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Volumn 58, Issue 12, 2014, Pages 2261-2273

Systemic absorption and metabolism of dietary procyanidin B4 in pigs

Author keywords

Absorption; Flavan 3 ols; Metabolism; Pigs; Procyanidins

Indexed keywords

SUIDAE;

EID: 84912127555     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201400435     Document Type: Article
Times cited : (22)

References (46)
  • 1
    • 85052890784 scopus 로고
    • Flavans and proanthocyanidins
    • in: Harborne, J. B. (Ed.), Chapman and Hall, London, England -.
    • Porter, L. J., Flavans and proanthocyanidins, in: Harborne, J. B. (Ed.), The Flavonoids: Advances in Research Since 1986, Chapman and Hall, London, England 1994, pp. 23-55.
    • (1994) The Flavonoids: Advances in Research Since 1986 , pp. 23-55
    • Porter, L.J.1
  • 2
    • 80053517354 scopus 로고    scopus 로고
    • Analysis of flavan-3-ols and procyanidins in food samples by reversed phase high-performance liquid chromatography coupled to electrospray ionization tandem mass spectrometry (RP-HPLC-ESI-MS/MS)
    • Rzeppa, S., Von Bargen, C., Bittner, K., Humpf, H.-U., Analysis of flavan-3-ols and procyanidins in food samples by reversed phase high-performance liquid chromatography coupled to electrospray ionization tandem mass spectrometry (RP-HPLC-ESI-MS/MS). J. Agric. Food Chem. 2012, 59, 10594-10603.
    • (2012) J. Agric. Food Chem. , vol.59 , pp. 10594-10603
    • Rzeppa, S.1    Von Bargen, C.2    Bittner, K.3    Humpf, H.-U.4
  • 3
    • 84884832180 scopus 로고    scopus 로고
    • Distribution and quantification of flavan-3-ols and procyanidins with low degree of polymerization in nuts, cereals, and legumes
    • Bittner, K., Rzeppa, S., Humpf, H.-U., Distribution and quantification of flavan-3-ols and procyanidins with low degree of polymerization in nuts, cereals, and legumes. J. Agric. Food Chem. 2013, 61, 9148-9154.
    • (2013) J. Agric. Food Chem. , vol.61 , pp. 9148-9154
    • Bittner, K.1    Rzeppa, S.2    Humpf, H.-U.3
  • 4
    • 0141850470 scopus 로고    scopus 로고
    • Screening of foods containing proanthocyanidins and their structural characterization using LC-MS/MS and thiolytic degradation
    • Gu, L., Kelm, M. A., Hammerstone, J. F., Beecher, G. et al., Screening of foods containing proanthocyanidins and their structural characterization using LC-MS/MS and thiolytic degradation. J. Agric. Food Chem. 2003, 51, 7513-7521.
    • (2003) J. Agric. Food Chem. , vol.51 , pp. 7513-7521
    • Gu, L.1    Kelm, M.A.2    Hammerstone, J.F.3    Beecher, G.4
  • 5
    • 0034657286 scopus 로고    scopus 로고
    • Proanthocyanidins and tannin-like compounds-nature, occurence, dietary intake and effects on nutrition and health (review)
    • Santos-Buelga, C., Scalbert, A., Proanthocyanidins and tannin-like compounds-nature, occurence, dietary intake and effects on nutrition and health (review). J. Sci. Food Agric. 2000, 80, 1094-1117.
    • (2000) J. Sci. Food Agric. , vol.80 , pp. 1094-1117
    • Santos-Buelga, C.1    Scalbert, A.2
  • 7
    • 77951891625 scopus 로고    scopus 로고
    • Flavanols and anthocyanins in cardiovascular health: a review of current evidence
    • de Pascual-Teresa, S., Moreno, D. A., García-Viguera, C., Flavanols and anthocyanins in cardiovascular health: a review of current evidence. Int. J. Mol. Sci. 2010, 11, 1679-1703.
    • (2010) Int. J. Mol. Sci. , vol.11 , pp. 1679-1703
    • de Pascual-Teresa, S.1    Moreno, D.A.2    García-Viguera, C.3
  • 8
    • 0032819143 scopus 로고    scopus 로고
    • Increase of antioxidative potential of rat plasma by oral administration of proanthocyanidin-rich extract from grape seeds
    • Koga, T., Moro, K., Nakamori, K., Yamakoshi, J. et al., Increase of antioxidative potential of rat plasma by oral administration of proanthocyanidin-rich extract from grape seeds. J. Agric. Food Chem. 1999, 47, 1892-1897.
