxicity and invitro transfection efficiency
    • Fant K., Esbjorner E.K., Jenkins A., Grossel M., Lincoln P., Norden B. Effects of pegylation and acetylation of pamam dendrimers on dna binding, cytotoxicity and invitro transfection efficiency. Mol Pharmaceutics 2010, 7:1734-1746.
    • (2010) Mol Pharmaceutics , vol.7 , pp. 1734-1746
    • Fant, K.1    Esbjorner, E.K.2    Jenkins, A.3    Grossel, M.4    Lincoln, P.5    Norden, B.6
  • 31
    • 72149101909 scopus 로고    scopus 로고
    • PEG-conjugated PAMAM dendrimers mediate efficient intramuscular gene expression
    • Qi R., Gao Y., Tang Y., He R.R., Liu T.L., He Y., et al. PEG-conjugated PAMAM dendrimers mediate efficient intramuscular gene expression. AAPS J 2009, 11:395-405.
    • (2009) AAPS J , vol.11 , pp. 395-405
    • Qi, R.1    Gao, Y.2    Tang, Y.3    He, R.R.4    Liu, T.L.5    He, Y.6
  • 32
    • 78449252867 scopus 로고    scopus 로고
    • PEGylated poly(amidoamine) dendrimer-based dual-targeting carrier for treating brain tumors
    • He H., Li Y., Jia X.R., Du J., Ying X., Lu W.L., et al. PEGylated poly(amidoamine) dendrimer-based dual-targeting carrier for treating brain tumors. Biomaterials 2011, 32:478-487.
    • (2011) Biomaterials , vol.32 , pp. 478-487
    • He, H.1    Li, Y.2    Jia, X.R.3    Du, J.4    Ying, X.5    Lu, W.L.6
  • 33
    • 2942632966 scopus 로고    scopus 로고
    • PEGylation significantly affects cellular uptake and intracellular trafficking of non-viral gene delivery particles
    • Mishra S., Webster P., Davis M.E. PEGylation significantly affects cellular uptake and intracellular trafficking of non-viral gene delivery particles. Eur J Cell Biol 2004, 83:97-111.
    • (2004) Eur J Cell Biol , vol.83 , pp. 97-111
    • Mishra, S.1    Webster, P.2    Davis, M.E.3
  • 34
    • 33748374275 scopus 로고    scopus 로고
    • Acetylation of polyethylenimine enhances gene delivery via weakened polymer/DNA interactions
    • Gabrielson N.P., Pack D.W. Acetylation of polyethylenimine enhances gene delivery via weakened polymer/DNA interactions. Biomacromolecules 2006, 7:2427-2435.
    • (2006) Biomacromolecules , vol.7 , pp. 2427-2435
    • Gabrielson, N.P.1    Pack, D.W.2
  • 35
    • 77953239685 scopus 로고    scopus 로고
    • Functionalization of poly(amidoamine) dendrimers with hydrophobic chains for improved gene delivery in mesenchymal stem cells
    • Santos J.L., Oliveira H., Pandita D., Rodrigues J., Pego A.P., Granja P.L., et al. Functionalization of poly(amidoamine) dendrimers with hydrophobic chains for improved gene delivery in mesenchymal stem cells. JControl Release 2010, 144:55-64.
    • (2010) JControl Release , vol.144 , pp. 55-64
    • Santos, J.L.1    Oliveira, H.2    Pandita, D.3    Rodrigues, J.4    Pego, A.P.5    Granja, P.L.6
  • 36
    • 70449521087 scopus 로고    scopus 로고
    • Transfection efficiencies of PAMAM dendrimers correlate inversely with their hydrophobicity
    • Shakhbazau A., Isayenka I., Kartel N., Goncharova N., Seviaryn I., Kosmacheva S., et al. Transfection efficiencies of PAMAM dendrimers correlate inversely with their hydrophobicity. Int J Pharm 2010, 383(1-2):228-235.
