Pig models of neurodegenerative disorders: Utilization in cell replacement-based preclinical safety and efficacy studies

Journal of Comparative Neurology

Volumn 522, Issue 12, 2014, Pages 2784-2801

  Dolezalova, Dasa ^a   Hruska Plochan, Marian ^a   Bjarkam, Carsten R ^b,c   Sørensen, Jens Christian H ^d   Cunningham, Miles ^e   Weingarten, David ^f   Ciacci, Joseph D ^f   Juhas, Stefan ^g   Juhasova, Jana ^g   Motlik, Jan ^g   Hefferan, Michael P ^h   Hazel, Tom ^h   Johe, Karl ^h   Carromeu, Cassiano ⁱ   Muotri, Alysson ⁱ   Bui, Jack ^j   Strnadel, Jan ^j   Marsala, Martin ^a,k  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b AALBORG UNIVERSITY HOSPITAL   (Denmark)

^c AARHUS UNIVERSITY   (Denmark)

^d AARHUS UNIVERSITY HOSPITAL   (Denmark)

^e HARVARD MEDICAL SCHOOL   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g INSTITUTE OF ANIMAL PHYSIOLOGY AND GENETICS   (Czech Republic)

^h Neuralstem Inc   (United States)

ⁱ UNIVERSITY OF CALIFORNIA   (United States)

^j UNIVERSITY OF CALIFORNIA   (United States)

^k INSTITUTE OF CHEMISTRY   (Slovakia)

more..

Author keywords

Cell replacement therapy; Neural precursors; Neurodegenerative models; Pig; Stem cells

Indexed keywords

ALLOGENEIC STEM CELL TRANSPLANTATION; ALZHEIMER DISEASE; AUTOLOGOUS STEM CELL TRANSPLANTATION; BRAIN DECOMPRESSION; BRAIN ISCHEMIA; CELL REPLACEMENT; CLINICAL EFFECTIVENESS; DEGENERATIVE DISEASE; DISEASE MODEL; DOSE CALCULATION; EMBRYONIC STEM CELL; FETAL STEM CELL; HISTOCOMPATIBILITY; HUMAN; HUNTINGTON CHOREA; IMMUNOLOGICAL TOLERANCE; IMMUNOSUPPRESSIVE TREATMENT; MINIPIG; NEURAL STEM CELL; NONHUMAN; OUTCOME ASSESSMENT; PARKINSON DISEASE; PATIENT SAFETY; PLURIPOTENT STEM CELL; RETINITIS PIGMENTOSA; REVIEW; SPINAL CORD ISCHEMIA; SPINAL MUSCULAR ATROPHY; SPINE INJURY; STEM CELL TRANSPLANTATION; SWINE; TRANSGENIC PIG; TRAUMATIC BRAIN INJURY; ANIMAL; BIOLOGICAL THERAPY; NEURODEGENERATIVE DISEASES; PROCEDURES;

ANIMALS; CELL- AND TISSUE-BASED THERAPY; DISEASE MODELS, ANIMAL; HUMANS; NEURODEGENERATIVE DISEASES; SWINE;

EID: 84912051121     PISSN: 00219967     EISSN: 10969861     Source Type: Journal    
DOI: 10.1002/cne.23575     Document Type: Review

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