    • (1999) J. Agric. Food Chem. , vol.47 , pp. 1892-1897
    • Koga, T.1    Moro, K.2    Nakamori, K.3    Yamakoshi, J.4
  • 9
    • 0042261671 scopus 로고    scopus 로고
    • Antioxidant protection of low density lipoprotein by procyanidins: structure/activity relationships
    • da Silva Porto, P. A. L., Laranjinha, J. A. N., de Freitas, V. A. P., Antioxidant protection of low density lipoprotein by procyanidins: structure/activity relationships. Biochem. Pharmacol. 2003, 66, 947-954.
    • (2003) Biochem. Pharmacol. , vol.66 , pp. 947-954
    • da Silva Porto, P.A.L.1    Laranjinha, J.A.N.2    de Freitas, V.A.P.3
  • 10
    • 84883179572 scopus 로고    scopus 로고
    • Transepithelial permeability studies of flavan-3-ol-C-glucosides and procyanidin dimers and trimers across the Caco-2 cell monolayer
    • Hemmersbach, S., Brauer, S. S., Hüwel, S., Galla, H. J. et al., Transepithelial permeability studies of flavan-3-ol-C-glucosides and procyanidin dimers and trimers across the Caco-2 cell monolayer. J. Agric. Food Chem. 2013, 61, 7932-7940.
    • (2013) J. Agric. Food Chem. , vol.61 , pp. 7932-7940
    • Hemmersbach, S.1    Brauer, S.S.2    Hüwel, S.3    Galla, H.J.4
  • 11
    • 84856911781 scopus 로고    scopus 로고
    • Transport of cranberry A-type procyanidin dimers, trimers, and tetramers across monolayers of human intestinal epithelial Caco-2 cells
    • Ou, K., Percival, S. S., Zou, T., Khoo, C. et al., Transport of cranberry A-type procyanidin dimers, trimers, and tetramers across monolayers of human intestinal epithelial Caco-2 cells. J. Agric. Food Chem. 2012, 60, 1390-1396.
    • (2012) J. Agric. Food Chem. , vol.60 , pp. 1390-1396
    • Ou, K.1    Percival, S.S.2    Zou, T.3    Khoo, C.4
  • 12
    • 84865474322 scopus 로고    scopus 로고
    • In vitro intestinal transport of oligomeric procyanidins (DP 2 to 4) across monolayers of Caco-2 cells
    • Zumdick, S., Deters, A., Hensel, A., In vitro intestinal transport of oligomeric procyanidins (DP 2 to 4) across monolayers of Caco-2 cells. Fitoterapia 2012, 83, 1210-1217.
    • (2012) Fitoterapia , vol.83 , pp. 1210-1217
    • Zumdick, S.1    Deters, A.2    Hensel, A.3
  • 13
    • 59649090878 scopus 로고    scopus 로고
    • Liquid chromatography tandem mass spectrometry identification of proanthocyanidins in rat plasma after oral administration of grape seed extract
    • Prasain, J. K., Peng, N., Dai, Y., Moore, R. et al., Liquid chromatography tandem mass spectrometry identification of proanthocyanidins in rat plasma after oral administration of grape seed extract. Phytomedicine 2009, 16, 233-243.
    • (2009) Phytomedicine , vol.16 , pp. 233-243
    • Prasain, J.K.1    Peng, N.2    Dai, Y.3    Moore, R.4
  • 14
    • 77951209860 scopus 로고    scopus 로고
    • Bioavailability of procyanidin dimers and trimers and matrix food effects in in vitro and in vivo models
    • Serra, A., Macià, A., Romero, M. P., Valls, J. et al., Bioavailability of procyanidin dimers and trimers and matrix food effects in in vitro and in vivo models. Br. J. Nutr. 2010, 103, 944-952.
    • (2010) Br. J. Nutr. , vol.103 , pp. 944-952
    • Serra, A.1    Macià, A.2    Romero, M.P.3    Valls, J.4
  • 15
    • 25444482129 scopus 로고    scopus 로고
    • The absorption, metabolism and excretion of flavan-3-ols and procyanidins following the ingestion of a grape seed extract by rats
    • Tsang, C., Auger, C., Mullen, W., Bornet, A. et al., The absorption, metabolism and excretion of flavan-3-ols and procyanidins following the ingestion of a grape seed extract by rats. Br. J. Nutr. 2005, 94, 170-181.
