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Volumn 60, Issue 6, 2014, Pages 1942-1956

Saturated free fatty acids induce cholangiocyte lipoapoptosis

Author keywords

[No Author keywords available]

Indexed keywords

BH3 PROTEIN; CASPASE 3; CASPASE 7; PALMITIC ACID; PUMA PROTEIN; SATURATED FATTY ACID; STEARIC ACID; TRANSCRIPTION FACTOR 3; APOPTOSIS REGULATORY PROTEIN; BBC3 PROTEIN, HUMAN; CASPASE; FATTY ACID; FORKHEAD TRANSCRIPTION FACTOR; FOXO3 PROTEIN, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE; ONCOPROTEIN; PALMITIC ACID DERIVATIVE;

EID: 84912047771     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.27175     Document Type: Article
Times cited : (42)

References (40)
  • 1
  • 2
    • 20844448737 scopus 로고    scopus 로고
    • A clinical-morphological study on cholestatic presentation of nonalcoholic fatty liver disease
    • Sorrentino P, Tarantino G, Perrella A, Micheli P, Perrella O, Conca P. A clinical-morphological study on cholestatic presentation of nonalcoholic fatty liver disease. Dig Dis Sci 2005;50:1130-1135.
    • (2005) Dig Dis Sci , vol.50 , pp. 1130-1135
    • Sorrentino, P.1    Tarantino, G.2    Perrella, A.3    Micheli, P.4    Perrella, O.5    Conca, P.6
  • 3
    • 79959330628 scopus 로고    scopus 로고
    • Participation of bile ductular cells in the pathological progression of non-alcoholic fatty liver disease
    • Chiba M, Sasaki M, Kitamura S, Ikeda H, Sato Y, Nakanuma Y. Participation of bile ductular cells in the pathological progression of non-alcoholic fatty liver disease. J Clin Pathol 2011;64:564-570.
    • (2011) J Clin Pathol , vol.64 , pp. 564-570
    • Chiba, M.1    Sasaki, M.2    Kitamura, S.3    Ikeda, H.4    Sato, Y.5    Nakanuma, Y.6
  • 4
    • 33744948514 scopus 로고    scopus 로고
    • Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis
    • Malhi H, Bronk SF, Werneburg NW, Gores GJ. Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis. J Biol Chem 2006;281:12093-12101.
    • (2006) J Biol Chem , vol.281 , pp. 12093-12101
    • Malhi, H.1    Bronk, S.F.2    Werneburg, N.W.3    Gores, G.J.4
  • 5
    • 33846208251 scopus 로고    scopus 로고
    • Mitogen-activated protein kinases, Erk and p38, phosphorylate and regulate Foxo1
    • Asada S, Daitoku H, Matsuzaki H, Saito T, Sudo T, Mukai H, et al. Mitogen-activated protein kinases, Erk and p38, phosphorylate and regulate Foxo1. Cell Signal 2007;19:519-527.
    • (2007) Cell Signal , vol.19 , pp. 519-527
    • Asada, S.1    Daitoku, H.2    Matsuzaki, H.3    Saito, T.4    Sudo, T.5    Mukai, H.6
  • 6
    • 84855496023 scopus 로고    scopus 로고
    • Phosphorylation of FOXO3a on Ser-7 by p38 promotes its nuclear localization in response to doxorubicin
    • Ho KK, McGuire VA, Koo CY, Muir KW, de Olano N, Maifoshie E, et al. Phosphorylation of FOXO3a on Ser-7 by p38 promotes its nuclear localization in response to doxorubicin. J Biol Chem 2012;287:1545-1555.
    • (2012) J Biol Chem , vol.287 , pp. 1545-1555
    • Ho, K.K.1    McGuire, V.A.2    Koo, C.Y.3    Muir, K.W.4    de Olano, N.5    Maifoshie, E.6
  • 8
    • 83755224665 scopus 로고    scopus 로고
    • Myc and PI3K/AKT signaling cooperatively repress FOXO3a-dependent PUMA and GADD45a gene expression
    • Amente S, Zhang J, Lavadera ML, Lania L, Avvedimento EV, Majello B. Myc and PI3K/AKT signaling cooperatively repress FOXO3a-dependent PUMA and GADD45a gene expression. Nucleic Acids Res 2011;39:9498-9507.
    • (2011) Nucleic Acids Res , vol.39 , pp. 9498-9507
    • Amente, S.1    Zhang, J.2    Lavadera, M.L.3    Lania, L.4    Avvedimento, E.V.5    Majello, B.6
  • 10
    • 84865568697 scopus 로고    scopus 로고
    • Activation of SIRT1 protects pancreatic beta-cells against palmitate-induced dysfunction
    • Wu L, Zhou L, Lu Y, Zhang J, Jian F, Liu Y, et al. Activation of SIRT1 protects pancreatic beta-cells against palmitate-induced dysfunction. Biochim Biophys Acta 2012;1822:1815-1825.
