Studies of isolated global brain ischaemia: I. A new large animal model of global brain ischaemia and its baseline perfusion studies

European Journal of Cardio-thoracic Surgery

Volumn 41, Issue 5, 2012, Pages 1138-1146

  Allen, Bradley S ^a   Ko, Yoshihiro ^b   Buckberg, Gerald D ^a   Sakhai, Sean ^a   Tan, Zhong ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Brain death; Brain ischaemia; Global brain ischaemic model; New model; Reperfusion injury; Sudden death

Indexed keywords

TRIPHENYLTETRAZOLIUM; OXYGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN DEATH; BRAIN EDEMA; BRAIN INFARCTION; BRAIN ISCHEMIA; BRAIN PERFUSION; CAROTID ARTERY; CONTROLLED STUDY; FLOW RATE; GLOBAL BRAIN ISCHEMIA; HEART FUNCTION; INCISION; LUNG FUNCTION; NEUROLOGIC DISEASE; NONHUMAN; OXIMETER; OXYGEN CONSUMPTION; OXYGEN SATURATION; PERFUSION PRESSURE; PRIORITY JOURNAL; REPERFUSION; SEIZURE; SHAM PROCEDURE; VERTEBRAL ARTERY; ANIMAL; BLOOD; BRAIN CIRCULATION; DISEASE MODEL; HEMODYNAMICS; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PHYSIOLOGY; REPERFUSION INJURY; SUDDEN DEATH; SWINE;

ANIMALS; BRAIN EDEMA; BRAIN ISCHEMIA; CEREBROVASCULAR CIRCULATION; DEATH, SUDDEN, CARDIAC; DISEASE MODELS, ANIMAL; HEMODYNAMICS; MAGNETIC RESONANCE IMAGING; OXYGEN; OXYGEN CONSUMPTION; REPERFUSION; REPERFUSION INJURY; SUS SCROFA;

EID: 84863834199     PISSN: 10107940     EISSN: 1873734X     Source Type: Journal    
DOI: 10.1093/ejcts/ezr316     Document Type: Article

References (25)

1. Liakopoulos OJ, Allen BS, Buckberg GD, Hristov N, Tan Z, Villablanca JP et al. Resuscitation after prolonged cardiac arrest: role of cardiopulmonary bypass and systemic hyperkalemia. Ann Thorac Surg 2010;89:1972-9.
2. Allen BS, Buckberg GD. Studies of isolated global brain ischaemia: I. Overview of irreversible brain injury and evolution of a new concept - redefining the time of brain death. Eur J Cardiothorc Surg 2012;41: 1132-7.
3. Boyle EM Jr, Pohlman TH, Cornejo CJ, Verrier ED. Endothelial cell injury in cardiovascular surgery: ischemia-reperfusion. Ann Thorac Surg 1996; 62:1868-75.
4. Allen BS. Pediatric myocardial protection: a cardioplegic strategy is the 'solution'. Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2004;7: 141-54.
5. Trummer G, Foerster K, Buckberg GD, Benk C, Heilmann C, Mader I. Successful resuscitation after prolonged periods of cardiac arrest: a new field in cardiac surgery. J Thorac Cardiovasc Surg 2010;139:1325-32.
6. Oltean M, Mera S, Olofsson R, Zhu C, Blomgren K, Hallberg E et al. Transplantation of preconditioned intestinal grafts is associated with lower inflammatory activation and remote organ injury in rats. Transplant Proc 2006;38:1775-8.
7. Husted TL, Lentsch AB. The role of cytokines in pharmacological modulation of hepatic ischemia/reperfusion injury. Curr Pharm Des 2006;12: 2867-73.
8. Allen BS, Veluz JS, Buckberg GD, Aeberhard E, Ignarro LJ. Deep hypothermic circulatory arrest and global reperfusion injury: avoidance by making a pump prime reperfusate-a new concept. J Thorac Cardiovasc Surg 2003;125:625-32.
9. Allen BS, Castella M, Buckberg GD, Tan Z. Conditioned blood reperfusion markedly enhances neurologic recovery after prolonged cerebral ischemia. J Thorac Cardiovasc Surg 2003;126:1851-8.
10. Lind NM, Moustgaard A, Jelsing J, Vajta G, Cumming P, Hansen AK. The use of pigs in neuroscience: modeling brain disorders. Neurosci Biobehav Rev 2007;31:728-51.
11. Traystman RJ. Animal models of focal and global cerebral ischemia. ILAR J 2003;44:85-95.
12. Allen BS, Ko Y, Buckberg GD, Sakhai S, Tan Z. Studies of isolated global brain ischaemia: II. Controlled reperfusion provides complete neurologic recovery following 30 min of warm ischaemia - the importance of perfusion pressure. Eur J Cardiothorac Surg 2012;41:1147-54.
13. Halldorsson AO, Kronon MT, Allen BS, Rahman S, Wang T. Lowering reperfusion pressure reduces the injury after pulmonary ischemia. Ann Thorac Surg 2000;69:198-203.
14. Kronon M, Bolling KS, Allen BS, Halldorsson AO, Wang T, Rahman S. The importance of cardioplegic infusion pressure in neonatal myocardial protection. Ann Thorac Surg 1998;66:1358-64.
15. Murkin JM, Arango M. Near-infrared spectroscopy as an index of brain and tissue oxygenation. Br J Anaesth 2009;103(Suppl 1):i3-i13.
16. Tobias JD. Cerebral oxygenation monitoring: near-infrared spectroscopy. Expert Rev Med Devices 2006;3:235-43
17. Allen BS, Okamoto F, Buckberg GD, Leaf J, Bugyi H. Effects of 'duration' of reperfusate administration versus reperfusate 'dose' on regional functional, biochemical, and histochemical recovery. J Thorac Cardiovasc Surg 1986;92:594-604.
18. Sack WO. Essentials of pig anatomy. In Sack WO (ed). Pig Anatomy and Atlas. Ithaca, NY: Veterinary Textbooks, 1982.
19. Gilber SG. Pictorial Anatomy of the Fetal Pig, 2nd edn. Seattle: University of Washington Press, 1963.
20. Wingerd BD. Pig Anatomy and Dissection Guide, 1st edn. St. Paul, MN: Bluedoor Publishing, LLC, 2006.
21. Miller JS. Fetal Pig Dissection Guide, 3rd edn. Goshen, IN: Goshen College, Department of Biology, 1997.
22. Gourley JK, Heistad DD. Characteristics of reactive hyperemia in the cerebral circulation. Am J Physiol 1984;246:H52-8.
23. Nordstrom CH, Siesjo BK. Effects of phenobarbital in cerebral ischemia. Part I: cerebral energy metabolism during pronounced incomplete ischemia. Stroke 1978;9:327-35.
24. Carrascal Y, Guerrero AL. Neurological damage related to cardiac surgery: pathophysiology, diagnostic tools and prevention strategies. Using actual knowledge for planning the future. Neurologist 2010;16: 152-64.
25. Funder KS, Steinmetz J, Rasmussen LS. Cognitive dysfunction after cardiovascular surgery. Minerva Anestesiol 2009;75:329-32.