    • (2010) Int J Pharm , vol.383 , Issue.1-2 , pp. 228-235
    • Shakhbazau, A.1    Isayenka, I.2    Kartel, N.3    Goncharova, N.4    Seviaryn, I.5    Kosmacheva, S.6
  • 37
    • 77953253240 scopus 로고    scopus 로고
    • Receptor-mediated gene delivery using pamam dendrimers conjugated with peptides recognized by mesenchymal stem cells
    • Santos J.L., Pandita D., Rodrigues J., Pego A.P., Granja P.L., Balian G., et al. Receptor-mediated gene delivery using pamam dendrimers conjugated with peptides recognized by mesenchymal stem cells. Mol Pharmaceutics 2010, 7:763-774.
    • (2010) Mol Pharmaceutics , vol.7 , pp. 763-774
    • Santos, J.L.1    Pandita, D.2    Rodrigues, J.3    Pego, A.P.4    Granja, P.L.5    Balian, G.6
  • 38
    • 77950948806 scopus 로고    scopus 로고
    • Tat-BMPs-PAMAM conjugates enhance therapeutic effect of small interference RNA on u251 glioma cells invitro and invivo
    • Han L., Zhang A.L., Wang H.J., Pu P.Y., Jiang X.G., Kang C.S., et al. Tat-BMPs-PAMAM conjugates enhance therapeutic effect of small interference RNA on u251 glioma cells invitro and invivo. Hum Gene Ther 2010, 21:417-426.
    • (2010) Hum Gene Ther , vol.21 , pp. 417-426
    • Han, L.1    Zhang, A.L.2    Wang, H.J.3    Pu, P.Y.4    Jiang, X.G.5    Kang, C.S.6
  • 39
    • 78649529378 scopus 로고    scopus 로고
    • Gold nanoparticle platforms as drug and biomacromolecule delivery systems
    • Duncan B., Kim C., Rotello V.M. Gold nanoparticle platforms as drug and biomacromolecule delivery systems. JControl Release 2010, 148:122-127.
    • (2010) JControl Release , vol.148 , pp. 122-127
    • Duncan, B.1    Kim, C.2    Rotello, V.M.3
  • 40
    • 0742321804 scopus 로고    scopus 로고
    • Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology
    • Daniel M.C., Astruc D. Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology. Chem Rev 2004, 104:293-346.
    • (2004) Chem Rev , vol.104 , pp. 293-346
    • Daniel, M.C.1    Astruc, D.2
  • 41
    • 36049038970 scopus 로고    scopus 로고
    • Thermosensitive nanostructures comprising gold nanoparticles grafted with block copolymers
    • Li D., Cui Y., Wang K., He Q., Yan X., Li J. Thermosensitive nanostructures comprising gold nanoparticles grafted with block copolymers. Adv Funct Mater 2007, 17:3134-3140.
    • (2007) Adv Funct Mater , vol.17 , pp. 3134-3140
    • Li, D.1    Cui, Y.2    Wang, K.3    He, Q.4    Yan, X.5    Li, J.6
  • 42
    • 33847187425 scopus 로고    scopus 로고
    • Fabrication of pH-responsive nanocomposites of gold nanoparticles/poly(4-vinylpyridine)
    • Li D., He Q., Cui Y., Li J. Fabrication of pH-responsive nanocomposites of gold nanoparticles/poly(4-vinylpyridine). Chem Mater 2007, 19:412-417.
    • (2007) Chem Mater , vol.19 , pp. 412-417
    • Li, D.1    He, Q.2    Cui, Y.3    Li, J.4
  • 43
    • 34250635352 scopus 로고    scopus 로고
    • Thermosensitive copolymer networks modify gold nanoparticles for nanocomposite entrapment
    • Li D., He Q., Cui Y., Wang K., Zhang X., Li J. Thermosensitive copolymer networks modify gold nanoparticles for nanocomposite entrapment. Chem-Eur J 2007, 13:2224-2229.
    • (2007) Chem-Eur J , vol.13 , pp. 2224-2229
    • Li, D.1    He, Q.2    Cui, Y.3    Wang, K.4    Zhang, X.5    Li, J.6
  • 44
    • 67349276985 scopus 로고    scopus 로고
    • Smart core/shell nanocomposites: intelligent polymers modified gold nanoparticles
    • Li D., He Q., Li J. Smart core/shell nanocomposites: intelligent polymers modified gold nanoparticles. Adv Colloid Interface Sci 2009, 149:28-38.