    • (2012) Biochim Biophys Acta , vol.1822 , pp. 1815-1825
    • Wu, L.1    Zhou, L.2    Lu, Y.3    Zhang, J.4    Jian, F.5    Liu, Y.6
  • 12
    • 42249110859 scopus 로고    scopus 로고
    • A novel "patient-like" model of cholangiocarcinoma progression based on bile duct inoculation of tumorigenic rat cholangiocyte cell lines
    • Sirica AE, Zhang Z, Lai GH, Asano T, Shen XN, Ward DJ, et al. A novel "patient-like" model of cholangiocarcinoma progression based on bile duct inoculation of tumorigenic rat cholangiocyte cell lines. Hepatology 2008;47:1178-1190.
    • (2008) Hepatology , vol.47 , pp. 1178-1190
    • Sirica, A.E.1    Zhang, Z.2    Lai, G.H.3    Asano, T.4    Shen, X.N.5    Ward, D.J.6
  • 13
    • 0027408634 scopus 로고
    • Cell-free activation of a DNA-binding protein by epidermal growth factor
    • Sadowski HB, Gilman MZ. Cell-free activation of a DNA-binding protein by epidermal growth factor. Nature 1993;362:79-83.
    • (1993) Nature , vol.362 , pp. 79-83
    • Sadowski, H.B.1    Gilman, M.Z.2
  • 15
    • 0034755341 scopus 로고    scopus 로고
    • Nutritional and metabolic considerations in the etiology of nonalcoholic steatohepatitis
    • Nehra V, Angulo P, Buchman AL, Lindor KD. Nutritional and metabolic considerations in the etiology of nonalcoholic steatohepatitis. Dig Dis Sci 2001;46:2347-2352.
    • (2001) Dig Dis Sci , vol.46 , pp. 2347-2352
    • Nehra, V.1    Angulo, P.2    Buchman, A.L.3    Lindor, K.D.4
  • 16
    • 79959755613 scopus 로고    scopus 로고
    • Apoptosis and insulin resistance in liver and peripheral tissues of morbidly obese patients is associated with different stages of non-alcoholic fatty liver disease
    • Ferreira DM, Castro RE, Machado MV, Evangelista T, Silvestre A, Costa A, et al. Apoptosis and insulin resistance in liver and peripheral tissues of morbidly obese patients is associated with different stages of non-alcoholic fatty liver disease. Diabetologia 2011;54:1788-1798.
    • (2011) Diabetologia , vol.54 , pp. 1788-1798
    • Ferreira, D.M.1    Castro, R.E.2    Machado, M.V.3    Evangelista, T.4    Silvestre, A.5    Costa, A.6
  • 18
    • 84864376260 scopus 로고    scopus 로고
    • Up-regulation of microRNA 506 leads to decreased Cl-/HCO3- anion exchanger 2 expression in biliary epithelium of patients with primary biliary cirrhosis
    • Banales JM, Saez E, Uriz M, Sarvide S, Urribarri AD, Splinter P, et al. Up-regulation of microRNA 506 leads to decreased Cl-/HCO3- anion exchanger 2 expression in biliary epithelium of patients with primary biliary cirrhosis. Hepatology 2012;56:687-697.
    • (2012) Hepatology , vol.56 , pp. 687-697
    • Banales, J.M.1    Saez, E.2    Uriz, M.3    Sarvide, S.4    Urribarri, A.D.5    Splinter, P.6
  • 19
    • 70549106259 scopus 로고    scopus 로고
    • Compensatory role of inducible annexin A2 for impaired biliary epithelial anion-exchange activity of inflammatory cholangiopathy
    • Kido O, Fukushima K, Ueno Y, Inoue J, Jefferson DM, Shimosegawa T. Compensatory role of inducible annexin A2 for impaired biliary epithelial anion-exchange activity of inflammatory cholangiopathy. Lab Invest 2009;89:1374-1386.
    • (2009) Lab Invest , vol.89 , pp. 1374-1386
    • Kido, O.1    Fukushima, K.2    Ueno, Y.3    Inoue, J.4    Jefferson, D.M.5    Shimosegawa, T.6
  • 20
    • 79959724636 scopus 로고    scopus 로고
    • Anandamide exerts its antiproliferative actions on cholangiocarcinoma by activation of the GPR55 receptor
    • Huang L, Ramirez JC, Frampton GA, Golden LE, Quinn MA, Pae HY, et al. Anandamide exerts its antiproliferative actions on cholangiocarcinoma by activation of the GPR55 receptor. Lab Invest 2011;91:1007-1017.
    • (2011) Lab Invest , vol.91 , pp. 1007-1017
    • Huang, L.1    Ramirez, J.C.2    Frampton, G.A.3    Golden, L.E.4    Quinn, M.A.5    Pae, H.Y.6
  • 21