    • (2005) Br. J. Nutr. , vol.94 , pp. 170-181
    • Tsang, C.1    Auger, C.2    Mullen, W.3    Bornet, A.4
  • 16
    • 84859743352 scopus 로고    scopus 로고
    • Urinary excretion and metabolism of procyanidins in pigs
    • Rzeppa, S., Bittner, K., Döll, S., Dänicke, S. et al., Urinary excretion and metabolism of procyanidins in pigs. Mol. Nutr. Food Res. 2012, 56, 653-665.
    • (2012) Mol. Nutr. Food Res. , vol.56 , pp. 653-665
    • Rzeppa, S.1    Bittner, K.2    Döll, S.3    Dänicke, S.4
  • 17
    • 0344613481 scopus 로고    scopus 로고
    • Procyanidin B1 is detected in human serum after intake of proanthocyanidin-rich grape seed extract
    • Sano, A., Yamakoshi, J., Tokutake, S., Tobe, K. et al., Procyanidin B1 is detected in human serum after intake of proanthocyanidin-rich grape seed extract. Biosci. Biotechnol. Biochem. 2003, 67, 1140-1143.
    • (2003) Biosci. Biotechnol. Biochem. , vol.67 , pp. 1140-1143
    • Sano, A.1    Yamakoshi, J.2    Tokutake, S.3    Tobe, K.4
  • 18
    • 0036784053 scopus 로고    scopus 로고
    • Procyanidin dimer B2 [epicatechin-(4beta-8)-epicatechin] in human plasma after the consumption of a flavanol-rich cocoa
    • Holt, R. R., Lazarus, S. A., Sullards, M. C., Zhu, Q. Y. et al., Procyanidin dimer B2 [epicatechin-(4beta-8)-epicatechin] in human plasma after the consumption of a flavanol-rich cocoa. Am. J. Clin. Nutr. 2002, 76, 798-804.
    • (2002) Am. J. Clin. Nutr. , vol.76 , pp. 798-804
    • Holt, R.R.1    Lazarus, S.A.2    Sullards, M.C.3    Zhu, Q.Y.4
  • 19
    • 79951609639 scopus 로고    scopus 로고
    • Insights into the metabolism and microbial biotransformation of dietary flavan-3-ols and the bioactivity of their metabolites
    • Monagas, M., Urpi-Sarda, M., Sánchez-Patán, F., Llorach, R. et al., Insights into the metabolism and microbial biotransformation of dietary flavan-3-ols and the bioactivity of their metabolites. Food. Funct. 2010, 1, 233-253.
    • (2010) Food. Funct. , vol.1 , pp. 233-253
    • Monagas, M.1    Urpi-Sarda, M.2    Sánchez-Patán, F.3    Llorach, R.4
  • 20
    • 0036628736 scopus 로고    scopus 로고
    • Absorption and urinary excretion of procyanidin B2 [epicatechin-(4beta-8)-epicatechin] in rats
    • Baba, S., Osakabe, N., Natsume, M., Terao, J., Absorption and urinary excretion of procyanidin B2 [epicatechin-(4beta-8)-epicatechin] in rats. Free Radic. Biol. Med. 2002, 33, 142-148.
    • (2002) Free Radic. Biol. Med. , vol.33 , pp. 142-148
    • Baba, S.1    Osakabe, N.2    Natsume, M.3    Terao, J.4
  • 21
    • 84856251116 scopus 로고    scopus 로고
    • Intestinal metabolism of two A-type procyanidins using the pig cecum model: detailed structure elucidation of unknown catabolites with Fourier transform mass spectrometry (FTMS)
    • Engemann, A., Hübner, F., Rzeppa, S., Humpf, H.-U., Intestinal metabolism of two A-type procyanidins using the pig cecum model: detailed structure elucidation of unknown catabolites with Fourier transform mass spectrometry (FTMS). J. Agric. Food Chem. 2012, 60, 749-757.
    • (2012) J. Agric. Food Chem. , vol.60 , pp. 749-757
    • Engemann, A.1    Hübner, F.2    Rzeppa, S.3    Humpf, H.-U.4
  • 22
    • 77955667460 scopus 로고    scopus 로고
    • Complex flavonoids in cocoa: synthesis and degradation by intestinal microbiota
    • Van't Slot, G., Mattern, W., Rzeppa, S., Grewe, D. et al., Complex flavonoids in cocoa: synthesis and degradation by intestinal microbiota. J. Agric. Food Chem. 2010, 58, 8879-8886.
