An annular lipid belt is essential for allosteric coupling and viral inhibition of the antigen translocation complex TAP (Transporter Associated with Antigen Processing)

Journal of Biological Chemistry

Volumn 289, Issue 48, 2014, Pages 33098-33108

  Eggensperger, Sabine ^a   Fisette, Olivier ^b   Parcej, David ^a   Schäfer, Lars V ^b   Tampé, Robert ^a  

^a GOETHE UNIVERSITY   (Germany)

^b RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGENS; CELL MEMBRANES; DEGRADATION; HYDROLYSIS; LIPIDS; MACHINERY; MOLECULAR DYNAMICS; PEPTIDES;

ADAPTIVE IMMUNE RESPONSE; ALLOSTERIC COUPLING; ATP-BINDING CASSETTE TRANSPORTERS; ENDOPLASMIC RETICULUM; MAJOR HISTOCOMPATIBILITY COMPLEX CLASS; MOLECULAR DYNAMICS SIMULATIONS; PROTEASOMAL DEGRADATION; TRANSPORTER ASSOCIATED WITH ANTIGEN PROCESSING (TAP);

LOADING;

ABC TRANSPORTER; ADENOSINE TRIPHOSPHATE; HETERODIMER; LIPID; TRANSPORTER ASSOCIATED WITH ANTIGEN PROCESSING 1; ADENOSINE TRIPHOSPHATASE; HLA ANTIGEN CLASS 1; ICP47 PROTEIN, HERPES SIMPLEX VIRUS; IMMEDIATE EARLY PROTEIN; MEMBRANE LIPID; MULTIPROTEIN COMPLEX; PEPTIDE; PROTEASOME;

ALLOSTERISM; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; ENZYME METABOLISM; HYDROLYSIS; MOLECULAR DYNAMICS; NONHUMAN; PROTEIN BINDING; PROTEIN LIPID INTERACTION; PROTEIN STRUCTURE; SIMULATION; STOICHIOMETRY; VIRUS INHIBITION; ANTIGEN PRESENTATION; GENETICS; HUMAN; IMMUNOLOGY; METABOLISM; PROTEIN TRANSPORT; TUMOR CELL LINE;

ADENOSINE TRIPHOSPHATASES; ADENOSINE TRIPHOSPHATE; ANTIGEN PRESENTATION; CELL LINE, TUMOR; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; IMMEDIATE-EARLY PROTEINS; MEMBRANE LIPIDS; MULTIPROTEIN COMPLEXES; PEPTIDES; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN TRANSPORT;

EID: 84912098870     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.592832     Document Type: Article

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