    • 78649495824 scopus 로고    scopus 로고
    • Primary and malignant cholangiocytes undergo CD40 mediated Fas dependent apoptosis, but are insensitive to direct activation with exogenous Fas ligand
    • Humphreys EH, Williams KT, Adams DH, Afford SC. Primary and malignant cholangiocytes undergo CD40 mediated Fas dependent apoptosis, but are insensitive to direct activation with exogenous Fas ligand. PLoS One 2010;5:e14037.
    • (2010) PLoS One , vol.5
    • Humphreys, E.H.1    Williams, K.T.2    Adams, D.H.3    Afford, S.C.4
  • 22
    • 79959550724 scopus 로고    scopus 로고
    • Deficiency of liver adipose triglyceride lipase in mice causes progressive hepatic steatosis
    • Wu JW, Wang SP, Alvarez F, Casavant S, Gauthier N, Abed L, et al. Deficiency of liver adipose triglyceride lipase in mice causes progressive hepatic steatosis. Hepatology 2011;54:122-132.
    • (2011) Hepatology , vol.54 , pp. 122-132
    • Wu, J.W.1    Wang, S.P.2    Alvarez, F.3    Casavant, S.4    Gauthier, N.5    Abed, L.6
  • 23
    • 84874596974 scopus 로고    scopus 로고
    • Caspase-2 and JNK activated by saturated fatty acids are not involved in apoptosis induction but modulate ER stress in human pancreatic beta-cells
    • Nemcova-Furstova V, Balusikova K, Sramek J, James RF, Kovar J. Caspase-2 and JNK activated by saturated fatty acids are not involved in apoptosis induction but modulate ER stress in human pancreatic beta-cells. Cell Physiol Biochem 2013;31:277-289.
    • (2013) Cell Physiol Biochem , vol.31 , pp. 277-289
    • Nemcova-Furstova, V.1    Balusikova, K.2    Sramek, J.3    James, R.F.4    Kovar, J.5
  • 24
    • 78650852744 scopus 로고    scopus 로고
    • NADPH oxidase 2-derived reactive oxygen species mediate FFAs-induced dysfunction and apoptosis of beta-cells via JNK, p38 MAPK and p53 pathways
    • Yuan H, Zhang X, Huang X, Lu Y, Tang W, Man Y, et al. NADPH oxidase 2-derived reactive oxygen species mediate FFAs-induced dysfunction and apoptosis of beta-cells via JNK, p38 MAPK and p53 pathways. PLoS One 2010;5:e15726.
    • (2010) PLoS One , vol.5
    • Yuan, H.1    Zhang, X.2    Huang, X.3    Lu, Y.4    Tang, W.5    Man, Y.6
  • 25
    • 77249148003 scopus 로고    scopus 로고
    • Ginsenoside Rg3 suppresses palmitate-induced apoptosis in MIN6N8 pancreatic beta-cells
    • Kim K, Park M, Young Kim H. Ginsenoside Rg3 suppresses palmitate-induced apoptosis in MIN6N8 pancreatic beta-cells. J Clin Biochem Nutr 2010;46:30-35.
    • (2010) J Clin Biochem Nutr , vol.46 , pp. 30-35
    • Kim, K.1    Park, M.2    Young Kim, H.3
  • 26
    • 38849139580 scopus 로고    scopus 로고
    • ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation
    • Yang JY, Zong CS, Xia W, Yamaguchi H, Ding Q, Xie X, et al. ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation. Nat Cell Biol 2008;10:138-148.
    • (2008) Nat Cell Biol , vol.10 , pp. 138-148
    • Yang, J.Y.1    Zong, C.S.2    Xia, W.3    Yamaguchi, H.4    Ding, Q.5    Xie, X.6
  • 27
    • 24344453386 scopus 로고    scopus 로고
    • Identification of a selective ERK inhibitor and structural determination of the inhibitor-ERK2 complex
    • Ohori M, Kinoshita T, Okubo M, Sato K, Yamazaki A, Arakawa H, et al. Identification of a selective ERK inhibitor and structural determination of the inhibitor-ERK2 complex. Biochem Biophys Res Commun 2005;336:357-363.
    • (2005) Biochem Biophys Res Commun , vol.336 , pp. 357-363
    • Ohori, M.1    Kinoshita, T.2    Okubo, M.3    Sato, K.4    Yamazaki, A.5    Arakawa, H.6
  • 28
    • 84930484351 scopus 로고    scopus 로고
    • Role of apoptosis-inducing factor, proline dehydrogenase, and NADPH oxidase in apoptosis and oxidative stress
    • 2012:-.
    • Natarajan SK, Becker DF. Role of apoptosis-inducing factor, proline dehydrogenase, and NADPH oxidase in apoptosis and oxidative stress. Cell Health Cytoskelet 2012;2012:11-27.
    • (2012) Cell Health Cytoskelet , pp. 11-27