    • (2010) J. Agric. Food Chem. , vol.58 , pp. 8879-8886
    • Van't Slot, G.1    Mattern, W.2    Rzeppa, S.3    Grewe, D.4
  • 23
    • 0242691717 scopus 로고    scopus 로고
    • Metabolism of grape seed polyphenol in the rat
    • Nakamura, Y., Tonogai, Y., Metabolism of grape seed polyphenol in the rat. J. Agric. Food Chem. 2003, 51, 7215-7225.
    • (2003) J. Agric. Food Chem. , vol.51 , pp. 7215-7225
    • Nakamura, Y.1    Tonogai, Y.2
  • 24
    • 0036229187 scopus 로고    scopus 로고
    • Procyanidins are not bioavailable in rats fed a single meal containing a grapeseed extract of the procyanidin B3
    • Donovan, J. L., Manach, C., Rios, L., Morand, C. et al., Procyanidins are not bioavailable in rats fed a single meal containing a grapeseed extract of the procyanidin B3. Br. J. Nutr. 2002, 87, 299-306.
    • (2002) Br. J. Nutr. , vol.87 , pp. 299-306
    • Donovan, J.L.1    Manach, C.2    Rios, L.3    Morand, C.4
  • 26
    • 4143081627 scopus 로고    scopus 로고
    • Supplementation with grape seed polyphenols results in increased urinary excretion of 3-hydroxyphenylpropionic acid, an important metabolite of proanthocyanidins in humans
    • Ward, N. C., Croft, K. D., Puddey, I. B., Hodgson, J. M., Supplementation with grape seed polyphenols results in increased urinary excretion of 3-hydroxyphenylpropionic acid, an important metabolite of proanthocyanidins in humans. J. Agric. Food Chem. 2004, 52, 5545-5549.
    • (2004) J. Agric. Food Chem. , vol.52 , pp. 5545-5549
    • Ward, N.C.1    Croft, K.D.2    Puddey, I.B.3    Hodgson, J.M.4
  • 27
    • 84859752238 scopus 로고    scopus 로고
    • Chocolate intake increases urinary excretion of polyphenol-derived phenolic acids in healthy human subjects
    • Rios, L. Y., Gonthier, M.-P., Remesy, C., Mila, I. et al., Chocolate intake increases urinary excretion of polyphenol-derived phenolic acids in healthy human subjects. Am. J. Clin. Nutr. 2003, 76, 1106-1110.
    • (2003) Am. J. Clin. Nutr. , vol.76 , pp. 1106-1110
    • Rios, L.Y.1    Gonthier, M.-P.2    Remesy, C.3    Mila, I.4
  • 28
    • 76149106136 scopus 로고    scopus 로고
    • In vivo bioavailability, absorption, excretion, and pharmacokinetics of [14C]procyanidin B2 in male rats
    • Stoupi, S., Williamson, G., Viton, F., Barron, D. et al., In vivo bioavailability, absorption, excretion, and pharmacokinetics of [14C]procyanidin B2 in male rats. Drug Metab. Dispos. 2010, 38, 287-291.
    • (2010) Drug Metab. Dispos. , vol.38 , pp. 287-291
    • Stoupi, S.1    Williamson, G.2    Viton, F.3    Barron, D.4
  • 29
    • 0023081945 scopus 로고
    • The pig as a model for human nutrition
    • Miller, E. R., Ullrey, D. E., The pig as a model for human nutrition. Annu. Rev. Nutr. 1987, 7, 361-382.
    • (1987) Annu. Rev. Nutr. , vol.7 , pp. 361-382
    • Miller, E.R.1    Ullrey, D.E.2
  • 30
    • 37149008678 scopus 로고    scopus 로고
    • Preparative isolation of procyanidins from grape seed extracts by high-speed counter-current chromatography
    • Köhler, N., Wray, V., Winterhalter, P., Preparative isolation of procyanidins from grape seed extracts by high-speed counter-current chromatography. J. Chromatogr. A 2008, 1177, 114-125.