    • (2009) Adv Colloid Interface Sci , vol.149 , pp. 28-38
    • Li, D.1    He, Q.2    Li, J.3
  • 45
    • 54849434643 scopus 로고    scopus 로고
    • Two-stage pH response of poly(4-vinylpyridine) grafted gold nanoparticles
    • Li D., He Q., Yang Y., Moehwald H., Li J. Two-stage pH response of poly(4-vinylpyridine) grafted gold nanoparticles. Macromolecules 2008, 41:7254-7256.
    • (2008) Macromolecules , vol.41 , pp. 7254-7256
    • Li, D.1    He, Q.2    Yang, Y.3    Moehwald, H.4    Li, J.5
  • 46
    • 58049206937 scopus 로고    scopus 로고
    • Efficient gene delivery vectors by tuning the surface charge density of amino acid-functionalized gold nanoparticles
    • Ghosh P.S., Kim C.K., Han G., Forbes N.S., Rotello V.M. Efficient gene delivery vectors by tuning the surface charge density of amino acid-functionalized gold nanoparticles. ACS Nano 2008, 2:2213-2218.
    • (2008) ACS Nano , vol.2 , pp. 2213-2218
    • Ghosh, P.S.1    Kim, C.K.2    Han, G.3    Forbes, N.S.4    Rotello, V.M.5
  • 47
    • 0004053611 scopus 로고
    • John Wiley & Sons, Inc, New York
    • Voet D., Voet J.G. Biochemistry 1995, John Wiley & Sons, Inc, New York. 2nd ed.
    • (1995) Biochemistry
    • Voet, D.1    Voet, J.G.2
  • 48
    • 0038674868 scopus 로고    scopus 로고
    • About dendrimers: structure, physical properties, and applications
    • Bosman A.W., Janssen H.M., Meijer E.W. About dendrimers: structure, physical properties, and applications. Chem Rev 1999, 99:1665-1688.
    • (1999) Chem Rev , vol.99 , pp. 1665-1688
    • Bosman, A.W.1    Janssen, H.M.2    Meijer, E.W.3
  • 49
    • 0032636884 scopus 로고    scopus 로고
    • Small-angle neutron scattering and surface force investigations of poly(amido amine) dendrimer with hydroxyl end groups
    • Imae T., Funayama K., Aoi K., Tsutsumiuchi K., Okada M., Furusaka M. Small-angle neutron scattering and surface force investigations of poly(amido amine) dendrimer with hydroxyl end groups. Langmuir 1999, 15:4076-4084.
    • (1999) Langmuir , vol.15 , pp. 4076-4084
    • Imae, T.1    Funayama, K.2    Aoi, K.3    Tsutsumiuchi, K.4    Okada, M.5    Furusaka, M.6
  • 50
    • 75149193440 scopus 로고    scopus 로고
    • X-ray attenuation property of dendrimer-entrapped gold nanoparticles
    • Guo R., Wang H., Peng C., Shen M.W., Pan M.J., Cao X.Y., et al. X-ray attenuation property of dendrimer-entrapped gold nanoparticles. JPhys Chem C 2010, 114:50-56.
    • (2010) JPhys Chem C , vol.114 , pp. 50-56
    • Guo, R.1    Wang, H.2    Peng, C.3    Shen, M.W.4    Pan, M.J.5    Cao, X.Y.6
  • 51
    • 34547171711 scopus 로고    scopus 로고
    • Dendrimer-entrapped gold nanoparticles as a platform for cancer-cell targeting and imaging
    • Shi X., Wang S., Meshinchi S., Van Antwerp M.E., Bi X., Lee I., et al. Dendrimer-entrapped gold nanoparticles as a platform for cancer-cell targeting and imaging. Small 2007, 3:1245-1252.
