Inhibition of Akt Phosphorylation Diminishes Mitochondrial Biogenesis Regulators, Tricarboxylic Acid Cycle Activity and Exacerbates Recognition Memory Deficit in Rat Model of Alzheimer’s Disease

Cellular and Molecular Neurobiology

Volumn 34, Issue 8, 2014, Pages 1223-1233

  Shaerzadeh, Fatemeh ^a   Motamedi, Fereshteh ^a   Khodagholi, Fariba ^a  

^a SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

3 MA; Akt; Alzheimer s disease; Mitochondrial biogenesis

Indexed keywords

ACONITATE HYDRATASE; CITRATE SYNTHASE; CYTOCHROME C; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MALATE DEHYDROGENASE; MITOCHONDRIAL TRANSCRIPTION FACTOR A; NUCLEAR RESPIRATORY FACTOR 1; OXOGLUTARATE DEHYDROGENASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PROTEIN KINASE B; 3-METHYLADENINE; ADENINE; AMYLOID BETA PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; PYRUVATE DEHYDROGENASE COMPLEX;

ALZHEIMER DISEASE; AMNESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOGENESIS; CELL PROLIFERATION; CELL SURVIVAL; CITRIC ACID CYCLE; CONTROLLED STUDY; DECARBOXYLATION; ENERGY YIELD; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GLYCOLYSIS; HIPPOCAMPUS; MALE; NERVOUS SYSTEM; NONHUMAN; RAT; RECOGNITION; SPATIAL MEMORY; STEREOTAXIC SURGERY; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; COMPLICATION; DISEASE MODEL; DOWN REGULATION; DRUG EFFECTS; ENZYMOLOGY; EXPLORATORY BEHAVIOR; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; MEMORY DISORDER; METABOLISM; MITOCHONDRION; PATHOLOGY; PATHOPHYSIOLOGY; PERCEPTIVE DISCRIMINATION; PHOSPHORYLATION; WISTAR RAT;

RATTUS;

ADENINE; ALZHEIMER DISEASE; AMP-ACTIVATED PROTEIN KINASES; AMYLOID BETA-PEPTIDES; ANIMALS; CITRIC ACID CYCLE; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DISCRIMINATION (PSYCHOLOGY); DISEASE MODELS, ANIMAL; DOWN-REGULATION; EXPLORATORY BEHAVIOR; HIPPOCAMPUS; INJECTIONS, INTRAVENTRICULAR; MALE; MEMORY DISORDERS; MITOCHONDRIA; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; PYRUVATE DEHYDROGENASE COMPLEX; RATS, WISTAR; RECOGNITION (PSYCHOLOGY);

EID: 84912047990     PISSN: 02724340     EISSN: 15736830     Source Type: Journal    
DOI: 10.1007/s10571-014-0099-9     Document Type: Article

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