    • (2008) J. Chromatogr. A , vol.1177 , pp. 114-125
    • Köhler, N.1    Wray, V.2    Winterhalter, P.3
  • 31
    • 0027982436 scopus 로고
    • The Bateman function revisited: a critical reevaluation of the quantitative expressions to characterize concentrations in the one compartment body model as a function of time with first-order invasion and first-order elimination
    • Garrett, E. R., The Bateman function revisited: a critical reevaluation of the quantitative expressions to characterize concentrations in the one compartment body model as a function of time with first-order invasion and first-order elimination. J. Pharmacokinet. Biopharm. 1994, 22, 103-128.
    • (1994) J. Pharmacokinet. Biopharm. , vol.22 , pp. 103-128
    • Garrett, E.R.1
  • 33
    • 84869162747 scopus 로고    scopus 로고
    • Systematic approach for structure elucidation of polyphenolic compounds using a bottom-up approach combining ion trap experiments and accurate mass measurements
    • von Bargen, C., Hübner, F., Cramer, B., Rzeppa, S. et al., Systematic approach for structure elucidation of polyphenolic compounds using a bottom-up approach combining ion trap experiments and accurate mass measurements. J. Agric. Food Chem. 2012, 60, 11274-11282.
    • (2012) J. Agric. Food Chem. , vol.60 , pp. 11274-11282
    • von Bargen, C.1    Hübner, F.2    Cramer, B.3    Rzeppa, S.4
  • 34
    • 64549146671 scopus 로고    scopus 로고
    • Preparation and characterization of catechin sulfates, glucuronides, and methylethers with metabolic interest
    • González-Manzano, S., González-Paramás, A., Santos-Buelga, C., Dueñas, M., Preparation and characterization of catechin sulfates, glucuronides, and methylethers with metabolic interest. J. Agric. Food Chem. 2009, 57, 1231-1238.
    • (2009) J. Agric. Food Chem. , vol.57 , pp. 1231-1238
    • González-Manzano, S.1    González-Paramás, A.2    Santos-Buelga, C.3    Dueñas, M.4
  • 35
    • 77953288297 scopus 로고    scopus 로고
    • Comparison of positive and negative ion detection of tea catechins using tandem mass spectrometry and ultra high performance liquid chromatography
    • Spáčil, Z., Nováková, L., Solich, P., Comparison of positive and negative ion detection of tea catechins using tandem mass spectrometry and ultra high performance liquid chromatography. Food Chem. 2010, 123, 535-541.
    • (2010) Food Chem. , vol.123 , pp. 535-541
    • Spáčil, Z.1    Nováková, L.2    Solich, P.3
  • 36
    • 0037358110 scopus 로고    scopus 로고
    • Measurement of plasma procyanidin B-2 and procyanidin B-3 levels after oral administration in rat
    • Tanaka, N., Sekiya, N., Hattori, M., Goto, H. et al., Measurement of plasma procyanidin B-2 and procyanidin B-3 levels after oral administration in rat. Phytomedicine 2003, 10, 122-126.
    • (2003) Phytomedicine , vol.10 , pp. 122-126
    • Tanaka, N.1    Sekiya, N.2    Hattori, M.3    Goto, H.4
  • 37
    • 67749147086 scopus 로고    scopus 로고
    • Procyanidin dimers A1, A2, and B2 are absorbed without conjugation or methylation from the small intestine of rats
    • Appeldoorn, M. M., Vincken, J. P., Gruppen, H., Hollman, P. C., Procyanidin dimers A1, A2, and B2 are absorbed without conjugation or methylation from the small intestine of rats. J. Nutr. 2009, 139, 1469-1473.
    • (2009) J. Nutr. , vol.139 , pp. 1469-1473
    • Appeldoorn, M.M.1    Vincken, J.P.2    Gruppen, H.3    Hollman, P.C.4
  • 38
    • 0037070377 scopus 로고    scopus 로고
    • Stability of the flavan-3-ols epicatechin and catechin and related dimeric procyanidins derived from cocoa
    • Zhu, Q. Y., Holt, R. R., Lazarus, S. A., Ensunsa, J. L. et al., Stability of the flavan-3-ols epicatechin and catechin and related dimeric procyanidins derived from cocoa. J. Agric. Food Chem. 2002, 50, 1700-1705.
    • (2002) J. Agric. Food Chem. , vol.50 , pp. 1700-1705
    • Zhu, Q.Y.1    Holt, R.R.2    Lazarus, S.A.3    Ensunsa, J.L.4
  • 39
    • 0036165985 scopus 로고    scopus 로고
    • Urinary excretion of catechin metabolites by human subjects after red wine consumption
    • Donovan, J. L., Kasim-Karakas, S., German, J. B., Waterhouse, A. L., Urinary excretion of catechin metabolites by human subjects after red wine consumption. Br. J. Nutr. 2002, 87, 31-37.
