Anti-angiogenic effect of triterpenoidal saponins from Polygala senega

Journal of Natural Medicines

Volumn 65, Issue 1, 2011, Pages 149-156

  Arai, Masayoshi ^a   Hayashi, Asami ^a   Sobou, Mari ^a   Ishida, Shunsuke ^a   Kawachi, Takashi ^a   Kotoku, Naoyuki ^a   Kobayashi, Motomasa ^a  

^a OSAKA UNIVERSITY   (Japan)

Author keywords

Angiogenesis; Cancer; HUVECs; Polygala senega; Senegasaponins; Tubular formation

Indexed keywords

ANGIOGENESIS INHIBITOR; BASIC FIBROBLAST GROWTH FACTOR; BEVACIZUMAB; CISPLATIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PIGMENT EPITHELIUM DERIVED FACTOR; PLANT EXTRACT; PROTEIN KINASE B; SAPONIN; SENEGA; SENEGASAPONIN; SENEGASAPONIN A; SENEGASAPONIN B; SENEGASAPONIN DESACYL MIXTURE; SENEGIN III; SENEGIN IV; SORAFENIB; SUNITINIB; TENUIFOLIN; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIANGIOGENIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; IC 50; NONHUMAN; POLYGALA SENEGA; POLYGALACEAE; PROTEIN PHOSPHORYLATION; SARCOMA; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; TUMOR VASCULARIZATION;

ANIMALS; CELL LINE; CELL LINE, TUMOR; CELL MOVEMENT; FEMALE; FIBROBLAST GROWTH FACTOR 2; HUMANS; IMMUNOBLOTTING; MICE; MOLECULAR STRUCTURE; NEOVASCULARIZATION, PHYSIOLOGIC; POLYGALA; SAPONINS; TRITERPENES; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 78651388092     PISSN: 13403443     EISSN: 18610293     Source Type: Journal    
DOI: 10.1007/s11418-010-0477-7     Document Type: Article

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