    • (2007) Small , vol.3 , pp. 1245-1252
    • Shi, X.1    Wang, S.2    Meshinchi, S.3    Van Antwerp, M.E.4    Bi, X.5    Lee, I.6
  • 52
    • 33845523299 scopus 로고    scopus 로고
    • Improved biocompatibility of surface functionalized dendrimer-entrapped gold nanoparticles
    • Shi X., Wang S., Sun H., Baker J.R. Improved biocompatibility of surface functionalized dendrimer-entrapped gold nanoparticles. Soft Matter 2007, 3:71-74.
    • (2007) Soft Matter , vol.3 , pp. 71-74
    • Shi, X.1    Wang, S.2    Sun, H.3    Baker, J.R.4
  • 53
    • 70449598099 scopus 로고    scopus 로고
    • Comparison of the internalization of targeted dendrimers and dendrimer-entrapped gold nanoparticles into cancer cells
    • Shi X., Wang S.H., Lee I., Shen M., Baker J.R. Comparison of the internalization of targeted dendrimers and dendrimer-entrapped gold nanoparticles into cancer cells. Biopolymers 2009, 91:936-942.
    • (2009) Biopolymers , vol.91 , pp. 936-942
    • Shi, X.1    Wang, S.H.2    Lee, I.3    Shen, M.4    Baker, J.R.5
  • 54
    • 82555195541 scopus 로고    scopus 로고
    • Ahighly effective polymerase chain reaction enhancer based on dendrimer-entrapped gold nanoparticles
    • Chen J., Cao X., Guo R., Shen M., Peng C., Xiao T., et al. Ahighly effective polymerase chain reaction enhancer based on dendrimer-entrapped gold nanoparticles. Analyst 2012, 137:223-228.
    • (2012) Analyst , vol.137 , pp. 223-228
    • Chen, J.1    Cao, X.2    Guo, R.3    Shen, M.4    Peng, C.5    Xiao, T.6
  • 55
    • 0030743086 scopus 로고    scopus 로고
    • The interaction of plasmid dna with polyamidoamine dendrimers: mechanism of complex formation and analysis of alterations induced in nuclease sensitivity and transcriptional activity of the complexed dna
    • Bielinska A.U., Kukowska-Latallo J.F., Baker J.R. The interaction of plasmid dna with polyamidoamine dendrimers: mechanism of complex formation and analysis of alterations induced in nuclease sensitivity and transcriptional activity of the complexed dna. Biochim Biophys Acta Gene Struct Expr 1997, 1353:180-190.
    • (1997) Biochim Biophys Acta Gene Struct Expr , vol.1353 , pp. 180-190
    • Bielinska, A.U.1    Kukowska-Latallo, J.F.2    Baker, J.R.3
  • 56
    • 33744805790 scopus 로고    scopus 로고
    • Polymers for gene delivery across length scales
    • Putnam D. Polymers for gene delivery across length scales. Nat Mater 2006, 5:439-451.
    • (2006) Nat Mater , vol.5 , pp. 439-451
    • Putnam, D.1
  • 58
    • 0142042448 scopus 로고    scopus 로고
    • Engineering of dendrimer surfaces to enhance transepithelial transport and reduce cytotoxicity
    • Jevprasesphant R., Penny J., Attwood D., McKeown N.B., D'Emanuele A. Engineering of dendrimer surfaces to enhance transepithelial transport and reduce cytotoxicity. Pharm Res 2003, 20:1543-1550.
    • (2003) Pharm Res , vol.20 , pp. 1543-1550
    • Jevprasesphant, R.1    Penny, J.2    Attwood, D.3    McKeown, N.B.4    D'Emanuele, A.5
  • 59
    • 33845350746 scopus 로고    scopus 로고
    • Transport of poly (amidoamine) dendrimers across caco-2 cell monolayers: influence of size, charge and fluorescent labeling
    • Kitchens K.M., Kolhatkar R.B., Swaan P.W., Eddington N.D., Ghandehari H. Transport of poly (amidoamine) dendrimers across caco-2 cell monolayers: influence of size, charge and fluorescent labeling. Pharm Res 2006, 23:2818-2826.
    • (2006) Pharm Res , vol.23 , pp. 2818-2826
    • Kitchens, K.M.1    Kolhatkar, R.B.2    Swaan, P.W.3    Eddington, N.D.4    Ghandehari, H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.