    • (2002) Br. J. Nutr. , vol.87 , pp. 31-37
    • Donovan, J.L.1    Kasim-Karakas, S.2    German, J.B.3    Waterhouse, A.L.4
  • 40
    • 0035167804 scopus 로고    scopus 로고
    • In vivo comparison of the bioavailability of (+)-catechin, (-)-epicatechin and their mixture in orally administered rats
    • Baba, S., Osakabe, N., Natsume, M., Muto, Y. et al., In vivo comparison of the bioavailability of (+)-catechin, (-)-epicatechin and their mixture in orally administered rats. J. Nutr. 2001, 131, 2885-2891.
    • (2001) J. Nutr. , vol.131 , pp. 2885-2891
    • Baba, S.1    Osakabe, N.2    Natsume, M.3    Muto, Y.4
  • 41
    • 84859768842 scopus 로고    scopus 로고
    • Epicatechin and catechin are O-methylated and glucuronidated in the small intestine
    • Kuhnle, K., Spencer, J. P., Shroeter, H., Shenoy, B. et al., Epicatechin and catechin are O-methylated and glucuronidated in the small intestine. Br. J. Nutr. 2000, 72, 467-477.
    • (2000) Br. J. Nutr. , vol.72 , pp. 467-477
    • Kuhnle, K.1    Spencer, J.P.2    Shroeter, H.3    Shenoy, B.4
  • 42
    • 0034994354 scopus 로고    scopus 로고
    • Catechin is metabolized by both the small intestine and liver of rats
    • Donovan, J. L., Crespy, V., Manach, C., Morand, C. et al., Catechin is metabolized by both the small intestine and liver of rats. J. Nutr. 2001, 131, 1753-1757.
    • (2001) J. Nutr. , vol.131 , pp. 1753-1757
    • Donovan, J.L.1    Crespy, V.2    Manach, C.3    Morand, C.4
  • 43
    • 80051732169 scopus 로고    scopus 로고
    • A metabolic system-wide characterisation of the pig: a model for human physiology
    • Merrifield, C. A., Lewis, M., Claus, S. P., Beckonert, O. P. et al., A metabolic system-wide characterisation of the pig: a model for human physiology. Mol. Bio. Syst. 2011, 7, 2577-2588.
    • (2011) Mol. Bio. Syst. , vol.7 , pp. 2577-2588
    • Merrifield, C.A.1    Lewis, M.2    Claus, S.P.3    Beckonert, O.P.4
  • 44
    • 0002854983 scopus 로고
    • Comparative aspects of detoxication in mammals
    • in: Jacoby, W. B. (Ed.), Academic Press, Inc., New York -.
    • Caldwell, J., Comparative aspects of detoxication in mammals, in: Jacoby, W. B. (Ed.), Enzymatic Basis of Detoxication, Academic Press, Inc., New York 1980, pp. 85-114.
    • (1980) Enzymatic Basis of Detoxication , pp. 85-114
    • Caldwell, J.1
  • 45
    • 0017405353 scopus 로고
    • The synthesis of hippurate from benzoate and glycine by rat liver mitochondria. Submitochondrial localization and kinetics
    • Gatley, S. J., Sherratt, H. S., The synthesis of hippurate from benzoate and glycine by rat liver mitochondria. Submitochondrial localization and kinetics. Biochem. J. 1977, 166, 39-47.
    • (1977) Biochem. J. , vol.166 , pp. 39-47
    • Gatley, S.J.1    Sherratt, H.S.2
  • 46
    • 67650809920 scopus 로고    scopus 로고
    • Epicatechin, procyanidins, and phenolic microbial metabolites after cocoa intake in humans and rats
    • Urpi-Sarda, M., Monagas, M., Khan, N., Lamuela-Raventos, R. et al., Epicatechin, procyanidins, and phenolic microbial metabolites after cocoa intake in humans and rats. Anal. Bioanal. Chem. 2009, 394, 1545-1556.
    • (2009) Anal. Bioanal. Chem. , vol.394 , pp. 1545-1556
    • Urpi-Sarda, M.1    Monagas, M.2    Khan, N.3    Lamuela-Raventos, R.4


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