    • Natarajan, S.K.1    Becker, D.F.2
  • 29
    • 84865464816 scopus 로고    scopus 로고
    • Proline dehydrogenase is essential for proline protection against hydrogen peroxide-induced cell death
    • Natarajan SK, Zhu W, Liang X, Zhang L, Demers AJ, Zimmerman MC, et al. Proline dehydrogenase is essential for proline protection against hydrogen peroxide-induced cell death. Free Radic Biol Med 2012;53:1181-1191.
    • (2012) Free Radic Biol Med , vol.53 , pp. 1181-1191
    • Natarajan, S.K.1    Zhu, W.2    Liang, X.3    Zhang, L.4    Demers, A.J.5    Zimmerman, M.C.6
  • 30
    • 12144290563 scopus 로고    scopus 로고
    • Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
    • Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, Lin Y, et al. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 2004;303:2011-2015.
    • (2004) Science , vol.303 , pp. 2011-2015
    • Brunet, A.1    Sweeney, L.B.2    Sturgill, J.F.3    Chua, K.F.4    Greer, P.L.5    Lin, Y.6
  • 31
    • 63249112836 scopus 로고    scopus 로고
    • Overexpression of SIRT1 protects pancreatic beta-cells against cytokine toxicity by suppressing the nuclear factor-kappaB signaling pathway
    • Lee JH, Song MY, Song EK, Kim EK, Moon WS, Han MK, et al. Overexpression of SIRT1 protects pancreatic beta-cells against cytokine toxicity by suppressing the nuclear factor-kappaB signaling pathway. Diabetes 2009;58:344-351.
    • (2009) Diabetes , vol.58 , pp. 344-351
    • Lee, J.H.1    Song, M.Y.2    Song, E.K.3    Kim, E.K.4    Moon, W.S.5    Han, M.K.6
  • 32
    • 65549122964 scopus 로고    scopus 로고
    • Acetylation of FoxO1 activates Bim expression to induce apoptosis in response to histone deacetylase inhibitor depsipeptide treatment
    • Yang Y, Zhao Y, Liao W, Yang J, Wu L, Zheng Z, et al. Acetylation of FoxO1 activates Bim expression to induce apoptosis in response to histone deacetylase inhibitor depsipeptide treatment. Neoplasia 2009;11:313-324.
    • (2009) Neoplasia , vol.11 , pp. 313-324
    • Yang, Y.1    Zhao, Y.2    Liao, W.3    Yang, J.4    Wu, L.5    Zheng, Z.6
  • 34
    • 0346055106 scopus 로고    scopus 로고
    • Red oil A5 inhibits proliferation and induces apoptosis in pancreatic cancer cells
    • Dong ML, Ding XZ, Adrian TE. Red oil A5 inhibits proliferation and induces apoptosis in pancreatic cancer cells. World J Gastroenterol 2004;10:105-111.
    • (2004) World J Gastroenterol , vol.10 , pp. 105-111
    • Dong, M.L.1    Ding, X.Z.2    Adrian, T.E.3
  • 36
    • 77955690182 scopus 로고    scopus 로고
    • Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: the central role of nontriglyceride fatty acid metabolites
    • Neuschwander-Tetri BA. Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: the central role of nontriglyceride fatty acid metabolites. Hepatology 2010;52:774-788.
    • (2010) Hepatology , vol.52 , pp. 774-788
    • Neuschwander-Tetri, B.A.1
  • 37
    • 34250356015 scopus 로고    scopus 로고
    • Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis
    • Yamaguchi K, Yang L, McCall S, Huang J, Yu XX, Pandey SK, et al. Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis. Hepatology 2007;45:1366-1374.
    • (2007) Hepatology , vol.45 , pp. 1366-1374
    • Yamaguchi, K.1    Yang, L.2    McCall, S.3    Huang, J.4    Yu, X.X.5    Pandey, S.K.6
  • 38
  • 39
    • 0037566201 scopus 로고    scopus 로고
    • Clinical and histologic spectrum of nonalcoholic fatty liver disease associated with normal ALT values
    • Mofrad P, Contos MJ, Haque M, Sargeant C, Fisher RA, Luketic VA, et al. Clinical and histologic spectrum of nonalcoholic fatty liver disease associated with normal ALT values. Hepatology 2003;37:1286-1292.
    • (2003) Hepatology , vol.37 , pp. 1286-1292
    • Mofrad, P.1    Contos, M.J.2    Haque, M.3    Sargeant, C.4    Fisher, R.A.5    Luketic, V.A.6


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